Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in an animal model of Alzheimer's disease
Open accessAbstract
It has widely been reported that the brain in Alzheimer's disease (AD) is affected by increased oxidative stress, and this may have a role in the pathogenesis of this disorder. Quercetin, a polyphenol extensively found in nature, has recently been considered. Also, physical activities have a paradoxical effect on brain function in older adults. Therefore, this study aimed at investigating the synergic effects of quercetin (as chemical treatment) and exercise (as physical treatment) on AD-induced learning and memory impairment. Fifty-six adult male Wistar rats were randomly assigned into one of the following eight groups (n=7): The Control, Sham (saline), AD (intracerebroventricular administration of streptozotocin (STZ)), AD+80 mg/kg Quercetin (STZ+Q80), Quercetin vehicle (1 % Ethanol)+STZ, Exercise pretreatment (EX)+STZ, Off the treadmill+STZ, and EX+Q80+STZ. Quercetin administration was done intraperitoneally for 21 days after STZ injection. The rats ran on the treadmill for one hour a day for 60 days at a speed of 20-22 m/min. After the treatment, the spatial memory and levels of oxidative stress parameters were evaluated. The results showed that STZ caused spatial memory impairment and increased oxidative stress in the hippocampus. Exercise pretreatment or Quercetin injection improved the spatial memory impairment and oxidative stress caused by STZ injection. However, the combination of quercetin and exercise pretreatment was more effective. It can be concluded that the combined exercise pretreatment and Quercetin injection affected the antioxidant defense system and improved STZ-induced memory impairment.
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Quercetin positively modulates Nrf2 signaling.
“to positively modulate Nrf2 signaling (Arredondo et al., 2010; Molaei et al., 2020; Yu et al., 2020)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Molaei et al., 2020
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Shirazpour, S., Taheri, F., Sepehri, G., Meymandi, M. S., Zangiabadizadeh, M., Zangiabadi, M., Hosseini, N. S., Rajizadeh, M. A., Sheikhi, S., & Sabet, N. (2025) · Brain and Behavior · doi:10.1002/brb3.70925
Liu, L., & Zhao, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1850414
- Authors
- Molaei, A., Hatami, H., Dehghan, G., Sadeghian, R., & Khajehnasiri, N.
- Affiliations
- University of Tabriz (IR)
- Mashhad University of Medical Sciences (IR)
- Venue
- IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- Publisher
- IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- Published
- 2020
- Volume
- 19
- Pages
- 596-612
- ISSN
- 1611-2156 (ISSN-L)
- PMC
- PMC7257248
- OpenAlex
- W3028711093
- Cited by
- 41
- References
- 58
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- www.excli.de
- Licence
- cc-by
- Locations
- EXCLI journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Technische Universität Dortmund Eldorado (Technische Universität Dortmund) (submittedVersion, cc-by)
- Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo)
- Technische Universität Dortmund Eldorado (Technische Universität Dortmund)
- PubMed
- Funders
- University of Tabriz
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- quercetin, physical activity, Alzheimer's disease, spatial memory, oxidative stress, streptozotocin, hippocampus, antioxidant defense, memory impairment, polyphenols, treadmill running, combination therapy
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