The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
Open accessAbstract
Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves RAR binding at specific response elements and a network of interactions with coregulatory protein complexes, the assembly of which is directed by the C-terminal ligand-binding domain of RARs. In addition to this scenario, new roles for the N-terminal domain and the ubiquitin-proteasome system recently emerged. Moreover, the functions of RARs are not limited to the regulation of cognate target genes, as they can transrepress other gene pathways. Finally, RARs are also involved in nongenomic biological activities such as the activation of translation and of kinase cascades. Here we will review these mechanisms, focusing on how kinase signaling and the proteasome pathway cooperate to influence the dynamics of RAR transcriptional activity.
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Cites
Intrinsically unstructured proteins and their functions
Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 4×
“On DR2 and DR5 elements, in vitro, RXR occupies the 5’ hexameric motif, whereas the RAR partner occupies the 3’ motif (5’-RXR-RAR-3’) [Chambon, 1996; Laudet and Gronemeyer, 2001].”
BackgroundInfluentialThe coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128
Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821 · cited 2×
“…heterodimers with RXRs, to specific DNA sequences or RA response elements (RAREs), composed typically of two direct repeats of a core hexameric motif, PuG (G/T) TCA [Germain et al., 2003; Leid et al., 1992; Mangelsdorf and Evans, 1995] and located in the regulatory sequences of target genes.”
BackgroundIntrinsic Disorder in Transcription Factors
Liu, J., Perumal, N. B., Oldfield, C. J., Su, E. W., Uversky, V. N., & Dunker, A. K. (2006) · Biochemistry · doi:10.1021/bi0602718 · Cited by 792
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688 · cited 5×
“…to as P, D, T and A boxes, that have been shown to define or contribute to the response element’s specificity, to a dimerization interface within the DBDs and to contacts with the DNA backbone and residues flanking the DNA core recognition sequence [Germain et al., 2003; Germain et al., 2006c].”
BackgroundInfluentialSelf-citation
Cited by
Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S. S., Samouda, H., La Frano, M. R., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 786
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“The nuclear RARs act as ligand-activated transcription factors to regulate gene transcription in a cell-type and tissue-specific manner [30].”
BackgroundRetinoids regulate stem cell differentiation
Gudas, L. J., & Wagner, J. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22417 · Cited by 395
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Self-citationVitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408
Self-citationPotent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists
Shimono, K., Tung, W.-E., Macolino, C., Chi, A. H.-T., Didizian, J. H., Mundy, C., Chandraratna, R. A., Mishina, Y., Enomoto-Iwamoto, M., Pacifici, M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2334 · Cited by 334
Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
Anguiano, J., Garner, T. P., Mahalingam, M., Das, B. C., Gavathiotis, E., & Cuervo, A. M. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1230 · Cited by 222
Shearer, K. D., Stoney, P. N., Morgan, P. J., & McCaffery, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.005 · Cited by 152
Piskunov, A., & Rochette-Egly, C. (2012) · Oncogene · doi:10.1038/onc.2011.499 · Cited by 95
Self-citationRegulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
le Maire, A., Teyssier, C., Balaguer, P., Bourguet, W., & Germain, P. (2019) · Cells · doi:10.3390/cells8111392 · Cited by 88
Self-citationStructural analysis of nuclear receptors: From isolated domains to integral proteins
Brélivet, Y., Rochel, N., & Moras, D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.015 · Cited by 64
McKenna, N. J. (2012) · Nuclear Receptor Signaling · doi:10.1621/nrs.10003 · Cited by 33
Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response
Ferry, C., Gaouar, S., Fischer, B., Boeglin, M., Paul, N., Samarut, E., Piskunov, A., Pankotai-Bodo, G., Brino, L., & Rochette-Egly, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102572108 · Cited by 33
Self-citationLalevee, S., Bour, G., Quinternet, M., Samarut, E., Kessler, P., Vitorino, M., Bruck, N., Delsuc, M., Vonesch, J., Kieffer, B., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-160572 · Cited by 32
Self-citationSamarut, E., Amal, I., Markov, G. V., Stote, R., Dejaegere, A., Laudet, V., & Rochette-Egly, C. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr035 · Cited by 26
Self-citationChebaro, Y., Amal, I., Rochel, N., Rochette-Egly, C., Stote, R. H., & Dejaegere, A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003012 · Cited by 25
Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ
Chebaro, Y., Sirigu, S., Amal, I., Lutzing, R., Stote, R. H., Rochette-Egly, C., Rochel, N., & Dejaegere, A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171043 · Cited by 8
Self-citation
Metadata
- Authors
- Rochette-Egly, C., & Germain, P.
- Venue
- Nuclear Receptor Signaling
- Publisher
- SAGE Publications
- Published
- 2009-01
- Volume
- 7
- Issue
- 1
- Pages
- e005-e005
- ISSN
- 1550-7629 (ISSN-L)
- OpenAlex
- W2134435180
- Cited by
- 243
- References
- 41
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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