CoChat
Sign Up
Cited by 12Urinary Tract Infections ManagementReproductive tract infections researchUrinary Bladder and Prostate Research

Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection

Open access
Garofalo, Luciano, Nakama, Claudia, Hanes, Douglas, Zwickey, Heather·2022·Antibiotics
DOI 10.3390/antibiotics11020218PMC PMC8868435
Open this paper in CoChat — free accountOpen PDF

Abstract

A healthy urinary tract contains a variety of microbes resulting in a diverse urobiome. Urobiome dysbiosis, defined as an imbalance in the microbial composition in the microenvironments along the urinary tract, is found in women with uncomplicated urinary tract infection (UTI). Historically, antibiotics have been used to address UTI. An alternative approach to uncomplicated UTI is warranted as the current paradigm fails to take urobiome dysbiosis into account and contributes to the communal problem of resistance. A whole-person, multi-modal approach that addresses vaginal and urinary tract dysbiosis may be more effective in reducing recurrent UTI. In this review, we discuss strategies that include reducing pathogenic bacteria while supporting commensal urogenital bacteria, encouraging diuresis, maintaining optimal pH levels, and reducing inflammation. Strategies for future research are suggested.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/antibiotics11020218

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 106

  1. [1]Harrabi H. Uncomplicated urinary tract infection N. Engl. J. Med. 2012 367 185 10.1056/NEJMc1205507 22784136 · DOI
  2. [2]Shapiro D.J. Hicks L.A. Pavia A.T. Hersh A.L. Antibiotic prescribing for adults in ambulatory care in the USA, 2007–09 J. Antimicrob. Chemother. 2014 69 234 240 10.1093/jac/dkt301 23887867 · DOI
  3. [3]Malik R.D. Wu Y.R. Zimmern P.E. Definition of Recurrent Urinary Tract Infections in Women: Which One to Adopt? Female Pelvic. Med. Reconstr. Surg. 2018 24 424 429 10.1097/SPV.0000000000000509 29135809 · DOI
  4. [4]Langford B.J. Brown K.A. Diong C. The Benefits and Harms of Antibiotic Prophylaxis for Urinary Tract Infection in Older Adults Clin. Infect. Dis. 2021 73 e782 e791 10.1093/cid/ciab116 33595621 · DOI
  5. [5]Wright S.W. Wrenn K.D. Haynes M.L. Trimethoprim-sulfamethoxazole resistance among urinary coliform isolates J. Gen. Intern. Med. 1999 14 606 609 10.1046/j.1525-1497.1999.10128.x 10571705 PMC1496756 · DOI
  6. [6]Kristiansen J.E. The antimicrobial activity of non-antibiotics. Report from a congress on the antimicrobial effect of drugs other than antibiotics on bacteria, viruses, protozoa, and other organisms APMIS Suppl. 1992 30 7 14 1295545
  7. [7]Gupta K. Hooton T.M. Naber K.G. Wult B. Colgan R. Miller L. G. Moran G.J. Nicolla L.E. Raz R. Schaeffer A.J. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases Clin. Infect. Dis. 2011 52 e103 e120 10.1093/cid/ciq257 21292654 · DOI · Paper page
  8. [8]Bryce A. Hay A.D. Lane I.F. Thornton H.V. Wootton M. Costelloe C. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: Systematic review and meta-analysis BMJ 2016 352 i939 10.1136/bmj.i939 26980184 PMC4793155 · DOI
  9. [9]Sanchez G.V. Master R.N. Karlowsky J.A. Bordon J.M. In vitro antimicrobial resistance of urinary Escherichia coli isolates among U.S. outpatients from 2000 to 2010 Antimicrob. Agents Chemother. 2012 56 2181 2183 10.1128/AAC.06060-11 22252813 PMC3318377 · DOI
  10. [10]Dalhoff A. Resistance surveillance studies: A multifaceted problem—the fluoroquinolone example Infection 2012 40 239 262 10.1007/s15010-012-0257-2 22460782 · DOI
  11. [11]Deshpande A. Pasupuleti V. Thota P. Pant C. Rolston D.K. Sferra T.J. Hernadez A.V. Donskey C.J. Community-associated Clostridium difficile infection and antibiotics: A meta-analysis J. Antimicrob. Chemother. 2013 68 1951 1961 10.1093/jac/dkt129 23620467 · DOI
  12. [13]Simmering J.E. Tang F. Cavanaugh J.E. Polgreen L.A. Polgreen P.M. The Increase in Hospitalizations for Urinary Tract Infections and the Associated Costs in the United States, 1998-2011 Open Forum Infect. Dis. 2017 4 ofw281 10.1093/ofid/ofw281 28480273 PMC5414046 · DOI
  13. [14]Gupta K. Hooton T.M. Roberts P.L. Stamm W.E. Patient-initiated treatment of uncomplicated recurrent urinary tract infections in young women Ann. Intern. Med. 2001 135 9 16 10.7326/0003-4819-135-1-200107030-00004 11434727 · DOI
  14. [15]Wiley Z. Jacob J.T. Burd E.M. Targeting Asymptomatic Bacteriuria in Antimicrobial Stewardship: The Role of the Microbiology Laboratory J. Clin. Microbiol. 2020 58 e00518-18 10.1128/JCM.00518-18 32051261 PMC7180236 · DOI
  15. [16]Nicolle L.E. Gupta K. Bradley S.F. Colgan R. DeMuri G.P. Drekonja D. Eckert L.O. Geerlings S.E. Koves B. Hooton T.M. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America Clin. Infect. Dis. 2019 68 e83 e110 10.1093/cid/ciz021 30895288 · DOI
  16. [17]Hagberg L. Engberg I. Freter R. Lam J. Olling S. Svanborg Eden C. Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin Infect. Immun. 1983 40 273 283 10.1128/iai.40.1.273-283.1983 6339403 PMC264845 · DOI
  17. [18]Svanborg Edén C. Hagberg L. Leffler H. Lomberg H. Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection Infection 1982 10 327 332 10.1007/BF01640890 6129198 · DOI
  18. [19]Storme O. Tirán Saucedo J. Garcia-Mora A. Dehesa-Dávila M. Naber K.G. Risk factors and predisposing conditions for urinary tract infection Ther. Adv. Urol. 2019 11 1756287218814382 10.1177/1756287218814382 31105772 PMC6502981 · DOI
  19. [20]Sabih A. Leslie S.W. Complicated Urinary Tract Infections StatPearls StatPearls Publishing Treasure Island, FL, USA 2022 Available online: https://www-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/books/NBK436013/ (accessed on 12 August 2021) 28613784
  20. [21]Leue C. Kruimel J. Vrijens D. Masclee A. van Os J. van Koeveringe G. Functional urological disorders: A sensitized defence response in the bladder-gut-brain axis Nat. Rev. Urol. 2017 14 153 163 10.1038/nrurol.2016.227 27922040 · DOI · Paper page
  21. [22]Markowitz M.A. Wood L.N. Raz S. Miller L.G. Haake D.A. Kim J.H. Lack of uniformity among United States recommendations for diagnosis and management of acute, uncomplicated cystitis Int. Urogynecol. J. 2019 30 1187 1194 10.1007/s00192-018-3750-z 30099566 · DOI
  22. [23]Jung C. Brubaker L. The etiology and management of recurrent urinary tract infections in postmenopausal women Climacteric 2019 22 242 249 10.1080/13697137.2018.1551871 30624087 PMC6629580 · DOI · Paper page
  23. [24]Cortes-Penfield N.W. Trautner B.W. Jump R.L.P. Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults Infect. Dis. Clin. N. Am. 2017 31 673 688 10.1016/j.idc.2017.07.002 29079155 PMC5802407 · DOI
  24. [25]Köves B. Wullt B. The Roles of the Host and the Pathogens in Urinary Tract Infections Eur. Urol. Suppl. 2016 15 88 94 10.1016/j.eursup.2016.04.005 · DOI
  25. [26]Wu J. Hayes B.W. Phoenix C. Macias G.S. Miao Y. Choi H.W. Hughes Jr. F.M. Purves J.T. Reinhardt R.L. Abraham S.N. A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections Nat. Immunol. 2020 21 671 683 10.1038/s41590-020-0688-3 32424366 PMC7480508 · DOI
  26. [27]Hilt E.E. McKinley K. Pearce M.M. Rosenfeld A.B. Zilliox M.J. Mueller E.R. Brubaker L. Gai X. Wolfe A.J. Schreckenberger P.C. Urine is not sterile: Use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder J. Clin. Microbiol. 2014 52 871 876 10.1128/JCM.02876-13 24371246 PMC3957746 · DOI
  27. [28]Pearce M.M. Hilt E.E. Rosenfeld A.B. Zilliox M.J. Thomas-White K. Fok C. Kliethermes S. Schreckenberger P.C. Brubaker L. Gai X. The female urinary microbiome: A comparison of women with and without urgency urinary incontinence mBio 2014 5 e01283-14 10.1128/mBio.01283-14 25006228 PMC4161260 · DOI
  28. [29]O’Brien V.P. Hannan T.J. Yu L. Livny J. Roberson E.D.O. Schwartz D.J. Souza S. Mendelsohn C.L. Colonna M. Lewis A.L. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease Nat. Microbiol. 2016 2 16196 10.1038/nmicrobiol.2016.196 27798558 PMC5308540 · DOI
  29. [30]Whiteside S.A. Razvi H. Dave S. Reid G. Burton J.P. The microbiome of the urinary tract—a role beyond infection Nat. Rev. Urol. 2015 12 81 90 10.1038/nrurol.2014.361 25600098 · DOI
  30. [31]Ursell L.K. Metcalf J.L. Parfrey L.W. Knight R. Defining the human microbiome Nutr. Rev. 2012 70 (Suppl. 1) S38 S44 10.1111/j.1753-4887.2012.00493.x 22861806 PMC3426293 · DOI · Paper page
  31. [32]Goneau L.W. Yeoh N.S. MacDonald K.W. Cadieux P.A. Burton J.P. Razvi H. Reid G. Selective target inactivation rather than global metabolic dormancy causes antibiotic tolerance in uropathogens Antimicrob. Agents Chemother. 2014 58 2089 2097 10.1128/AAC.02552-13 24449771 PMC4023725 · DOI
  32. [33]Waller T.A. Pantin S.A.L. Yenior A.L. Pujalte G.G.A. Urinary Tract Infection Antibiotic Resistance in the United States Prim. Care 2018 45 455 466 10.1016/j.pop.2018.05.005 30115334 · DOI
  33. [34]Meštrović T. Matijašić M. Perić M. Paljetak H.C. Barešić A. Verbanac D. The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside Diagnostics 2020 11 7 10.3390/diagnostics11010007 PMC7822161 33375202 · DOI
  34. [35]Visconti A. Le Roy C.I. Rosa F. Rossi N. Martin T.C. Mohney R.P. Li W. de Rinaldis E. Bell J.T. Venter J.C. Interplay between the human gut microbiome and host metabolism Nat. Commun. 2019 10 4505 10.1038/s41467-019-12476-z 31582752 PMC6776654 · DOI · Paper page
  35. [36]Stapleton A.E. Urinary tract infection pathogenesis: Host factors Infect. Dis. Clin. N. Am. 2014 28 149 159 10.1016/j.idc.2013.10.006 24484581 · DOI
  36. [37]Knottnerus B.J. Geerlings S.E. Moll van Charante E.P. ter Riet G. Women with symptoms of uncomplicated urinary tract infection are often willing to delay antibiotic treatment: A prospective cohort study BMC Fam. Pract. 2013 14 71 10.1186/1471-2296-14-71 23721260 PMC3671219 · DOI
  37. [38]Christiaens T.C. De Meyere M. Verschraegen G. Peersman W. Heytens S. De Maeseneer J.M. Randomised controlled trial of nitrofurantoin versus placebo in the treatment of uncomplicated urinary tract infection in adult women Br. J. Gen. Pract. 2002 52 729 734 12236276 PMC1314413
  38. [39]Little P. Moore M.V. Turner S. Rumsby K. Warner G. Lowes J.A. Smith H. Hawke C. Leydon G. Arscott A. Effectiveness of five different approaches in management of urinary tract infection: Randomised controlled trial BMJ 2010 340 c199 10.1136/bmj.c199 20139214 PMC2817051 · DOI
  39. [40]Ferry S.A. Holm S.E. Stenlund H. Lundholm R. Monsen T.J. The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study Scand. J. Infect. Dis. 2004 36 296 301 10.1080/00365540410019642 15198188 · DOI
  40. [41]Gágyor I. Bleidorn J. Kochen M.M. Schmiemann G. Wegscheider K. Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: Randomised controlled trial BMJ 2015 351 h6544 10.1136/bmj.h6544 26698878 PMC4688879 · DOI
  41. [42]Wojciuk B. Salabura A. Grygorcewicz B. Kędzierska K. Ciechanowski K. Dolęgowska B. Urobiome: In Sickness and in Health Microorganisms 2019 7 548 10.3390/microorganisms7110548 PMC6921077 31717688 · DOI
  42. [43]Anand U. Jacobo-Herrera N. Altemimi A. Lakhssassi N. A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery Metabolites 2019 9 258 10.3390/metabo9110258 31683833 PMC6918160 · DOI
  43. [44]McCollum B.J. Garigan T. Earwood J. PURL: Can drinking more water prevent urinary tract infections? J. Fam. Pract. 2020 69 E19 E20 32289134 PMC7271893
  44. [45]Beerepoot M. Geerlings S. Non-Antibiotic Prophylaxis for Urinary Tract Infections Pathogens 2016 5 36 10.3390/pathogens5020036 27092529 PMC4931387 · DOI
  45. [46]Beerepoot M.A. ter Riet G. Nys S. van der Wal W.M. de Borgie C.A.J.M. Reijke T.M. Prins J.M. Koeijers J. Verbon A. Stobberingh E. Lactobacilli vs antibiotics to prevent urinary tract infections: A randomized, double-blind, noninferiority trial in postmenopausal women Arch. Intern. Med. 2012 172 704 712 10.1001/archinternmed.2012.777 22782199 · DOI
  46. [47]Mueller E.R. Wolfe A.J. Brubaker L. Female urinary microbiota Curr. Opin. Urol. 2017 27 282 286 10.1097/MOU.0000000000000396 28234750 PMC5521999 · DOI
  47. [48]Stapleton A.E. Au-Yeung M. Hooton T.M. Fredricks D.N. Roberts P.L. Czaja C.A. Yarova-Yarovaya Y. Fiedler T. Cox M. Stamm W.E. Randomized, placebo-controlled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection Clin. Infect. Dis. 2011 52 1212 1217 10.1093/cid/cir183 21498386 PMC3079401 · DOI · Paper page
  48. [49]Reid G. Charbonneau D. Erb J. Kochanowski B. Beuerman D. Poehner R. Bruce A.W. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: Randomized, placebo-controlled trial in 64 healthy women FEMS Immunol. Med. Microbiol. 2003 35 131 134 10.1016/S0928-8244(02)00465-0 12628548 · DOI · Paper page
  49. [50]Schwenger E.M. Tejani A.M. Loewen P.S. Probiotics for preventing urinary tract infections in adults and children Cochrane Database Syst Rev. 2015 2015 CD008772 10.1002/14651858.CD008772.pub2 PMC8720415 26695595 · DOI
  50. [51]Markowiak P. Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health Nutrients 2017 9 1021 10.3390/nu9091021 PMC5622781 28914794 · DOI · Paper page
  51. [52]Klein T. Abgottspon D. Wittwer M. Rabbani S. Herold J. Jiang X. Kleeb S. Lüthi C. Scharenberg M. Bezençon J. FimH antagonists for the oral treatment of urinary tract infections: From design and synthesis to in vitro and in vivo evaluation J. Med. Chem. 2010 53 8627 8641 10.1021/jm101011y 21105658 · DOI
  52. [53]Domenici L. Monti M. Bracchi C. Giorgini M. Colagiovanni V. Muzii L. Panici P.B. D-mannose: A promising support for acute urinary tract infections in women. A pilot study Eur. Rev. Med. Pharmacol. Sci. 2016 20 2920 2925 27424995
  53. [54]Lenger S.M. Bradley M.S. Thomas D.A. Bertolet M.H. Lowder J.L. Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: A systematic review and meta-analysis Am. J. Obstet. Gynecol. 2020 223 265.e1 265.e13 10.1016/j.ajog.2020.05.048 32497610 PMC7395894 · DOI
  54. [55]De Nunzio C. Bartoletti R. Tubaro A. Simonato A. Ficarra V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives Antibiotics 2021 10 373 10.3390/antibiotics10040373 33915821 PMC8066587 · DOI
  55. [56]Scribano D. Sarshar M. Prezioso C. d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications Molecules 2020 25 316 10.3390/molecules25020316 PMC7024335 31941080 · DOI
  56. [57]Cooper T.E. Teng C. Howell M. Teixeira-Pinto A. Tong A. Wong G. D-mannose for preventing and treating urinary tract infections Cochrane Database Syst Rev. 2020 2020 CD013608 10.1002/14651858.CD013608 PMC9427198 36041061 · DOI
  57. [58]Feliciano R.P. Meudt J.J. Shanmuganayagam D. Krueger C.G. Reed J.D. Ratio of “A-type” to “B-type” proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells J. Agric. Food Chem. 2014 62 3919 3925 10.1021/jf403839a 24215458 · DOI
  58. [59]Huang Y. Nikolic D. Pendland S. Doyle B.J. Locklear T.D. Mahady G.B. Effects of cranberry extracts and ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-kappabeta transcriptional response in vitro Pharm. Biol. 2009 47 18 25 10.1080/13880200802397996 20376297 PMC2849675 · DOI
  59. [60]Vostalova J. Vidlar A. Simanek V. Galandakova A. Kosina P. Vacek J. Vrbkova J. Zimmermann B.F. Ulrickova J. Student V. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection? Phytother. Res. 2015 29 1559 1567 10.1002/ptr.5427 26268913 · DOI
  60. [61]Özcan E. Sun J. Rowley D.C. Sela D.A. A Human Gut Commensal Ferments Cranberry Carbohydrates To Produce Formate Appl. Environ. Microbiol. 2017 83 e01097-17 10.1128/AEM.01097-17 28667113 PMC5561279 · DOI
  61. [63]Straub T.J. Chou W.-C. Manson A.L. Schreiber IV H.L. Walker B.J. Desjardins C.A. Chapman S.B. Kaspar K.L. Kahsai O.J. Traylor E. Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections BMC Microbiol. 2021 21 53 10.1186/s12866-021-02106-4 33596852 PMC7890861 · DOI
  62. [64]Valles-Colomer M. Falony G. Darzi Y. Tigchelaar E.F. Wang J. Tito R.Y. Schiweck C. Kurilshikov A. Joossens M. Wijmenga C. The neuroactive potential of the human gut microbiota in quality of life and depression Nat. Microbiol. 2019 4 623 632 10.1038/s41564-018-0337-x 30718848 · DOI · Paper page
  63. [65]Huang S. Mao J. Zhou L. Xiong X. Deng Y. The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients Scand. J. Immunol. 2019 90 e12799 10.1111/sji.12799 31211854 PMC9286422 · DOI
  64. [66]Degnan P.H. Taga M.E. Goodman A.L. Vitamin B12 as a modulator of gut microbial ecology Cell Metab. 2014 20 769 778 10.1016/j.cmet.2014.10.002 25440056 PMC4260394 · DOI
  65. [67]Rowley C.A. Kendall M.M. To B12 or not to B12: Five questions on the role of cobalamin in host-microbial interactions PLoS Pathog. 2019 15 e1007479 10.1371/journal.ppat.1007479 30605490 PMC6317780 · DOI
  66. [68]Gonyar L.A. Kendall M.M. Ethanolamine and choline promote expression of putative and characterized fimbriae in enterohemorrhagic Escherichia coli O157:H7 Infect. Immun. 2014 82 193 201 10.1128/IAI.00980-13 24126525 PMC3911853 · DOI
  67. [69]Yarbrough M.L. Briden K.E. Mitsios J.V. Weindel A.L. Terrill C.M. Hunstad D.A. Dietzen D.J. Mass spectrometric measurement of urinary kynurenine-to-tryptophan ratio in children with and without urinary tract infection Clin. Biochem. 2018 56 83 88 10.1016/j.clinbiochem.2018.04.014 29679555 PMC6007864 · DOI
  68. [70]Fu Z. Liska D. Talan D. Chung M. Cranberry Reduces the Risk of Urinary Tract Infection Recurrence in Otherwise Healthy Women: A Systematic Review and Meta-Analysis J. Nutr. 2017 147 2282 2288 10.3945/jn.117.254961 29046404 · DOI
  69. [71]Bruyère F. Azzouzi A.R. Lavigne J.-P. Droupy S. Coloby P. Game X. Karsenty G. Issartel B. Ruffion A. Misrai V. A multicenter, randomized, placebo-controlled study evaluating the efficacy of a combination of Propolis and cranberry (Vaccinium macrocarpon) (DUAB®) in preventing low urinary tract infection recurrence in women complaining of recurrent cystitis Urol. Int. 2019 103 41 48 10.1159/000496695 31117097 · DOI
  70. [72]Sticher O. Soldati F. Lehmann D. Hochleistungsflüssigchromotographische Trennung und quantitative Bestimmung von Arbutin, Methylarbutin, Hydrochinon und Hydrochinonmonomethylaether in Arctostaphylos-, Bergenia-, Calluna- und Vaccinium Arten [High-performance liquid chromatographic separation and quantitative determination of arbutin, methylarbutin, hydroquinone and hydroquinone-monomethylether in Arctostaphylos, Bergenia, Calluna and Vaccinium species (author’s transl)] Planta Med. 1979 35 253 261 10.1055/s-0028-1097213 432304 · DOI
  71. [73]Żbikowska B. Franiczek R. Sowa A. Polukord G. Krzyżanowska B. Sroka Z. Antimicrobial and Antiradical Activity of Extracts Obtained from Leaves of Five Species of the Genus Bergenia: Identification of Antimicrobial Compounds Microb. Drug Resist. 2017 23 771 780 10.1089/mdr.2016.0251 28118088 · DOI
  72. [74]Ma C. He N. Zhao Y. Xia D. Wei J. Kang W. Antimicrobial Mechanism of Hydroquinone Appl. Biochem. Biotechnol. 2019 189 1291 1303 10.1007/s12010-019-03067-1 31254228 · DOI
  73. [75]Zhang B. Zeng M. Li B. Kan Y. Wang S. Cao B. Huang Y. Zheng X. Feng W. Arbutin attenuates LPS-induced acute kidney injury by inhibiting inflammation and apoptosis via the PI3K/Akt/Nrf2 pathway Phytomedicine 2021 82 153466 10.1016/j.phymed.2021.153466 33494001 · DOI
  74. [76]Madić V. Petrović A. Jušković M. Jugović D. Djordjević L. Stojanović G. Vasiljević P. Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes J. Ethnopharmacol. 2021 265 113210 10.1016/j.jep.2020.113210 32795501 · DOI
  75. [77]Jurica K. Benković V. Sikirić S. Karačonji I.B. Kopjar N. The effects of strawberry tree (Arbutus unedo L.) water leaf extract and arbutin upon kidney function and primary DNA damage in renal cells of rats Nat. Prod. Res. 2020 34 2354 2357 10.1080/14786419.2018.1534106 30417709 · DOI
  76. [78]Jurica K. Brčić Karačonji I. Mikolić A. Milojković-Opsenica D. Benković V. Kopjar N. In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes Cytotechnology 2018 70 1261 1278 10.1007/s10616-018-0218-4 29696482 PMC6081932 · DOI
  77. [79]Genovese C. Davinelli S. Mangano K. Tempera G. Nicolosi D. Corsello S. Vergalito F. Tartaglia E. Scapagnini G. Di Marco R. Effects of a new combination of plant extracts plus d-mannose for the management of uncomplicated recurrent urinary tract infections J. Chemother. 2018 30 107 114 10.1080/1120009X.2017.1393587 29078739 · DOI
  78. [80]Czaja C.A. Stamm W.E. Stapleton A.E. Roberts P.L. Hawn T.R. Scholes D. Samadpour M. Hultgren S.J. Hooton T.M. Prospective cohort study of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection in women J. Infect. Dis. 2009 200 528 536 10.1086/600385 19586416 PMC3674869 · DOI · Paper page
  79. [81]Riepl M. Compounding to Prevent and Treat Dysbiosis of the Human Vaginal Microbiome Int. J. Pharm. Compd. 2018 22 456 465 30384345
  80. [82]Hooton T.M. Fihn S.D. Johnson C. Roberts P.L. Stamm W.E. Association between bacterial vaginosis and acute cystitis in women using diaphragms Arch. Intern. Med. 1989 149 1932 1936 10.1001/archinte.1989.00390090014003 2673116 · DOI
  81. [83]Hooton T.M. Vecchio M. Iroz A. Tack I. Dornic Q. Seksek I. Lotan Y. Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial JAMA Intern. Med. 2018 178 1509 1515 10.1001/jamainternmed.2018.4204 30285042 PMC6584323 · DOI
  82. [84]Kontiokari T. Laitinen J. Järvi L. Pokka T. Sundqvist K. Uhari M. Dietary factors protecting women from urinary tract infection Am. J. Clin. Nutr. 2003 77 600 604 10.1093/ajcn/77.3.600 12600849 · DOI
  83. [85]Vincent C. Boerlin P. Daignault D. Dozois C.M. Dutil L. Galankis C. Reid-Smith R.J. Tellier P.P. Tellis P.A. Ziebell K. Food reservoir for Escherichia coli causing urinary tract infections Emerg. Infect. Dis. 2010 16 88 95 10.3201/eid1601.091118 20031048 PMC2874376 · DOI
  84. [86]Jakobsen L. Kurbasic A. Skjøt-Rasmussen L. Ejrnæs K. Porsbo L.J. Pedersen K. Jensen L.B. Emborg H.D. Agersø Y. Olsen K.E.P. Escherichia coli isolates from broiler chicken meat, broiler chickens, pork, and pigs share phylogroups and antimicrobial resistance with community-dwelling humans and patients with urinary tract infection Foodborne Pathog. Dis. 2010 7 537 547 10.1089/fpd.2009.0409 20039794 · DOI
  85. [87]Mulder M. Kiefte-de Jong J.C. Goessens W.H.F. de Visser H. Ikram M.A. Verbon A. Stricker B.H. Diet as a risk factor for antimicrobial resistance in community-acquired urinary tract infections in a middle-aged and elderly population: A case-control study Clin. Microbiol. Infect. 2019 25 613 619 10.1016/j.cmi.2018.07.029 30099137 · DOI
  86. [88]Chen Y.C. Chang C.C. Chiu T.H.T. Lin M.N. Lin C.L. The risk of urinary tract infection in vegetarians and non-vegetarians: A prospective study Sci. Rep. 2020 10 906 10.1038/s41598-020-58006-6 32001729 PMC6992707 · DOI
  87. [89]Makki K. Deehan E.C. Walter J. Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease Cell Host Microbe 2018 23 705 715 10.1016/j.chom.2018.05.012 29902436 · DOI · Paper page
  88. [90]Daïen C.I. Pinget G.V. Tan J.K. Macia L. Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview Front. Immunol. 2017 8 548 10.3389/fimmu.2017.00548 28553291 PMC5427073 · DOI
  89. [91]Jones-freeman B. Chonwerawong M. Marcelino V.R. Deshpande A.V. Forster S.C. Starkey M.R. The microbiome and host mucosal interactions in urinary tract diseases Mucosal Immunol. 2021 14 779 792 10.1038/s41385-020-00372-5 33542492 · DOI
  90. [93]Russo T.A. Stapleton A. Wenderoth S. Hooton T.M. Stamm W.E. Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women J. Infect. Dis. 1995 172 440 445 10.1093/infdis/172.2.440 7622887 · DOI
  91. [94]Pfau A. Sacks T. The bacterial flora of the vaginal vestibule, urethra and vagina in premenopausal women with recurrent urinary tract infections J. Urol. 1981 126 630 634 10.1016/S0022-5347(17)54661-3 7029007 · DOI
  92. [95]Gupta K. Stapleton A.E. Hooton T.M. Roberts P.L. Fennell C.L. Stamm W.E. Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections J. Infect. Dis. 1998 178 446 450 10.1086/515635 9697725 · DOI
  93. [97]Ekong G. Kavookjian J. Motivational interviewing and outcomes in adults with type 2 diabetes: A systematic review Patient Educ. Couns. 2016 99 944 952 10.1016/j.pec.2015.11.022 26699083 · DOI
  94. [98]Samdal G.B. Eide G.E. Barth T. Williams G. Meland E. Effective behaviour change techniques for physical activity and healthy eating in overweight and obese adults; systematic review and meta-regression analyses Int. J. Behav. Nutr. Phys. Act. 2017 14 42 10.1186/s12966-017-0494-y 28351367 PMC5370453 · DOI · Paper page
  95. [99]Garofalo L. Zwickey H. Bradley R. Hanes D. Naturopathic Management of Urinary Tract Infections: A Retrospective Chart Review J. Altern. Complement. Med. 2021 27 1116 1123 10.1089/acm.2021.0163 34424727 PMC8713254 · DOI
  96. [100]Chandra H. Singh C. Kumari P. Yadav S. Mishra A.P. Laishevtcev A. Brisc C. Brisc M.C. Munteanu M.A. Bungau S. Promising Roles of Alternative Medicine and Plant-Based Nanotechnology as Remedies for Urinary Tract Infections Molecules 2020 25 5593 10.3390/molecules25235593 PMC7731396 33260701 · DOI
  97. [101]Liu J.P. Flower A. Wang L.-Q. Lewith G. Li Q. Chinese herbal medicine for treating recurrent urinary tract infections in women Cochrane Database Syst. Rev. 2015 2015 CD010446 10.1002/14651858.cd010446.pub2 PMC6481503 26040964 · DOI
  98. [103]Langeveld W.T. Veldhuizen E.J. Burt S.A. Synergy between essential oil components and antibiotics: A review Crit. Rev. Microbiol. 2014 40 76 94 10.3109/1040841X.2013.763219 23445470 · DOI
  99. [104]Stokes J.M. Yang K. Swanson K. Jin W. Cubillos-Ruiz A. Donghia N.M. MacNair C.R. French S. Carfrae L.A. Bloom-Ackermann Z. A Deep Learning Approach to Antibiotic Discovery Cell 2020 180 688 702.e13 10.1016/j.cell.2020.01.021 32084340 PMC8349178 · DOI · Paper page
  100. [105]Andersson J.A. Fitts E.C. Kirtley M.L. Ponnusamy D. Peniche A.G. Dann S.M. Motin V.L. Chauhan S. Rosenzweig J.A. Sha J. New Role for FDA-Approved Drugs in Combating Antibiotic-Resistant Bacteria Antimicrob. Agents Chemother. 2016 60 3717 3729 10.1128/AAC.00326-16 27067323 PMC4879411 · DOI · Paper page
  101. [106]Chen L. Hu C. Hood M. Kan J. Gan X. Zhang X. Zhang Y. An Integrated Approach Exploring the Synergistic Mechanism of Herbal Pairs in a Botanical Dietary Supplement: A Case Study of a Liver Protection Health Food Int. J. Genom. Proteom. 2020 2020 9054192 10.1155/2020/9054192 32351982 PMC7171619 · DOI
  102. [107]Del Popolo G. Nelli F. Recurrent bacterial symptomatic cystitis: A pilot study on a new natural option for treatment Arch. Ital. Urol. Androl. 2018 90 101 103 10.4081/aiua.2018.2.101 29974728 · DOI
  103. [108]Wagenlehner F.M. Abramov-Sommariva D. Höller M. Steindl H. Naber K.G. Non-Antibiotic Herbal Therapy (BNO 1045) versus Antibiotic Therapy (Fosfomycin Trometamol) for the Treatment of Acute Lower Uncomplicated Urinary Tract Infections in Women: A Double-Blind, Parallel-Group, Randomized, Multicentre, Non-Inferiority Phase III Trial Urol. Int. 2018 101 327 336 10.1159/000493368 30231252 PMC6262678 · DOI
  104. [109]Asadi Karam M.R. Habibi M. Bouzari S. Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli Mol. Immunol. 2019 108 56 67 10.1016/j.molimm.2019.02.007 30784763 · DOI
  105. [110]Brumbaugh A.R. Mobley H.L.T. Preventing urinary tract infection: Progress toward an effective Escherichia coli vaccine Expert Rev. Vaccines. 2012 11 663 676 10.1586/erv.12.36 22873125 PMC3498450 · DOI
  106. [111]Das S. Natural therapeutics for urinary tract infections-a review Future J. Pharm. Sci. 2020 6 64 10.1186/s43094-020-00086-2 PMC7498302 33215041 · DOI

Cited by

Sorted by citations

Authors
Garofalo, L., Nakama, C., Hanes, D., & Zwickey, H.
Affiliations
  • University of Washington (US)
  • National University of Natural Medicine (US)
Corresponding author
Garofalo, Luciano
ORCID
Venue
Antibiotics
Publisher
MDPI AG
Published
2022-02-09
Volume
11
Issue
2
Pages
218
ISSN
2079-6382 (ISSN-L)
DOI
10.3390/antibiotics11020218
PMC
PMC8868435
OpenAlex
W4211170668
Cited by
12
References
4
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Antibiotics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Center for Complementary and Integrative Health (T90 AT008544)
Topics
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
uncomplicated urinary tract infection, urinary microbiome, recurrent urinary tract infection, vaginal dysbiosis, antibiotic resistance, diuresis, urine pH, inflammation, non-antibiotic therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review