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Roles of Rap1 signaling in tumor cell migration and invasion
Open accessAbstract
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression.
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“We observed enrichment in the PI3K-Akt signaling pathway as well as the Rap1 signaling pathway which has crosstalk with the PI3K-Akt pathway (Fig. 7B) (41).”
From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [41]
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Cites
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
The Guanine Nucleotide-Binding Switch in Three Dimensions
Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875
cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway
Vossler, M. R., Yao, H. W., York, R. D., Pan, M., Rim, C. S., & Stork, P. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80184-1 · Cited by 1,044
A ras-related gene with transformation suppressor activity
Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y., & Noda, M. (1989) · Cell · doi:10.1016/0092-8674(89)90985-9 · Cited by 942
The structural basis of the activation of Ras by Sos
Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., & Kuriyan, J. (1998) · Nature · doi:10.1038/28548 · Cited by 799
Rap1 signalling: adhering to new models
Bos, J. L., de Rooij, J., & Reedquist, K. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073073 · Cited by 625
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10
Chiang, S.-H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., & Saltiel, A. R. (2001) · Nature · doi:10.1038/35073608 · Cited by 611
Transcriptional Enhancers in Animal Development and Evolution
Levine, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.070 · Cited by 468
Research works printed but not linked: 2
- [16]Rebhun JF Castro AF Quilliam LA Regulating Rap small G-proteins in time and space Trends Cell Biol 2011 21 615 23 21820312
- [75]Dong X Korch C Meinkoth JL Rap1 stabilizes β-catenin and enhances β-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck Clin Cancer Res 2010 16 65 76 20028760 PMC2844500
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Yang, J., Liao, Q., & Lu, C.-L. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02740-w · Cited by 10
Li, J., Xie, Y., Zhao, J., Zhao, F., Bahatibieke, A., Liu, G., Meng, H., & Zheng, Y. (2025) · Composites Part B Engineering · doi:10.1016/j.compositesb.2025.112246 · Cited by 10
Xiao, Y., Huang, P., Zhang, Y., Lu, X., Zhou, C., Wu, F., Wang, Y., Zeng, M., & Yang, C. (2024) · Abdominal Radiology · doi:10.1007/s00261-023-04174-8 · Cited by 10
Nie, J., Li, H., Wu, M., Lin, X.-M., Xiong, L., & Liu, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010191 · Cited by 10
Li, C., Liu, L., & Dinu, V. (2018) · PeerJ · doi:10.7717/peerj.4571 · Cited by 9
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Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells
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Luo, Z., Li, W., Zheng, W., Shi, Y., Ye, M., Guo, X., Fu, K., Yan, C., Wang, B., Lv, B., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70114 · Cited by 8
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Banu, H., Al-Shammari, E., Shahanawaz, S., Azam, F., Patel, M. B., Alarifi, N. A., Ahmad, M. F., Adnan, M., & Ashraf, S. A. (2025) · Pharmaceuticals · doi:10.3390/ph18040453 · Cited by 9
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Xiao, J., McGill, J. R., Nasir, A., Lekan, A. A., Johnson, B., Wilkins, D. J., Pearson, G. W., Tanner, K., Goodarzi, H., Glasgow, E. F., et al. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00080-5 · Cited by 10
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Li, C., & Dinu, V. (2018) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2018.03.013 · Cited by 7
Kang, Y., Li, G., Wang, G., Huo, Z., Feng, X., Du, L., Li, Y., Yang, Q., Ma, X., Yu, B., et al. (2022) · Journal of Oncology · doi:10.1155/2022/7596122 · Cited by 7
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Jin, Y., & Qin, X. (2020) · Bioscience Reports · doi:10.1042/bsr20193349 · Cited by 7
Wu, P., Liu, Z., Zheng, L., Du, Y., Zhou, Z., Wang, W., & Lu, C. (2025) · Communications Biology · doi:10.1038/s42003-025-07954-8 · Cited by 6
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Zhang, Z., Wu, Y., Yu, C., Li, Z., & Xu, L. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-21-594 · Cited by 5
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Liu, Y., Qu, H., Chang, X., Mentch, F. D., Qiu, H., Nguyen, K., Wang, X., Saeidian, A. H., Watson, D. J., Glessner, J., et al. (2022) · Biomarker Research · doi:10.1186/s40364-022-00431-y · Cited by 5
Zhang, R., Wu, J., Yang, Y., Xia, D., Li, J., Quan, H., Niu, Z., Yang, Y., & Wu, J. (2020) · Journal of Cancer · doi:10.7150/jca.39712 · Cited by 5
Sun, X., Yu, G., Zhang, Y., Zhao, P., Wang, Z., Wei, Z., & Qiao, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.789587 · Cited by 5
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Ferrier, S. T., Li, M., & Burnier, J. V. (2024) · BMC Cancer · doi:10.1186/s12885-024-13037-4 · Cited by 4
Xuan, D., Chen, B., Zhou, Z., Ye, S., Cui, Y., Li, W., & Ding, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106506 · Cited by 4
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Huo, Y., Gao, Y., Ruan, J., Wang, L., Li, H., & Hong, G. (2025) · Epigenetics · doi:10.1080/15592294.2025.2487316 · Cited by 3
Dong, Z., Whitehead, J., Fu, M., MacIsaac, J. L., Rehkopf, D. H., Rosero‐Bixby, L., Kobor, M. S., & Korthauer, K. D. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115755 · Cited by 6
Yang, J., Kuan, P. F., & Li, J. (2019) · Statistical Methods in Medical Research · doi:10.1177/0962280219882047 · Cited by 3
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Phan, T. L., Kim, H., Lee, S. J., Choi, M., & Kim, S.-H. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s317285 · Cited by 3
Mohseni, N., Zarch, M. G., Afshar, S., & Hosseini, M. (2022) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-022-00873-5 · Cited by 3
Mechanism of morusin on breast cancer via network pharmacology and in vitro experiments
Li, H., Xiao, J., Li, X., Huang, Q., Liu, Q., & Zhang, Q. (2023) · Medicine · doi:10.1097/md.0000000000034300 · Cited by 3
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Khayer, N., Shabani, S., Jalessi, M., Joghataei, M. T., & Mahjoubi, F. (2025) · Scientific Reports · doi:10.1038/s41598-024-82668-1 · Cited by 3
Dandesena, D., Suresh, A., Budhwar, R., Godwin, J., Singh, S., Subudhi, M., Amruthanjali, T., Roy, S., Vengatachala Moorthy, A., Bhandari, V., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.20.581323 · Cited by 4
Thomsen, A. A., Rabjerg, M., Marcussen, N., Lund, L. C., & Jensen, O. N. (2026) · medRxiv · doi:10.64898/2026.01.13.26343935 · Cited by 2
Niu, J., Chen, Y., Chai, H. C., & Sasidharan, S. (2024) · Biomedicines · doi:10.3390/biomedicines12040909 · Cited by 2
Oh, J., Han, J., & Lee, H. (2025) · Pharmaceuticals · doi:10.3390/ph18081181 · Cited by 2
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Sidhu, R. S., Ramar, V., Safir, T., Jones, T., Guo, S., Wang, G., & Liu, M. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112457 · Cited by 2
Zhen, X., Choe, S.-H., Kim, E. Y., Mao, Y., Kim, R. E., Huh, J., Kim, M., & Lee, J. (2026) · Foods · doi:10.3390/foods15061074 · Cited by 2
Cao, L., Cao, Z., Liu, H., Liang, N., Bing, Z., Tian, C., & Li, S. (2022) · Current Oncology · doi:10.3390/curroncol29080451 · Cited by 2
Self-citationSugai, T., Uesugi, N., Osakabe, M., Yamamoto, R., Hamada, K., Honda, M., Yanagawa, N., & Suzuki, H. (2024) · Gastric Cancer · doi:10.1007/s10120-024-01543-0 · Cited by 2
Bashar, M. A., Hossain, M. A., Kavey, M. R. H., Shazib, R., Islam, M. S., Ansari, S. A., & Rahman, M. H. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128348876241017101729 · Cited by 2
Laragione, T., Harris, C. L., & Gulko, P. S. (2025) · Cells · doi:10.3390/cells14070483 · Cited by 2
Peng, J., He, J., Ma, C., & Xue, J. (2025) · Toxics · doi:10.3390/toxics13040320 · Cited by 2
The role of abnormal epigenetic regulation of small GTPases in glioma (Review)
Zhang, M., Huang, Y., Zhang, Q., Zhang, X., Kang, L., & Wang, J. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5769 · Cited by 2
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Shahrear, S., Zinnia, M. A., Ahmed, T., & Islam, A. B. M. M. K. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166537 · Cited by 2
Jiang, Y., Wang, D., Xu, D. H., & Joshi, T. (2018) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm.2018.8621465 · Cited by 2
Song, D. E., Dong, L., Wang, M., & Xiaoping, G. (2024) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2024051787 · Cited by 2
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Zhang, K., Miao, J., Du, J., Yu, Y., Xia, B., Peng, H., Xu, S., Fan, J., Wang, Y., Schroyen, M., et al. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000667 · Cited by 3
Sianturi, M., Syaifulanwar, A., Darmawi, D., Adikusuma, W., Irham, L. M., Yusuf, M., Fani, R. T., & Febriani, F. (2025) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v23i5.19265 · Cited by 1
Abdelrazig, R., Ali, K., Abubaker, M. A. H., Youssouf, N. I., Alshikh, S. A., Mohammedosman, S. M., & Alfaki, M. (2025) · Cureus · doi:10.7759/cureus.90765 · Cited by 1
Saeidi, Y., Ghorbani, M., Najafi, A., & Moghaddam, M. M. (2025) · bioRxiv · doi:10.30699/ijp.2025.2067802.3499 · Cited by 1
Singh, A., Ohri, D., Wolkenhauer, O., Gautam, N. K., Gupta, S. K., & Singh, K. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010191 · Cited by 2
Hargadon, K. M., Győrffy, B., & Wall, J. B. (2025) · Clinical and Translational Discovery · doi:10.1002/ctd2.70104 · Cited by 1
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Hou, F., Zhou, X., Huang, Y., Liu, H., Yuan, M., Chen, J., Wang, Q., & Jiang, W. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02058-4 · Cited by 1
Hossain, M. M., Adhikari, J., & Shibly, A. Z. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100774 · Cited by 1
Klaihmon, P., Muangtate, P., Thongphayong, S., Saetan, P., Chanthateyanonth, S., Thuwajit, C., Issargrisil, S., & Phannasil, P. (2026) · PLoS ONE · doi:10.1371/journal.pone.0356726 · Cited by 1
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Zhang, B., Jin, B., Wu, X., Xing, J., Liu, X., Wan, X., Xu, H., Xu, Y., Mao, Y., Chen, Q., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.70135 · Cited by 1
Messer, C. L., Burghardt, E., & McDonald, J. A. (2025) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaf040 · Cited by 1
Zhou, Y., Zhu, H., Zhao, L., Zhao, G., & Sun, J. (2025) · Medicine · doi:10.1097/md.0000000000042245 · Cited by 1
Qian, X., Pantsar, T., Papageorge1, A. G., Tripathi, B. K., Sánchez‐Solana, B., Durkin, M. E., Gao, Y., Esposito, D., Waybright, T. J., Stephen, A. G., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1521657/v1 · Cited by 1
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Ongaba, T. (2023) · medRxiv · doi:10.1101/2023.10.12.23296974 · Cited by 1
Bathaie, S. Z., Faridi, N., Hydrazideh, H., Hashemi, S. A., Abroun, S., Tamanoi, F., & Mohagheghi, M. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4711052/v1 · Cited by 1
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Linan, M. K., Wang, J., & Dinu, V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/599225
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Rukat, T., & Yau, C. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1907.00063
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Shorning, B. Y., Trent, N., Griffiths, D. J., Worzfeld, T., Offermanns, S., Masters, J. R., Clarke, A. R., Smalley, M. J., & Williamson, M. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.19.203695
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Hasan, M. S. (2019) · VTechWorks (Virginia Tech)
Jermakowicz, A. M., Kurimchak, A., Sarkaria, J. N., Komotar, R. J., Ivan, M. E., Schürer, S. C., Duncan, J. S., & Ayad, N. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.21.306910
Rajwar, A., Vaswani, P., & Bhatia, D. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.28.478149
Metadata
- Authors
- Yi-Lei, Z., Yi-Lei, Z., Ruo-Chen, W., Ken, C., Brian Z., R., Li, S., Ruo-Chen, W., Ken, C., Brian Z., R., & Li, S.
- Venue
- Cancer Biology & Medicine
- Publisher
- China Anti-cancer Association
- Published
- 2017
- Volume
- 14
- Issue
- 1
- Pages
- 90-99
- ISSN
- 2095-3941 (ISSN-L)
- PMC
- PMC5365179
- OpenAlex
- W2592760610
- Cited by
- 244
- References
- 80
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 32 · 2023: 24 · 2022: 33 · 2021: 23 · 2020: 28 · 2019: 23 · 2018: 22 · 2017: 1
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Cancer Biology and Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Shenzhen Municipal Science and Technology Innovation Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- Rap1, tumor cell migration, tumor invasion, metastasis, guanine nucleotide exchange factor, GTPase-activating protein, integrin regulation, Rho GTPases, matrix metalloproteinase expression, cell adhesion, cell polarity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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