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Cited by 254Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Obesity, insulin resistance and comorbidities? Mechanisms of association

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Castro, Ana Valeria B., Kolka, Cathryn M., Kim, Stella P., Bergman, Richard N.·2014·Arquivos Brasileiros de Endocrinologia & Metabologia
DOI 10.1590/0004-2730000003223PMC PMC4423826
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Abstract

Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non-metabolic derangements. On the other hand, observations suggest that individuals who present peripheral adiposity, characterized by large hip and thigh circumferences, have better glucose tolerance, reduced incidence of T2DM and of metabolic syndrome. Insulin resistance (IR) is one of the main culprits in the association between obesity, particularly visceral, and metabolic as well as non-metabolic diseases. In this review we will highlight the current pathophysiological and molecular mechanisms possibly involved in the link between increased VAT, ectopic fat, IR and comorbidities. We will also provide some insights in the identification of these abnormalities.

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  1. Geloneze B, 2006, [Laboratorial evaluation and diagnosis of insulin resistance]., Arq Bras Endocrinol Metabol, 50, 208

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Metadata

Authors
Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N.
Affiliations
  • Universidade de São Paulo (BR)
  • Cedars-Sinai Medical Center (US)
ORCID
Venue
Arquivos Brasileiros de Endocrinologia & Metabologia
Publisher
FapUNIFESP (SciELO)
Published
2014-08
Volume
58
Issue
6
Pages
600-609
ISSN
0004-2730 (ISSN-L)
DOI
10.1590/0004-2730000003223
PMC
PMC4423826
OpenAlex
W2065496456
Cited by
254
References
63
Citations by year
2026: 6 · 2025: 17 · 2024: 14 · 2023: 18 · 2022: 21 · 2021: 35 · 2020: 37 · 2019: 33 · 2018: 29 · 2017: 20 · 2016: 14 · 2015: 10
FWCI
1.96
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Arquivos Brasileiros de Endocrinologia & Metabologia (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • PubMed Central (acceptedVersion)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027619, R01DK029867)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, insulin resistance, visceral adipose tissue, ectopic fat, type 2 diabetes, metabolic syndrome, dyslipidemia, impaired glucose tolerance, non-alcoholic fatty liver disease, polycystic ovary syndrome, comorbidities, body fat distribution
MeSH terms
Adipose Tissue, Animals, Endoplasmic Reticulum, Humans, Hyperinsulinism, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Apoptosis, Oxidative Stress, Risk Assessment, Body Fat Distribution

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