Angiogenesis, adipokines and breast cancer

Obesity is associated with macrophage accumulation in adipose tissue

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The biology of VEGF and its receptors

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Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

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Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells

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Distinct role of macrophages in different tumor microenvironments

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Recent advances in the relationship between obesity, inflammation, and insulin resistance.

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Biological Action of Leptin as an Angiogenic Factor

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

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Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

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Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

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Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

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Macrophages and angiogenesis

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Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

Gerber, H., Dixit, V. M., & Ferrara, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13313 · Cited by 990 · see citing works

Basic fibroblast growth factor induces angiogenesis in vitro.

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Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

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Role of Adiponectin in Preventing Vascular Stenosis

Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., Kumada, M., Okamoto, Y., Nagaretani, H., Nishizawa, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206083200 · Cited by 809 · see citing works

Angiogenesis modulates adipogenesis and obesity

Cao, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32239 · Cited by 736 · see citing works

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis

Bråkenhielm, E., Veitonmäki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T., & Cao, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308671100 · Cited by 734 · see citing works

Leptin, the Product of Ob Gene, Promotes Angiogenesis

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Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

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Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

Vona-Davis, L., & Rose, D. P. (2007) · Endocrine-Related Cancer · doi:10.1677/erc-06-0068 · Cited by 496 · see citing works

Microvessel Density as a Prognostic Factor in Women with Breast Cancer

Uzzan, B., Nicolas, P., Cucherat, M., & Perret, G. Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1957 · Cited by 470 · see citing works

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

Park, H., Kwon, H. M., Lim, H. J., Hong, B., Lee, J. Y., Park, B. E., Jang, Y., Cho, S. Y., & Kim, H. S. (2001) · Experimental & Molecular Medicine · doi:10.1038/emm.2001.17 · Cited by 464 · see citing works

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.

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Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Cao, R., Brakenhielm, E., Wahlestedt, C., Thyberg, J., & Cao, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101564798 · Cited by 446 · see citing works

Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis

Fukumura, D., Ushiyama, A., Duda, D. G., Xu, L., Tam, J., Krishna, V., Chatterjee, K., Garkavtsev, I., & Jain, R. K. (2003) · Circulation Research · doi:10.1161/01.res.0000099243.20096.fa · Cited by 365 · see citing works

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

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Dual role of tumor necrosis factor-alpha in angiogenesis.

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Interleukin-6, Secreted by Human Ovarian Carcinoma Cells, Is a Potent Proangiogenic Cytokine

Nilsson, M. B., Langley, R. R., & Fidler, I. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0623 · Cited by 353 · see citing works

Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation

Zhang, Y.-W., Su, Y., Volpert, O. V., & Woude, G. F. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135113100 · Cited by 348 · see citing works

Heparin-Binding EGF-Like Growth Factor

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Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

Mignatti, P., & Rifkin, D. B. (2017) · Enzyme and Protein · doi:10.1159/000468621 · Cited by 331 · see citing works

Adipocyte Produces Matrix Metalloproteinases 2 and 9

Bouloumié, A., Sengenès, C., Portolan, G., Galitzky, J., & Lafontan, M. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2080 · Cited by 329 · see citing works

Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice

Bråkenhielm, E., Cao, R., Gao, B., Angelin, B., Cannon, B., Parini, P., & Cao, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000132745.76882.70 · Cited by 326 · see citing works

Obesity and Outcomes in Premenopausal and Postmenopausal Breast Cancer

Loi, S., Milne, R. L., Friedlander, M. L., McCredie, M. R. E., Giles, G. G., Hopper, J. L., & Phillips, K. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0042 · Cited by 319 · see citing works

Angiogenesis: update 2005

Dvorak, H. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01361.x · Cited by 296 · see citing works

Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer

Vona-Davis, L. C., Howard-McNatt, M. M., & Rose, D. P. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00396.x · Cited by 260 · see citing works

Breast Cancer and Obesity: An Update

Stephenson, G. D., & Rose, D. P. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4501_1 · Cited by 258 · see citing works

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects

Miyazawa-Hoshimoto, S., Takahashi, K., Bujo, H., Hashimoto, N., & Saito, Y. (2003) · Diabetologia · doi:10.1007/s00125-003-1221-6 · Cited by 254 · see citing works

Leptin Signaling Promotes the Growth of Mammary Tumors and Increases the Expression of Vascular Endothelial Growth Factor (VEGF) and Its Receptor Type Two (VEGF-R2)

González, R. R., Cherfils, S., Escobar, M., Yoo, J. H., Cariño, C., Styer, A. K., Sullivan, B. T., Sakamoto, H., Olawaiye, A., Serikawa, T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601991200 · Cited by 242 · see citing works

HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis

Ongusaha, P. P., Kwak, J. C., Zwible, A. J., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0925 · Cited by 219 · see citing works

Leptin: a multifunctional hormone

Huang, L., & Cai, L. (2000) · Cell Research · doi:10.1038/sj.cr.7290038 · Cited by 217 · see citing works

Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics

Schraw, T., Wang, Z. V., Halberg, N., Hawkins, M. A., & Scherer, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1561 · Cited by 216 · see citing works

Angiogenesis in an in vivo model of adipose tissue development

Neels, J. G., Thinnes, T., & Loskutoff, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1101fje · Cited by 194 · see citing works

Elevated Production of Interleukin-6 Is Associated With a Lower Incidence of Disease-Related Ischemic Events in Patients With Giant-Cell Arteritis

Hernández‐Rodríguez, J., Segarra, M., Vilardell, C., Sánchez, M., García‐Martínez, A., Esteban, M., Grau, J. M., Urbano-Márquez, A., Colomer, D., Kleinman, H. K., et al. (2003) · Circulation · doi:10.1161/01.cir.0000066907.83923.32 · Cited by 190 · see citing works

In vivo targeting of SF/HGF and c‐met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis

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High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels

Miyoshi, Y., Funahashi, T., Tanaka, S., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21543 · Cited by 183 · see citing works

Nonclassic Endogenous Novel Regulators of Angiogenesis

Ribatti, D., Conconi, M. T., & Nussdorfer, G. G. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.3 · Cited by 178 · see citing works

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

Gruen, M. L., Hao, M., Piston, D. W., & Hasty, A. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2007 · Cited by 171 · see citing works

Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism

Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158 · see citing works

HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways

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Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)

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ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis

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Mechanisms of Disease: angiogenesis and the management of breast cancer

Banerjee, S. N., Dowsett, M., Ashworth, A., & Martin, L. (2007) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0905 · Cited by 142 · see citing works

Angiogenic activity of adipose tissue

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p53 induction of heparin‐binding EGF‐like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

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Evidence ofin SituProliferation of Adult Adipose Tissue-Derived Progenitor Cells: Influence of Fat Mass Microenvironment and Growth

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Scatter factor/hepatocyte growth factor gene transfer enhances glioma growth and angiogenesis in vivo.

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Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells

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Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters.

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Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity

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Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.

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Modulation by leptin of proliferation and apoptosis in vascular endothelial cells

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Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: Evidence that tumor necrosis factor-α- and interleukin-1β-treated human preadipocytes are potent leptin producers

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Angiogenic Property of Hepatocyte Growth Factor Is Dependent on Upregulation of Essential Transcription Factor for Angiogenesis, ets-1

Tomita, N., Morishita, R., Taniyama, Y., Koike, H., Aoki, M., Shimizu, H., Matsumoto, K., Nakamura, T., Kaneda, Y., & Ogihara, T. (2003) · Circulation · doi:10.1161/01.cir.0000055331.41937.aa · Cited by 115 · see citing works

Drug Insight: VEGF as a therapeutic target for breast cancer

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Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells

Mahadev, K., Wu, X., Donnelly, S., Ouedraogo, R., Eckhart, A. D., & Goldstein, B. J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn034 · Cited by 113 · see citing works

The role of the matrix metalloproteinases during in vitro vessel formation

Burbridge, M. F., Cogé, F., Galizzi, J.-P., et al. (2002) · Angiogenesis · doi:10.1023/a:1023889805133 · Cited by 106 · see citing works

Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in three-dimensional collagen gels

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Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo

Rega‐Kaun, G., Kaun, C., Demyanets, S., Pfaffenberger, S., Rychli, K., Hohensinner, P. J., Kastl, S., Speidl, W. S., Weiss, T. W., Breuss, J. M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.143081 · Cited by 104 · see citing works

White Adipocyte Vascular Endothelial Growth Factor: Regulation by Insulin

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Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice.

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Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin‐binding epidermal growth factor‐like growth factor and vascular endothelial growth factor

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Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival

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TNF-alpha, soluble TNF receptor and interleukin-6 plasma levels in the general population.

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Increased Plasma HB-EGF Associated with Obesity and Coronary Artery Disease

Matsumoto, S., Kishida, K., Shimomura, I., Maeda, N., Nagaretani, H., Matsuda, M., Nishizawa, H., Kihara, S., Funahashi, T., & Matsuzawa, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6720 · Cited by 86 · see citing works

HGF/SF in Angiogenesis

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Human leptin induces angiogenesis in vivo

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Glycine increases mRNA adiponectin and diminishes pro-inflammatory adipokines expression in 3T3-L1 cells

García-Macedo, R., Sánchez‐Muñoz, F., Almanza-Pérez, J. C., Durán-Reyes, G., Alarcón-Aguilar, F. J., & Cruz, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.051 · Cited by 80 · see citing works

FGF-2 Enhances Vascularization for Adipose Tissue Engineering

Marra, K. G., Defail, A. J., Clavijo‐Alvarez, J. A., Badylak, S. F., Taieb, A., Schipper, B. M., Bennett, J., & Rubin, J. P. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000305517.93747.72 · Cited by 78 · see citing works

A central role for hepatocyte growth factor in adipose tissue angiogenesis

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Cell-Mediated Delivery of Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor onto the Chick Chorioallantoic Membrane: Endothelial Fenestration and Angiogenesis

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Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells

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C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression

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Triamcinolone Acetonide Inhibits IL-6– and VEGF-Induced Angiogenesis Downstream of the IL-6 and VEGF Receptors

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Differential mitogenic responses of human macrovascular and microvascular endothelial cells to cytokines underline their phenotypic heterogeneity

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Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma

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Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4

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Role of α v β 3 -integrin in TNF-α-induced endothelial cell migration

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Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion

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