Caloric restriction: implications for sarcopenia and potential mechanisms
Open accessAbstract
Sarcopenia is a potential risk factor for weakness, disability and death in elderly individuals. Therefore, seeking effective methods to delay and treat sarcopenia and to improve the quality of life of elderly individuals is a trending topic in geriatrics. Caloric restriction (CR) is currently recognized as an effective means to extend the lifespan and delay the decline in organ function caused by aging. In this review, we describe the effects of CR on improving muscle protein synthesis, delaying muscle atrophy, regulating muscle mitochondrial function, maintaining muscle strength, promoting muscle stem cell (MuSC) regeneration and differentiation, and thus protecting against sarcopenia. We also summarize the possible cellular mechanisms by which CR delays sarcopenia. CR can delay sarcopenia by reducing the generation of oxygen free radicals, reducing oxidative stress damage, enhancing mitochondrial function, improving protein homeostasis, reducing iron overload, increasing autophagy and apoptosis, and reducing inflammation. However, the relationships between CR and genetics, sex, animal strain, regimen duration and energy intake level are complex. Therefore, further study of the proper timing and application method of CR to prevent sarcopenia is highly important for the aging population.
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A long-term calorie-restricted diet extends lifespan and reduces age-related physiological impairments in a variety of organisms.
“a long-term calorie-restricted diet has been recognized for many years as a way to extend lifespan and reduce age-related physiological impairments in a variety of organisms [114–116].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [116]
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“Indeed, a long-term calorie-restricted diet has been recognized for many years as a way to extend lifespan and reduce age-related physiological impairments in a variety of organisms [114–116].”
- Authors
- Xie, W.-Q., Xiao, W.-F., Tang, K., Wu, Y.-X., Hu, P.-W., Li, Y.-S., Duan, Y., & Lv, S.
- Affiliations
- Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
- Central South University (CN)
- School of Kinesiology, Jianghan University, Wuhan 430056, China
- Department of Scientific Research, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
- Jiangsu Province Hospital (CN)
- Corresponding author
- Duan, Yu
- Lv, Shan
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-11-21
- Volume
- 12
- Issue
- 23
- Pages
- 24441-24452
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC7762489
- OpenAlex
- W3110494428
- Cited by
- 46
- References
- 85
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- caloric restriction, sarcopenia, muscle protein synthesis, muscle atrophy, mitochondrial function, muscle stem cells, muscle strength, oxidative stress, iron overload, autophagy, apoptosis, inflammation, proteostasis, longevity, older adults
- MeSH terms
- Age Factors, Aging, Animals, Body Composition, Humans, Mitochondria, Muscle, Risk Factors, Sex Factors, Treatment Outcome, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Caloric Restriction, Muscle Strength, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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