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Cited by 110Hormonal and reproductive studiesAdrenal Hormones and DisordersAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency

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Corrales, J J, Almeida, M, Burgo, R, Mories, M T, Miralles, J M, Orfao, A·2006·Journal of Endocrinology
DOI 10.1677/joe.1.06779
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Abstract

Androgens are considered to have immunomodulatory effects but their cellular mechanisms of action remain largely unknown. In the present study we prospectively analyzed the serial effects of androgen-replacement therapy on both the distribution of peripheral blood lymphocytes, monocytes and dendritic cells as well as on the production of interleukin (IL)-1β, IL-6 and tumor necrosis factor α (TNFα) inflammatory cytokines by circulating monocytes and CD33 myeloid, CD16 and plasmacytoid dendritic cell subsets, the most potent antigen-presenting cells (APCs) in type-2 diabetic men with partial androgen deficiency. Analyses were performed before therapy and at 1, 3, 6 and 12 months after treatment with 150 mg testosterone enanthate every 2 weeks in a group of 13 type-2 diabetic men. Our results show for the first time that testosterone-replacement therapy is associated with a reduction or complete abrogation of spontaneous ex vivo production of IL-1β, IL-6 and TNFα by APCs. Meanwhile, the in vitro production of inflammatory cytokines by these cells after stimulation with lipopolysaccharide plus recombinant human interferon-γ remained unchanged, suggesting that APCs preserve their constitutive machinery to produce inflammatory cytokines under androgen treatment. These results confirm and extend previous observations about the anti-inflammatory effects of androgen therapy on APCs in a new, previously unexplored model of androgen deficiency; namely, aging type-2 diabetic men. A decreased production of inflammatory cytokines by APCs might have important consequences for sex differences in susceptibility to autoimmune diseases, inflammatory response to injury and atheromatosis.

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Metadata

Authors
Corrales, J. J., Almeida, M., Burgo, R., Mories, M. T., Miralles, J. M., & Orfao, A.
Affiliations
  • Universidad de Salamanca (ES)
  • Complejo Hospitalario de Salamanca (ES)
ORCID
Venue
Journal of Endocrinology
Publisher
Bioscientifica
Published
2006-06
Volume
189
Issue
3
Pages
595-604
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
DOI
10.1677/joe.1.06779
OpenAlex
W2139503270
Cited by
110
References
56
Citations by year
2026: 5 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 8
FWCI
4.08
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
testosterone replacement therapy, testosterone enanthate, androgen deficiency, type 2 diabetes, older men, antigen-presenting cells, dendritic cells, monocytes, inflammatory cytokines, IL-1β, interleukin-6, TNF-α, immunomodulation, atheromatosis
MeSH terms
Aged, Androgens, Anti-Inflammatory Agents, Antigen-Presenting Cells, Depression, Chemical, Diabetes Mellitus, Type 2, Humans, Interleukin-1, Lymphocytes, Male, Middle Aged, Testosterone, Tumor Necrosis Factor-alpha, Interleukin-6, Case-Control Studies, Lymphocyte Subsets, Cytokines, Lymphocyte Count, Statistics, Nonparametric, Hormone Replacement Therapy

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