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Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)

Amessou, Mohamed, Ebrahim, Abdul Shukkur, Dilly, Ashok, Joseph, Melvin, Tabolina, Marina, Chukkapalli, Sahiti, Meroueh, Louay, Syed, Joseph T., Liddane, Allison, Lang, Siera Lanae, Al-Katib, Ayad, Kandouz, Mustapha·2016·Oncotarget
DOI 10.18632/oncotarget.13008PMC PMC5346708
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  • Doxycycline-inducible EHD3 expression in EHD3-deleted glioblastoma cell lines increases basal levels of EGFR.

    “although doxycycline (Dox)-inducible EHD3 expression in EHD3-deleted glioblastoma cell lines increased the basal levels of EGFR (48).”

    From EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling (2020) · cites this paper as [48]

  • EHD3 may function in targeting ligand-stimulated EGFR to lysosomal degradation by diverting it from endocytic recycling.

    “A recent study suggested that EHD3 may function in targeting the ligand-stimulated EGFR to lysosomal degradation by diverting it from endocytic recycling (48), consistent with EHD3 deletion in glioblastoma (49), although doxycycline (Dox)-inducible EHD3 expression in EHD3-deleted glioblastoma cell lines increased the basal levels of EGFR (48).”

    From EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling (2020) · cites this paper as [48]

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Metadata

Authors
Amessou, M., Ebrahim, A. S., Dilly, A., Joseph, M., Tabolina, M., Chukkapalli, S., Meroueh, L., Syed, J. T., Liddane, A., Lang, S. L., Al-Katib, A., & Kandouz, M.
Affiliations
  • Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA
  • Lymphoma Research Lab, Wayne State University School of Medicine, Detroit, Michigan, USA
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-11-01
Volume
7
Issue
48
Pages
79203-79216
ISSN
1949-2553
DOI
10.18632/oncotarget.13008
PMC
PMC5346708
Cited by
5
References
0
Language
en

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