The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Anti-Inflammatory and Anti-Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury
Abstract
To investigate the anti-inflammatory and anti-angiogenic effects of mesenchymal stem cells (MSC) in the chemically burned corneas, we mechanically removed the corneal epithelium of rats after 100% alcohol instillation. The rats were then randomized into four groups: fresh media, conditioned media derived from the MSC culture (MSC-CM), MSC applied topically to the damaged corneas for 2 hours immediately after the injury or MSC-CM applied either once or 3 times per day for 3 consecutive days. Corneal surface was evaluated every week. After 3 weeks, the corneas were stained with the hematoxylin-eosin, and the expression of interleukin (IL)-2, interferon (IFN)-γ, IL-6, IL-10, transforming growth factor (TGF)-β1, thrombospondin-1 (TSP-1), matrix metalloproteinase-2 (MMP-2), and vascular endothelial growth factor (VEGF) were analyzed. CD4+ cells were assessed in the corneas. We found that both MSC and three-time applied MSC-CM (1) reduced corneal inflammation and neovascularization, (2) decreased IL-2 and IFN-γ, although increased IL-10 and TGF-β1 as well as IL-6, (3) reduced the infiltration of CD4+ cells, and (4) upregulated the expression of TSP-1, although downregulated that of MMP-2. Interestingly, whereas three-time application of MSC-CM was partially effective, transplantation of MSC achieved a better outcome in suppressing corneal inflammation. The results of this study suggest that the anti-inflammatory and anti-angiogenic action of MSC in the chemically burned corneas might be mediated in part through paracrine pathways involving soluble factors such as IL-10, TGF-β1, IL-6 and TSP-1. Disclosure of potential conflicts of interest is found at the end of this article.
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Cites
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Cited by
Mesenchymal Stem Cells for Regenerative Medicine
Han, Y., Li, X., Zhang, Y., Han, Y., Chang, F., & Ding, J. (2019) · Cells · doi:10.3390/cells8080886 · Cited by 1,093
Mesenchymal Stem Cells: Mechanisms of Inflammation
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Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair
Hocking, A. M., & Gibran, N. S. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.009 · Cited by 408
MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
He, X., Dong, Z., Cao, Y., Wang, H., Liu, S., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019) · Stem Cells International · doi:10.1155/2019/7132708 · Cited by 404
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Metadata
- Authors
- Oh, J. Y., Kim, M. K., Shin, M. S., Lee, H. J., Ko, J. H., Wee, W. R., & Lee, J. H.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-10
- Volume
- 26
- Issue
- 4
- Pages
- 1047-1055
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2049655446
- Cited by
- 400
- References
- 36
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Anti-Inflammatory and Anti-Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury. https://app.cochat.ai/papers/10.1634/stemcells.2007-0737
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- Oh, J. Y., Kim, M. K., Shin, M. S., Lee, H. J., Ko, J. H., Wee, W. R., & Lee, J. H. (2008). The Anti-Inflammatory and Anti-Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury. Stem Cells. https://doi.org/10.1634/stemcells.2007-0737
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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