The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine
Open accessAbstract
Uncomplicated urinary tract infections (UTIs) are common, with nearly half of all women experiencing at least one UTI in their lifetime. This high frequency of infection results in huge annual economic costs, decreased workforce productivity and high patient morbidity. At least 80% of these infections are caused by uropathogenic Escherichia coli (UPEC). UPEC can reside side by side with commensal strains in the gastrointestinal tract and gain access to the bladder via colonization of the urethra. Antibiotics represent the current standard treatment for UTI; however, even after treatment, patients frequently suffer from recurrent infection with the same or different strains. In addition, successful long-term treatment has been complicated by a rise in both the number of antibiotic-resistant strains and the prevalence of antibiotic-resistance mechanisms. As a result, preventative approaches to UTI, such as vaccination, have been sought. This review summarizes recent advances in UPEC vaccine development and outlines future directions for the field.
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Garcia, E. C., Brumbaugh, A. R., & Mobley, H. L. T. (2011) · Infection and Immunity · doi:10.1128/iai.01222-10 · Cited by 256
Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection
Alteri, C. J., Hagan, E. C., Sivick, K. E., Smith, S. N., & Mobley, H. L. T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000586 · Cited by 201
Self-citationThe O75X adhesin of uropathogenic Escherichia coli is a type IV collagen‐binding protein
Westerlund, B., Kuusela, P., Risteli, J., Risteli, L., Vartio, T., Rauvala, H., Virkola, R., & Korhonen, T. K. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00178.x · Cited by 142
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Fowler, V. G., & Proctor, R. A. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12570 · Cited by 241
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics
Timm, M. R., Russell, S. K., & Hultgren, S. J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01092-4 · Cited by 190
Nesta, B., Valeri, M., Spagnuolo, A., Rosini, R., Mora, M., Donato, P., Alteri, C. J., Del Vecchio, M., Buccato, S., Pezzicoli, A., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004124 · Cited by 68
Self-citationWhole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection
Garofalo, L., Nakama, C., Hanes, D., & Zwickey, H. (2022) · Antibiotics · doi:10.3390/antibiotics11020218 · Cited by 12
From mucosal infection to successful cancer immunotherapy
Goubet, A.-G., Rouanne, M., Derosa, L., Kroemer, G., & Zitvogel, L. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00784-5 · Cited by 11
Metadata
- Authors
- Brumbaugh, A. R., & Mobley, H. L.
- Venue
- Expert Review of Vaccines
- Publisher
- Informa UK Limited
- Published
- 2012-06
- Volume
- 11
- Issue
- 6
- Pages
- 663-676
- ISSN
- 1476-0584 (ISSN-L)
- 1744-8395
- OpenAlex
- W1988020274
- Cited by
- 202
- References
- 6
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
