The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
AMPK as a mediator of hormonal signalling
Abstract
AMP-activated protein kinase (AMPK) is a key molecular player in energy homeostasis at both cellular and whole-body levels. AMPK has been shown to mediate the metabolic effects of hormones such as leptin, ghrelin, adiponectin, glucocorticoids and insulin as well as cannabinoids. Generally, activated AMPK stimulates catabolic pathways (glycolysis, fatty acid oxidation and mitochondrial biogenesis) and inhibits anabolic pathways (gluconeogenesis, glycogen, fatty acid and protein synthesis), and has a direct appetite-regulating effect in the hypothalamus. Drugs that activate AMPK, namely metformin and thiazolidinediones, are often used to treat metabolic disorders. Thus, AMPK is now recognised as a potential target for the treatment of obesity and associated co-morbidities.
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Cites
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Cited by
Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
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Leptin in Human Physiology and Pathophysiology
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The interface between thyroid and diabetes mellitus
Duntas, L. H., Orgiazzi, J., & Brabant, G. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04029.x · Cited by 247
Insulin Signal Transduction Perturbations in Insulin Resistance
Khalid, M., Alkaabi, J., Khan, M. A. B., & Adem, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168590 · Cited by 233
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Diversity and plasticity of microglial cells in psychiatric and neurological disorders
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Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases
Nakagawa, Y., & Chiba, K. (2014) · Pharmaceuticals · doi:10.3390/ph7121028 · Cited by 215
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Activation of AMPK under Hypoxia: Many Roads Leading to Rome
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Regulation of longevity by FGF21: interaction between energy metabolism and stress responses
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“Leptin regulation of AMPK in peripheral tissues is opposite to that exhibited in the hypothalamus [18].”
Augmenting energy expenditure by mitochondrial uncoupling: A role of AMP-activated protein kinase
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Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology
Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34
Self-citationAmengual-Cladera, E., Lladó, I., Gianotti, M., & Proenza, A. M. (2012) · Steroids · doi:10.1016/j.steroids.2012.02.012 · Cited by 29
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Metadata
- Authors
- Lim, C. T., Kola, B., & Korbonits, M.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2009-07-22
- Volume
- 44
- Issue
- 2
- Pages
- 87-97
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2118819459
- Cited by
- 298
- References
- 28
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- closed
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