Potentiating effect of beta-glucans on photodynamic therapy of implanted cancer cells in mice

Akramiene, Dalia; Aleksandraviciene, Ceslava; Grazeliene, Grazina; Zalinkevicius, Rimantas; Suziedelis, Kestutis; Didziapetriene, Janina; Simonsen, Ulf; Stankevicius, Edgaras; Kevelaitis, Egidijus

doi:10.1620/tjem.220.299

Cited by 17Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsImmunotherapy and Immune Responses

Potentiating effect of beta-glucans on photodynamic therapy of implanted cancer cells in mice

Open access

Akramiene, Dalia, Aleksandraviciene, Ceslava, Grazeliene, Grazina, Zalinkevicius, Rimantas, Suziedelis, Kestutis, Didziapetriene, Janina, Simonsen, Ulf, Stankevicius, Edgaras +1 more·2010·The Tohoku Journal of Experimental Medicine

DOI 10.1620/tjem.220.299

Open this paper in CoChat — free account Open PDF

Abstract

Photodynamic therapy (PDT) combines a drug or photosensitizer with a specific type of light to kill cancer cells. The cellular damage induced by PDT leads to activation of the DNA damage repair, which is an important factor for modulating tumor sensitivity to this treatment. beta-Glucans are natural polysaccharides that bind complement receptor 3 on the effector cells, thereby activating them to kill tumor cells during PDT. The hypothesis of the present study was that adjuvant therapy with beta-glucans would increase the efficacy of PDT. C57BL/6 female mice were subcutaneously implanted with Lewis lung carcinoma cells. Ten days after implantation, the mice were administered intravenously sodium porfimer (10 mg/kg) 24 h prior to laser irradiation, with or without oral administration of beta-glucan (400 microg/d/mouse, 5 days) from either barley, baker's yeast, or marine brown algae that contains the storage glucan, laminarin. Tumor volume and necrotic area in excised tumors were measured. The expression of proliferating cell nuclear antigen (PCNA) was determined as an indicator of the activity of the DNA damage repair system. PDT in combination with each beta-glucan significantly reduced tumor growth (P < 0.05, n = 10) and expression of PCNA (P < 0.001, n = 9), and increased necrosis in tumor tissues (P < 0.001, n = 9). Furthermore, each structurally different

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1620/tjem.220.299

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Fermentation of laminaran by intestinal bacteria could suppress risk of colorectal cancer.
“These results suggest that the fermentation of laminaran by intestinal bacteria could suppress the risk of colorectal cancer [87,88].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [87]
Laminarans noticeably inhibited formation of putrefactive and harmful compounds such as indoles, p-cresol, ammonia, phenol, and sulfide produced by fecal microflora.
“Laminarans noticeably inhibited the formation of putrefactive and harmful compounds, such as indoles, p-cresol, ammonia, phenol, and sulfide, produced by the fecal microflora.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [87]
Polysaccharides were fermented into propionic and butyric acids by intestinal microbiota, similar to prebiotics.
“Polysaccharides were fermented into propionic and butyric acids by intestinal microbiota, similar to the effects of prebiotics.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [87]
In both experiments (laminaran and alginic acid), intestinal bacterial flora of rats was changed.
“In both experiments (with laminaran and with alginic acid) the intestinal bacterial flora of rats was changed.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [87]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1071 · Cited by 6,769 · see citing works
Photodynamic Therapy
Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716 · see citing works
Photodynamic Therapy
Gomer, C. J. (1988) · Cited by 4,169 · see citing works
Dectin-1 Is A Major β-Glucan Receptor On Macrophages
Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martínez‐Pomares, L., Wong, S. Y. C., & Gordon, S. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020470 · Cited by 1,015 · see citing works
PCNA: structure, functions and interactions
Kelman, Z. (1997) · Oncogene · doi:10.1038/sj.onc.1200886 · Cited by 929 · see citing works
(1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships
Bohn, J. A., & BeMiller, J. N. (1995) · Carbohydrate Polymers · doi:10.1016/0144-8617(95)00076-3 · Cited by 924 · see citing works
Basic principles, applications in oncology and improved selectivity of photodynamic therapy.
Vrouenraets, M. B., Visser, G. W. M., Snow, G. B., & van Dongen, G. A. M. S. (2003) · PubMed · Cited by 920 · see citing works
Immunomodulation and Anti-Cancer Activity of Polysaccharide-Protein Complexes
Ooi, V. E. C., & Liu, F. (2000) · Current Medicinal Chemistry · doi:10.2174/0929867003374705 · Cited by 871 · see citing works
Fungal β-Glucans and Mammalian Immunity
Brown, G. D., & Gordon, S. (2003) · Immunity · doi:10.1016/s1074-7613(03)00233-4 · Cited by 668 · see citing works
The Photobiology of Photodynamic Therapy: Cellular Targets and Mechanisms
Oleinick, N. L., & Evans, H. H. (1998) · Radiation Research · doi:10.2307/3579816 · Cited by 571 · see citing works
Mechanism by Which Orally Administered β-1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models
Hong, F., Yan, J., Baran, J. T., Allendorf, D. J., Hansen, R., Ostroff, G. R., Xing, P., Cheung, N. V., & Ross, G. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.797 · Cited by 472 · see citing works
DNA damage checkpoints in mammals
Niida, H., & Nakanishi, M. (2005) · Mutagenesis · doi:10.1093/mutage/gei063 · Cited by 431 · see citing works
The β-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria
Yadav, M., & Schorey, J. S. (2006) · Blood · doi:10.1182/blood-2006-05-024406 · Cited by 422 · see citing works
Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells.
Větvička, V., Thornton, B. P., & Ross, G. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118777 · Cited by 407 · see citing works
Proliferating cell nuclear antigen (PCNA): ringmaster of the genome
Paunesku, T., Mittal, S., Protić, M., Oryhon, J., Korolev, S., Joachimiak, A., & Woloschak, G. E. (2001) · International Journal of Radiation Biology · doi:10.1080/09553000110069335 · Cited by 342 · see citing works
Oral Delivery and Gastrointestinal Absorption of Soluble Glucans Stimulate Increased Resistance to Infectious Challenge
Rice, P. J., Adams, E. L., Ozment-Skelton, T. R., Gonzalez, A. J., Goldman, M. P., Lockhart, B. E., Barker, L. A., Breuel, K. F., DePonti, W. K., Kalbfleisch, J. H., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085415 · Cited by 333 · see citing works
The influence of glucan polymer structure and solution conformation on binding to (1->3)- -D-glucan receptors in a human monocyte-like cell line
Mueller, A., Raptis, J., Rice, P. J., Kalbfleisch, J. H., Stout, R. D., Ensley, H. E., Browder, W., & Williams, D. L. (2000) · Glycobiology · doi:10.1093/glycob/10.4.339 · Cited by 300 · see citing works
Pattern recognition: recent insights from Dectin-1
Reid, D. M., Gow, N. A. R., & Brown, G. D. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.003 · Cited by 291 · see citing works
Direct tumor damage mechanisms of photodynamic therapy.
Nowis, D., Makowski, M., Stokłosa, T., Legat, M., Issat, T., & Gołąb, J. (2005) · Acta Biochimica Polonica · doi:10.18388/abp.2005_3447 · Cited by 282 · see citing works
The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells.
Xia, Y., Vetvicka, V., Yan, J., Hanikýřová, M., Mayadas, T. N., & Ross, G. D. (1999) · PubMed · Cited by 265 · see citing works
Complement function in mAb-mediated cancer immunotherapy
Gelderman, K. A., Tomlinson, S., Ross, G. D., & Gorter, A. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.01.008 · Cited by 262 · see citing works
The β-Glucan-Binding Lectin Site of Mouse CR3 (CD11b/CD18) and Its Function in Generating a Primed State of the Receptor That Mediates Cytotoxic Activation in Response to iC3b-Opsonized Target Cells
Xia, Y., Větvička, V., Yan, J., Hanikýřová, M., Mayadas, T. N., & Ross, G. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2281 · Cited by 244 · see citing works
β-Glucans in promoting health: Prevention against mutation and cancer
Mantovani, M. S., Bellini, M. F., Angeli, J. P. F., Oliveira, R. J., Silva, A. F., & Ribeiro, L. R. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.07.002 · Cited by 240 · see citing works
Photodynamic Therapy for Cancer: Principles
Wilson, B. C. (2002) · Canadian Journal of Gastroenterology · doi:10.1155/2002/743109 · Cited by 235 · see citing works
Photodynamic Therapy Enhancement of Antitumor Immunity Is Regulated by Neutrophils
Kousis, P. C., Henderson, B. W., Maier, P. G., & Gollnick, S. O. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1778 · Cited by 224 · see citing works
Regulation of the Adhesion versus Cytotoxic Functions of the Mac-1/CR3/αMβ2 - lntegrin Glycoprotein
Ross, G. D. (2000) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v20.i3.20 · Cited by 218 · see citing works
Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells.
Hong, F., Hansen, R., Yan, J., Allendorf, D. J., Baran, J., Ostroff, G. R., & Ross, G. D. (2003) · PubMed · Cited by 165 · see citing works
Yeast β-Glucan Amplifies Phagocyte Killing of iC3b-Opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-Kinase Pathway
Li, B., Allendorf, D. J., Hansen, R., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1661 · Cited by 164 · see citing works
β-Glucan, a “Specific” Biologic Response Modifier That Uses Antibodies to Target Tumors for Cytotoxic Recognition by Leukocyte Complement Receptor Type 3 (CD11b/CD18)
Yan, J., Větvička, V., Xia, Y., Coxon, A., Carroll, M. C., Mayadas, T. N., & Ross, G. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.6.3045 · Cited by 148 · see citing works
Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).
Yan, J., Větvička, V., Xia, Y., et al. (1999) · PubMed · Cited by 140 · see citing works
Regulation of Cytosolic Phospholipase A2 Activation and Cyclooxygenase 2 Expression in Macrophages by the β-Glucan Receptor
Suram, S., Brown, G. D., Ghosh, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509824200 · Cited by 128 · see citing works
Oral (1-->3),(1-->4)-beta-D-glucan synergizes with antiganglioside GD2 monoclonal antibody 3F8 in the therapy of neuroblastoma.
Cheung, N. V., & Modak, S. I. (2002) · PubMed · Cited by 91 · see citing works
Relationship between Solubility of Grifolan, a Fungal 1,3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro
Ishibashi, K., Miura, N. N., Adachi, Y., Ohno, N., & Yadomae, T. (2001) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.65.1993 · Cited by 79 · see citing works
Combined yeast-derived β-glucan with anti-tumor monoclonal antibody for cancer immunotherapy
Liu, J., Gunn, L., Hansen, R., & Yan, J. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.01.006 · Cited by 77 · see citing works
Rituximab therapy of lymphoma is enhanced by orally administered (1→3),(1→4)-d-β-glucan
Modak, S. I., Koehne, G., Vickers, A. J., O’Reilly, R. J., & Cheung, N. V. (2005) · Leukemia Research · doi:10.1016/j.leukres.2004.10.008 · Cited by 75 · see citing works
Potentiation of photodynamic therapy of cancer by complement: the effect of γ-inulin
Korbelik, M., & Cooper, P. D. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603508 · Cited by 70 · see citing works
Potentiation of photodynamic therapy by immunotherapy: the effect of schizophyllan (SPG)
Krosl, G., & Korbelik, M. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90356-5 · Cited by 63 · see citing works
Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice
Ho, J., Konerding, M. A., Gaumann, A. K. A., Groth, M., & Liu, W. K. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.02.021 · Cited by 62 · see citing works
The phothobiology of photodynamic therapy : cellular tagets and mechanisms
Oleinick, N. (1998) · Radiation Research · Cited by 61 · see citing works
Characteristics of complement activation in mice bearing Lewis lung carcinomas treated by photodynamic therapy
Cecić, I., Serrano, K., Gyöngyössy‐Issa, M. I. C., & Korbelik, M. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.11.059 · Cited by 55 · see citing works
Mutagenicity of Photodynamic Therapy as Compared to UVC and Ionizing Radiation in Human and Murine Lymphoblast Cell Lines
Evans, H. H., Horng, M., Ricanati, M., et al. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03208.x · Cited by 50 · see citing works
Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice.
Baran, J., Allendorf, D. J., Hong, F., et al. (2007) · PubMed · doi:10.5603/4540 · Cited by 49 · see citing works
Adjuvant treatment for complement activation increases the effectiveness of photodynamic therapy of solid tumors
Korbelik, M., Sun, J., Cecić, I., et al. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b315663j · Cited by 44 · see citing works
Combined Yeast β-Glucan and Antitumor Monoclonal Antibody Therapy Requires C5a-Mediated Neutrophil Chemotaxis via Regulation of Decay-Accelerating Factor CD55
Li, B., Allendorf, D. J., Hansen, R., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1465 · Cited by 42 · see citing works
Synthesis of benzylidenated hexopyranosides in ionic liquids
Zhang, J., & Ragauskas, A. J. (2005) · Carbohydrate Research · doi:10.1016/j.carres.2005.10.007 · Cited by 14 · see citing works
Treatment of Lewis lung carcinoma by photodynamic therapy and glucan from barley
Akramienė, D., Graželienė, G., Didžiapetrienė, J., et al. (2009) · Medicina · doi:10.3390/medicina45060063 · Cited by 13 · see citing works
Biological Activities of (1.RAR.3)-.BETA.-D-Glucans with Reducing Glucose Side Chains.
Kiho, T., MATSUSHITA, M., Usui, S., & Ukai, S. (1998) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.62.570 · Cited by 12 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Taylor, C. & Cote, R.J. (1994) Immunomicroscopy: A Diagnostic Tool of the Surgical Pathologist. 2nd ed., WB Saunders, Phila.

Sorted by citations

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works

Authors: Akramiene, D., Aleksandraviciene, C., Grazeliene, G., Zalinkevicius, R., Suziedelis, K., Didziapetriene, J., Simonsen, U., Stankevicius, E., & Kevelaitis, E.
Affiliations: Department of Physiology, Kaunas University of Medicine
Vilnius University (LT)
Institute of Oncology, Vilnius University
Institute of Endocrinology, Kaunas University of Medicine
Aarhus University (DK)
ORCID: Simonsen, Ulf
Venue: The Tohoku Journal of Experimental Medicine
Publisher: Tohoku University Medical Press
Published: 2010
Volume: 220
Issue: 4
Pages: 299-306
ISSN: 0040-8727 (ISSN-L)
1349-3329
DOI: 10.1620/tjem.220.299
OpenAlex: W2076616337
Cited by: 17
References: 47
Citations by year: 2025: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 2.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Tohoku Journal of Experimental Medicine (publishedVersion)
PubMed (publishedVersion)
Lithuanian University of Health Sciences (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: β-glucan, photodynamic therapy, Lewis lung carcinoma, complement receptor 3, DNA repair, proliferating cell nuclear antigen, laminarin, barley β-glucan, tumor necrosis, adjuvant therapy, tumor growth inhibition
MeSH terms: Animals, Combined Modality Therapy, Female, Lasers, Mice, Inbred C57BL, Neoplasms, Photochemotherapy, Xenograft Model Antitumor Assays, beta-Glucans, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Potentiating effect of beta-glucans on photodynamic therapy of implanted cancer cells in mice

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks