The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
The role of oxytocin in cardiovascular regulation
Open accessAbstract
Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem cells. OT treatment of mesenchymal stem cells stimulates paracrine factors beneficial for cardioprotection. Cardiovascular actions of OT include: i) lowering blood pressure, ii) negative inotropic and chronotropic effects, iii) parasympathetic neuromodulation, iv) vasodilatation, v) anti-inflammatory activity, vi) antioxidant activity, and vii) metabolic effects. OT actions are mediated by nitric oxide and ANP. The beneficial actions of OT may include the increase in glucose uptake by CMs and stem cells, reduction in CM hypertrophy, oxidative stress, and mitochondrial protection of several cell types. In experimentally induced myocardial infarction in rats, continuous in vivo OT delivery improves cardiac healing and cardiac work, reduces inflammation, and stimulates angiogenesis. Because OT plays anti-inflammatory and cardioprotective roles and improves vascular and metabolic functions, it demonstrates potential for therapeutic use in various pathologic conditions.
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“There has also been some suggestion that oxytocin has important effects in the periphery, moderating cardiovascular functioning and the peripheral cortisol response, which may influence social behaviour (Cardoso et al., 2014b;Gutkowska et al., 2014).”
From Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions (2017) · cites this paper as Gutkowska et al., 2014
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BaHammam, A. S. (2026) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2026.06.008 · Cited by 2
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Güncel Anesteziyoloji ve Ağrı Çalışmaları IX
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Metadata
- Authors
- Gutkowska, J., Jankowski, M., & Antunes-Rodrigues, J.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Universidade de São Paulo, Brasil
- ORCID
- Jankowski, M.
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2014-03-18
- Volume
- 47
- Issue
- 3
- Pages
- 206-214
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- PMC
- PMC3982941
- OpenAlex
- W2167829495
- Cited by
- 131
- References
- 73
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 8 · 2021: 13 · 2020: 20 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 3
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cardiovascular regulation, atrial natriuretic peptide, anteroventral third ventricle, median eminence, oxytocinergic neurons, cardiomyocyte development, mesenchymal stem cells, cardioprotection, nitric oxide, myocardial infarction, angiogenesis, oxidative stress, mitochondrial protection, anti-inflammatory activity, vasodilation, blood pressure, cardiomyocyte hypertrophy, glucose uptake
- MeSH terms
- Animals, Cardiotonic Agents, Cell Differentiation, Heart, Humans, Atrial Natriuretic Factor, Nitric Oxide, Oxytocin, Signal Transduction, Receptors, Oxytocin, Oxidative Stress, Myocytes, Cardiac, Rats
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