The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
AMPK as a mediator of hormonal signalling
Abstract
AMP-activated protein kinase (AMPK) is a key molecular player in energy homeostasis at both cellular and whole-body levels. AMPK has been shown to mediate the metabolic effects of hormones such as leptin, ghrelin, adiponectin, glucocorticoids and insulin as well as cannabinoids. Generally, activated AMPK stimulates catabolic pathways (glycolysis, fatty acid oxidation and mitochondrial biogenesis) and inhibits anabolic pathways (gluconeogenesis, glycogen, fatty acid and protein synthesis), and has a direct appetite-regulating effect in the hypothalamus. Drugs that activate AMPK, namely metformin and thiazolidinediones, are often used to treat metabolic disorders. Thus, AMPK is now recognised as a potential target for the treatment of obesity and associated co-morbidities.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
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Cited by
Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593
The interface between thyroid and diabetes mellitus
Duntas, L. H., Orgiazzi, J., & Brabant, G. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04029.x · Cited by 247
Insulin Signal Transduction Perturbations in Insulin Resistance
Khalid, M., Alkaabi, J., Khan, M. A. B., & Adem, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168590 · Cited by 233
Metadata
- Authors
- Lim, C. T., Kola, B., & Korbonits, M.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2009-07-22
- Volume
- 44
- Issue
- 2
- Pages
- 87-97
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2118819459
- Cited by
- 298
- References
- 28
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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