Correlation between 5-HTTLPR Gene Polymorphism and Cognitive Function of Traumatic Stress in Chinese Han Children
Open accessAbstract
Background: Post-traumatic stress disorder (PTSD) is a trauma-related psychological disorder with serious social and familial impacts. The involvement of 5-hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) in numerous mental disorders has been documented. This study explored the correlation between 5-HTTLPR gene polymorphism and cognitive function in Chinese Han children with PTSD. Methods: A total of 60 PTSD children treated from December 2019 to December 2021 were selected as study participants, with another 60 healthy children selected as controls. We assessed the cognitive function of participants using the Mini-Mental State Examination (MMSE). Additionally, the PTSD level was estimated by the Children’s Revised Impact of Event Scale (CRIES). The 5-HTTLPR gene polymorphism was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The genotype and allele frequency were evaluated via case-control association analysis. Results: Children in the PTSD group showed low MMSE scores and high CRIES scores. In terms of genotype, cases of LL, LS, and SS in PTSD children were 4 (6.67%), 20 (33.3%), and 36 (60.00%), and 18 (30.00%), 28 (46.67%), and 14 (23.33%) cases in healthy controls. In terms of allele gene frequency, incidences of L and S were 23.33% and 76.67% in PTSD children, respectively, and were 53.33% and 46.67% in healthy controls, respectively. Moreover, the CRIES and MMSE scores of LS and SS genotypes were evidently different from those of LL genotype in PTSD children. Conclusions: Polymorphism of the 5-HTTLPR gene is correlated with cognitive dysfunction in Chinese Han children with PTSD.
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Altered expression of the PPM1F gene in the amygdala and medial prefrontal cortex is linked to PTSD and depression.
“An altered expression of the PPM1F gene in the amygdala and medial prefrontal cortex (mPFC) is linked to PTSD and depression.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [50]
Polymorphisms in the 5-HTTLPR gene correlate with cognitive dysfunction in PTSD-affected individuals.
“Similarly, polymorphisms in the 5-HTTLPR gene correlate with cognitive dysfunction in PTSD-affected individuals [33,45,48,49,50].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [50]
Carrying the short allele of the 5-HTTLPR in high-stress environments increases depression risk.
“For example, carrying the short allele of the 5-HTTLPR in high-stress environments increases depression risk.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [50]
Polymorphisms in genes such as EPHX2, OXTR, and NRG1 are associated with depression symptoms.
“Polymorphisms in genes such as EPHX2, OXTR, and NRG1 are associated with depression symptoms, further underscoring the complex interplay between genetics and environment.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [50]
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- Authors
- Wu, M., Lin, L., Wu, Y., Zheng, Y., & Chen, H.
- Affiliations
- The Fourth People's Hospital (CN)
- Sanya Central Hospital (CN)
- Corresponding author
- Chen, Haidan
- ORCID
- Venue
- Translational Pediatrics
- Publisher
- AME Publishing Company
- Published
- 2022-07
- Volume
- 11
- Issue
- 7
- Pages
- 1251-1260
- ISSN
- 2224-4336 (ISSN-L)
- 2224-4344
- PMC
- PMC9360820
- OpenAlex
- W4288458652
- Cited by
- 6
- References
- 55
- Citations by year
- 2025: 3 · 2024: 3
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Translational Pediatrics (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Hainan Province
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- 5-HTTLPR, serotonin transporter gene polymorphism, post-traumatic stress disorder, children, cognitive function, cognitive impairment, gene-gene association, Han Chinese children, genotype frequency, allele frequency
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