Cited by 46Nutrition and Health in AgingMuscle Physiology and DisordersGenetics, Aging, and Longevity in Model Organisms

Caloric restriction: implications for sarcopenia and potential mechanisms

Open access
Xie, Wen-Qing, Xiao, Wen-Feng, Tang, Kun, Wu, Yu-Xiang, Hu, Pei-Wu, Li, Yu-Sheng, Duan, Yu, Lv, Shan·2020·Aging

Abstract

Sarcopenia is a potential risk factor for weakness, disability and death in elderly individuals. Therefore, seeking effective methods to delay and treat sarcopenia and to improve the quality of life of elderly individuals is a trending topic in geriatrics. Caloric restriction (CR) is currently recognized as an effective means to extend the lifespan and delay the decline in organ function caused by aging. In this review, we describe the effects of CR on improving muscle protein synthesis, delaying muscle atrophy, regulating muscle mitochondrial function, maintaining muscle strength, promoting muscle stem cell (MuSC) regeneration and differentiation, and thus protecting against sarcopenia. We also summarize the possible cellular mechanisms by which CR delays sarcopenia. CR can delay sarcopenia by reducing the generation of oxygen free radicals, reducing oxidative stress damage, enhancing mitochondrial function, improving protein homeostasis, reducing iron overload, increasing autophagy and apoptosis, and reducing inflammation. However, the relationships between CR and genetics, sex, animal strain, regimen duration and energy intake level are complex. Therefore, further study of the proper timing and application method of CR to prevent sarcopenia is highly important for the aging population.

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  • A long-term calorie-restricted diet extends lifespan and reduces age-related physiological impairments in a variety of organisms.

    “a long-term calorie-restricted diet has been recognized for many years as a way to extend lifespan and reduce age-related physiological impairments in a variety of organisms [114–116].”

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Authors
Xie, W.-Q., Xiao, W.-F., Tang, K., Wu, Y.-X., Hu, P.-W., Li, Y.-S., Duan, Y., & Lv, S.
Affiliations
  • Deparment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
  • Central South University (CN)
  • School of Kinesiology, Jianghan University, Wuhan 430056, China
  • Department of Scientific Research, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
  • Jiangsu Province Hospital (CN)
Corresponding author
  • Duan, Yu
  • Lv, Shan
Venue
Aging
Published
2020-11-21
Volume
12
Issue
23
Pages
24441-24452
ISSN
1945-4589 (ISSN-L)
OpenAlex
W3110494428
Cited by
46
References
85
Citations by year
2026: 8 · 2025: 12 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 2
FWCI
0.54
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
caloric restriction, sarcopenia, muscle protein synthesis, muscle atrophy, mitochondrial function, muscle stem cells, muscle strength, oxidative stress, iron overload, autophagy, apoptosis, inflammation, proteostasis, longevity, older adults
MeSH terms
Age Factors, Aging, Animals, Body Composition, Humans, Mitochondria, Muscle, Risk Factors, Sex Factors, Treatment Outcome, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Caloric Restriction, Muscle Strength, Sarcopenia

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