Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

Zhu, M.-L.; Kyprianou, N.

doi:10.1677/erc-08-0084

Cited by 288Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

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Zhu, M.-L., Kyprianou, N.·2008·Endocrine Related Cancer

DOI 10.1677/erc-08-0084PMC PMC2740735

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Abstract

Androgens promote the growth and differentiation of prostate cells through ligand activation of the androgen receptor (AR). Sensitization of the androgenic response by multifunctional growth factor signaling pathways is one of the mechanisms via which AR contributes to the emergence of androgen-independent prostate tumors. The ability of AR to cross-talk with key growth factor signaling events toward the regulation of cell cycle, apoptosis, and differentiation outcomes in prostate cancer cells is established. In this paper, we review the functional interaction between AR and an array of growth factor signal transduction events (including epidermal growth factor; fibroblast growth factor; IGF1; vascular endothelial growth factor; transforming growth factor-beta) in prostate tumors. The significance of this derailed cross-talk between androgens and key signaling networks in prostate cancer progression and its value as a therapeutic forum targeting androgen-independent metastatic prostate cancer is discussed.

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The expression of EGF and its receptor EGFR is increased in patients with advanced, aggressive prostate cancer, and both molecules have been implicated in the development and progression of many other kinds of tumors.
“The expression of EGF and its receptor (EGFR) are increased in patients with advanced, aggressive prostate cancer, and both molecules have been implicated in the development and progression of many other kinds of tumors (33).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [33]
Mitogenic growth factors such as EGF and IGF stimulate intracellular signaling that cross talks with AR signaling.
“The ability of mitogenic growth factors such as EGF and IGF to stimulate intracellular signaling that cross talks with those of the AR has been extensively reviewed elsewhere (33).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [33]

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Androgen-Stimulated Human Prostate Epithelial Growth Mediated by Stromal-Derived Fibroblast Growth Factor-10.
Nakano, K., Fukabori, Y., Itoh, N., Lu, W., Kan, M., McKeehan, W. L., & Yamanaka, H. (1999) · Endocrine Journal · doi:10.1507/endocrj.46.405 · Cited by 51 · see citing works
Transforming growth factor-beta expression in prostate neoplasia.
Cardillo, M. R., Petrangeli, E., Perracchio, L., Salvatori, L., Ravenna, L., & Silverio, F. D. (2000) · PubMed · Cited by 50 · see citing works
Neutralizing VEGF bioactivity with a soluble chimeric VEGF‐receptor protein flt(1‐3)IgG inhibits testosterone‐stimulated prostate growth in castrated mice
Lissbrant, I. F., Hammarsten, P., Lissbrant, E., Ferrara, N., Rudolfsson, S. H., & Bergh, A. R. J. (2003) · The Prostate · doi:10.1002/pros.10312 · Cited by 49 · see citing works
Androgen receptor expression induces FGF2, FGF‐binding protein production, and FGF2 release in prostate carcinoma cells: Role of FGF2 in growth, survival, and androgen receptor down‐modulation
Rosini, P., Bonaccorsi, L., Baldi, E., Chiasserini, C., Forti, G., Chiara, G. D., Lucibello, M., Mongiat, M., Iozzo, R. V., Garaci, E., et al. (2002) · The Prostate · doi:10.1002/pros.10164 · Cited by 47 · see citing works
Direct activation of TGF‐β1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude mice
Yoon, G., Kim, J. Y., Choi, Y., Won, Y. S., & Lim, I. K. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20638 · Cited by 47 · see citing works
An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells.
Aaronson, D. S., Muller, M., Neves, S. R., Chung, W.-C., Jayaram, G., Iyengar, R., & Ram, P. T. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.02.006 · Cited by 47 · see citing works
Transforming Growth Factor-β1 Induces Nuclear to Cytoplasmic Distribution of Androgen Receptor and Inhibits Androgen Response in Prostate Smooth Muscle Cells1
Gerdes, M. J., Dang, T. D., Larsen, M., & Rowley, D. R. (1998) · Endocrinology · doi:10.1210/endo.139.8.6138 · Cited by 46 · see citing works
ErbB1 and prostate cancer: ErbB1 activity is essential for androgen‐induced proliferation and protection from the apoptotic effects of LY294002
Tørring, N., Dagnæs‐Hansen, F., Sørensen, B. S., Nexø, E., & Hynes, N. E. (2003) · The Prostate · doi:10.1002/pros.10245 · Cited by 45 · see citing works
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines
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Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the Androgen receptor in prostate cancer but is not directly regulated by Androgens or hypoxia
Banham, A. H., Boddy, J., Launchbury, R., Han, C., Turley, H., Malone, P. R., Harris, A. L., & Fox, S. B. (2007) · The Prostate · doi:10.1002/pros.20583 · Cited by 41 · see citing works
Androgens Induce the Expression of Vascular Endothelial Growth Factor in Human Fetal Prostatic Fibroblasts
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RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation
Rinaldo, F. M., Li, J., Wang, E., Muders, M. H., & Datta, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209971 · Cited by 40 · see citing works
Mesenchymal-Epithelial Interactions in the Growth and Development of the Prostate
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Androgenic regulation of growth factor and growth factor receptor expression in the cwr22 model of prostatic adenocarcinoma
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AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3‐induced T cell signaling
Bauer, B., Jenny, M., Fresser, F., Überall, F., & Baier, G. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00287-4 · Cited by 35 · see citing works
bcl‐2 antagonizes the combined apoptotic effect of transforming growth factor‐β and dihydrotestosterone in prostate cancer cells
Bruckheimer, E. M., & Kyprianou, N. (2002) · The Prostate · doi:10.1002/pros.10143 · Cited by 29 · see citing works
Self-citation
In vitro androgenic induction of a major protein in epithelial cell subcultures from mouse vas deferens
Manin, M., VEYSSIERE, G., Cheyvialle, D., Chevalier, M., Lecher, P., & Jean, C. (1992) · Endocrinology · doi:10.1210/endo.131.5.1385102 · Cited by 29 · see citing works
Acquisition of Androgen‐Mediated Expression of Mouse Vas Deferens Protein (MVDP) Gene in Cultured Epithelial Cells and in Vas Deferens During Postnatal Development
Manin, M., Martinez, A., van der SCHUEREN, B., Reynaert, I., & Jean, C. (2000) · Journal of Andrology · doi:10.1002/j.1939-4640.2000.tb02131.x · Cited by 16 · see citing works
Androgen regulation of prostate cancer cell FGF-1, FGF-2, and FGF-8: Preferential down-regulation of FGF-2 transcripts
ScarSari, T., & Shain, S. A. (1998) · Growth Factors · doi:10.3109/08977199809017492 · Cited by 16 · see citing works
Tumor Cell Hypoxia and the Hypoxia-Response Signaling System as a Target for Prostate Cancer Therapy
Anastasiadis, A. G., Bemis, D. L., Stisser, B. C., Salomon, L., Ghafar, M. A. A., & Buttyan, R. (2003) · Current Drug Targets · doi:10.2174/1389450033491136 · Cited by 15 · see citing works
IGF Binding Protein-5 Synthesis is Regulated by Testosterone through Transcriptional Mechanisms in Androgen Responsive Cells
Yoshizawa, A., & Ogikubo, S. (2006) · Endocrine Journal · doi:10.1507/endocrj.k06-017 · Cited by 9 · see citing works
Testosterone regulates FGF‐2 expression during testis maturation by an IRES‐dependent translational mechanism
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Androgen receptor signaling in prostate cancer development and progression
Tindall, D. J., & Lonergan, P. E. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.83937 · Cited by 544 · see citing works
Androgen receptors in hormone-dependent and castration-resistant prostate cancer
Shafi, A. A., Yen, A. E., & Weigel, N. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.003 · Cited by 422 · see citing works
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
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Inflammation and prostate cancer: the role of interleukin 6 ( IL ‐6)
Nguyen, D. P., Li, J., & Tewari, A. K. (2013) · British Journal of Urology · doi:10.1111/bju.12452 · Cited by 357 · see citing works
Drug resistance in metastatic castration-resistant prostate cancer
Šeruga, B., Ocaña, A., & Tannock, I. F. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.136 · Cited by 337 · see citing works
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
Li, S., Overman, J. J., Katsman, D., Kozlov, S. V., Donnelly, C. J., Twiss, J. L., Giger, R. J., Coppola, G., Geschwind, D. H., & Carmichael, S. T. (2010) · Nature Neuroscience · doi:10.1038/nn.2674 · Cited by 329 · see citing works
Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer
Knudsen, K. E., & Scher, H. I. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2660 · Cited by 305 · see citing works
Molecular cell biology of androgen receptor signalling
Bennett, N. C., Gardiner, R. A., Hooper, J. D., Johnson, D. W., & Gobe, G. C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.013 · Cited by 292 · see citing works
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
Knudsen, K. E., & Penning, T. M. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.002 · Cited by 291 · see citing works
Role of androgens and the androgen receptor in epithelial‐mesenchymal transition and invasion of prostate cancer cells
Zhu, M., & Kyprianou, N. (2009) · The FASEB Journal · doi:10.1096/fj.09-136994 · Cited by 228 · see citing works
Self-citation
Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
Lu, X., Yang, F., Chen, D., Zhao, Q., Chen, D., Ping, H., & Xing, N. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.41686 · Cited by 209 · see citing works
LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
Luo, J., Wang, K., Yeh, S., Sun, Y., Liang, L., Xiao, Y., Xu, W., Niu, Y., Liang Cheng, C., Maity, S. N., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09784-9 · Cited by 205 · see citing works
Angiogenesis in prostate cancer: onset, progression and imaging
Russo, G., Mischi, M., Scheepens, W. A., de la Rosette, J. J. M. C. H., & Wijkstra, H. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11444.x · Cited by 196 · see citing works
The role of progesterone signaling in the pathogenesis of uterine leiomyoma
Kim, J. J., & Sefton, E. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.044 · Cited by 191 · see citing works
Epithelial-mesenchymal transition in prostate cancer: an overview
Montanari, M., Rossetti, S., Cavaliere, C., D’Aniello, C., Malzone, M. G., Vanacore, D., Franco, R. D., Mantia, E. L., Iovane, G., Piscitelli, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15686 · Cited by 182 · see citing works
Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival
Tan, P. Y., Chang, C. W., Chng, K. R., Wansa, K. D. S. A., Sung, W.-K. K., & Cheung, E. C. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05958-11 · Cited by 180 · see citing works
CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents
Yin, L., & Hu, Q. (2013) · Nature Reviews Urology · doi:10.1038/nrurol.2013.274 · Cited by 171 · see citing works
Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works
MicroRNAs Profiling in Murine Models of Acute and Chronic Asthma: A Relationship with mRNAs Targets
Garbacki, N., Valentin, E. D., Huynh‐Thu, V. A., Geurts, P., Irrthum, A., Crahay, C., Arnould, T., Deroanne, C., Piette, J. G., Cataldo, D. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016509 · Cited by 147 · see citing works
Growth Hormone’s Links to Cancer
Boguszewski, C. L., & Boguszewski, M. C. D. S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00166 · Cited by 147 · see citing works
Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer
Mishra, S., Deng, J., Gowda, P. S., Rao, M. K., Lin, C.-L., Chen, C., Huang, T. H. ‐., & Sun, L. (2013) · Oncogene · doi:10.1038/onc.2013.374 · Cited by 145 · see citing works
Preclinical Study using Malat1 Small Interfering RNA or Androgen Receptor Splicing Variant 7 Degradation Enhancer ASC-J9 ® to Suppress Enzalutamide-resistant Prostate Cancer Progression
Wang, R., Sun, Y., Li, L., Niu, Y., Lin, W.-Y., Lin, C.-Y., Antonarakis, E. S., Luo, J., Yeh, S., & Chang, C. (2017) · European Urology · doi:10.1016/j.eururo.2017.04.005 · Cited by 141 · see citing works
Recent insights into NF ‐κ B signalling pathways and the link between inflammation and prostate cancer
Nguyen, D. P., Li, J., Yadav, S. S., & Tewari, A. K. (2013) · British Journal of Urology · doi:10.1111/bju.12488 · Cited by 140 · see citing works
Altered Signaling Pathways in Prostate Cancer Drive Metabolic Fate
Antico Arciuch, V. G., Gueron, G., Cotignola, J. H., & Vazquez, E. S. (2017) · CONICET Digital (CONICET) · Cited by 139 · see citing works
Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth
Traish, A. M., & Morgentaler, A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605376 · Cited by 137 · see citing works
The Influence of Sex Hormones in Liver Function and Disease
Kasarinaite, A., Sinton, M. C., Saunders, P. T. K., & Hay, D. C. (2023) · Cells · doi:10.3390/cells12121604 · Cited by 134 · see citing works
Posttranslational Modification of the Androgen Receptor in Prostate Cancer
der Steen, T. V., Tindall, D. J., & Huang, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714833 · Cited by 133 · see citing works
Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles
Hoang, D. T., Iczkowski, K. A., Kilari, D., See, W. A., & Nevalainen, M. T. (2016) · Oncotarget · doi:10.18632/oncotarget.12554 · Cited by 128 · see citing works
Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09)
Rothermundt, C. A., Hayoz, S., Templeton, A. J., Winterhalder, R., Strebel, R. T., Bärtschi, D., Pollak, M., Lui, L., Endt, K., Schiess, R., et al. (2014) · European Urology · doi:10.1016/j.eururo.2013.12.057 · Cited by 120 · see citing works
Bypass Mechanisms of the Androgen Receptor Pathway in Therapy-Resistant Prostate Cancer Cell Models
Marques, R. B., Dits, N. F. J., Erkens‐Schulze, S., van Weerden, W. M., & Jenster, G. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013500 · Cited by 120 · see citing works
Targeting TGF-β in prostate cancer: therapeutic possibilities during tumor progression
Jones, E., Pu, H., & Kyprianou, N. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220802705696 · Cited by 107 · see citing works
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Cabazitaxel: A novel taxane for metastatic castration-resistant prostate cancer-current implications and future prospects
Abidi, A. (2013) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.119704 · Cited by 106 · see citing works
Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation
Sen, A., Castro, I. D., DeFranco, D. B., Deng, F.-M., Melamed, J., Kapur, P., Raj, G. V., Rossi, R. M., & Hammes, S. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62044 · Cited by 103 · see citing works
Receptor-Targeted Nanomedicine for Cancer Therapy
Prajapati, A., Rangra, S., Patil, R., Desai, N., Jyothi, V. G. S. S., Salave, S., Amate, P., Benival, D. M., & Kommineni, N. (2024) · Receptors · doi:10.3390/receptors3030016 · Cited by 98 · see citing works
Endothelial Cells Enhance Prostate Cancer Metastasis via IL-6→Androgen Receptor→TGF-β→MMP-9 Signals
Wang, X., Lee, S. O., Xia, S., Jiang, Q., Luo, J., Li, L., Yeh, S., & Chang, C. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0895 · Cited by 95 · see citing works
Paxillin Regulates Androgen- and Epidermal Growth Factor-induced MAPK Signaling and Cell Proliferation in Prostate Cancer Cells
Sen, A., O’Malley, K. J., Wang, Z., Raj, G. V., DeFranco, D. B., & Hammes, S. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134064 · Cited by 89 · see citing works
Mechanisms navigating the TGF-β pathway in prostate cancer
Cao, Z., & Kyprianou, N. (2015) · Asian journal of urology · doi:10.1016/j.ajur.2015.04.011 · Cited by 88 · see citing works
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Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer
Chakravarty, G., Moroz, K., Makridakis, N. M., Lloyd, S. A., Galvez, S. E., Canavello, P. R., Lacey, M. R., Agrawal, K. C., & Mondal, D. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010086 · Cited by 86 · see citing works
Androgen receptor signaling regulates growth of glioblastoma multiforme in men
Yu, X., Jiang, Y., Wei, W., Cong, P., Ding, Y., Xiang, L., & Wu, K. (2014) · Tumor Biology · doi:10.1007/s13277-014-2709-z · Cited by 85 · see citing works
CYP17A1 inhibitors in castration-resistant prostate cancer
Gomez, L., Kovac, J. R., & Lamb, D. J. (2015) · Steroids · doi:10.1016/j.steroids.2014.12.021 · Cited by 83 · see citing works
The FGF/FGFR system in the physiopathology of the prostate gland
Giacomini, A., Grillo, E., Rezzola, S., Ribatti, D., Rusnati, M., Ronca, R., & Presta, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2020 · Cited by 80 · see citing works
Transcriptional network of androgen receptor in prostate cancer progression
Takayama, K., & Inoue, S. (2013) · International Journal of Urology · doi:10.1111/iju.12146 · Cited by 79 · see citing works
From pathogenesis to prevention of castration resistant prostate cancer
Bonkhoff, H., & Berges, R. R. (2009) · The Prostate · doi:10.1002/pros.21042 · Cited by 78 · see citing works
Testosterone Promotes Glioblastoma Cell Proliferation, Migration, and Invasion Through Androgen Receptor Activation
Rodríguez-Lozano, D. C., Piña-Medina, A. G., Hansberg-Pastor, V., Bello‐Alvarez, C., & Camacho‐Arroyo, I. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00016 · Cited by 78 · see citing works
Targeting silibinin in the antiproliferative pathway
Li, L., Zeng, J., Gao, Y., & He, D. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903533631 · Cited by 76 · see citing works
Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf
Pitchakarn, P., Suzuki, S., Ogawa, K., Pompimon, W., Takahashi, S., Asamoto, M., Limtrakul, P., & Shirai, T. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.041 · Cited by 76 · see citing works
Meibomian Gland Dysfunction in Primary and Secondary Sjögren Syndrome
Sullivan, D. A., Dana, R., Sullivan, R. M., Krenzer, K. L., Şahin, A., Arica, B., Liu, Y., Kam, W. R., Papas, A., & Cermak, J. M. (2018) · Ophthalmic Research · doi:10.1159/000487487 · Cited by 76 · see citing works
Persistent androgen receptor addiction in castration-resistant prostate cancer
Schweizer, M. T., & Yu, E. Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0225-2 · Cited by 75 · see citing works
aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
Ishiguro, H., Akimoto, K., Nagashima, Y., Kojima, Y., Sasaki, T., Ishiguro-Imagawa, Y., Nakaigawa, N., Ohno, S., Kubota, Y., & Uemura, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907044106 · Cited by 74 · see citing works
Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
Linder, S., van der Poel, H. G., Bergman, A. M., Zwart, W. T., & Preković, S. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0289 · Cited by 74 · see citing works
The activation of OR51E1 causes growth suppression of human prostate cancer cells
Maßberg, D., Jovancevic, N., Offermann, A., Simon, A., Baniahmad, A., Perner, S., Pungsrinont, T., Luko, K., Philippou, S., Ubrig, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10197 · Cited by 72 · see citing works
Androgen receptor‐related diseases: what do we know?
Shukla, G. C., Plaga, A. R., Shankar, E., & Gupta, S. (2016) · Andrology · doi:10.1111/andr.12167 · Cited by 72 · see citing works
Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer
Antonarakis, E. S., & Armstrong, A. J. (2011) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2011.23 · Cited by 71 · see citing works
The role of proteomics in prostate cancer research: Biomarker discovery and validation
Pin, E., Fredolini, C., & Petricoin, E. F. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.12.012 · Cited by 71 · see citing works
Overcoming Chemotherapy Resistance in Prostate Cancer
Madan, R. A., Pal, S. K., Sartor, O. A., & Dahut, W. L. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2654 · Cited by 70 · see citing works
Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer
Ferrari, A. C., Alumkal, J. J., Stein, M. N., Taplin, M., Babb, J. S., Barnett, E. S., Gómez-Pinillos, A., Liu, X., Moore, D. F., DiPaola, R. S., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1589 · Cited by 70 · see citing works
In silico molecular docking study of natural compounds on wild and mutated epidermal growth factor receptor
Singh, P., & Bast, F. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-1090-1 · Cited by 68 · see citing works
Suppressed Prostate Epithelial Development with Impaired Branching Morphogenesis in Mice Lacking Stromal Fibromuscular Androgen Receptor
Lai, K.-P., Yamashita, S., Vitkus, S., Shyr, C., Yeh, S., & Chang, C. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1189 · Cited by 67 · see citing works
Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: A review
Özkan, E. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.002 · Cited by 67 · see citing works
Newly Diagnosed Metastatic Prostate Cancer: Has the Paradigm Changed?
Damodaran, S., Kyriakopoulos, C. E., & Jarrard, D. F. (2017) · Urologic Clinics of North America · doi:10.1016/j.ucl.2017.07.008 · Cited by 66 · see citing works
Chemotherapy in metastatic castration-resistant prostate cancer: Current scenario and future perspectives
Ruiz de Porras, V., Font, A., & Aytes, A. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.033 · Cited by 65 · see citing works
Androgen Therapy in Neurodegenerative Diseases
Bianchi, V. E., Rizzi, L., Bresciani, E., Omeljaniuk, R. J., & Torsello, A. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa120 · Cited by 65 · see citing works
Cross-talk between EGFR and IL-6 drives oncogenic signaling and offers therapeutic opportunities in cancer
Ray, K., Újvári, B., Ramana, V., & Donald, J. A. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.04.002 · Cited by 62 · see citing works
Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands
Carrión-Salip, D., Panosa, C., Menéndez, J. A., Puig, T., Oliveras, G., Pandiella, A., Llorens, R., & Massaguer, A. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1509 · Cited by 62 · see citing works
The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer
Melnik, B. C., John, S. M., Carrera‐Bastos, P., & Cordain, L. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-74 · Cited by 62 · see citing works
Dual EGFR/HER2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Withdrawal by Suppressing ErbB3
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Authors: Zhu, M.-L., & Kyprianou, N.
Affiliations: University of Kentucky HealthCare (US)
ORCID: Zhu, M.-L.
Kyprianou, N.
Venue: Endocrine Related Cancer
Publisher: Bioscientifica
Published: 2008-09-10
Volume: 15
Issue: 4
Pages: 841-849
ISSN: 1351-0088 (ISSN-L)
1479-6821
DOI: 10.1677/erc-08-0084
PMC: PMC2740735
OpenAlex: W2167609397
Cited by: 286
References: 105
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 18 · 2015: 23 · 2014: 10 · 2013: 29 · 2012: 17
FWCI: 3.48
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrine Related Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-53525-08, R01DK053525)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, growth factor signaling, signaling crosstalk, prostate cancer, castration-resistant prostate cancer, metastatic prostate cancer, epidermal growth factor, fibroblast growth factor, insulin-like growth factor I, vascular endothelial growth factor, TGF-beta, cell cycle regulation, apoptosis, therapeutic target
MeSH terms: Animals, Humans, Male, Prostatic Neoplasms, Receptors, Androgen, Signal Transduction, Gene Expression Regulation, Neoplastic, Receptor Cross-Talk, Intercellular Signaling Peptides and Proteins

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Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

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