Masitinib for the treatment of mild to moderate Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is a degenerative neurological disorder that is the most common cause of dementia and disability in older patients. Available treatments are symptomatic in nature and are only sufficient to improve the quality of life of AD patients temporarily. A potential strategy, currently under investigation, is to target cell-signaling pathways associated with neurodegeneration, in order to decrease neuroinflammation, excitotoxicity, and to improve cognitive functions. Current review centers on the role of neuroinflammation and the specific contribution of mast cells to AD pathophysiology. The authors look at masitinib therapy and the evidence presented through preclinical and clinical trials. Dual actions of masitinib as an inhibitor of mast cell-glia axis and a Fyn kinase blocker are discussed in the context of AD pathology. Masitinib is in Phase III clinical trials for the treatment of malignant melanoma, mastocytosis, multiple myeloma, gastrointestinal cancer and pancreatic cancer. It is also in Phase II/III clinical trials for the treatment of multiple sclerosis, rheumatoid arthritis and AD. Additional research is warranted to better investigate the potential effects of masitinib in combination with other drugs employed in AD treatment.
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Peptide Aβ42 seems to promote mast cell degranulation and a consequent generalized inflammatory response.
“Peptide Aβ42 seems to promote mast cells degranulation and a consequent generalized inflammatory response.73”
From From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology (2021) · cites this paper as [73]
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Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment
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- Authors
- Folch, J., Petrov, D., Ettcheto, M., Pedrós, I., Abad, S., Beas-Zarate, C., Lazarowski, A., Marin, M., Olloquequi, J., Auladell, C., & Camins, A.
- Affiliations
- Universitat Rovira i Virgili (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Universidad de Buenos Aires (AR)
- Universidad Autónoma de Chile (CL)
- Universitat de Barcelona (ES)
- Corresponding author
- Camins, Antoni
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2015-05-11
- Volume
- 15
- Issue
- 6
- Pages
- 587-596
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W2285288278
- Cited by
- 80
- References
- 88
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- masitinib, Alzheimer's disease, mast cells, neuroinflammation, neurodegeneration, cognitive impairment, mastocytosis, multiple myeloma, clinical trials
- MeSH terms
- Alzheimer Disease, Animals, Benzamides, Humans, Piperidines, Pyridines, Thiazoles, Proto-Oncogene Proteins c-kit, Protein Kinase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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