Cited by 80Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsCholinesterase and Neurodegenerative Diseases

Masitinib for the treatment of mild to moderate Alzheimer’s disease

Folch, Jaume, Petrov, Dmitry, Ettcheto, Miren, Pedrós, Ignacio, Abad, Sonia, Beas-Zarate, Carlos, Lazarowski, Alberto, Marin, Miguel +3 more·2015·Expert Review of Neurotherapeutics

Abstract

Alzheimer's disease (AD) is a degenerative neurological disorder that is the most common cause of dementia and disability in older patients. Available treatments are symptomatic in nature and are only sufficient to improve the quality of life of AD patients temporarily. A potential strategy, currently under investigation, is to target cell-signaling pathways associated with neurodegeneration, in order to decrease neuroinflammation, excitotoxicity, and to improve cognitive functions. Current review centers on the role of neuroinflammation and the specific contribution of mast cells to AD pathophysiology. The authors look at masitinib therapy and the evidence presented through preclinical and clinical trials. Dual actions of masitinib as an inhibitor of mast cell-glia axis and a Fyn kinase blocker are discussed in the context of AD pathology. Masitinib is in Phase III clinical trials for the treatment of malignant melanoma, mastocytosis, multiple myeloma, gastrointestinal cancer and pancreatic cancer. It is also in Phase II/III clinical trials for the treatment of multiple sclerosis, rheumatoid arthritis and AD. Additional research is warranted to better investigate the potential effects of masitinib in combination with other drugs employed in AD treatment.

Integrity signals

Registry

Crossref · 10.1586/14737175.2015.1045419

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88 of 88 references verified0 citation errors · 0 not checkable

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Authors
Folch, J., Petrov, D., Ettcheto, M., Pedrós, I., Abad, S., Beas-Zarate, C., Lazarowski, A., Marin, M., Olloquequi, J., Auladell, C., & Camins, A.
Affiliations
  • Universitat Rovira i Virgili (ES)
  • Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
  • Universidad de Buenos Aires (AR)
  • Universidad Autónoma de Chile (CL)
  • Universitat de Barcelona (ES)
Corresponding author
Camins, Antoni
Venue
Expert Review of Neurotherapeutics
Published
2015-05-11
Volume
15
Issue
6
Pages
587-596
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
OpenAlex
W2285288278
Cited by
80
References
88
Citations by year
2026: 4 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 1
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
masitinib, Alzheimer's disease, mast cells, neuroinflammation, neurodegeneration, cognitive impairment, mastocytosis, multiple myeloma, clinical trials
MeSH terms
Alzheimer Disease, Animals, Benzamides, Humans, Piperidines, Pyridines, Thiazoles, Proto-Oncogene Proteins c-kit, Protein Kinase Inhibitors

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