An Overview of NO Signaling Pathways in Aging

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716 · see citing works

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works

Nitric oxide synthases: regulation and function

Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110 · see citing works

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., Cooper, C. E., & Knowles, R. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570593 · Cited by 4,106 · see citing works

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,612 · see citing works

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837 · see citing works

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555 · see citing works

Role of nitric oxide synthesis in macrophage antimicrobial activity

Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523 · see citing works

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

Wink, D. A., Kasprzak, K. S., Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., et al. (1991) · Science · doi:10.1126/science.1948068 · Cited by 1,235 · see citing works

Guanylyl Cyclases and Signaling by Cyclic GMP

Lucas, K. A., Pitari, G. M., Kazerounian, S., Ruiz‐Stewart, I., Park, J. Y., Schulz, S., Chepenik, K. P., & Waldman, S. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01457-1 · Cited by 1,229 · see citing works

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

Förstermann, U., Closs, E. I., Pollock, J. S., Nakane, M., Schwarz, P., Gath, I., & Kleinert, H. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.1121 · Cited by 1,115 · see citing works

Cellular and molecular mechanisms of endothelial cell dysfunction.

Harrison, D. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119751 · Cited by 1,048 · see citing works

Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission

Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006 · see citing works

Nitric oxide in skeletal muscle

Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 955 · see citing works

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 941 · see citing works

SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase

Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881 · see citing works

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

Collin, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102407 · Cited by 822 · see citing works

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806 · see citing works

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

Barouch, L. A., Harrison, R. W., Skaf, M. W., Rosas, G. O., Cappola, T. P., Kobeissi, Z. A., Hobai, I. A., Lemmon, C. A., Burnett, A. L. “., O'Rourke, B. P., et al. (2002) · Nature · doi:10.1038/416337a · Cited by 760 · see citing works

The Role of Catechins in Cellular Responses to Oxidative Stress

Bernatonienė, J., & Kopustinskienė, D. M. (2018) · Molecules · doi:10.3390/molecules23040965 · Cited by 704 · see citing works

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works

Enhanced Peroxynitrite Formation Is Associated with Vascular Aging

van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works

Endothelial Nitric Oxide Synthase Targeting to Caveolae

Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 670 · see citing works

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., & Tainer, J. A. (1998) · Science · doi:10.1126/science.279.5359.2121 · Cited by 668 · see citing works

Age-Related Reduction of NO Availability and Oxidative Stress in Humans

Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664 · see citing works

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

Zhou, L., & Zhu, D. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.03.001 · Cited by 659 · see citing works

Calmodulin is a subunit of nitric oxide synthase from macrophages.

Cho, H. J., Xie, Q. W., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.599 · Cited by 635 · see citing works

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

Mikkelsen, R. B., & Wardman, P. (2003) · Oncogene · doi:10.1038/sj.onc.1206663 · Cited by 591 · see citing works

Endothelial dysfunction in diabetes mellitus.

Hadi, H. A. R., & Suwaidi, J. M. S. A. (2007) · Europe PMC (PubMed Central) · Cited by 568 · see citing works

Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function

Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works

Brain aging and neurodegeneration: from a mitochondrial point of view

Grimm, A., & Eckert, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14037 · Cited by 565 · see citing works

Mechanisms of Vascular Aging: New Perspectives

Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

Li, J., Billiar, T. R., Talanian, R. V., & Kim, Y. M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7672 · Cited by 529 · see citing works

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

Rybalkin, S. D., Chen, Y., Bornfeldt, K., & Beavo, J. A. (2003) · Circulation Research · doi:10.1161/01.res.0000087541.15600.2b · Cited by 511 · see citing works

Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486 · see citing works

Age and the Cardiovascular System

Epstein, F. H., & Wei, J. Y. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212103272408 · Cited by 483 · see citing works

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Palmieri, E. M., Gonzalez-Cotto, M., Baseler, W. A., Davies, L. C., Ghesquière, B., Maio, N., Rice, C. M., Rouault, T. A., Cassel, T., Higashi, R. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14433-7 · Cited by 472 · see citing works

Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria

Brown, G. C., & Bal‐Price, A. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:325 · Cited by 461 · see citing works

Superoxide Excess in Hypertension and Aging

Hamilton, C., Brosnan, M. J., McIntyre, M., Graham, D., & Dominiczak, A. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.529 · Cited by 438 · see citing works

Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration

Liu, B., Gao, H., Wang, J., Jeohn, G., Cooper, C. L., & Hong, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04077.x · Cited by 425 · see citing works

Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression

Dimmeler, S., & Zeiher, A. M. (2000) · Circulation Research · doi:10.1161/01.res.87.6.434 · Cited by 420 · see citing works

Oxygen Reduction by Nitric-oxide Synthases

Stuehr, D. J., Pou, S., & Rosen, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100011200 · Cited by 400 · see citing works

Vascular endothelial senescence: from mechanisms to pathophysiology

Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399 · see citing works

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

Brown, G. C., & Borutaite, V. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01112-7 · Cited by 377 · see citing works

Angiotensin II Induces Apoptosis of Human Endothelial Cells

Dimmeler, S., Rippmann, V., Weiland, U., Haendeler, J., & Zeiher, A. M. (1997) · Circulation Research · doi:10.1161/01.res.81.6.970 · Cited by 373 · see citing works

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

Dimmeler, S., Haendeler, J., Galle, J., & Zeiher, A. M. (1997) · Circulation · doi:10.1161/01.cir.95.7.1760 · Cited by 371 · see citing works

Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium

Bredt, D. S., & Snyder, S. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90348-4 · Cited by 368 · see citing works

Hormonal regulation of apoptosis in early antral follicles: follicle- stimulating hormone as a major survival factor

Chun, S. Y., Eisenhauer, K. M., Minami, S., Billig, H., Perlas, E., & Hsueh, A. J. W. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625923 · Cited by 360 · see citing works

Satellite cells in human skeletal muscle plasticity

Snijders, T., Nederveen, J. P., McKay, B. R., Joanisse, S., Verdijk, L. B., van Loon, L. J. C., & Parise, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00283 · Cited by 359 · see citing works

Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli

Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 355 · see citing works

Untitled work

(1991) · doi:10.1172/jci115266 · Cited by 354 · see citing works

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., Heneka, M. T., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6209-10.2011 · Cited by 351 · see citing works

The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

Bouché, C., Serdy, S., Kahn, C. R., & Goldfine, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0026 · Cited by 348 · see citing works

Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats

Chou, T.-C., Yen, M., Li, C., & Ding, Y.-A. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.643 · Cited by 339 · see citing works

Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase

Pritchard, K. A., Ackerman, A. W., Gross, E. R., Stepp, D. W., Shi, Y., Fontana, J. T., Baker, J. E., & Sessa, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100084200 · Cited by 338 · see citing works

Reactive Nitrogen Species: Molecular Mechanisms and Potential Significance in Health and Disease

Martínez, M. C., & Andriantsitohaina, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1993 · Cited by 329 · see citing works

Reconstitution of an Endothelial Nitric-oxide Synthase (eNOS), hsp90, and Caveolin-1 Complex in Vitro

Gratton, J., Fontana, J. T., O’Connor, D. S., García‐Cardeña, G., McCabe, T. J. D., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001644200 · Cited by 327 · see citing works

Endothelial dysfunction and aging: An update

Herrera, M. D., Mingorance, C., Rodríguez‐Rodríguez, R., & de Sotomayor, M. Á. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.002 · Cited by 322 · see citing works

Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase

Donato, A. J., Gano, L. B., Eskurza, I., Silver, A., Gates, P. E., Jablonski, K., & Seals, D. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00689.2008 · Cited by 318 · see citing works

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

Law, A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00051-5 · Cited by 312 · see citing works

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

Kincaid, B., & Bossy‐Wetzel, E. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00048 · Cited by 312 · see citing works

Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats

Cernadas, M. R., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, A. P., de Frutos, T., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.3.279 · Cited by 310 · see citing works

Age alters the cardiovascular response to direct passive heating

Minson, C. T., Wladkowski, S. L., Cardell, A. F., Pawelczyk, J. A., & Kenney, W. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.4.1323 · Cited by 288 · see citing works

Arginine Nutrition and Cardiovascular Function

Wu, G., & Meininger, C. J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2626 · Cited by 288 · see citing works

Can the immune system be harnessed to repair the CNS?

Popovich, P. G., & Longbrake, E. E. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2398 · Cited by 287 · see citing works

Long-Term Homeostasis of Extracellular Glutamate in the Rat Cerebral Cortex across Sleep and Waking States

Dash, M. B., Douglas, C. L., Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5486-08.2009 · Cited by 278 · see citing works

SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans

Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works

The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis

Kitada, M., Ogura, Y., & Koya, D. (2016) · Aging · doi:10.18632/aging.101068 · Cited by 270 · see citing works

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Bailey, J. D., Diotallevi, M., NICOL, T., McNeill, E., Shaw, A., Chuaiphichai, S., Hale, A., Starr, A., Nandi, M., Stylianou, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.018 · Cited by 266 · see citing works

Expression and regulation of genes associated with cell death during murine preimplantation embryo development

Jurisicova, A., Latham, K. E., Casper, R. F., & Varmuza, S. (1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199811)51:3 · Cited by 263 · see citing works

Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating

Minson, C. T., Holowatz, L. A., Wong, B. J., Kenney, W. L., & Wilkins, B. W. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00229.2002 · Cited by 262 · see citing works

New roles for an old enzyme: Na,K‐ATPase emerges as an interesting drug target

Aperia, A. C. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01745.x · Cited by 259 · see citing works

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257 · see citing works

Upregulation of Renal and Vascular Nitric Oxide Synthase in Young Spontaneously Hypertensive Rats

Vaziri, N. D., Ni, Z., & Oveisi, F. (1998) · Hypertension · doi:10.1161/01.hyp.31.6.1248 · Cited by 244 · see citing works

Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

Mattson, M. P., & Liu, D. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:215 · Cited by 242 · see citing works

Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles

Muller‐Delp, J. M., Spier, S. A., Ramsey, M. W., & Delp, M. D. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2002 · Cited by 238 · see citing works

Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237 · see citing works

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

Murad, F. (1994) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60049-6 · Cited by 236 · see citing works

Distinction between signaling mechanisms in lipid rafts vs. caveolae

Sowa, G., Pypaert, M., & Sessa, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241409998 · Cited by 233 · see citing works

Cellular oxygen sensing need in CNS function: physiological and pathological implications

Acker, T., & Acker, H. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01075 · Cited by 231 · see citing works

The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating

Roddie, I. C., Shepherd, J. T., & Whelan, R. F. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005775 · Cited by 228 · see citing works

Effect of Aging on Glucose Homeostasis

Szoke, E., Shrayyef, M. Z., Messing, S. P., Woerle, H. J., van Haeften, T. W., Meyer, C., Mitrakou, A., Pimenta, W. P., & Gerich, J. E. (2008) · Diabetes Care · doi:10.2337/dc07-1443 · Cited by 221 · see citing works

Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice

Didion, S. P., Ryan, M. J., Didion, L. A., Fegan, P. E., Sigmund, C. D., & Faraci, F. M. (2002) · Circulation Research · doi:10.1161/01.res.0000043280.65241.04 · Cited by 221 · see citing works

Essential Role of Estrogen for Improvements in Vascular Endothelial Function With Endurance Exercise in Postmenopausal Women

Moreau, K. L., Stauffer, B. L., Kohrt, W. M., & Seals, D. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2183 · Cited by 213 · see citing works

Cyclooxygenase Inhibition Restores Nitric Oxide Activity in Essential Hypertension

Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., & Salvetti, A. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.274 · Cited by 206 · see citing works

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle‐derived nitric oxide

Wang, Y., Wehling‐Henricks, M., Samengo, G., & Tidball, J. G. (2015) · Aging Cell · doi:10.1111/acel.12350 · Cited by 205 · see citing works

Calcium/calmodulin-dependent kinase II and Alzheimer’s disease

Ghosh, A., & Giese, K. P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0166-2 · Cited by 205 · see citing works

Inhibition of Cyclic GMP-Binding Cyclic GMP-Specific Phosphodiesterase (Type 5) by Sildenafil and Related Compounds

Turko, I. V., Ballard, S. A., Francis, S. H., & Corbin, J. D. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.1.124 · Cited by 194 · see citing works

Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.

Li, L. M., Kilbourn, R. G., Adams, J. M., & Fidler, I. J. (1991) · PubMed · Cited by 189 · see citing works

Nitric Oxide in the Central Nervous System

Paakkari, I., & Lindsberg, P. J. (1995) · Annals of Medicine · doi:10.3109/07853899509002590 · Cited by 189 · see citing works

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

Fehsel, K., Jalowy, A., Qi, S., Burkart, V., Hartmann, B., & Kolb, H. (1993) · Diabetes · doi:10.2337/diab.42.3.496 · Cited by 188 · see citing works

Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from l-arginine by macrophages and hepatocytes

Green, S. J., Mellouk, S., Hoffman, S. L., Meltzer, M. S., & Nacy, C. A. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90083-3 · Cited by 185 · see citing works

Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans

Schrage, W. G., Joyner, M. J., & Dinenno, F. A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.061283 · Cited by 184 · see citing works

The Role of Nitric Oxide in Oocyte Meiotic Maturation and Ovulation: Meiotic Abnormalities of Endothelial Nitric Oxide Synthase Knock-Out Mouse Oocytes1

Jablonka‐Shariff, A., & OLSON, L. M. (1998) · Endocrinology · doi:10.1210/endo.139.6.6054 · Cited by 182 · see citing works

Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases

Hayashi, Y., Nishio, M., Naito, Y., Yokokura, H., Nimura, Y., Hidaka, H., & Watanabe, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20597 · Cited by 181 · see citing works

MicroRNA changes in human arterial endothelial cells with senescence: Relation to apoptosis, eNOS and inflammation

Rippe, C., Blimline, M., Magerko, K. A., Lawson, B. R., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.10.004 · Cited by 176 · see citing works

Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans

Shastry, S., Dietz, N. M., Halliwill, J. R., Reed, A. S., & Joyner, M. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.830 · Cited by 174 · see citing works

Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation

Wong, B. J., Wilkins, B. W., Holowatz, L. A., & Minson, C. T. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00254.2003 · Cited by 172 · see citing works

Insulin says NO to cardiovascular disease

Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works

Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats

Sun, D., Huang, A., Yan, E. H., Wu, Z., Yan, C., Kaminski, P. M., Oury, T. D., Wolin, M. S., & Kaley, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2003 · Cited by 167 · see citing works

Endothelin-1 Vasoconstrictor Tone Increases With Age in Healthy Men But Can Be Reduced by Regular Aerobic Exercise

Guilder, G. P. V., Westby, C. M., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.088294 · Cited by 167 · see citing works

Caveolins and the regulation of endothelial nitric oxide synthase in the heart

Féron, O., & Balligand, J. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.014 · Cited by 163 · see citing works

Endothelium‐dependent contractions in SHR: a tale of prostanoid TP and IP receptors

Félétou, M., Verbeuren, T. J., & Vanhoutte, P. M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00060.x · Cited by 162 · see citing works

Decreased active vasodilator sensitivity in aged skin

Kenney, W. L., Morgan, A. L., Farquhar, W. B., Brooks, E. M., Pierzga, J. M., & Derr, J. A. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.4.h1609 · Cited by 159 · see citing works

Consequences on offspring of abnormal function in ageing gametes

Tarín, J. J. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.6.532 · Cited by 158 · see citing works

Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans.

Dyke, C. K., Proctor, D. N., Dietz, N. M., & Joyner, M. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020964 · Cited by 157 · see citing works

Suppression of neuronal apoptosis by S-nitrosylation of caspases

Tenneti, L., D’Emilia, D. M., & Lipton, S. A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00780-5 · Cited by 154 · see citing works

Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat

Champion, H. C., Bivalacqua, T. J., Hyman, A. L., Ignarro, L. J., Hellstrom, W. J. G., & Kadowitz, P. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11648 · Cited by 152 · see citing works

Amyloid β Prevents Activation of Calcium/Calmodulin-Dependent Protein Kinase II and AMPA Receptor Phosphorylation During Hippocampal Long-Term Potentiation

Zhao, D., Watson, J. B., & Xie, C.-W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00485.2004 · Cited by 151 · see citing works

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

Bharadwaj, P. R., Dubey, A. K., Masters, C. L., Martins, R. N., & Macreadie, I. G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00609.x · Cited by 147 · see citing works

Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

Pourbagher‐Shahri, A. M., Farkhondeh, T., Ashrafizadeh, M., Talebi, M., & Samarghandian, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111214 · Cited by 143 · see citing works

Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin

Holowatz, L. A., Houghton, B. L., Wong, B. J., Wilkins, B. W., Harding, A. W., Kenney, W. L., & Minson, C. T. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00871.2002 · Cited by 142 · see citing works

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

Rouschop, K. M. A., Ramaekers, C. H. M. A., Schaaf, M. B. E., Keulers, T. G., Savelkouls, K. G. M., Lambin, P., Koritzinsky, M., & Wouters, B. G. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.029 · Cited by 141 · see citing works

Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases

Costa, E. D., Rezende, B. A., Côrtes, S. F., & Lemos, V. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00206 · Cited by 140 · see citing works

Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging

Oelze, M. W., Kröller‐Schön, S., Steven, S., Lubos, E., Doppler, C. E. J., Hausding, M., Tobias, S., Brochhausen, C., Li, H., Torzewski, M., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01602 · Cited by 136 · see citing works

Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat

Ratajczak, P. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00660-0 · Cited by 132 · see citing works

Inactivation of NADP+-dependent Isocitrate Dehydrogenase by Peroxynitrite

Lee, J. H., Yang, E. S., & Park, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302332200 · Cited by 132 · see citing works

Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging

Reckelhoff, J. F., Kellum, J. A., Blanchard, E. J., Bacon, E. E., Wesley, A. J., & Kruckeberg, W. C. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00521-4 · Cited by 129 · see citing works

Effect of aging on nitric oxide-mediated penile erection in rats

Garbán, H., Vernet, D. A., Freedman, A. I., Rajfer, J., & González-Cadavid, N. F. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.1.h467 · Cited by 128 · see citing works

Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells.

Choi, S. K., Park, Y. S., Choi, D., & Chang, H. I. (2008) · PubMed · Cited by 127 · see citing works

An Overview of the Role of Adipokines in Cardiometabolic Diseases

Farkhondeh, T., Llorens, S., Pourbagher‐Shahri, A. M., Ashrafizadeh, M., Talebi, M., Shakibaei, M., & Samarghandian, S. (2020) · Molecules · doi:10.3390/molecules25215218 · Cited by 127 · see citing works

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Bruning, R. S., Santhanam, L., Stanhewicz, A. E., Smith, C. J. W., Berkowitz, D. E., Kenney, W. L., & Holowatz, L. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01354.2011 · Cited by 126 · see citing works

The cortical reaction and development of activation competence in mammalian oocytes

Ducibella, T. (1996) · Human Reproduction Update · doi:10.1093/humupd/2.1.29 · Cited by 124 · see citing works

Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production

Bal‐Price, A., Matthias, A., & Brown, G. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00675.x · Cited by 122 · see citing works

Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease

Kopustinskienė, D. M., & Bernatonienė, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020129 · Cited by 120 · see citing works

Enzymology of Nitric Oxide Synthases

Hemmens, B., & Mayer, B. (2003) · Humana Press eBooks · doi:10.1385/1-59259-749-1:1 · Cited by 119 · see citing works

Inhibition of arginase by in alveolar macrophages: implications for the utilization of l ‐arginine for nitric oxide synthesis

Hecker, M., Nematollahi, H., Hey, C., Busse, R., & Racké, K. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00039-c · Cited by 119 · see citing works

Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme

Lv, L., Zheng, L., Dong, D., Xu, L., Yin, L., Xu, Y., Qi, Y., Han, X., & Peng, J. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.012 · Cited by 119 · see citing works

Control of heat-induced cutaneous vasodilatation in relation to age

Kenney, W. L. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00691250 · Cited by 118 · see citing works

Potentiometric Analysis of the Flavin Cofactors of Neuronal Nitric Oxide Synthase

Noble, M. A., Munro, A. W., Rivers, S. L., Robledo, L., Daff, S. N., Yellowlees, L. J., Shimizu, T., Sagami, I., Guillemette, J. G., & Chapman, S. K. (1999) · Biochemistry · doi:10.1021/bi992150w · Cited by 117 · see citing works

Increased nitric oxide levels as an early sign of premature aging in diabetes

Stadler, K., Jenei, V., von Bölcsházy, G., Somogyi, A., & Jakus, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00499-4 · Cited by 116 · see citing works

Tolerance to ischemia and hypoxia is reduced in aged human myocardium

Mariani, J. A., Ou, R., Bailey, M., Rowland, M. A., Nagley, P., Rosenfeldt, F., & Pepe, S. (2000) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2000.106528 · Cited by 115 · see citing works

Effects of Nitric Oxide on Ovulation and Ovarian Steroidogenesis and Prostaglandin Production in the Rabbit

Yamauchi, J., Miyazaki, T., Iwasaki, S., Kishi, I., Kuroshima, M., Tei, C., & Yoshimura, Y. (1997) · Endocrinology · doi:10.1210/en.138.9.3630 · Cited by 115 · see citing works

Effects of α‐lipoic acid on endothelial function in aged diabetic and high‐fat fed rats

Sena, C. M., Nunes, E., Louro, T. M., Proença, T., Fernandes, R., Boarder, M. R., & Seiça, R. M. F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707474 · Cited by 109 · see citing works

Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production

Higashi, Y., Sasaki, S., Nakagawa, K., Kimura, M., Noma, K., Hara, K., Jitsuiki, D., Goto, C., Oshima, T., Chayama, K., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.07.025 · Cited by 109 · see citing works

Maximal skin vascular conductance in subjects aged 5-85 yr

Martin, H. L., Loomis, J. L., & Kenney, W. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.297 · Cited by 108 · see citing works

Aging-Related Expression of Inducible Nitric Oxide Synthase and Markers of Tissue Damage in the Rat Penis1

Ferrini, M. G., Magee, T. R., Vernet, D. A., Rajfer, J., & González-Cadavid, N. F. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.3.974 · Cited by 108 · see citing works

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

Benigni, A., Cassis, P., Conti, S., Perico, L., Corna, D., Cerullo, D., Zentilin, L., Zoja, C., Perna, A., Lionetti, V., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7703 · Cited by 106 · see citing works

Elevated RhoA/Rho‐kinase activity in the aged rat penis: mechanism for age‐associated erectile dysfunction

Jin, L., Liu, T., Lagoda, G. A., Champion, H. C., Bivalacqua, T. J., & Burnett, A. L. “. (2006) · The FASEB Journal · doi:10.1096/fj.05-4232fje · Cited by 104 · see citing works

Thromboxane A 2 Receptor Signaling Inhibits Vascular Endothelial Growth Factor–Induced Endothelial Cell Differentiation and Migration

Ashton, A. W., & Ware, J. A. (2004) · Circulation Research · doi:10.1161/01.res.0000138300.41642.15 · Cited by 100 · see citing works

Sexual dimorphism in the aging kidney: Effects on injury and nitric oxide system

Erdely, A., Greenfeld, Z., Wagner, L. J., & Baylis, C. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00830.x · Cited by 99 · see citing works

Activation of muscle satellite cells in single-fiber cultures

Anderson, J. E., & Pilipowicz, O. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00011-3 · Cited by 99 · see citing works

Sweating and Cardiovascular Responses of Aged Men to Heat Exposure

Sagawa, S., Shiraki, K., YOUSEF, M. K., & Miki, K. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.1.m1 · Cited by 99 · see citing works

Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-α

Sobrino, A., Oviedo, P. J., Novella, S., Laguna-Fernández, A., Bueno, C., García‐Pérez, M. Á., Tarín, J. J., Cano, A., & Hermenegildo, C. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0112 · Cited by 98 · see citing works

Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells

Tanaka, J., Qiang, L., Banks, A. S., Welch, C. L., Matsumoto, M., Kitamura, T., Ido-Kitamura, Y., DePinho, R. A., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-0167 · Cited by 97 · see citing works

Aging of the Nitric Oxide System: Are We as Old as Our NO?

Sverdlov, A. L., Ngo, D. T. M., Chan, W. P. A., Chirkov, Y. Y., & Horowitz, J. D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000973 · Cited by 97 · see citing works

Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)

Islam, B. U., Habib, S., Ahmad, P., Allarakha, S., Moinuddin, M., & Ali, A. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-014-0475-8 · Cited by 96 · see citing works

Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media

Ferrini, M. G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.006 · Cited by 95 · see citing works

Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system

Baylis, C. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.01.008 · Cited by 95 · see citing works

Age‐related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain<i>S</i>‐nitrosylation that increase myofibril degradation and sarcopenia

Samengo, G., Avik, A., Fedor, B., Whittaker, D., Myung, K. H., Wehling‐Henricks, M., & Tidball, J. G. (2012) · Aging Cell · doi:10.1111/acel.12003 · Cited by 95 · see citing works

Active hepatocyte growth factor is present in skeletal muscle extracellular matrix

Tatsumi, R., & Allen, R. E. (2004) · Muscle & Nerve · doi:10.1002/mus.20114 · Cited by 94 · see citing works

Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum

Chalimoniuk, M., & Strosznajder, J. B. (1998) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815117 · Cited by 94 · see citing works

Molecular mechanism-based therapeutic properties of honey

Talebi, M., Talebi, M., Farkhondeh, T., & Samarghandian, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110590 · Cited by 94 · see citing works

Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects

Thijssen, D. H. J., Rongen, G. A. P. J. M., van Dijk, A. P. J., Smits, P., & Hopman, M. T. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00357.2007 · Cited by 93 · see citing works

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Talebi, M., Talebi, M., Farkhondeh, T., Simal‐Gándara, J., Kopustinskienė, D. M., Bernatonienė, J., & Samarghandian, S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01906-y · Cited by 93 · see citing works

Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition

Devan, B. D., Bowker, J. L., Duffy, K. B., Bharati, I. S., Jimenez, M. A., Sierra‐Mercado, D., Nelson, C. M., Spangler, E. L., & Ingram, D. K. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0232-z · Cited by 89 · see citing works

Nitric oxide production in the basal forebrain is required for recovery sleep

Kalinchuk, A. V., Lu, Y., Stenberg, D., Rosenberg, P. A., & Porkka‐Heiskanen, T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04077.x · Cited by 88 · see citing works

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Talebi, M., Talebi, M., Farkhondeh, T., Mishra, G., İlgün, S., & Samarghandian, S. (2021) · Phytotherapy Research · doi:10.1002/ptr.7033 · Cited by 87 · see citing works

Nitric Oxide Delays Oocyte Aging

Goud, A. P., Goud, P. T., Diamond, M. P., & Abu‐Soud, H. M. (2005) · Biochemistry · doi:10.1021/bi050711f · Cited by 87 · see citing works

Matrix metalloproteinases are involved in mechanical stretch–induced activation of skeletal muscle satellite cells

Yamada, M., Tatsumi, R., Kikuiri, T., Okamoto, S., Nonoshita, S., Mizunoya, W., Ikeuchi, Y., Shimokawa, H., Sunagawa, K., & Allen, R. E. (2006) · Muscle & Nerve · doi:10.1002/mus.20601 · Cited by 87 · see citing works

Statin Treatment Upregulates Vascular Neuronal Nitric Oxide Synthase Through Akt/NF-κB Pathway

Nakata, S., Tsutsui, M., Shimokawa, H., Yamashita, T., Tanimoto, A., Tasaki, H., Ozumi, K., Sabanai, K., Morishita, T., Suda, O., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251615.61858.33 · Cited by 85 · see citing works

Long-Term Depression: A Learning-Related Type of Synaptic Plasticity in the Mammalian Central Nervous System

Zhuo, M., & Hawkins, R. D. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.3.259 · Cited by 84 · see citing works

REVIEW

Törnell, J., Billig, H., & Hillensjø, T. (1991) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137351 · Cited by 84 · see citing works

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

Schwartz, M., & Baruch, K. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.08.002 · Cited by 82 · see citing works

Nitrite uptake and metabolism and oxidant stress in human erythrocytes

May, J. M., Qu, Z., Li, X., & Cobb, C. E. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1946 · Cited by 82 · see citing works

Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels

Behnke, B. J., & Delp, M. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00970.2009 · Cited by 80 · see citing works

MK-801 and 7-Ni attenuate the activation of brain NF-κB induced by LPS

Glezer, I., Munhoz, C. D., Kawamoto, E. M., Marcourakis, T., Avellar, M. C. W., & Scavone, C. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00279-x · Cited by 79 · see citing works

Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence via the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Sun, Y., Hu, X., Hu, G., Xu, C., & Jiang, H. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00012 · Cited by 79 · see citing works

Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders

Ganie, S. A., Dar, T. A., Bhat, A. H., Dar, K. B., Anees, S., Zargar, M. A., & Masood, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1704 · Cited by 79 · see citing works

Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species

Gerassimou, C., Kotanidou, A. N., Zhou, Z., Simoes, D. C. M., Roussos, C., & Papapetropoulos, A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707179 · Cited by 78 · see citing works

Zingiber officinale ameliorates Alzheimer’s disease and Cognitive Impairments: Lessons from preclinical studies

Talebi, M., İlgün, S., Ebrahimi, V., Talebi, M., Farkhondeh, T., Ebrahimi, H., & Samarghandian, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111088 · Cited by 78 · see citing works

Age-Related Changes in Phosphorylation of Endothelial Nitric Oxide Synthase in the Rat Penis

Musicki, B., Kramer, M. F., Becker, R. E., & Burnett, A. L. “. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20349.x · Cited by 77 · see citing works

Erectile dysfunction in aging: upregulation of endothelial nitric oxide synthase

HAAS, C. A., Seftel, A. D., Razmjouei, K., Ganz, M. B., Hampel, N., & Ferguson, K. (1998) · Urology · doi:10.1016/s0090-4295(97)00715-2 · Cited by 77 · see citing works

Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction

Kalinchuk, A. V., Stenberg, D., Rosenberg, P. A., & Porkka‐Heiskanen, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05019.x · Cited by 76 · see citing works

Peroxynitrite: cellular pathology and implications in autoimmunity

Ahmad, R., Hussain, A., & Ahsan, H. (2019) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2019.1583109 · Cited by 76 · see citing works

Cerebral nitric oxide represses choroid plexus NFκB‐dependent gateway activity for leukocyte trafficking

Baruch, K., Kertser, A., Porat, Z., & Schwartz, M. (2015) · The EMBO Journal · doi:10.15252/embj.201591468 · Cited by 75 · see citing works

Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice

Ropelle, E. R., Pauli, J. R., Cintra, D. E., da Silva, A. S. R., de Souza, C. T., Guadagnini, D., Carvalho, B. M., Caricilli, A. M., Katashima, C. K., Filho, C., et al. (2012) · Diabetes · doi:10.2337/db12-0339 · Cited by 73 · see citing works

Nitric Oxide-Stimulated Increase in Extracellular Adenosine Accumulation in Rat Forebrain Neurons in Culture Is Associated with ATP Hydrolysis and Inhibition of Adenosine Kinase Activity

Rosenberg, P. A., Li, Y., Le, M., & Zhang, Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06294.2000 · Cited by 73 · see citing works

Mechanisms of endothelial dysfunction in the metabolic syndrome

DEEDWANIA, P. C. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0019-8 · Cited by 73 · see citing works

Effects of Rosuvastatin on Nitric Oxide–Dependent Function in Aorta and Corpus Cavernosum of Diabetic Mice

Nangle, M. R., Cotter, M. A., & Cameron, N. E. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2396 · Cited by 72 · see citing works

Can we prevent Parkinson's and Alzheimer's disease?

Kedar, N. (2003) · PubMed · Cited by 69 · see citing works

Aging Negatively Affects Estrogens-Mediated Effects on Nitric Oxide Bioavailability by Shifting ERα/ERβ Balance in Female Mice

Novensà, L., Novella, S., Medina, P., Segarra, G., Castillo, N., Heras, M., Hermenegildo, C., & Dantas, A. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025335 · Cited by 69 · see citing works

Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice

Yu, S. Y., Zhang, M., Luo, J., Zhang, L., Shao, Y., & Li, G. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.001 · Cited by 69 · see citing works

Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice

Wang, H., Wang, L., Liu, X., Li, C., Xu, S., & Farooq, A.-D. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.016 · Cited by 68 · see citing works

Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway.

He, L., Pan, Y.-F., Yu, J.-P., Wang, B., Dai, G., & Ying, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107657 · Cited by 68 · see citing works

In Vivo Antioxidant Role of Glutathione Peroxidase: Evidence from Knockout Mice

Lei, X. G. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)47021-8 · Cited by 67 · see citing works

Enzymology of Nitric Oxide Synthases

Stuehr, D. J., & Ghosh, S. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57077-3_3 · Cited by 67 · see citing works

Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.

Saleh, D. O., Mansour, D. F., Hashad, I. M., & Bakeer, R. M. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.04.043 · Cited by 65 · see citing works

Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

Talebi, M., Talebi, M., Farkhondeh, T., & Samarghandian, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6905 · Cited by 65 · see citing works

Lactobacillus plantarum CQPC11 Isolated from Sichuan Pickled Cabbages Antagonizes d-galactose-Induced Oxidation and Aging in Mice

Qian, Y., Zhang, J., Zhou, X., Yi, R., Mu, J., Long, X., Pan, Y., Zhao, X., & Liu, W. (2018) · Molecules · doi:10.3390/molecules23113026 · Cited by 65 · see citing works

Inhibition of Superoxide Generation from Neuronal Nitric Oxide Synthase by Heat Shock Protein 90: Implications in NOS Regulation

Song, Y. H., Cardounel, A. J., Zweier, J. L., & Xia, Y. (2002) · Biochemistry · doi:10.1021/bi026060u · Cited by 63 · see citing works

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis

Vaknin, I., Kunis, G., Miller, O., Butovsky, O., Bukshpan, S., Beers, D. R., Henkel, J. S., Yoles, E., Appel, S., & Schwartz, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026921 · Cited by 62 · see citing works

Exposure to High or Low Glucose Levels Accelerates the Appearance of Markers of Endothelial Cell Senescence and Induces Dysregulation of Nitric Oxide Synthase

Rogers, S. C., Zhang, X., Azhar, G., Luo, S., & Wei, J. Y. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt033 · Cited by 62 · see citing works

The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases

Maccallini, C., Mollica, A., & Amoroso, R. (2017) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-017-0220-9 · Cited by 62 · see citing works

ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

de Almeida, A. J. P. O., de Oliveira, J. C. P. L., Pontes, L. V. D. S., Júnior, J. F. D. S., Gonçalves, T. A. F., Dantas, S. H., Feitosa, M. S. D. A., Silva, A. O., & de Medeiros, I. A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1225578 · Cited by 521 · see citing works

Nitric Oxide/Nitric Oxide Synthase System in the Pathogenesis of Neurodegenerative Disorders—An Overview

Iova, O.-M., Marin, G.-E., Lazar, I., Stănescu, I., Dogaru, G., Nicula, C. A., & Bulboacă, A. E. (2023) · Antioxidants · doi:10.3390/antiox12030753 · Cited by 120 · see citing works

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction

Yu, H., Liao, K., Hu, Y., Lv, D., Luo, M., Liu, Q., Huang, L., & Luo, S. (2022) · Aging and disease · doi:10.14336/ad.2022.0316 · Cited by 84 · see citing works

Dual role of nitric oxide in Alzheimer's disease

Azargoonjahromi, A. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.03.003 · Cited by 83 · see citing works

The interplay between oxidative stress and autophagy: focus on the development of neurological diseases

Talebi, M., Vadoud, S. A. M., Haratian, A., Talebi, M., Farkhondeh, T., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2022) · Behavioral and Brain Functions · doi:10.1186/s12993-022-00187-3 · Cited by 71 · see citing works

Advances in the molecular mechanisms of statins in regulating endothelial nitric oxide bioavailability: Interlocking biology between eNOS activity and L-arginine metabolism

Chen, W., Chen, C.-H., Hsu, M., Chang, R.-W., Wang, C., & Lee, T. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116192 · Cited by 70 · see citing works

Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

Belenichev, I. F., Popazova, O., Bukhtiyarova, N. V., Savchenko, D., Oksenych, V., & Kamyshnyi, O. (2024) · Antioxidants · doi:10.3390/antiox13050504 · Cited by 80 · see citing works

Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro

Katoh, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216518 · Cited by 64 · see citing works

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Punziano, C., Trombetti, S., Cesaro, E., Grosso, M., & Faraonio, R. (2024) · Antioxidants · doi:10.3390/antiox13030298 · Cited by 67 · see citing works

MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence

Lettieri-Barbato, D., Aquilano, K., Punziano, C., Minopoli, G., & Faraonio, R. (2022) · Antioxidants · doi:10.3390/antiox11030480 · Cited by 51 · see citing works

Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders

Oyovwi, M. O., & Atere, A. D. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100175 · Cited by 51 · see citing works

Systemic aging and aging‐related diseases

Li, Q., Xiao, N., Zhang, H., Liang, G., Lin, Y., Qian, Z., Yang, X. Y., Yang, J., Fu, Y., Zhang, C., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402479rrr · Cited by 43 · see citing works

Pharmacological modulation of vascular ageing: A review from VascAgeNet

Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 36 · see citing works

Nitric oxide in exercise physiology: past and present perspectives

Mueller, B. J., Roberts, M. D., Mobley, C. B., Judd, R. L., & Kavazis, A. N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2024.1504978 · Cited by 32 · see citing works

Mechanosensory entities and functionality of endothelial cells

Mierke, C. T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446452 · Cited by 32 · see citing works

Time-restricted feeding and cognitive function in sedentary and physically active elderly individuals: Ramadan diurnal intermittent fasting as a model

Boujelbane, M. A., Trabelsi, K., Jahrami, H., Masmoudi, L., Ammar, A., Khacharem, A., Boukhris, O. F., Puce, L., Garbarino, S., Scoditti, E., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1041216 · Cited by 30 · see citing works

Alcohol consumption and epigenetic age acceleration in young adults

Nannini, D. R., Joyce, B. T., Zheng, Y., Gao, T., Wang, J., Liu, L., Jacobs, D. R., Schreiner, P. J., Liu, C., Dai, Q., et al. (2023) · Aging · doi:10.18632/aging.204467 · Cited by 27 · see citing works

Nitric Oxide Signaling and Sensing in Age-Related Diseases

Mazuryk, O., Gurgul, I., Oszajca, M., Polaczek, J., Kieca, K., Bieszczad-Żak, E., Martyka, T., & Stochel, G. (2024) · Antioxidants · doi:10.3390/antiox13101213 · Cited by 28 · see citing works

The Effect of Sodium Nitroprusside Treatment on Storage Ability of Fresh-Cut Potato

Dai, Y., Xie, H., Zhao, X., & Zheng, Y. (2023) · Foods · doi:10.3390/foods12010221 · Cited by 21 · see citing works

Nitric Oxide as a Determinant of Human Longevity and Health Span

Pöeggeler, B., Singh, S. K., Sambamurti, K., & Pappolla, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914533 · Cited by 19 · see citing works

Nitric Oxide as a Determinant of Human Longevity and Health Span

Poeggeler, B., Singh, K. S., Sambamurti, K., & Pappolla, M. A. (2023) · doi:10.20944/preprints202309.0213.v1 · Cited by 20 · see citing works

Menopause, androgens, and cardiovascular ageing: a narrative review

Armeni, E., & Lambrinoudaki, I. V. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221129946 · Cited by 19 · see citing works

Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation

Bonfante, S., Netto, M. B., de Oliveira, A. N., Mathias, K., Machado, R. S., Joaquim, L. D. S., Cidreira, T., da Silva, M. G., Daros, G. C., Danielski, L. G., et al. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01425-5 · Cited by 19 · see citing works

New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer

Carriòn, M. D., Rubio‐Ruíz, B., Franco-Montalbán, F., Amoia, P., Zuccarini, M., Simone, C. D., Camacho, M. E., Amoroso, R., & Maccallini, C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115112 · Cited by 18 · see citing works

Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar rat

Besong, E. E., Ashonibare, P. J., Akhigbe, T. M., Obimma, J. N., & Akhigbe, R. E. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02696-y · Cited by 18 · see citing works

Is vitamin C a booster of the effects of dietary nitrate on endothelial function? Physiologic rationale and implications for research

Lbban, E., Ashor, A. W., Shannon, O. M., IDRIS, I. R., & Siervo, M. (2023) · Nutrition · doi:10.1016/j.nut.2023.111995 · Cited by 17 · see citing works

Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity

Al-Wahaibi, L. H., Abou‐Zied, H. A., Abdelrahman, M. H., Morcoss, M. M., Trembleau, L., Youssif, B. G. M., & Bräse, S. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1432920 · Cited by 16 · see citing works

Modern Strategies of Drug Therapy: Multi-Target Drug Delivery, Bioimaging, Diagnostics

Fedorova, O. V., Ovchinnikova, I. G., Rusinov, G. L., Avdeeva, V. V., Zhdanov, А. P., Zhizhin, K. Y., Kuznetsov, N. T., Zakharova, L. Y., Kuznetsova, D. A., Razuvayeva, Y. S., et al. (2025) · Russian Journal of General Chemistry · doi:10.1134/s1070363225606726 · Cited by 15 · see citing works

Targeting Gut Microbiota to Combat Vascular Aging and Cardiovascular Disease: Mechanisms and Therapeutic Potential

Li, J., Wang, Y., Shrestha, S., Gewirtz, A. T., Ding, Y., & Zou, J. (2025) · Nutrients · doi:10.3390/nu17172887 · Cited by 12 · see citing works

Too hard to die: Exercise training mediates specific and immediate SARS-CoV-2 protection

Papadopoulos, K. I., Sutheesophon, W., & Aw, T. C. (2022) · World Journal of Virology · doi:10.5501/wjv.v11.i2.98 · Cited by 12 · see citing works

Increased Neuronal Nitric Oxide Synthase in Alzheimer's Disease Mediates Spontaneous Calcium Signaling and Divergent Glutamatergic Calcium Responses

Balez, R., Stevens, C. H., Lenk, K., Maksour, S., Sidhu, K., Sutherland, G. T., & Ooi, L. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0395 · Cited by 12 · see citing works

Calorie restriction mimetics against aging and inflammation

Chaudhary, S., Chaudhary, M. R., Jena, M. K., Rath, P. K., Mishra, B. P., Paital, B., Vyas, A., Sahoo, D. K., Singh, P., & Mehdi, M. M. (2025) · Biogerontology · doi:10.1007/s10522-025-10269-0 · Cited by 13 · see citing works

Recent advances in the investigation of the regulatory network underlying reactive nitrogen species-mediated tumorigenesis: molecular mechanisms and targeted therapeutic strategies

Wu, Y., Chen, Z., Chen, X., Hu, Y., & Ma, Y. (2025) · Redox Report · doi:10.1080/13510002.2025.2564593 · Cited by 11 · see citing works

The Role of Ca2+/PI3K/Akt/eNOS/NO Pathway in Astragaloside IV–Induced Inhibition of Endothelial Inflammation Triggered by Angiotensin II

Zhang, S., Li, S., Xie, S., Cui, L., Gao, Y., & Wang, Y. (2024) · Mediators of Inflammation · doi:10.1155/2024/3193950 · Cited by 11 · see citing works

Neuroprotective effect of mildronate and L-carnitine on the cognitive parameters of aged mice and mice with LPS-induced inflammation

Shaforostova, E. A., Gureev, A. P., Volodina, D. E., & Popov, V. N. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01047-9 · Cited by 11 · see citing works

Environmental toxicant-mediated cardiovascular diseases: an insight into the mechanism and possible preventive strategy

Asiwe, J. N., & Oritsemuelebi, B. (2023) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-023-00196-3 · Cited by 10 · see citing works

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging

Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 11 · see citing works

Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells

Zou, W., Liu, B., Wang, Y., Shi, F., & Pang, S. (2022) · Bioengineered · doi:10.1080/21655979.2022.2033411 · Cited by 10 · see citing works

Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases

Abolfazli, S., Karav, S., Johnston, T. P., & Sahebkar, A. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00694-w · Cited by 9 · see citing works

Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

Zhou, B., Shi, G., Xie, D., Zhao, X., Hao, B., Liu, D., Wang, M., Wu, L., Lin, L., & Qian, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24586 · Cited by 9 · see citing works

Anti-SARS-CoV-2 Action of Fluvoxamine may be Mediated by Endothelial Nitric Oxide Synthase

Papadopoulos, K. I., Sutheesophon, W., & Aw, T. C. (2021) · Pharmacopsychiatry · doi:10.1055/a-1641-0357 · Cited by 9 · see citing works

Monoterpenes in Vascular Function: A Review of Bioactivity and Mechanisms of Action

Gonçalves, T. A. F., Almeida, A., Pontes, L. V. D. S., Oliveira, J., Feitosa, M. S. D. A., Júnior, J. F. D. S., Veras, R. C., & de Medeiros, I. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189243 · Cited by 8 · see citing works

Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions

Adhikari, H., Patel, P., Javvaji, N., Crabtree, M. J., & Simon, J. N. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.14 · Cited by 10 · see citing works

Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation

Wada, Y., Umeno, R., Nagasu, H., Kondo, M., Tokuyama, A., Kadoya, H., Kidokoro, K., Taniguchi, S., Takahashi, M., Sasaki, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179269 · Cited by 8 · see citing works

Association between Glucose-6-Phosphate Dehydrogenase Deficiency and Asthma

Fois, A. G., Dore, M. P., Manca, A., Scano, V., Pirina, P., & Pes, G. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235639 · Cited by 7 · see citing works

Sodium valproate treatment reverses endothelial dysfunction in aorta from rabbits with acute myocardial infarction

Guerra‐Ojeda, S., Suárez, A., Belmonte, B., Marchio, P., Genovés, P., Arias-Mutis, O. J., Aldasoro, M., Vila, J. M., Serna, E., & Mauricio, M. D. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176475 · Cited by 8 · see citing works

Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease

Wang, H., Lin, F., Zhang, Y., Lin, Y., Gao, B., & Kang, D. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03140-4 · Cited by 7 · see citing works

The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease

Hooshmand, S. A. A., Rameshrad, M., Sahebkar, A., & Iranshahi, M. (2025) · Journal of Cannabis Research · doi:10.1186/s42238-025-00332-5 · Cited by 7 · see citing works

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Phua, T. J. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1196648 · Cited by 7 · see citing works

Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan

Phua, T. J. (2025) · Frontiers in Aging · doi:10.3389/fragi.2024.1526230 · Cited by 8 · see citing works

Differences in mitochondrial function between brain and heart of senile rats exposed to acute hypobaric hypoxia. Role of nitric oxide

Padula, P. H. L., Costa, L. E., Karadayian, A. G., Lores‐Arnaiz, S., & Czerniczyniec, A. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112100 · Cited by 7 · see citing works

Comparative assessment of Omega-3 and CoQ10 as adjuncts to periodontal therapy and total antioxidant capacity of saliva in patients with chronic periodontitis: A double-blind, randomized clinical trial

Farahmand, A., Talebi, M., Ramezani, F., Karami, R., Nodoushani, Z. J., Ayatollahi, N. A., Ayatollahi, S. A., & Alaee, A. (2024) · The Saudi Dental Journal · doi:10.1016/j.sdentj.2024.09.014 · Cited by 6 · see citing works

Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases

Mahamud, A. G. M. S. U., Tanvir, I. A., Kabir, M. E., Samonty, I., Chowdhury, M. A. H., & Rahman, M. A. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10501-w · Cited by 7 · see citing works

Microvascular Health as a Key Determinant of Organismal Aging

Cenciarini, M., Uccelli, A., Mangili, F., Grunewald, M., & Bersini, S. (2025) · Advanced Science · doi:10.1002/advs.202508659 · Cited by 7 · see citing works

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Tsubaki, S., Nashimoto, S., Tanaka, R., Toyomoto, T., Tsutsuki, H., Kato, K., Nakayama, J., Kimura, K., Oshima, K., Yamamoto, Y., et al. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70262 · Cited by 6 · see citing works

Antiaging properties of chlorogenic acid through protein and gene biomarkers in human skin fibroblast cells as photoaging model

Girsang, E., Ginting, C. N., Lister, I. N. E., Widowati, W., Yati, A., Kusuma, H. S. W., & Azis, R. (2024) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_177_22 · Cited by 6 · see citing works

Evaluating senescence-targeted approaches in Alzheimer’s Disease: What we know and what lies ahead

Doshi, P. P., Desale, S. H., Khutale, A. A., Sabarathinam, S., & Suresh, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103029 · Cited by 5 · see citing works

Treatment with Ginkgo biloba supplement modulates oxidative disturbances, inflammation and vascular functions in oxygen deprived hypothyroid mice: Involvement of endothelin‐1/NO signaling pathways

Adebayo, O. G., Aduema, W., Iwueke, A. V., Asiwe, J. N., Onyeleonu, I., Akpotu, A. E., Wopara, I., Adebayo, O. R., Onuoha, O. G., Eleazar, E. S., et al. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14477 · Cited by 5 · see citing works

Exploring the Mechanism of Edaravone for Oxidative Stress in Rats with Cerebral Infarction Based on Quantitative Proteomics Technology

Wang, G., Zeng, X., Gong, S., Wang, S., Ge, A., Liu, W., Ge, J., & He, Q. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8653697 · Cited by 4 · see citing works

The Protective Role of Grape Seed in Obesity and Lipid Profile: An Updated Narrative Overview of Preclinical and Clinical Studies

Samarghandian, S., Talebi, M., Esmaeeli, H., İlgün, S., Talebi, M., Farkhondeh, T., & Mishra, G. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220630091859 · Cited by 4 · see citing works

Neuronal NO Synthase in the Pathogenesis of Metabolic Syndrome

Kuznetsova, L. A., Basova, N. E., & Shpakov, A. O. (2023) · Cell and Tissue Biology · doi:10.1134/s1990519x23010108 · Cited by 4 · see citing works

An oxidized chondroitin sulfate-crosslinked and CuCDs-loaded decellularized bovine pericardium with improved anti-coagulation, pro-endothelialization and anti-calcification properties for BHVs

Shi, S., Wei, X., Xu, P., Pu, X., Feng, S., Gao, X., & Yu, X. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00827a · Cited by 3 · see citing works

Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner

Wu, W., Lei, R., Xu, H., Lü, L., Song, C., Wu, D., Li, M., Chen, L., Yu, Y., & Fang, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.048 · Cited by 3 · see citing works

Cardiovascular Aging: From Molecular Mechanisms to Targeted Therapies

Fuentes‐Mendoza, J. M., Concepción‐Zavaleta, M. J., Moreno, J. M. M., Urteaga, L. A. C., Paz‐Ibarra, J., Garza‐Boullosa, R., & Cardoso-Pérez, V. (2025) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-025-00812-7 · Cited by 3 · see citing works

Glycosylated β-lactoglobulin-nanofibril-stabilized Pickering emulsions for enhanced intestinal cell compatibility

Qin, X., Hu, F., Zhou, L., Di, X., Liu, L., & Liu, G. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.148578 · Cited by 3 · see citing works

Nitric oxide signaling in Alzheimer's disease: A double-edged sword

Wasim, R. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178986 · Cited by 3 · see citing works

Lysosome-targeted ratiometric fluorescent probe for dynamic assessment of nitric oxide in cellular senescence

Chang, L., Li, J., Zhang, J., Yuan, F., Gao, L.-L., Shen, J., Zhang, J., & Guo, Y. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111745 · Cited by 3 · see citing works

Epimedin C protects dexamethasone-induced osteoblasts through NRF1/RhoA pathway

Huang, M. N., Yu, L., Wang, Y., & Yang, C. (2023) · Aging · doi:10.18632/aging.204588 · Cited by 4 · see citing works

Association between the recommended volume of leisure-time physical activity and erectile dysfunction: A cross-sectional analysis of the national health and nutrition examination survey, 2001–2004

Zhang, M., Wang, Z., Liu, W., Wang, M., Wu, H., & An, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32884 · Cited by 3 · see citing works

Preface to Nitric Oxide Modulators in Health and Disease I

Maccallini, C., & Amoroso, R. (2022) · Molecules · doi:10.3390/molecules27206820 · Cited by 3 · see citing works

Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations

Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3 · see citing works

Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model

Wang, W., Liu, Y., Zhou, Z., Pang, K., Wang, J.-K., Huan, P.-F., Lu, J., Zhu, T., Zhu, Z., & Han, C.-H. (2025) · Asian Journal of Andrology · doi:10.4103/aja2024115 · Cited by 3 · see citing works

Berberine nanoemulsion attenuates bisphenol A-induced metabolic impairment through NF-κB signaling in the liver of rat

Hormozi, A., Salehi, H., Hosseini, S. M. A., Rajabi, S., Kabiri-Rad, H., Mansori, A., Fakhrtaha, T., Samarghandian, S., & Farkhondeh, T. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.102069 · Cited by 2 · see citing works

Immediate Effect of Modified Bhramari Pranayama on Salivary Nitric Oxide Level among Type 2 Diabetes Mellitus with Xerostomia: A Randomized Controlled Trial

Poojary, G., Shetty, S., Shetty, P., Patil, K., Gupta, S., & Nanjeshgowda, H. L. (2025) · International Journal of Yoga · doi:10.4103/ijoy.ijoy_253_24 · Cited by 2 · see citing works

hPSC-derived sacral neural crest cells restore erectile function in pelvic ganglia injury

Yang, T., Liu, W., Wu, Y., Wang, X., Lei, T., Tang, Q., Zhang, Y., Wang, H., Zhou, Y., & Song, W. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04734-3 · Cited by 2 · see citing works

Lower FT3 levels are associated with a poor prognosis in patients with acute type A aortic dissection: a retrospective study

Tao, Y., Peng, Y., Chen, Y., Ni, H., Chen, L., & Lin, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-03180-4 · Cited by 2 · see citing works

H2S-Mediated Dilation of Pial Arteries in Rats of Different Ages: Contribution of KATP and BKCa Channels

Gorshkova, O. P., & Sokolova, I. B. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s1234567823040328 · Cited by 2 · see citing works

Role of induced nitric oxide synthases in orofacial nociception/discomfort after dental tooth bleaching with hydrogen peroxide

Pinto, M. R., Medeiros, K. I. D. S., Maia, L. M., Coelho, A. A., Alves, A. P. N. N., Caetano, C. F. F., Mesquita, K. C., Silva, P. G. D. B., & Sousa, F. B. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.105937 · Cited by 2 · see citing works

Neuronal nitric oxide synthases in the pathogenesis of metabolic syndrome

Kuznetsova, L. A., Basova, N. E., & Shpakov, A. O. (2022) · Сибирский научный медицинский журнал · doi:10.18699/ssmj20220403 · Cited by 2 · see citing works

Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia

Alyabyeva, P. V., Петрова, М. М., Дмитренко, Д. В., Garganeeva, N. P., Chumakova, G. A., Al-Zamil, M., Trefilova, V. V., Nasyrova, R. F., & Shnayder, N. A. (2023) · Genes · doi:10.3390/genes14020513 · Cited by 2 · see citing works

Senolytic Treatment Prevents Endothelial Dysfunction in Arterial AgingPreprint

Lin, J. M., Tan, D., Guo, W., Yang, X., Cang, P., Yang, Z., Zha, J., Lin, H., Zhang, Q., Yang, J. H., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5129394 · Cited by 2 · see citing works

Fluvoxamine Mediates Specific, Early, and Delayed SARS-CoV-2 Protection through Antioxidant and Cytoprotective Pathways via Sigma-1 Receptor Agonism

Papadopoulos, K. I., Papadopoulou, A., & Aw, T. C. (2022) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2023.045 · Cited by 1 · see citing works

Taxonomic Identification, Complete Genome Sequencing, and In Silico Genome Mining of the Actinobacterium Lentzea sp. JNUCC 0626 Isolated from Jeju Gotjawal

Hyun, K.-A., Boo, K.-H., & Hyun, C. (2025) · Acta Microbiologica Hellenica · doi:10.3390/amh70010008 · Cited by 1 · see citing works

Comparative Effects of Microwave and Ultrasonic Pretreatments on the Antioxidant, Anti-Aging, and Moisturizing Activities of Yellow Silkworm Cocoon Extracts (Bombyx mori L., var. Nang Lai)

Chareegun, S., Somwongin, S., Inthorn, J., Juntrapirom, S., Kanjanakawinkul, W., & Chaiyana, W. (2025) · Cosmetics · doi:10.3390/cosmetics12040170 · Cited by 1 · see citing works

Beyond lifespan and healthspan: a biological framework for experienced longevity

Liubertas, T. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1815030 · Cited by 1 · see citing works

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Zhou, X., Zhang, X., Chen, S., Yu, M., Hu, Y., Gan, C., Meng, X., Li, L., & Song, N. (2026) · Advanced Science · doi:10.1002/advs.202524169 · Cited by 1 · see citing works

Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration

Vega-García, A., Apolinar, L. M., Feria-Romero, I. A., Campos‐Bedolla, P., Alberto, G.-G. C., Luna‐Munguía, H., Sofía, R.-H., & Orozco-Suárez, S. A. (2026) · Brain Sciences · doi:10.3390/brainsci16101019 · Cited by 1 · see citing works

Ageing and Vasoreactivity

Gao, Y. (2022) · Springer eBooks · doi:10.1007/978-981-19-7122-8_21

Plant and marine-derived antimalarial agents

Talebi, M., Samarghandian, S., Farkhondeh, T., & Talebi, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91942-5.00002-1

H2S-Mediated Dilation of Pial Arteries in Rats of Different Ages: Contribution of KATP and BKCa-Channels

Gorshkova, O. P., & Sokolova, I. B. (2023) · Российский физиологический журнал им  И  М  Сеченова · doi:10.31857/s0869813923080034

Effect of Aloe Vera against Natural and Chemical Toxicities

Shirvanian, K., Naghizadeh, M., Vali, R., Farkhondeh, T., Pourbagher‐Shahri, A. M., Aschner, M., Ahmadian, M., & Samarghandian, S. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013307300240906055446

Diagnostic accuracy of ultrasound in hyperthyroidism: A comprehensive review of recent studies

Wang, D., Xie, C., Zheng, X., & Li, M. (2025) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2025.101370

Effect of Formulated Edible Oils From Groundnut and African Walnut Oils on Some Hematological, Inflammation, and Oxidative Stress Markers in High‐Fat Diet‐Induced Obese Wistar Rats

Taku, T. B., Djikeng, F. T., Tambe, A. B., Ninying, V. Z. S., & Mainsah, E. N. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70130

Intérêt de la consommation de cacao pour optimiser le fonctionnement du système nerveux

Vulliez, C., & Payrau, B. (2025) · HEGEL - HEpato-GastroEntérologie Libérale · doi:10.3917/heg.152.0071

Changes in the Regulation of Cerebral Vasoactive Reactions in Aging: The Contribution of H2S to cGMP-Induced Dilation

Gorshkova, O. P., & Николаевна, Ш. В. (2025) · Advances in Gerontology · doi:10.1134/s207905702560034x

Genetic analysis reveals a causal relationship between air pollution and erectile dysfunction

Wang, Z., Zheng, Z., Fan, C., Jing, Z., Cao, X., Guan, R., Yuan, W., & Wang, J. (2025) · The Aging Male · doi:10.1080/13685538.2025.2557339

H2S КАК АКТИВАТОР СИГНАЛЬНОГО ПУТИ NO–sGC В ДИЛАТАЦИИ МОЗГОВЫХ СОСУДОВ: ИЗМЕНЕНИЯ ПРИ СТАРЕНИИ*

Gorshkova, O. P. (2025) · Успехи геронтологии · doi:10.34922/ae.2025.38.4.016

GSNOR is a critical regulator of both age- and sex-dependent cardiac function

Bhattarai, N., & Scott, I. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00037.2026

Pathophysiology Fundamentals Of Hypogonadotropic Amenorrhea: A Literature Review

Lavrentieva, I. V., Prokhorova, O. V., Milyaeva, N. M., & Обоскалова, Т. А. (2026) · Ural Medical Journal · doi:10.52420/umj.25.4.175

Disruption of amino acid metabolism in acute cerebrovascular diseases: diagnostic and pathobiochemical perspectives

Battakova, S., Grigolashvili, M. A., Кlyuyev, D., Kasatkin, D. S., Shayakhmetova, Y., Beisembayeva, M., Сабитовна, М. Ш., Koshelyuk, A., & Marchenko, A. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1876777

Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities

Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 121 · see citing works

Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions

Adhikari, H., Patel, P., Javvaji, N., Crabtree, M. J., & Simon, J. N. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.14 · Cited by 10 · see citing works

Changes of nitric oxide concentration in rats tissue and the role of modulating nitric oxide synthesis in aging

Ma, H. (2000) · Zhonghua laonian yixue zazhi

Endothelium-mediated signaling and vascular aging

van der Loo, B., & Lüscher, T. F. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)11028-5 · Cited by 3 · see citing works

Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells

Yoon, H. J., Cho, S. W., Ahn, B. W., & Yang, S. Y. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.010 · Cited by 63 · see citing works