USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.
Open accessAbstract
A large number of patients are resistant to taxane-based chemotherapy. Functional mitotic checkpoints are essential for taxane sensitivity. Thus, mitotic regulators are potential markers for therapy response and could be targeted for anticancer therapy. In this study, we identified a novel function of ubiquitin (Ub)-specific processing protease-7 (USP7) that interacts and cooperates with protein death domain-associated protein (Daxx) in the regulation of mitosis and taxane resistance. Depletion of USP7 impairs mitotic progression, stabilizes cyclin B and reduces stability of the mitotic E3 Ub ligase, checkpoint with forkhead and Ring-finger (CHFR). Consequently, cells with depleted USP7 accumulate Aurora-A kinase, a CHFR substrate, thus elevating multipolar mitoses. We further show that these effects are independent of the USP7 substrate p53. Thus, USP7 and Daxx are necessary to regulate proper execution of mitosis, partially via regulation of CHFR and Aurora-A kinase stability. Results from colony formation assay, in silico analysis across the NCI60 platform and in breast cancer patients suggest that USP7 levels inversely correlate with response to taxanes, pointing at the USP7 protein as a potential predictive factor for taxane response in cancer patients. In addition, we demonstrated that inhibition of Aurora-A attenuates USP7-mediated taxane resistance, suggesting that combinatorial drug regimens of Taxol and Aurora-A inhibitors may improve the outcome of chemotherapy response in cancer patients resistant to taxane treatment. Finally, our study offers novel insights on USP7 inhibition as cancer therapy.
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Similar chromosomal abnormalities were detected in both p53 positive and null cell lines following USP7 depletion, suggesting this phenotype might be caused by means other than p53 deregulation.
“Although p53 status was not a reported parameter in these analyses, similar chromosomal abnormalities were detected in both p53 positive and null cell lines following USP7 depletion, suggesting this phenotype might be caused by means other than p53 deregulation (Giovinazzi et al., 2013, 2014).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Giovinazzi et al., 2013
Another proposed use for USP7 inhibitors is in sensitizing taxane-resistant tumors to taxane therapies.
“Another proposed use for USP7 inhibitors is in sensitizing taxane-resistant tumors to taxane therapies (Giovinazzi et al., 2013; Zhang et al., 2016; Peng et al., 2019).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Giovinazzi et al., 2013
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- Authors
- Giovinazzi, S., Morozov, V. M., Summers, M. K., Reinhold, W. C., & Ishov, A. M.
- Affiliations
- University of Florida (US)
- University of Florida Health (US)
- Cleveland Clinic Research (US)
- National Institutes of Health (US)
- Corresponding author
- Ishov, A M
- Venue
- Cell Death & Differentiation
- Published
- 2013-01-25
- Volume
- 20
- Issue
- 5
- Pages
- 721-731
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3619237
- OpenAlex
- W2082231793
- Cited by
- 65
- References
- 60
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cleveland Clinic
- National Institutes of Health (/ NCI R01)
- National Cancer Institute (T32CA009151, HCT116, R01CA127378)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- USP7, DAXX, AURKA, taxane resistance, CHFR, cyclin B, protein stability, multipolar mitosis, spindle assembly checkpoint, p53-independent regulation, predictive biomarkers, breast cancer, Aurora A inhibitor, chemotherapy response
- MeSH terms
- Poly-ADP-Ribose Binding Proteins, Ubiquitin-Specific Peptidase 7, Antineoplastic Agents, Benzazepines, Breast Neoplasms, Bridged-Ring Compounds, Female, Humans, Mitosis, Neoplasm Proteins, Nuclear Proteins, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Molecular Chaperones, Drug Resistance, Neoplasm, Cyclin B, RNA Interference, RNA, Small Interfering, Ubiquitin Thiolesterase, Taxoids, Ubiquitin-Protein Ligases, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Co-Repressor Proteins, Aurora Kinases
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