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Cited by 1,080

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Acute phase reaction and acute phase proteins

Open access
Gruys, E., Toussaint, M. J. M., Niewold, T. A., Koopmans, S. J.·2005·Journal of Zhejiang University-SCIENCE B

Abstract

A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.

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Metadata

Authors
Gruys, E., Toussaint, M. J. M., Niewold, T. A., & Koopmans, S. J.
Venue
Journal of Zhejiang University-SCIENCE B
Published
2005-11
Volume
6
Issue
11
Pages
1045-1056
ISSN
  • 1673-1581 (ISSN-L)
  • 1862-1783
OpenAlex
W2163230336
Cited by
1,080
References
87
FWCI
21.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Acute phase reaction and acute phase proteins. https://app.cochat.ai/papers/10.1631/jzus.2005.b1045
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Gruys, E., Toussaint, M. J. M., Niewold, T. A., & Koopmans, S. J. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University-SCIENCE B. https://doi.org/10.1631/jzus.2005.b1045

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