The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Roles of Rap1 signaling in tumor cell migration and invasion
Open accessAbstract
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression.
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“We observed enrichment in the PI3K-Akt signaling pathway as well as the Rap1 signaling pathway which has crosstalk with the PI3K-Akt pathway (Fig. 7B) (41).”
From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [41]
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Cites
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Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis
Chadchan, S. B., Popli, P., Ambati, C. R., Tycksen, E., Han, S. J., Bulun, S. E., Putluri, N., Biest, S. W., & Kommagani, R. (2021) · Life Science Alliance · doi:10.26508/lsa.202101224 · Cited by 119
Metadata
- Authors
- Yi-Lei, Z., Yi-Lei, Z., Ruo-Chen, W., Ken, C., Brian Z., R., Li, S., Ruo-Chen, W., Ken, C., Brian Z., R., & Li, S.
- Venue
- Cancer Biology & Medicine
- Publisher
- China Anti-cancer Association
- Published
- 2017
- Volume
- 14
- Issue
- 1
- Pages
- 90-99
- ISSN
- 2095-3941 (ISSN-L)
- PMC
- PMC5365179
- OpenAlex
- W2592760610
- Cited by
- 244
- References
- 80
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 32 · 2023: 24 · 2022: 33 · 2021: 23 · 2020: 28 · 2019: 23 · 2018: 22 · 2017: 1
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Cancer Biology and Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Shenzhen Municipal Science and Technology Innovation Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- Rap1, tumor cell migration, tumor invasion, metastasis, guanine nucleotide exchange factor, GTPase-activating protein, integrin regulation, Rho GTPases, matrix metalloproteinase expression, cell adhesion, cell polarity
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