USP7 protects genomic stability by regulating Bub3.
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// Serena Giovinazzi 1,2 , Pietro Sirleto 3 , Vasilisa Aksenova 4 , Viacheslav M. Morozov 1,2 , Roberto Zori 5 , William C. Reinhold 6 and Alexander M. Ishov 1,2 1 Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 2 University of Florida Health Cancer Center, Gainesville, FL 3 Bambino Gesu’ Children’s Hospital, Rome, Italy 4 Molecular Pharmacology laboratory, Institute of Technology and Institute of Cytology, St-Petersburg, Russia 5 Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 6 Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD Correspondence: Alexander M. Ishov, email: // Keywords : deubiquitinase USP7, Bub3, spindle assembly checkpoint (SAC), genomic instability, USP7 inhibitors Received : April 15, 2014 Accepted : May 17, 2014 Published : May 19, 2014 Abstract USP7 (Ubiquitin Specific processing Protease-7) is a deubiquitinase which, over the past decade emerged as a critical regulator of cellular processes. Deregulation of USP7 activity has been linked to cancer, making USP7 inhibition an appealing anti-cancer strategy. The identification of novel USP7 substrates and additional USP7-dependent cellular activities will broaden our knowledge towards potential clinical application of USP7 inhibitors. Results presented in this study uncover a novel and pivotal function of USP7 in the maintenance of genomic stability. Upon USP7 depletion we observed prolonged mitosis and mitotic abnormalities including micronuclei accumulation, lagging chromosomes and karyotype instability. Inhibition of USP7 with small molecule inhibitors stabilizes cyclin B and causes mitotic abnormalities. Our results suggest that these USP7-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC) component Bub3, which we characterized as an interacting partner and substrate of USP7. In silico analysis across the NCI-60 panels of cell lines supports our results where lower levels of USP7 strongly correlate with genomic instability. In conclusion, we identified a novel role of USP7 as regulator of the SAC component Bub3 and genomic stability.
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USP7 influences proper chromatid alignment and segregation by deubiquitinating Bub3 during M phase.
“Aside from PLK1-mediated regulation, USP7 also influences proper chromatid alignment and segregation by deubiquitinating Bub3 during M phase (Giovinazzi et al., 2014).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Giovinazzi et al., 2014
Similar chromosomal abnormalities were detected in both p53 positive and null cell lines following USP7 depletion, suggesting this phenotype might be caused by means other than p53 deregulation.
“Although p53 status was not a reported parameter in these analyses, similar chromosomal abnormalities were detected in both p53 positive and null cell lines following USP7 depletion, suggesting this phenotype might be caused by means other than p53 deregulation (Giovinazzi et al., 2013, 2014).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Giovinazzi et al., 2014
USP7 mRNA expression levels correlate with genomic instability across the NCI-60 panel of cancer cell lines.
“For instance, USP7 mRNA expression levels were found to correlate with genomic instability across the NCI-60 panel of cancer cell lines (Giovinazzi et al., 2014).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Giovinazzi et al., 2014
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785 · see citing works
The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227 · see citing works
Defining the Human Deubiquitinating Enzyme Interaction Landscape
Sowa, M. E., Bennett, E. J., Gygi, S. P., & Harper, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.04.042 · Cited by 1,512 · see citing works
Fenech, M. F., Chang, W. P., Kirsch‐Volders, M., Holland, N., Bonassi, S., & Zeiger, E. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00249-8 · Cited by 1,394 · see citing works
Fenech, M., Kirsch-Volders, M., Natarajan, A. T., Surralles, J., Crott, J. W., Parry, J., Norppa, H., Eastmond, D. A., Tucker, J. D., & Thomas, P. (2011) · Mutagenesis · doi:10.1093/mutage/geq052 · Cited by 1,244 · see citing works
On the road to cancer: aneuploidy and the mitotic checkpoint
Kops, G. J. P. L., Weaver, B. A. A., & Cleveland, D. W. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1714 · Cited by 1,188 · see citing works
The cellular geography of Aurora kinases
Carmena, M., & Earnshaw, W. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1245 · Cited by 1,151 · see citing works
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
Hoyt, M. A., Totis, L., & Roberts, B. T. (1991) · Cell · doi:10.1016/0092-8674(81)90014-3 · Cited by 1,138 · see citing works
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., & Gu, W. J. (2002) · Nature · doi:10.1038/nature737 · Cited by 1,027 · see citing works
Sudakin, V., Chan, G. K. T., & Yen, T. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102093 · Cited by 907 · see citing works
Reinhold, W. C., Sunshine, M., Liu, H., Varma, S., Kohn, K. W., Morris, J., Doroshow, J., & Pommier, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1370 · Cited by 887 · see citing works
Self-citationCountryman, P. I., & Heddle, J. A. (1976) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(76)90105-6 · Cited by 815 · see citing works
Rajagopalan, H., & Christoph Lengauer, C. (2004) · Nature · doi:10.1038/nature03099 · Cited by 730 · see citing works
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729 · see citing works
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W. L., Dobles, M., Sorger, P. K., Murty, V. V. V. S., & Benezra, R. (2001) · Nature · doi:10.1038/35053094 · Cited by 725 · see citing works
Weaver, B. A. A., & Cleveland, D. W. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.002 · Cited by 560 · see citing works
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J., & Pandolfi, P. P. (2008) · Nature · doi:10.1038/nature07290 · Cited by 548 · see citing works
Timing and checkpoints in the regulation of mitotic progression.
Meraldi, P., Draviam, V. M., & Sorger, P. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.006 · Cited by 528 · see citing works
Everett, R. D., Meredith, M., Orr, A., Cross, A., Kathoria, M., & Parkinson, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1519 · Cited by 491 · see citing works
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
van der Horst, A., de Vries-Smits, A. M. M., Brenkman, A. B., van Triest, M. H., van den Broek, N. J. F., Colland, F., Maurice, M. M., & Burgering, B. M. T. (2006) · Nature Cell Biology · doi:10.1038/ncb1469 · Cited by 479 · see citing works
Genome stability is ensured by temporal control of kinetochore–microtubule dynamics
Bakhoum, S. F., Thompson, S. L., Manning, A. L., & Compton, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1809 · Cited by 453 · see citing works
What do human micronuclei contain?
Norppa, H. (2003) · Mutagenesis · doi:10.1093/mutage/18.3.221 · Cited by 391 · see citing works
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Stegmeier, F. P., Rapé, M., Draviam, V. M., Nalepa, G., Sowa, M. E., Cambronne, X. A., McDonald, E. R., Li, M. Z., Hannon, G. J., Sorger, P. K., et al. (2007) · Nature · doi:10.1038/nature05694 · Cited by 368 · see citing works
Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability
Bakhoum, S. F. W., Genovese, G., & Compton, D. A. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.055 · Cited by 349 · see citing works
Babu, J. R., Jeganathan, K. B., Baker, D. J., Wu, X., Kang, N., & van Deursen, J. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211048 · Cited by 342 · see citing works
Losada, A., Hirano, M., & Hirano, T. (2002) · Genes & Development · doi:10.1101/gad.249202 · Cited by 335 · see citing works
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Colland, F., Formstecher, É., Jacq, X., Reverdy, C., Planquette, C., Conrath, S., Trouplin, V., Bianchi, J., Aushev, V. N., Camonis, J., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0097 · Cited by 322 · see citing works
The spindle checkpoint: tension versus attachment
Pinsky, B. A., & Biggins, S. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.07.005 · Cited by 294 · see citing works
Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency
Dai, W. H., Wang, Q., Liu, T., Swamy, M. V., Fang, Y., Xie, S., Mahmood, R., Yang, Y., Xu, M., & Rao, C. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3119 · Cited by 291 · see citing works
Karyotypic complexity of the NCI-60 drug-screening panel.
Roschke, A. V., Tonon, G., Gehlhaus, K., Mctyre, N., Bussey, K. J., Lababidi, S., Scudiero, D. A., Weinstein, J. N., & Kirsch, I. R. (2003) · PubMed · Cited by 289 · see citing works
Chromosomal instability determines taxane response
Swanton, C., Nicke, B., Schuett, M., Eklund, A. C., Ng, C. K. Y., Li, Q., Hardcastle, T. J., Lee, A. J. X., Roy, R., East, P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811835106 · Cited by 287 · see citing works
Immunoaffinity Purification of Mammalian Protein Complexes
Nakatani, Y., & Ogryzko, V. V. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)70037-8 · Cited by 285 · see citing works
Tang, Z., Shu, H., Öncel, D., Chen, S., & Yu, H. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.031 · Cited by 281 · see citing works
Resolution of anaphase bridges in cancer cells
Hoffelder, D. R., Luo, L., Burke, N., Watkins, S. C., Gollin, S. M., & Saunders, W. S. (2004) · Chromosoma · doi:10.1007/s00412-004-0284-6 · Cited by 277 · see citing works
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme.
Reverdy, C., Conrath, S., Lopez, R., Planquette, C., Atmanene, C., Collura, V., Harpon, J., Battaglia, V., Vivat, V., Sippl, W., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.02.007 · Cited by 270 · see citing works
GMP Synthetase Stimulates Histone H2B Deubiquitylation by the Epigenetic Silencer USP7
van der Knaap, J. A., Kumar, B. R. P., Moshkin, Y. M., Langenberg, K. P. S., Krijgsveld, J., Heck, A. J. R., Karch, F., & Verrijzer, C. P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.013 · Cited by 258 · see citing works
The Multifaceted Roles of USP7: New Therapeutic Opportunities
Nicholson, B., & Kumar, S. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9185-5 · Cited by 243 · see citing works
Kalitsis, P., Earle, E., Fowler, K. J., & Choo, K. H. A. (2000) · Genes & Development · doi:10.1101/gad.827500 · Cited by 241 · see citing works
Jeganathan, K. B., Malureanu, L. A., Baker, D., Abraham, S., & van Deursen, J. (2007) · Journal of Cell Biology · doi:10.1083/jcb.200706015 · Cited by 238 · see citing works
Holowaty, M. N., Zeghouf, M., Wu, H., Tellam, J., Athanasopoulos, V., Greenblatt, J., & Frappier, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303977200 · Cited by 228 · see citing works
Baker, D. J., Jin, F., Jeganathan, K. B., & van Deursen, J. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.023 · Cited by 219 · see citing works
A dual role for Bub1 in the spindle checkpoint and chromosome congression
Meraldi, P., & Sorger, P. K. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600641 · Cited by 210 · see citing works
Felle, M., Joppien, S., Németh, A., Diermeier, S. D., Thalhammer, V., Dobner, T., Kremmer, E., Kappler, R., & Längst, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr528 · Cited by 198 · see citing works
Aneuploidy: Instigator and Inhibitor of Tumorigenesis
Weaver, B. A. A., & Cleveland, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2266 · Cited by 195 · see citing works
HAUSP is Required for p53 Destabilization
Cummins, J. M., & Vogelstein, B. (2004) · Cell Cycle · doi:10.4161/cc.3.6.924 · Cited by 188 · see citing works
Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal
Maresca, T. J., & Salmon, E. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.064790 · Cited by 170 · see citing works
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
Zhang, Y., Foreman, O., Wigle, D. A., Kosari, F., Vasmatzis, G., Salisbury, J. L., van Deursen, J., & Galardy, P. J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63084 · Cited by 168 · see citing works
Cimini, D., Fioravanti, D., Salmon, E. D., & Degrassi, F. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.507 · Cited by 162 · see citing works
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells
Huang, Z., Wu, Q., Guryanova, O. A., Cheng, L., Shou, W., Rich, J. N., & Bao, S. (2011) · Nature Cell Biology · doi:10.1038/ncb2153 · Cited by 160 · see citing works
Centrosome function in cancer: guilty or innocent?
Zyss, D., & Gergely, F. V. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.04.001 · Cited by 149 · see citing works
Canning, M., Boutell, C., Parkinson, J., & Everett, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402885200 · Cited by 142 · see citing works
DUESBERG, P. H., Fabarius, A. C., & Hehlmann, R. (2004) · IUBMB Life · doi:10.1080/15216540410001667902 · Cited by 135 · see citing works
Boutell, C., Canning, M., Orr, A., & Everett, R. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12342-12354.2005 · Cited by 134 · see citing works
The therapeutic potential of deubiquitinating enzyme inhibitors
Colland, F. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380137 · Cited by 124 · see citing works
Ma, H., Chen, H., Guo, X., Wang, Z., Sowa, M. E., Zheng, L., Hu, S., Zeng, P.-Y., Guo, R., Diao, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116349109 · Cited by 117 · see citing works
Sarkari, F., Sanchez-Alcaraz, T., Wang, S., Holowaty, M. N., Sheng, Y., & Frappier, L. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000624 · Cited by 115 · see citing works
USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin
Faustrup, H., Bekker-Jensen, S., Bartek, J., Lukas, J., & Mailand, N. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807137 · Cited by 113 · see citing works
Rao, C. V., Yamada, H. Y., Yao, Y., & Dai, W. H. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp081 · Cited by 110 · see citing works
Classification of chromosome segregation errors in cancer
Gisselsson, D. (2008) · Chromosoma · doi:10.1007/s00412-008-0169-1 · Cited by 102 · see citing works
Logarinho, E., Resende, T. P., Torres, C., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0633 · Cited by 95 · see citing works
Retention of the Bub3 checkpoint protein on lagging chromosomes
Martínez-Expósito, M. J., Kaplan, K. B., Copeland, J., & Sorger, P. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8493 · Cited by 93 · see citing works
The role of aneuploidy in promoting and suppressing tumors
Weaver, B. A. A., & Cleveland, D. W. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200905098 · Cited by 90 · see citing works
Logarinho, E., & Bousbaa, H. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6180 · Cited by 84 · see citing works
Chromosomal Instability, Colorectal Cancer and Taxane Resistance
Swanton, C., Tomlinson, I. P. M., & Downward, J. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2682 · Cited by 83 · see citing works
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint
Braunstein, I., Miniowitz-Shemtov, S., Moshe, Y., & Hershko, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700523104 · Cited by 73 · see citing works
van der Knaap, J. A., Kozhevnikova, E. N., Langenberg, K. P. S., Moshkin, Y. M., & Verrijzer, C. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01121-09 · Cited by 72 · see citing works
Giovinazzi, S., Morozov, V. M., Summers, M. K., Reinhold, W. C., & Ishov, A. M. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.169 · Cited by 65 · see citing works
Self-citationJäger, W., Santag, S., Weidner-Glunde, M., Gellermann, E., Kati, S., Pietrek, M., Viejo‐Borbolla, A., & Schulz, T. F. (2012) · Journal of Virology · doi:10.1128/jvi.06840-11 · Cited by 65 · see citing works
Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity
Oh, Y. M., Yoo, S. J., & Seol, J. H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.193 · Cited by 52 · see citing works
Gisselsson, D., Håkanson, U., Stoller, P. C., Marti, D., Jin, Y., Rosengren, A. H., Stewénius, Y., Kahl, F., & Panagopoulos, I. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001871 · Cited by 52 · see citing works
Aneuploidy Drives a Mutator Phenotype in Cancer
Kolodner, R. D., Cleveland, D. W., & Putnam, C. D. (2011) · Science · doi:10.1126/science.1211154 · Cited by 45 · see citing works
Cross-species genomic and epigenomic landscape of retinoblastoma
Benavente, C. A., McEvoy, J. D., Finkelstein, D., Wei, L., Kang, G., Wang, Y., Neale, G. A. M., Ragsdale, S. T., Valentine, V. A., Bahrami, A., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1051 · Cited by 38 · see citing works
Regulation of mitosis and taxane response by Daxx and Rassf1
Giovinazzi, S., Lindsay, C. R., Morozov, V. M., Escobar-Cabrera, E., Summers, M. K., Han, H. S., McIntosh, L. P., & Ishov, A. M. (2011) · Oncogene · doi:10.1038/onc.2011.211 · Cited by 34 · see citing works
Self-citationKinetochore-Microtubule Interactions
Clayton, L., & Tanaka, T. U. (2008) · Springer eBooks · doi:10.1007/978-0-387-69076-6_9 · Cited by 20 · see citing works
Bakhoum, S. F. W., & Compton, D. A. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.039 · Cited by 17 · see citing works
Lindsay, C., Giovinazzi, S., & Ishov, A. M. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8379 · Cited by 17 · see citing works
Self-citationTo-Ho, K. W., Cheung, H. W., Ling, M., Wong, Y. C., & Wang, X. (2007) · Oncogene · doi:10.1038/sj.onc.1210633 · Cited by 16 · see citing works
Giovinazzi, S., Morozov, V. M., Summers, M. K., Reinhold, W. C., & Ishov, A. M. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-573 · Cited by 1 · see citing works
Self-citationAbstract 2988: Regulation of mitosis and taxane response by Daxx
Giovinazzi, S., Lindsay, C., Morozov, V. M., Han, H. S., & Ishov, A. M. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-2988 · Cited by 1 · see citing works
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USP7: Structure, substrate specificity, and inhibition
Pozhidaeva, A., & Bezsonova, I. (2019) · DNA Repair · doi:10.1016/j.dnarep.2019.02.005 · Cited by 178 · see citing works
USP7 Is a Master Regulator of Genome Stability
Valles, G. J., Bezsonova, I., Woodgate, R., & Ashton, N. W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00717 · Cited by 114 · see citing works
“For instance, USP7 mRNA expression levels were found to correlate with genomic instability across the NCI-60 panel of cancer cell lines (Giovinazzi et al., 2014).”
BackgroundZhang, C., Lu, J., Zhang, Q.-W., Zhao, W., Guo, J.-H., Liu, S.-L., Wu, Y.-L., Jiang, B., & Gao, F.-H. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.08.025 · Cited by 67 · see citing works
- Authors
- Giovinazzi, S., Sirleto, P., Aksenova, V., Morozov, V. M., Zori, R., Reinhold, W. C., & Ishov, A. M.
- Affiliations
- University of Florida Health (US)
- Institute of Cytology (RU)
- National Institutes of Health (US)
- ORCID
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2014-05-19
- Volume
- 5
- Issue
- 11
- Pages
- 3728-3742
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC4116516
- OpenAlex
- W1504025592
- Cited by
- 34
- References
- 81
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 13 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2016: 5 · 2015: 3
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University (HCT116)
- National Institutes of Health (/ NCI R01)
- Medical Research Council
- National Cancer Institute (HCT116, R01CA127378)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- USP7, Bub3, deubiquitinase, spindle assembly checkpoint, genome stability, mitotic abnormalities, cyclin B, USP7 inhibitors, karyotype instability, micronuclei, lagging chromosomes, NCI-60 cell lines
- MeSH terms
- Poly-ADP-Ribose Binding Proteins, Ubiquitin-Specific Peptidase 7, Humans, Neoplasms, Transfection, Gene Expression, Cell Cycle Proteins, Genomic Instability, Ubiquitin Thiolesterase, HCT116 Cells, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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