ULTRADIAN AND CIRCADIAN RHYTHMS IN THE PLASMA CONCENTRATION OF CORTISOL IN SHEEP

FULKERSON, W. J.; TANG, B. Y.

doi:10.1677/joe.0.0810135

Cited by 115Adrenal Hormones and DisordersStress Responses and CortisolCircadian rhythm and melatonin

ULTRADIAN AND CIRCADIAN RHYTHMS IN THE PLASMA CONCENTRATION OF CORTISOL IN SHEEP

FULKERSON, W. J., TANG, B. Y.·1979·Journal of Endocrinology

DOI 10.1677/joe.0.0810135

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Abstract

Three Merino ewes, adapted for about 3 weeks to their environment, were bled at 10 min intervals through a jugular venous cannula. Radioimmunoassay of plasma samples for cortisol revealed marked diurnal variations with peak levels just after midnight and lowest values in the afternoon. This rhythm appeared to result from a changing amplitude associated with a distinct ultradian rhythm (frequency 0·8–1·2 cycles/h) in the plasma level of cortisol. Calculation of the daily rate of secretion of cortisol from the hormone profiles gave a mean value of 8·49 mg. Arguments are put forward in favour of this method for obtaining the true rate of secretion of cortisol.

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Several physiological systems exhibit ultradian rhythms in the 1-3 h range, including the HPG axis, HPA axis, and suprachiasmatic nucleus.
“Several physiological systems exhibit ultradian rhythms (URs) in the 1–3 h range, including the HPG axis60–65, the HPA axis66–72, and the suprachiasmatic nucleus73, 74 – the principal orchestrating brain area for circadian rhythms.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [67]

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“However, cortisol concentrations are usually lowest in the afternoon (Fulkerson and Tang, 1979; Simonetta et al., 1991) when the post-transport sample was taken and the baseline and slaughter samples were taken at approximately the same time of day, therefore the values found in the present…”
Background
Comparison of serum cortisol and prolactin in sheep blood sampled by two methods
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“In heifers (Fulkerson et al, 1980 ) and sheep (Fulkerson & Tang, 1979 ) high night-time and low afternoon cortisol concentrations have been reported.”
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Rapid pulsatile corticosterone secretion in the rat is not confirmed
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Effect of a targeted pain management protocol for the treatment of dermatitis interdigitalis contagiosa in Merino meat sheep in a tilt squeeze chute
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“Instead, previous studies have identified at most an ultradian rhythm with a concentration minimum in the morning (Fulkerson and Tang, 1979) and a possible effect of stress (Przekop et al.”
Background

Authors: FULKERSON, W. J., & TANG, B. Y.
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 1979-04-01
Volume: 81
Issue: 1
Pages: 135-141
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1677/joe.0.0810135
OpenAlex: W2039679866
Cited by: 115
References: 0
Citations by year: 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 2.98
Type: journal article
Language: en
Open access: closed
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: ultradian rhythms, circadian rhythm, cortisol, diurnal variation, cortisol secretion rate, Merino ewes, sheep, radioimmunoassay
MeSH terms: Animals, Circadian Rhythm, Female, Hydrocortisone, Periodicity, Radioimmunoassay, Sheep

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ULTRADIAN AND CIRCADIAN RHYTHMS IN THE PLASMA CONCENTRATION OF CORTISOL IN SHEEP

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