Cited by 82Gut microbiota and healthMitochondrial Function and PathologyGastrointestinal motility and disorders

Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock

Open access
Duan, Chenyang, Kuang, Lei, Xiang, Xinming, Zhang, Jie, Zhu, Yu, Wu, Yue, Yan, Qingguang, Liu, Liangming +1 more·2020·Aging

Abstract

, was markedly decreased in mice after shock, and was inversely correlated with both the distribution of the tight junction protein ZO1 and intestinal permeability. Together, these data suggest that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock. Our findings provide novel insights for targeting Drp1-mediated mitochondrial function as well as the microbiome in the treatment of intestinal barrier dysfunction after shock.

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Crossref · 10.18632/aging.102690

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  • Blocking Drp1-induced ROS accumulation by N-acetylcysteine in IECs protected TJs and improved intestinal barrier function after hypoxia.

    “Further, blocking Drp1-induced ROS accumulation by N-acetylcysteine in IECs protected TJs and improved intestinal barrier function after hypoxia.198”
  • Activation of mitochondrial dynamin-related protein (Drp1) regulates gut barrier function through regulating SCFA-producing gut microbiota in hemorrhagic shock mouse models.

    “Activation of mitochondrial dynamin-related protein (Drp1) regulates gut barrier function through regulating SCFA-producing gut microbiota in hemorrhagic shock mouse models.198”
  • Activated Drp1 led to distribution of ZO1 protein and increased intestinal permeability in a ROS-specific manner.

    “It was shown that activated Drp1 led to distribution of ZO1 protein and increased intestinal permeability in a ROS-specific manner.”

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Authors
Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T.
Affiliations
Army Medical University (CN)
Corresponding author
  • Liu, Liangming
  • Li, Tao
Venue
Aging
Published
2020-01-18
Volume
12
Issue
2
Pages
1397-1416
ISSN
1945-4589 (ISSN-L)
OpenAlex
W2999679411
Cited by
82
References
57
Citations by year
2026: 9 · 2025: 6 · 2024: 20 · 2023: 14 · 2022: 21 · 2021: 9 · 2020: 2
FWCI
3.73
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Drp1, mitochondrial fission, reactive oxygen species, gut microbiota, intestinal barrier, hemorrhagic shock, short-chain fatty acids, tight junctions, ZO-1, intestinal permeability, mitochondrial dysfunction
MeSH terms
Gastrointestinal Microbiome, Animals, Disease Models, Animal, Fatty Acids, Volatile, Intestinal Mucosa, Male, Mitochondria, Permeability, RNA, Ribosomal, 16S, Shock, Hemorrhagic, Biomarkers, Reactive Oxygen Species, Dynamins, Mice, Metabolomics, Metagenomics

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