Cited by 114Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Streptozotocin-induced sporadic Alzheimer’s disease: Selection of appropriate dose

Mehla, Jogender, Pahuja, Monika, Gupta, Yogendra Kumar·2012·Journal of Alzheimer s Disease

Abstract

The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.

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Crossref · 10.3233/jad-2012-120958

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Authors
Mehla, J., Pahuja, M., & Gupta, Y. K.
Affiliations
All India Institute of Medical Sciences (IN)
Corresponding author
Gupta, Yogendra Kumar
Venue
Journal of Alzheimer s Disease
Published
2012-12-03
Volume
33
Issue
1
Pages
17-21
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1670803694
Cited by
113
References
25
Citations by year
2026: 6 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 11 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
streptozotocin, Alzheimer's disease model
MeSH terms
Alzheimer Disease, Animals, Avoidance Learning, Disease Models, Animal, Injections, Intraventricular, Male, Streptozocin, Rats, Wistar, Maze Learning, Rats

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