Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas
Abstract
Learning Objectives: After completing this course, the reader will be able to: Describe the pathways involved in the natural resistance of cancer cells to cytotoxic insults including radio-/chemotherapy.Explain autophagic cell death as a potent alternative tumor-suppressing mechanism.Identify the common targets in apoptosis and autophagy resistance pathways and the surrogate markers that could be used in clinical practice for proautophagic therapy.Discuss the rationale for incorporating endoplasmic reticulum stress inhibitors as adjuvant chemotherapies against apoptosis-resistant cancers. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
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HDAC10 is an emerging target for treatment of advanced-stage neuroblastoma.
“As the suppression of autophagy to sustain the cytotoxicity of chemotherapeutic drugs is a novel strategy for cancer chemotherapy3435, HDAC10 is an emerging target for the treatment of advanced-stage neuroblastoma32.”
From Histone deacetylase 10 structure and molecular function as a polyamine deacetylase (2017) · cites this paper as [35]
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- Authors
- Lefranc, F., Facchini, V., & Kiss, R.
- Affiliations
- Université Libre de Bruxelles (BE)
- c Unibioscreen SA, Brussels, Belgium
- b Laboratory of Toxicology, Institute of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium
- Corresponding author
- Lefranc, Florence
- Venue
- The Oncologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-01
- Volume
- 12
- Issue
- 12
- Pages
- 1395-1403
- ISSN
- 1083-7159 (ISSN-L)
- 1549-490X
- OpenAlex
- W2099551830
- Cited by
- 237
- References
- 93
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 19
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Oncologist (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- autophagic cell death, apoptosis resistance, glioblastoma, temozolomide, mTOR inhibitors, PI3K/Akt signaling, endoplasmic reticulum stress, combination chemotherapy, caspase-independent cell death
- MeSH terms
- Temozolomide, Antineoplastic Agents, Autophagy, Dacarbazine, Glioblastoma, Humans, Neoplasms, Drug Delivery Systems, Apoptosis, Drug Resistance, Neoplasm
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