The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
Open accessAbstract
Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves RAR binding at specific response elements and a network of interactions with coregulatory protein complexes, the assembly of which is directed by the C-terminal ligand-binding domain of RARs. In addition to this scenario, new roles for the N-terminal domain and the ubiquitin-proteasome system recently emerged. Moreover, the functions of RARs are not limited to the regulation of cognate target genes, as they can transrepress other gene pathways. Finally, RARs are also involved in nongenomic biological activities such as the activation of translation and of kinase cascades. Here we will review these mechanisms, focusing on how kinase signaling and the proteasome pathway cooperate to influence the dynamics of RAR transcriptional activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intrinsically unstructured proteins and their functions
Dyson, H. J., & Wright, P. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1589 · Cited by 3,871
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · cited 4×
“On DR2 and DR5 elements, in vitro, RXR occupies the 5’ hexameric motif, whereas the RAR partner occupies the 3’ motif (5’-RXR-RAR-3’) [Chambon, 1996; Laudet and Gronemeyer, 2001].”
BackgroundInfluentialThe coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128
Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821 · cited 2×
“…heterodimers with RXRs, to specific DNA sequences or RA response elements (RAREs), composed typically of two direct repeats of a core hexameric motif, PuG (G/T) TCA [Germain et al., 2003; Leid et al., 1992; Mangelsdorf and Evans, 1995] and located in the regulatory sequences of target genes.”
BackgroundIntrinsic Disorder in Transcription Factors
Liu, J., Perumal, N. B., Oldfield, C. J., Su, E. W., Uversky, V. N., & Dunker, A. K. (2006) · Biochemistry · doi:10.1021/bi0602718 · Cited by 792
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688 · cited 5×
“…to as P, D, T and A boxes, that have been shown to define or contribute to the response element’s specificity, to a dimerization interface within the DBDs and to contacts with the DNA backbone and residues flanking the DNA core recognition sequence [Germain et al., 2003; Germain et al., 2006c].”
BackgroundInfluentialSelf-citationInternational Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
Self-citationThe Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling
Epping, M. T., Wang, L., Edel, M. J., Carlée, L., Hernandez, M., & Bernards, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.003 · Cited by 432
Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M., & Colburn, N. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.609 · Cited by 386
Dong, D., Ruuska, S. E., Levinthal, D. J., & Noy, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23695 · Cited by 362
Rochette-Egly, C., Adam, S., Rossignol, M., Egly, J.-M., & Chambon, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80317-7 · Cited by 308 · cited 5×
“Interestingly, region F is phosphorylated at multiple positions that might modify the properties of RARs [Bastien et al., 2000; Rochette-Egly et al., 1997].”
BackgroundMethodInfluentialSelf-citationWärnmark, A., Treuter, E., Wright, A. P. H., & Gustafsson, J.-A. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0384 · Cited by 308
Is there a code embedded in proteins that is based on post-translational modifications?
Sims, R. J., & Reinberg, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2502 · Cited by 289
Dilworth, F. J., & Chambon, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204329 · Cited by 269
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II
Elmlund, H., Baraznenok, V., Lindahl, M., Samuelsen, C. O., Koeck, P. J. B., Holmberg, S., Hebert, H., & Gustafsson, C. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607483103 · Cited by 230
Lavery, D. N., & Mcewan, I. J. (2005) · Biochemical Journal · doi:10.1042/bj20050872 · Cited by 227
Vicent, G. P., Ballaré, C., Nacht, A. S., Clausell, J., Subtil-Rodríguez, A., Quiles, I., Jordan, A., & Beato, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.10.011 · Cited by 223
Keriel, A., Stary, A., Sarasin, A., Rochette-Egly, C., & Egly, J.-M. (2002) · Cell · doi:10.1016/s0092-8674(02)00692-x · Cited by 192
Self-citationMasiá, S., Alvarez, S., de Lera, A. R., & Barettino, D. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0062 · Cited by 184
Lee, D., Ezhkova, E., Li, B., Pattenden, S. G., Tansey, W. P., & Workman, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.08.015 · Cited by 178
Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Y., & Noy, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709981105 · Cited by 172
Chen, N., & Napoli, J. L. (2008) · The FASEB Journal · doi:10.1096/fj.07-8739com · Cited by 166
Alsayed, Y., Uddin, S., Mahmud, N., Lekmine, F., Kalvakolanu, D. V., Minucci, S., Bokoch, G., & Platanias, L. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007431200 · Cited by 161
Kopf, E., Plassat, J.-L., Vivat, V., de Thé, H., Chambon, P., & Rochette-Egly, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002840200 · Cited by 155
Self-citationGiannì, M., Bauer, A., Garattini, E., Chambon, P., & Rochette‐Egly, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf374 · Cited by 151
Self-citationReceptor-interacting Protein 140 Directly Recruits Histone Deacetylases for Gene Silencing
Wei, L.-N., Hu, X., Chandra, D., Seto, E., & Farooqui, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004821200 · Cited by 150
Maghsoodi, B., Poon, M. M., Nam, C. I., Aoto, J., Ting, P., & Chen, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804801105 · Cited by 138
Retinoic acid-gated sequence-specific translational control by RARα
Poon, M. M., & Chen, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807740105 · Cited by 138
Phosphorylation of the retinoic acid receptor-alpha by protein kinase A
Rochette-Egly, C. (1995) · Molecular Endocrinology · doi:10.1210/me.9.7.860 · Cited by 124
Self-citationChen, N., Onisko, B., & Napoli, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802314200 · Cited by 89 · cited 1×
“Indeed, they found that RARα is exported to neuronal dendrites, where it is associated with a subset of mRNAs such as the glutamate receptor 1 (GluR1) mRNA [Chen et al., 2008].”
BackgroundGaillard, E., Bruck, N., Brelivet, Y., Bour, G., Lalevée, S., Bauer, A., Poch, O., Moras, D., & Rochette-Egly, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509717103 · Cited by 76
Self-citationGupta, P., Ho, P.-C., Huq, M. M., Ha, S. G., Park, S. W., Khan, A. A., Tsai, N.-P., & Wei, L.-N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710561105 · Cited by 74
Srinivas, H., Juroske, D. M., Kalyankrishna, S., Cody, D. D., Price, R. E., Xu, X.-C., Narayanan, R., Weigel, N. L., & Kurie, J. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1054-1069.2005 · Cited by 68
Dey, N., De, P. K., Wang, M., Zhang, H., Dobrota, E. A., Robertson, K. A., & Durden, D. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01352-06 · Cited by 62
Nuclear receptor superfamily: Principles of signaling
Germain, P., Altucci, L., Bourguet, W., Rochette-Egly, C., & Gronemeyer, H. (2003) · Pure and Applied Chemistry · doi:10.1351/pac200375111619 · Cited by 53
Self-citationAkt phosphorylates and suppresses the transactivation of retinoic acid receptor α
Srinivas, H., Xia, D., Moore, N. L., Uray, I. P., Kim, H., Ma, L., Weigel, N. L., Brown, P. H., & Kurie, J. M. (2006) · Biochemical Journal · doi:10.1042/bj20051794 · Cited by 49
Ferry, C., Gianni, M., Lalevée, S., Bruck, N., Plassat, J.-L., Raska, I., Garattini, E., & Rochette-Egly, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808815200 · Cited by 24
Self-citation
Cited by
Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S. S., Samouda, H., La Frano, M. R., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 786
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“The nuclear RARs act as ligand-activated transcription factors to regulate gene transcription in a cell-type and tissue-specific manner [30].”
BackgroundRetinoids regulate stem cell differentiation
Gudas, L. J., & Wagner, J. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22417 · Cited by 395
Metadata
- Authors
- Rochette-Egly, C., & Germain, P.
- Venue
- Nuclear Receptor Signaling
- Publisher
- SAGE Publications
- Published
- 2009-01
- Volume
- 7
- Issue
- 1
- Pages
- e005-e005
- ISSN
- 1550-7629 (ISSN-L)
- OpenAlex
- W2134435180
- Cited by
- 243
- References
- 41
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
