Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock
Open accessAbstract
, was markedly decreased in mice after shock, and was inversely correlated with both the distribution of the tight junction protein ZO1 and intestinal permeability. Together, these data suggest that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock. Our findings provide novel insights for targeting Drp1-mediated mitochondrial function as well as the microbiome in the treatment of intestinal barrier dysfunction after shock.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Blocking Drp1-induced ROS accumulation by N-acetylcysteine in IECs protected TJs and improved intestinal barrier function after hypoxia.
“Further, blocking Drp1-induced ROS accumulation by N-acetylcysteine in IECs protected TJs and improved intestinal barrier function after hypoxia.198”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [198]
Activation of mitochondrial dynamin-related protein (Drp1) regulates gut barrier function through regulating SCFA-producing gut microbiota in hemorrhagic shock mouse models.
“Activation of mitochondrial dynamin-related protein (Drp1) regulates gut barrier function through regulating SCFA-producing gut microbiota in hemorrhagic shock mouse models.198”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [198]
Activated Drp1 led to distribution of ZO1 protein and increased intestinal permeability in a ROS-specific manner.
“It was shown that activated Drp1 led to distribution of ZO1 protein and increased intestinal permeability in a ROS-specific manner.”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [198]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Alterations of the human gut microbiome in multiple sclerosis
Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Losón, O. C., Song, Z., Chen, H., & Chan, D. C. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0721 · Cited by 1,235 · see citing works
A community-driven global reconstruction of human metabolism
Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., Haraldsdottir, H., Mo, M. L., Rolfsson, O., Stobbe, M. D., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2488 · Cited by 1,019 · see citing works
Interaction between the gut microbiome and mucosal immune system
Shi, N., Li, N., Duan, X., & Niu, H. (2017) · Military Medical Research · doi:10.1186/s40779-017-0122-9 · Cited by 940 · see citing works
Mitochondria as a therapeutic target for common pathologies
Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works
The immune system and the gut microbiota: friends or foes?
Cerf-Bensussan, N., & Gaboriau-Routhiau, V. (2010) · Nature Reviews Immunology · doi:10.1038/nri2850 · Cited by 704 · see citing works
Bordt, E. A., Clerc, P., Roelofs, B. A., Saladino, A. J., Tretter, L., Ádám‐Vizi, V., Cherok, E., Khalil, A., Yadava, N., Ge, S. X., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.020 · Cited by 598 · see citing works
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
Rehman, J., Zhang, H. J., Tóth, P. T., Zhang, Y., Marsboom, G., Hong, Z., Salgia, R., Husain, A. N., Wietholt, C., & Archer, S. L. (2012) · The FASEB Journal · doi:10.1096/fj.11-196543 · Cited by 594 · see citing works
Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis
Sivaprakasam, S., Prasad, P. D., & Singh, N. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.007 · Cited by 573 · see citing works
Lü, K., Abo, R., Schlieper, K. A., Graffam, M. E., Levine, S. S., Wishnok, J. S., Swenberg, J. A., Tannenbaum, S. R., & Fox, J. G. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307429 · Cited by 517 · see citing works
Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T., & Danesh, F. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.009 · Cited by 476 · see citing works
Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease
Mottawea, W., Chiang, C., Mühlbauer, M., Starr, A. E., Butcher, J., Abujamel, T. S., Deeke, S. A., Brandel, A., Zhou, H., Shokralla, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms13419 · Cited by 444 · see citing works
Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0333-1 · Cited by 425 · see citing works
Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Montessuit, S., Somasekharan, S. P., Terrones, O., Lucken‐Ardjomande, S., Herzig, S., Schwarzenbacher, R., Manstein, D. J., Bossy‐Wetzel, E., Basáñez, G., Meda, P., et al. (2010) · Cell · doi:10.1016/j.cell.2010.08.017 · Cited by 422 · see citing works
A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis
Brandsma, E. T., Kloosterhuis, N., Koster, M. H., Dekker, D., Gijbels, M. J., van der Velden, S., Ríos-Morales, M., van Faassen, M. H. J. R., Loreti, M. G., de Bruin, A., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313234 · Cited by 376 · see citing works
On the origin of mitochondria: a genomics perspective
Andersson, G., Karlberg, O., Canbäck, B., & Kurland, C. G. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1193 · Cited by 360 · see citing works
Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate†
Lewis, K. J., Lutgendorff, F., Phan, V., Söderholm, J. D., Sherman, P. M., & McKay, D. M. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21177 · Cited by 338 · see citing works
The Crosstalk between the Gut Microbiota and Mitochondria during Exercise
Clark, A. P., & Mach, N. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00319 · Cited by 338 · see citing works
MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death
Prudent, J., Zunino, R., Sugiura, A., Mattie, S., Shore, G. C., & McBride, H. M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.001 · Cited by 321 · see citing works
Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis
Rath, E., Moschetta, A., & Haller, D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0021-x · Cited by 306 · see citing works
Hu, C., Huang, Y., & Li, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010144 · Cited by 302 · see citing works
Piret, J., Mottet, D., Raes, M. J., & Michiels, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04680.x · Cited by 258 · see citing works
Kim, M., Galan, C., Hill, A. A., Wu, W.-J., Fehlner-Peach, H., Song, H. W., Schady, D., Bettini, M. L., Simpson, K. W., Longman, R. S., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.009 · Cited by 202 · see citing works
Han, Y., Kim, B., Cho, U., Park, I. S., Kim, S. I., Dhanasekaran, D. N., Tsang, B. K., & Song, Y. S. (2019) · Oncogene · doi:10.1038/s41388-019-0949-5 · Cited by 188 · see citing works
Wang, A., Keita, Å. V., Phan, V., McKay, C. M., Schoultz, I., Lee, J., Murphy, M. P., Fernando, M., Ronaghan, N. J., Balce, D. R., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.05.019 · Cited by 177 · see citing works
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0393-7 · Cited by 176 · see citing works
Hagenbuchner, J., Kuznetsov, A. V., Obexer, P., & Ausserlechner, M. J. (2012) · Oncogene · doi:10.1038/onc.2012.500 · Cited by 175 · see citing works
Li, J., Shu, Y., Hao, T., Wang, Y., Qian, Y., Duan, C., Sun, H., Lin, Q., & Wang, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.031 · Cited by 165 · see citing works
Qi, B., & Han, M. (2018) · Cell · doi:10.1016/j.cell.2018.07.032 · Cited by 164 · see citing works
Žaja, I., Bai, X., Liu, Y., Kikuchi, C., Došenović, S., Yan, Y., Canfield, S. G., & Bosnjak, Z. J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.144 · Cited by 156 · see citing works
Hu, J. J., Wong, N.-K., Lu, M.-Y., Chen, X., Ye, S., Zhao, A. Q., Gao, P., Kao, R. Y. T., Shen, J., & Yang, D. (2016) · Chemical Science · doi:10.1039/c5sc03855c · Cited by 156 · see citing works
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum
Ji, W.-K., Chakrabarti, R., Fan, X., Schoenfeld, L. W., Strack, S., & Higgs, H. N. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610057 · Cited by 144 · see citing works
Frye, R. E., Rose, S., Slattery, J. M., & MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.27458 · Cited by 142 · see citing works
Kučera, O., Endlicher, R., Roušar, T., Lotková, H., Garnol, T., Drahota, Z., & Červinková, Z. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/752506 · Cited by 138 · see citing works
Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions
Gao, B., Bian, X., Mahbub, R., & Lü, K. (2016) · Environmental Health Perspectives · doi:10.1289/ehp202 · Cited by 125 · see citing works
Fan, L., He, P., Peng, Y., Du, Q.-H., Ma, Y.-J., Jin, J., Xu, H., Li, J., Wang, Z., Cao, S., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.003 · Cited by 117 · see citing works
Mitochondria: A target for bacteria
Lobet, E., Letesson, J., & Arnould, T. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.02.007 · Cited by 115 · see citing works
Zhao, Y., Sun, X., Hu, D., Prosdocimo, D. A., Hoppel, C. L., Jain, M. K., Ramachandran, R., & Qi, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09291-x · Cited by 109 · see citing works
Mimoun, S., Andriamihaja, M., Chaumontet, C., Atanasiu, C., Benamouzig, R., Blouin, J. M., Tomé, D., Bouillaud, F., & Blachier, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4186 · Cited by 107 · see citing works
Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability
Horn, S. R. G.-V., Thomenius, M. J., Johnson, E. S., Freel, C. D., Wu, J. Q., Coloff, J. L., Yang, C., Tang, W., An, J., Ilkayeva, O., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0567 · Cited by 101 · see citing works
mtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities
Ma, J., Coarfa, C., Qin, X., Bonnen, P. E., Milosavljevic, A., Versalovic, J. A., & Aagaard, K. M. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-257 · Cited by 99 · see citing works
Czyż, D. M., Potluri, L., Jain‐Gupta, N., Riley, S. P., Martinez, J. J., Steck, T. L., Crosson, S., Shuman, H. A., & Gabay, J. E. (2014) · mBio · doi:10.1128/mbio.01534-14 · Cited by 95 · see citing works
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Santoro, A. N., Campolo, M., Liu, C., Sesaki, H., Meli, R., Liu, Z.-W., Kim, J. D., & Diano, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.003 · Cited by 92 · see citing works
才原一浩, Kamikubo, R., Ikemoto, K., Uchida, K., & Akagawa, M. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b01185 · Cited by 78 · see citing works
Zhang, X., Tang, X., Wang, M., Zhang, W., Zhou, B., & Wang, Y. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.05.038 · Cited by 71 · see citing works
Liu, L., & Dubick, M. A. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2004.12.008 · Cited by 70 · see citing works
Moeser, A. J., Haskell, M. M., Shifflett, D. E., Little, D., Schultz, B. D., & Blikslager, A. T. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.004 · Cited by 69 · see citing works
Microbe-mitochondrion crosstalk and health: An emerging paradigm
Bajpai, P., Darra, A., & Agrawal, A. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.08.008 · Cited by 55 · see citing works
Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria
Gruber, J., & Kennedy, B. K. (2017) · Cell · doi:10.1016/j.cell.2017.05.048 · Cited by 40 · see citing works
Li, P., Meng, X., Bian, H., Burns, N., Zhao, K., & Song, R. (2015) · Oncotarget · doi:10.18632/oncotarget.6076 · Cited by 38 · see citing works
Li, T., Fang, Y., Yang, G., Xu, J., Zhu, Y., & Liu, L. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3181f9b88b · Cited by 38 · see citing works
Jacouton, E., Mach, N., Cadiou, J., Lapaque, N., Clément, K., Doré, J., van Hylckama Vlieg, J. E. T., Smokvina, T., & Blottière, H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138880 · Cited by 32 · see citing works
Song, Y., Li, T., Liu, Z., Xu, Z., Zhang, Z., Chi, L., & Liu, Y. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.03.013 · Cited by 31 · see citing works
Chen, A. Y., Lü, J.-M., Yao, Q. C., & Chen, C. (2016) · Medical Science Monitor · doi:10.12659/msm.896462 · Cited by 30 · see citing works
Eri, T., Kawahata, K., Kanzaki, T., Imamura, M., Michishita, K., Akahira, L., Bannai, E., Yoshikawa, N., Kimura, Y., Satoh, T., et al. (2017) · Scientific Reports · doi:10.1038/srep46037 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Liu, P., Wang, Y., Yang, G., Zhang, Q., Meng, L., Xin, Y., & Jiang, X. M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105420 · Cited by 787 · see citing works
Zeng, X., Zhang, Y., Ma, R., Chen, Y.-J., Xiang, X., Hou, D., Li, X.-H., Huang, H., Li, T., & Duan, C. (2022) · Military Medical Research · doi:10.1186/s40779-022-00383-2 · Cited by 276 · see citing works
Guo, C., Wang, Y., Zhang, S., Zhang, X., Du, Z., Li, M., & Ding, K. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.137 · Cited by 272 · see citing works
Duan, C., Wang, L., Zhang, J., Xiang, X., Wu, Y., Zhang, Z., Li, Q., Tian, K. L., Xue, M., Li, T., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101706 · Cited by 106 · see citing works
Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling
Zuo, K., Chen, F., Liu, Z., Fu, Y., Liu, Y., Liu, L., Wang, Y., Yin, X., Liu, X., Li, J., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70644 · Cited by 89 · see citing works
Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2461-9 · Cited by 87 · see citing works
Pu, X., Zhang, Q., Liu, J., Wang, Y., Guan, X., Wu, Q., Liu, Z., Liu, Z., & Chang, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155880 · Cited by 84 · see citing works
Duan, C., Kuang, L., Hong, C., Xiang, X., Liu, J., Li, Q., Peng, X., Zhou, Y., Wang, H., Liu, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04343-x · Cited by 76 · see citing works
Deng, L., Yang, Y., & Xu, G. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159234 · Cited by 73 · see citing works
Gut microbiome and attention deficit/hyperactivity disorder: a systematic review
Gkougka, D., Mitropoulos, K., Tzanakaki, G., Panagouli, E., Psaltopoulou, T., Thomaidis, L., Tsolia, M., Sergentanis, T. N., & Tsitsika, A. (2022) · Pediatric Research · doi:10.1038/s41390-022-02027-6 · Cited by 69 · see citing works
She, H., Hu, Y., Zhou, Y., Tan, L., Zhu, Y., Ma, C., Wu, Y., Chen, W., Wang, L., Zhang, Z., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s340420 · Cited by 66 · see citing works
Targeting mitochondrial quality control: new therapeutic strategies for major diseases
Hong, W., Huang, H., Zeng, X., & Duan, C. (2024) · Military Medical Research · doi:10.1186/s40779-024-00556-1 · Cited by 65 · see citing works
Lv, W., Ma, Y., Huang, J., He, S., Li, S.-P., Lin, J., Chen, R., Lun, J., Liu, J., & Guo, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.246 · Cited by 59 · see citing works
Alterations of the Gut Microbiota in Response to Total Sleep Deprivation and Recovery Sleep in Rats
Wang, Z., Yuan, K., Ji, Y.-B., Li, S.-X., Shi, L., Wang, Z., Zhou, X.-Y., Bao, Y.-P., Xie, W., Han, Y., et al. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s334985 · Cited by 56 · see citing works
Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus
Zhao, L., Hu, X., Xiao, F., Zhang, X., Zhao, L., & Wang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929520 · Cited by 52 · see citing works
Zhang, Y., Qi, X., Zhang, Z., Jin, Z., Wang, G., & Ling, F. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108693 · Cited by 53 · see citing works
Hou, D., Liao, H., Hao, S., Liu, R., Huang, H., & Duan, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28501 · Cited by 51 · see citing works
Hao, S., Huang, H., Ma, R., Zeng, X., & Duan, C. (2023) · Military Medical Research · doi:10.1186/s40779-023-00482-8 · Cited by 52 · see citing works
Tong, Z., Du, X., Zhou, Y., Jing, F., Ma, J., Feng, Y., Lou, S., Wang, Q. A., & Dong, Z. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111075 · Cited by 42 · see citing works
Han, J., Rajoka, M. S. R., Xu, X., Liao, N., Pang, B., Yan, L., Liu, G., Sun, H., Jiang, C., Shao, D., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119062 · Cited by 41 · see citing works
Duan, C., Liu, R., Kuang, L., Zhang, Z., Hou, D., Zheng, D., Xiang, X., Huang, H., Liu, L., & Li, T. (2023) · Advanced Science · doi:10.1002/advs.202304885 · Cited by 39 · see citing works
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02542-7 · Cited by 33 · see citing works
She, H., Zhu, Y., Deng, H., Kuang, L., He, F., Zhang, Z., Duan, C., Ye, J., Zhang, J., Liu, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636327 · Cited by 33 · see citing works
Protective Effects of Inhibition of Mitochondrial Fission on Organ Function After Sepsis
Zhu, Y., Kuang, L., Wu, Y., Deng, H., She, H., Zhou, Y., Zhang, J., Liu, L., & Li, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.712489 · Cited by 33 · see citing works
Chen, Y., Chen, J., Wei, H., Gong, K., Meng, J., Long, T.-L., Guo, J.-F., Hong, J., Yang, L.-J., Qiu, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1172710 · Cited by 23 · see citing works
Wang, Q., & Qiu, H. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03095-7 · Cited by 24 · see citing works
The Intestinal Microbiome after Traumatic Injury
Munley, J. A., Kirkpatrick, S. L., Gillies, G. S., Bible, L. E., Efron, P. A., Nagpal, R., & Mohr, A. M. (2023) · Microorganisms · doi:10.3390/microorganisms11081990 · Cited by 23 · see citing works
Navigating Hemorrhagic Shock: Biomarkers, Therapies, and Challenges in Clinical Care
Monge, K. M., Rosa, C., Sublette, C. M., Pratap, A., Kovacs, E. J., & Idrovo, J. (2024) · Biomedicines · doi:10.3390/biomedicines12122864 · Cited by 22 · see citing works
Cao, B., Zhao, R., Li, H.-H., Xu, X., Cui, H., Deng, H., Chen, L., & Wei, B. (2022) · Military Medical Research · doi:10.1186/s40779-022-00397-w · Cited by 20 · see citing works
Multi-omics revealed anti-fatigue property of polyphenol from areca nut
Zhang, Y., He, Y., Yuan, L., Shi, J., Zhao, J., Tan, C., Liu, Y., & Xu, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155838 · Cited by 19 · see citing works
Cao, C., Yu, P., Chu, C., Wang, Z., Xu, W., Cheng, F., Zhao, H., & Qiu, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111688 · Cited by 18 · see citing works
Exosomes: an innovative therapeutic target for cerebral ischemia-reperfusion injury
Yang, Y., Duan, Y., Yue, J., Yin, Y., Ma, Y., Wan, X., & Shao, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1552500 · Cited by 15 · see citing works
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Bao, D., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03811-y · Cited by 15 · see citing works
Hou, D., Liu, R., Hao, S., Dou, Y., Chen, G., Liu, L., Li, T., Cao, Y., Huang, H., & Duan, C. (2024) · Pharmaceutical Biology · doi:10.1080/13880209.2024.2318349 · Cited by 14 · see citing works
Lai, Y., Tang, W., Luo, X., Zheng, H., Zhang, Y., Wang, M., Yu, G., & Yang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369116 · Cited by 12 · see citing works
Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock
Ye, H., He, S., Du, Y., Wang, Y., Hu, Y., Zhao, C., Jin, Y., Liu, F., & Guo, Y. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01894-6 · Cited by 12 · see citing works
Niu, X., Zhang, N., Li, S., Li, N., Wang, R., Zhang, Q., He, J., Sun, E., Kang, X., & Zhan, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.992947 · Cited by 11 · see citing works
The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis
Tian, H., Huang, D., Wang, J., Li, H., Gao, J., Zhong, Y., Xia, L., Zhang, A., Lin, Z., & Ke, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1404995 · Cited by 12 · see citing works
Liu, J., Liu, X., Guo, L., Liu, X., Gao, Q., Wang, E., & Dong, Z. (2024) · PLoS ONE · doi:10.1371/journal.pone.0310947 · Cited by 11 · see citing works
Sun, Q., Zhang, H., Du, H.-B., Zhao, Z., Li, C.-J., Chen, S.-J., Li, Y., Zhang, S.-L., Liu, J., Niu, C., et al. (2023) · Shock · doi:10.1097/shk.0000000000002102 · Cited by 11 · see citing works
Kang, Y., & Kang, B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152508 · Cited by 8 · see citing works
Ge, Y., Lin, D., Cui, B., Zhang, L., Li, S., Wang, Z., & Ma, J. (2021) · NeuroImmunoModulation · doi:10.1159/000519124 · Cited by 8 · see citing works
Cao, B., Gao, J., Zhang, Q., Xu, X., Zhao, R., Li, H.-H., & Wei, B. (2023) · iMeta · doi:10.1002/imt2.141 · Cited by 6 · see citing works
Guangliang, H., Wang, T., Danxin, W., Liu, L., & Ye, M. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.05.105 · Cited by 6 · see citing works
Liu, Y., Zhu, Y., Zhang, Z., Bao, D., Deng, H., Liu, L., & Li, T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831514 · Cited by 5 · see citing works
Luyens, B., Felgueroso-Bueno, F., Everard, A., & Massat, I. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.038 · Cited by 4 · see citing works
Hu, Y., He, F., Tan, L., She, H., Du, Y., Zhu, Y., Wu, Y., Liu, L., & Li, T. (2024) · Shock · doi:10.1097/shk.0000000000002459 · Cited by 4 · see citing works
SUMOylation in peripheral tissues under low perfusion‐related pathological states
Oliveira, F. R. M. B., Soares, E. S., Harms, C., Cimarosti, H., & Sordi, R. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30293 · Cited by 4 · see citing works
Wu, Y., Li, Q., Zhu, Y., Zhou, Y., Liu, L., & Li, T. (2023) · Advanced Biology · doi:10.1002/adbi.202300024 · Cited by 3 · see citing works
Yang, L.-C., Jiang, Z., Sun, Q., Karako, K., Yuan, L.-W., & Song, P. (2025) · BioScience Trends · doi:10.5582/bst.2025.01279 · Cited by 3 · see citing works
Metabolomics after trauma in experimental models- a systematic review
Stückelberger, G., Weuster, M., Hana, A., Hübner, C. T., Kalbas, Y., Pape, H., Klingebiel, F. K.-L., & Pfeifer, R. (2026) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-025-03917-z · Cited by 1 · see citing works
An Aedes aegypti seryl-tRNA synthetase paralog controls bacteroidetes growth in the midgutPreprint
Silveira, G. O., Talyuli, O. A. C., Walter‐Nuno, A. B., Crnković, A., Gandara, A. C. P., Gaviraghi, A., Bottino-Rojas, V., Söll, D. G., & Polycarpo, C. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.25.505225 · Cited by 1 · see citing works
Sâmbrian, O. A. (2010) · Dialnet (Universidad de la Rioja)
Wang, X., Wu, J., Qi, S., Huang, R., Wu, X., Tian, L., Wang, P., & Wang, S. (2021) · International Journal of Diabetes and Endocrinology · doi:10.11648/j.ijde.20210604.15
Liu, R., Hao, S., Hou, D., Tian, H., Hong, W., Huang, H., & Duan, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3210579/v1
Probiotics as Chemical Decontamination Candidates
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65455-8_21
Zhang, Y., Lu, Q., Gao, J., Sun, Y., Lu, W., & Luo, Y. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08871-x
Deng, G., Wu, L., Xiong, S., Zhou, J., & Li, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07364-8
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553860
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553851
Zeng, X., Zhang, Y.-D., Ma, R.-Y., Chen, Y.-J., Xinming, X., Hou, D.-Y., Li, X.-H., Huang, H., Li, T., & Duan, C.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.19914898
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553857
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553854
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20786828
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20786831
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553878
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20786834
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20786825
Tan, L., She, H., Zheng, J., Peng, X., Guo, N., Zhang, B., Sun, Y., Ma, C., Xu, S., Daiqin, B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26553848
Sun, H., Li, X., Chen, X., Xiong, Y., Cao, Y., & Wang, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20786822
Izhytska, N. V., ЛЕВЧУК, Р. Д., Hudyma, А. А., & Антонишин, І. В. (2025) · Polski Merkuriusz Lekarski · doi:10.36740/merkur202506101
Wang, Y., Wang, X.-Y., Lin, J., Zhang, W.-H., Sun, Y., Geng, Q., Chen, S., Zhang, C., Jin, L., & Hu, C.-M. (2026) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2026.03.063
Yang, J., Zhao, S.-L., Ma, Y., Jiang, J., & Zhang, X. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108854
Chi, Y., Zhang, H., Jia, C., Zeng, S., Li, X., Chen, D.-P., & Ma, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093828
Chen, Y., Zhou, C., Gong, M.-Q., Lai, F., Wan, H., & He, Y. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05920-x
Targeting the gut-brain axis: microbial interventions for neurological disorders
Hao, Y.-Y., Zhao, Z., Zhang, L.-M., & Zhao, Z. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01877-x
Li, X., & Yang, B. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109883
ЛЕВЧУК, Р. Д., Рудинська, С. М., Hudyma, А. А., & Shekera, O. (2026) · Ukrainian Journal of Military Medicine · doi:10.46847/ujmm.2026.3(7)-170
- Authors
- Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T.
- Affiliations
- Army Medical University (CN)
- Corresponding author
- Liu, Liangming
- Li, Tao
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-01-18
- Volume
- 12
- Issue
- 2
- Pages
- 1397-1416
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC7053642
- OpenAlex
- W2999679411
- Cited by
- 82
- References
- 57
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 20 · 2023: 14 · 2022: 21 · 2021: 9 · 2020: 2
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Drp1, mitochondrial fission, reactive oxygen species, gut microbiota, intestinal barrier, hemorrhagic shock, short-chain fatty acids, tight junctions, ZO-1, intestinal permeability, mitochondrial dysfunction
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Fatty Acids, Volatile, Intestinal Mucosa, Male, Mitochondria, Permeability, RNA, Ribosomal, 16S, Shock, Hemorrhagic, Biomarkers, Reactive Oxygen Species, Dynamins, Mice, Metabolomics, Metagenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review