Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through yap1
Open accessAbstract
Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in EC proliferation are largely unknown. Here, we have demonstrated that aged ECs are larger than young ECs and that age-dependent increases in EC size control EC proliferation and senescence through CDC42-Yes-associated protein (YAP1) signaling. Reduction of aged EC size by culturing on single-cell sized fibronectin-coated smaller islands decreases CDC42 activity, stimulates YAP1 nuclear translocation and attenuates EC senescence. Stimulation of YAP1 or inhibition of CDC42 activity in aged ECs also restores blood vessel formation. Age-dependent changes in EC size and/or CDC42 and YAP1 activity may be the key control point of age-related decline in angiogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Senescent cells generally demonstrate an enlarged and flattened cell morphology, expanded nucleoli, enhanced SA-β-gal activity, telomere shortening, elevation of p16 or p21, macromolecular damage and metabolism dysfunction.
“Senescent cells generally demonstrate an enlarged and flattened cell morphology [27] and expanded nucleoli [28,29], enhanced senescence-associated beta-galactosidase (SA-β-gal) activity [30], telomere shortening, elevation of the cyclin-dependent kinase inhibitor p16 [11,31] or p21 [32], macromolecular damage and metabolism dysfunction [1].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467 · see citing works
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,628 · see citing works
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 1× · see citing works
“Consistent with others’ reports [46, 47], EC proliferation measured by BrdU nuclear incorporation was lower by 69% in ECs isolated from aged human adipose tissue, while cellular senescence detected by P16INK4A immunocytochemical (ICC) analysis and SA-β galactosidase (Gal) staining increased in aged human adipose ECs;…”
ResultThe Biology of YAP/TAZ: Hippo Signaling and Beyond
Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works
Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works
Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works
The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094 · see citing works
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874 · see citing works
Age-Dependent Impairment of Angiogenesis
Rivard, A., Fabre, J., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T., & Isner, J. M. (1999) · Circulation · doi:10.1161/01.cir.99.1.111 · Cited by 774 · see citing works
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Shao, D. D., Xue, W., Krall, E. B., Bhutkar, A., Piccioni, F., Wang, X., Schinzel, A. C., Sood, S., Rosenbluh, J., Kim, J. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.004 · Cited by 744 · see citing works
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P. J., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 736 · see citing works
Integrins in Mechanotransduction
Katsumi, A., Orr, A. W., Tzima, E., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300038200 · Cited by 724 · see citing works
Developmental and Pathological Angiogenesis
Chung, A. S., & Ferrara, N. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154002 · Cited by 722 · see citing works
YAP regulates cell mechanics by controlling focal adhesion assembly
Nardone, G., Cruz, J. O. L., Vrbský, J., Martini, C., Přibyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15321 · Cited by 669 · see citing works
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 666 · see citing works
Endothelial fluid shear stress sensing in vascular health and disease
Baeyens, N., Bandyopadhyay, C., Coon, B. G., Yun, S., & Schwartz, M. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83083 · Cited by 577 · see citing works
A mechanosensitive transcriptional mechanism that controls angiogenesis
Mammoto, A., Connor, K. M., Mammoto, T., Yung, C. W., Huh, D., Aderman, C. M., Mostoslavsky, G., Smith, L. E. H., & Ingber, D. E. (2009) · Nature · doi:10.1038/nature07765 · Cited by 529 · see citing works
Self-citationFlow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis
Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613121113 · Cited by 471 · see citing works
Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
Huynh, J., Nishimura, N., Rana, K., Peloquin, J. M., Califano, J. P., Montague, C. R., King, M. R., Schaffer, C. B., & Reinhart‐King, C. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002761 · Cited by 403 · see citing works
Quantitative identification of senescent cells in aging and disease
Biran, A., Zada, L., Abou Karam, P., Vadai, E., Roitman, L., Ovadya, Y., Porat, Z., & Krizhanovsky, V. (2017) · Aging Cell · doi:10.1111/acel.12592 · Cited by 402 · see citing works
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93825 · Cited by 402 · see citing works
Mechanosensitive mechanisms in transcriptional regulation
Mammoto, A., Mammoto, T., & Ingber, D. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.093005 · Cited by 393 · see citing works
Self-citationOta, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 391 · see citing works
Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance
Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.019 · Cited by 308 · see citing works
Integrin signalling regulates YAP/TAZ to control skin homeostasis
Elbediwy, A., Vincent‐Mistiaen, Z. I., Spencer‐Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., et al. (2016) · Development · doi:10.1242/dev.133728 · Cited by 307 · see citing works
Xu, M., Zhang, D., Luo, R., Wu, Y., Zhou, H., Kong, L., Bi, R., & Yao, Y. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.08.012 · Cited by 294 · see citing works
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292 · see citing works
Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing
Brock, A., Chang, E. I., Ho, C., LeDuc, P. R., Jiang, X., Whitesides, G. M., & Ingber, D. E. (2003) · Langmuir · doi:10.1021/la026394k · Cited by 252 · see citing works
Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2
Choi, H.-J., Zhang, H., Park, H., Choi, K.-S., Lee, H., Agrawal, V., Kim, Y., & Kwon, Y. (2015) · Nature Communications · doi:10.1038/ncomms7943 · Cited by 247 · see citing works
MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration
Liu, Z., Wu, H., Jiang, K., Wang, Y., Zhang, W., Chu, Q., Li, J., Huang, H., Cai, T., Ji, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.020 · Cited by 239 · see citing works
Cau, J., & Hall, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02385 · Cited by 226 · see citing works
Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli
McDonald, D. M. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.266.1.l61 · Cited by 222 · see citing works
Mammoto, A., Huang, S., Moore, K. A., Oh, P., & Ingber, D. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402725200 · Cited by 210 · see citing works
Self-citationYAP/TAZ-CDC42 signaling regulates vascular tip cell migration
Sakabe, M., Fan, J., Odaka, Y., Liu, N., Hassan, A., Duan, X., Stump, P., Byerly, L., Donaldson, M., Hao, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704030114 · Cited by 204 · see citing works
Flow detection and calcium signalling in vascular endothelial cells
Ando, J., & Yamamoto, K. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt084 · Cited by 198 · see citing works
Role of Collagen Matrix in Tumor Angiogenesis and Glioblastoma Multiforme Progression
Mammoto, T., Jiang, A. R., Jiang, E., Panigrahy, D., Kieran, M. W., & Mammoto, A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.06.026 · Cited by 193 · see citing works
Self-citation3D microniches reveal the importance of cell size and shape
Bao, M., Xie, J., Piruska, A., & Huck, W. T. S. (2017) · Nature Communications · doi:10.1038/s41467-017-02163-2 · Cited by 177 · see citing works
Ohgushi, M., Minaguchi, M., & Sasai, Y. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.07.009 · Cited by 173 · see citing works
YAP/TEAD–Mediated Transcription Controls Cellular Senescence
Xie, Q., Chen, J., Han, F., Peng, S., Adams, U., Bai, Y., Huang, L., Li, J., Huang, J., Meng, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3793 · Cited by 172 · see citing works
Cell size and growth rate are major determinants of replicative lifespan
Yang, J., Dungrawala, H., Hua, H. M., Manukyan, A., Abraham, L., Lane, W., Mead, H. B., Wright, J., & Schneider, B. L. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14455 · Cited by 162 · see citing works
Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion
Zhang, H., von Gise, A., Liu, Q., Hu, T., Tian, X., He, L., Pu, W., Huang, X., He, L., Cai, C., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554584 · Cited by 162 · see citing works
Yeh, Y.-C., Ling, J.-Y., Chen, W.-C., Lin, H., & Tang, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-14932-6 · Cited by 162 · see citing works
Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis
Piccolo, S., Cordenonsi, M., & Dupont, S. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3172 · Cited by 152 · see citing works
Mammoto, A., Mammoto, T., Kanapathipillai, M., Yung, C. W., Jiang, E., Jiang, A. R., Lofgren, K. A., Gee, E. P. S., & Ingber, D. E. (2013) · Nature Communications · doi:10.1038/ncomms2774 · Cited by 149 · see citing works
Self-citationSurvival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer
Merino, M. M., Levayer, R., & Moreno, E. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.009 · Cited by 144 · see citing works
Mitochondrial Function and Cell Size: An Allometric Relationship
Miettinen, T. P., & Björklund, M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.02.006 · Cited by 142 · see citing works
Loforese, G., Malinka, T., Keogh, A., Baier, F. A., Simillion, C., Montani, M., Halazonetis, T. D., Candinas, D., & Stroka, D. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201506089 · Cited by 126 · see citing works
Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse
Osmanagic‐Myers, S., Kiss, A., Manakanatas, C., Hamza, O., Sedlmayer, F., Szabó, P. L., Fischer, I., Fichtinger, P., Podesser, B. K., Eriksson, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121297 · Cited by 121 · see citing works
PGC-1 coactivators in the cardiovascular system
Patten, I. S., & Arany, Z. P. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.09.007 · Cited by 119 · see citing works
Basagiannis, D., Zografou, S., Murphy, C., Fotsis, T., Morbidelli, L., Ziche, M., Bleck, C. K. E., Mercer, J., & Christoforidis, S. (2016) · Journal of Cell Science · doi:10.1242/jcs.188219 · Cited by 116 · see citing works
Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium.
Booyse, F. M., Osikowicz, G., & Quarfoot, A. J. (1981) · PubMed · Cited by 108 · see citing works
The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 108 · see citing works
Lung Vascular Cell Heterogeneity: Endothelium, Smooth Muscle, and Fibroblasts
Stevens, T., Phan, S. H., Frid, M. G., Alvarez, D. F., Herzog, E. L., & Stenmark, K. R. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200803-027hr · Cited by 107 · see citing works
Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β–Smad Signaling
Mammoto, T., Muyleart, M., Konduri, G. G., & Mammoto, A. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0323oc · Cited by 88 · see citing works
Self-citationPositional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo
Marsh, E. D., Gonzalez, D. G., Lathrop, E., Boucher, J. D., & Greco, V. (2018) · Cell · doi:10.1016/j.cell.2018.10.013 · Cited by 82 · see citing works
Cellular Senescence and Lung Function during Aging. Yin and Yang
Campisi, J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201609-703aw · Cited by 74 · see citing works
Mammoto, T., Jiang, E., Jiang, A. R., & Mammoto, A. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0147oc · Cited by 70 · see citing works
Self-citationTelomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential
Adnot, S., Amsellem, V., Boyer, L., Marcos, É., Saker, M., Houssaini, A., Kebe, K., Dagouassat, M., Lipskaia, L., & Boczkowski, J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.007 · Cited by 69 · see citing works
Lee, S. H., Lee, J. H., Yoo, S. Y., Hur, J., Kim, H.-S., & Kwon, S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301931 · Cited by 68 · see citing works
YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α
Mammoto, A., Muyleart, M., Kadlec, A. O., Gutterman, D. D., & Mammoto, T. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.04.003 · Cited by 60 · see citing works
Self-citationSero, J., Thodeti, C. K., Mammoto, A., Bakal, C., Thomas, S. Μ., & Ingber, D. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028303 · Cited by 54 · see citing works
Self-citationRole of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis
Mammoto, T., Jiang, A. R., Jiang, E., & Mammoto, A. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0012oc · Cited by 48 · see citing works
Self-citationFu, J., Zheng, M., Zhang, X., Zhang, Y., Chen, Y., Li, H., Wang, X., & Zhang, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.105 · Cited by 40 · see citing works
Chaker, D., Mouawad, C., Azar, A., Quilliot, D., Achkar, I., Fajloun, Z., & Makdissy, N. (2018) · Stem cell research & therapeutics · doi:10.1186/s13287-018-0910-5 · Cited by 38 · see citing works
Florian, M. C., Klenk, J., Marka, G., Soller, K., Kiryakos, H., Peter, R., Herbolsheimer, F., Rothenbacher, D., Denkinger, M. D., & Geiger, H. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx091 · Cited by 32 · see citing works
Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells
Umbayev, B. A., Masoud, A., Tsoy, A., Alimbetov, D. S., Olzhayev, F., Shramko, A. Y., Kaiyrlykyzy, A., Safarova, Y., Davis, T., & Askarova, S. (2018) · Biogerontology · doi:10.1007/s10522-018-9757-5 · Cited by 26 · see citing works
Ames, J. J., Contois, L. W., Caron, J. M., Tweedie, E., Yang, X., Friesel, R. E., Vary, C., & Brooks, P. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.669614 · Cited by 24 · see citing works
LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung
Mammoto, A., Muyleart, M., & Mammoto, T. (2019) · Aging · doi:10.18632/aging.101722 · Cited by 17 · see citing works
Self-citationCdc42 regulates branching in angiogenic sprouting in vitro
Nguyen, D.-H. T., Gao, L., Wong, A., & Chen, C. S. (2017) · Microcirculation · doi:10.1111/micc.12372 · Cited by 15 · see citing works
Mammoto, A., Sero, J., Mammoto, T., & Ingber, D. E. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)02012-0 · Cited by 8 · see citing works
Self-citationSokolov, I. Y., Guz, N., Iyer, S. P., Hewitt, A. J., Sokolov, N. A., Erlichman, J. S., & Woodworth, C. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122774 · Cited by 8 · see citing works
Haynes, B. A., Huyck, R. W., James, A., Carter, M. E., Gaafer, O. U., Day, M., Pinto, A., & Dobrian, A. D. (2018) · Journal of Visualized Experiments · doi:10.3791/57804 · Cited by 8 · see citing works
Dynamic self-guiding analysis of Alzheimer's disease
Kurakin, A. V., & Bredesen, D. E. (2015) · Oncotarget · doi:10.18632/oncotarget.4221 · Cited by 7 · see citing works
Ota, M., & Sasaki, H. (2008) · Journal of Cell Science · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198 · see citing works
“Senescent cells generally demonstrate an enlarged and flattened cell morphology [27] and expanded nucleoli [28,29], enhanced senescence-associated beta-galactosidase (SA-β-gal) activity [30], telomere shortening, elevation of the cyclin-dependent kinase inhibitor p16 [11,31] or p21 [32], macromolecular damage and meta…”
BackgroundLamin A involvement in ageing processes
Cenni, V., Capanni, C., Mattioli, E., Schena, E., Squarzoni, S., Bacalini, M. G., Garagnani, P., Salvioli, S., Franceschi, C., & Lattanzi, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101073 · Cited by 83 · see citing works
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 76 · see citing works
The cellular mechanobiology of aging: from biology to mechanics
Bajpai, A., Li, R., & Chen, W. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14529 · Cited by 67 · see citing works
Balachandra, S., Sarkar, S., & Amodeo, A. A. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-080320-030537 · Cited by 65 · see citing works
Ansari, A., Bhowmik, S., Zhang, K., Reeves, C. L., Vahala, D., Choi, Y. S., Gelmi, A. A., Combes, A. N., Tuan, R. S., Truong, V. X., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202501585 · Cited by 36 · see citing works
Cellular enlargement - A new hallmark of aging?
Davies, D., van den Handel, K., Bharadwaj, S., & Lengefeld, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1036602 · Cited by 35 · see citing works
Role of a small GTPase Cdc42 in aging and age-related diseases
Umbayev, B. A., Safarova, Y., Yermekova, A., Nessipbekova, A., Syzdykova, A., & Askarova, S. (2023) · Biogerontology · doi:10.1007/s10522-022-10008-9 · Cited by 33 · see citing works
Mesenchymal stromal cell senescence in haematological malignancies
Plakhova, N., Panagopoulos, V., Vandyke, K., Zannettino, A. C. W., & Mrozik, K. M. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10069-9 · Cited by 33 · see citing works
Nailfold capillary patterns correlate with age, gender, lifestyle habits, and fingertip temperature
Nakajima, T., Nakano, S., Kikuchi, A., & Matsunaga, Y. T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269661 · Cited by 31 · see citing works
Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
Hunyenyiwa, T., Hendee, K., Matus, K., Kyi, P., Mammoto, T., & Mammoto, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693410 · Cited by 30 · see citing works
Self-citationMaiti, S., Bhattacharya, K., Wider, D., Hany, D., Panasenko, O. O., Bernasconi, L., Hulo, N., & Picard, D. (2023) · eLife · doi:10.7554/elife.88658 · Cited by 25 · see citing works
The role of cardiomyocyte senescence in cardiovascular diseases: a molecular biology update.
He, S., Yan, L., Yuan, C., Li, W., Wu, T., Chen, S., Li, N., Wu, M., & Jiang, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176961 · Cited by 19 · see citing works
Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
Long, Y., Wang, P., Lei, J., Su, B., Wei, Q., & Liu, X. (2025) · MedComm · doi:10.1002/mco2.70523 · Cited by 25 · see citing works
Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Kyi, P., Hendee, K., Hunyenyiwa, T., Matus, K., Mammoto, T., & Mammoto, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.908639 · Cited by 22 · see citing works
Self-citationTsikis, S. T., Hirsch, T. I., Fligor, S. C., Quigley, M., & Puder, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1093369 · Cited by 19 · see citing works
Microphysiological systems for human aging research
Park, S., Laskow, T. C., Chen, J., Guha, P., Dawn, B., & Kim, D. (2024) · Aging Cell · doi:10.1111/acel.14070 · Cited by 20 · see citing works
Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration
Hendee, K., Hunyenyiwa, T., Matus, K., Toledo, M., Mammoto, A., & Mammoto, T. (2021) · Aging · doi:10.18632/aging.202875 · Cited by 14 · see citing works
Self-citationUmbayev, B. A., Saliev, T. M., Safarova, Y., Yermekova, A., Olzhayev, F., Bulanin, D. S., Tsoy, A., & Askarova, S. (2023) · Nutrients · doi:10.3390/nu15234964 · Cited by 14 · see citing works
Patntirapong, S., Khankhow, J., & Julamorn, S. (2024) · PeerJ · doi:10.7717/peerj.17913 · Cited by 9 · see citing works
Teng, M. F., Wu, T.-J., Pritchard, K. A., Day, B. W., Naylor, S., & Teng, R. (2025) · Antioxidants · doi:10.3390/antiox14070844 · Cited by 9 · see citing works
Terwoord, J. D., Toro, L. N., Hader, S. N., Hammond, S. T., Hockenberry, J. C., Linn, J. M., Vazirabad, I., Kong, A. L., Kriegel, A. J., Liu, Z., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.194316 · Cited by 9 · see citing works
Self-citationMaiti, S., Bhattacharya, K., Wider, D., Hany, D., Panasenko, O. O., Bernasconi, L., Hulo, N., & Picard, D. (2023) · eLife · doi:10.7554/elife.88658.3 · Cited by 9 · see citing works
Simulating flow induced migration in vascular remodelling
Tabibian, A., Ghaffari, S., Vargas, D. A., Oosterwyck, H. V., & Jones, E. A. V. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007874 · Cited by 10 · see citing works
Promise and Perspective of Nanomaterials in Antisenescence Tissue Engineering Applications
Lu, Z., Singh, G., Lesani, P., & Zreiqat, H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01298 · Cited by 8 · see citing works
Cellular senescence—from solid organs to vascularized composite allotransplants
Knoedler, L., Schroeter, A., Iske, J., Dean, J., Boroumand, S., Schaschinger, T., Niederegger, T., Knoedler, S. A., Panayi, A. C., Heiland, M., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01788-2 · Cited by 5 · see citing works
Aging and Altered Gravity: A Cellular Perspective
van Rijthoven, S., & van Loon, J. J. W. A. (2025) · The FASEB Journal · doi:10.1096/fj.202402989r · Cited by 5 · see citing works
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Lim, J., Sirisereephap, K., Wang, H., Trimaglio, G., Chung, K., Korostoff, J. M., Kajikawa, T., Li, X., Surboyo, M. D. C., Maekawa, T., et al. (2026) · Advanced Science · doi:10.1002/advs.202509263 · Cited by 5 · see citing works
Implantation of human mesenchymal stromal cell pellet for therapeutic angiogenesis
Mammoto, A., Kyi, P., Scheer, M., & Mammoto, T. (2025) · Cytotherapy · doi:10.1016/j.jcyt.2025.102009 · Cited by 3 · see citing works
Self-citationAlonso-Puyo, J., Izagirre-Fernandez, O., Crende, O., Seco‐Calvo, J., Fernández‐Atutxa, A., Fernández‐Lázaro, D., García-Gallastegui, P., & Sanz, B. (2024) · Proteomes · doi:10.3390/proteomes12040034 · Cited by 3 · see citing works
Tumour Cell Size Control and Its Impact on Tumour Cell Function
Zhou, M., Zhou, M. L., & Jin, Y. (2025) · Cell Proliferation · doi:10.1111/cpr.70080 · Cited by 4 · see citing works
Menon, R., Kimmel, P., Otto, E., Subramanian, L., Berthier, C., O'Connor, C., Godfrey, B., Naik, A., Sarwal, M., Woodle, E. S., et al. (2025) · medRxiv · doi:10.1101/2025.03.17.25324134 · Cited by 3 · see citing works
Afzal, B., Tran, V., Nguyen, N., Le, S. Q.-T., Nguyen, T. P., Nguyen, K. T., Liu, L., & Mason, R. P. (2026) · Diagnostics · doi:10.3390/diagnostics16121783 · Cited by 1 · see citing works
Kakinoki, R., Hara, Y., Yoshimoto, K., Kaizawa, Y., Hashimoto, K., Tanaka, H., Kobayashi, T., Ohtani, K., Noguchi, T., Ikeguchi, R., et al. (2024) · Bioengineering · doi:10.3390/bioengineering11040409 · Cited by 1 · see citing works
Alveolar epithelial paxillin in postnatal lung alveolar development
Scheer, M., Kyi, P., Mammoto, T., & Mammoto, A. (2025) · Biology Open · doi:10.1242/bio.061939 · Cited by 1 · see citing works
Self-citationMurine Dermal Lymphatic Endothelial Cell Isolation
Akwii, R. G., Λάμπρου, Μ., Georgomanoli, M., Plevriti, A., Marazioti, A., Mouzaki, Α., Mattheolabakis, G., & Mikelis, C. M. (2023) · Journal of Visualized Experiments · doi:10.3791/65393 · Cited by 1 · see citing works
Maiti, S., Bhattacharya, K., Wider, D., Hany, D., Panasenko, O. O., Bernasconi, L., Hulo, N., & Picard, D. (2023) · eLife · doi:10.7554/elife.88658.1 · Cited by 1 · see citing works
Maiti, S., Bhattacharya, K., Wider, D., et al. (2023) · eLife · doi:10.7554/elife.88658.1.sa2
Maiti, S., Bhattacharya, K., Wider, D., Hany, D., Panasenko, O. O., Bernasconi, L., Hulo, N., & Picard, D. (2023) · eLife · doi:10.7554/elife.88658.1.sa4
Maiti, S., Bhattacharya, K., Wider, D., Hany, D., Panasenko, O. O., Bernasconi, L., Hulo, N., & Picard, D. (2023) · eLife · doi:10.7554/elife.88658.2
Unbounded Cell Growth and Proteome Imbalance in Doxorubicin-Induced Senescent RPE-1 CellsPreprint
Liu, X., Sonnett, M., & Kirschner, M. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.27.684969
Angiogenesis in Lung Regeneration and Aging
Kyi, P., Scheer, M., Mammoto, T., & Mammoto, A. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.126.324410
Self-citation
- Authors
- Mammoto, T., Torisawa, Y.-S., Muyleart, M., Hendee, K., Anugwom, C., Gutterman, D., & Mammoto, A.
- Affiliations
- Medical College of Wisconsin (US)
- Kyoto University (JP)
- Corresponding author
- Mammoto, Tadanori
- Mammoto, Akiko
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2019-09-05
- Volume
- 11
- Issue
- 17
- Pages
- 7051-7069
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6756888
- OpenAlex
- W2971392559
- Cited by
- 43
- References
- 78
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 6 · 2021: 2 · 2020: 5
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association (18TPA34170129)
- Japan Society for the Promotion of Science (17H02082)
- National Institute on Aging (R21AG062893, R21AG054830)
- National Heart, Lung, and Blood Institute (R01HL139638, R01HL142578, R01HL135901)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endothelial cell size, endothelial cell proliferation, cellular senescence, YAP, Cdc42, angiogenesis, YAP1 nuclear translocation
- MeSH terms
- YAP-Signaling Proteins, Adult, Aging, Animals, Female, Humans, Male, Mice, Inbred C57BL, Middle Aged, Transcription Factors, Cell Cycle Proteins, Neovascularization, Physiologic, cdc42 GTP-Binding Protein, Endothelial Cells, Cell Size, Adaptor Proteins, Signal Transducing, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
