Cited by 875Resilience and Mental HealthPosttraumatic Stress Disorder ResearchStress Responses and Cortisol

The science of resilience: implications for the prevention and treatment of depression

Southwick, Steven M., Charney, Dennis S.·2012·Science

Abstract

Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.

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Crossref · 10.1126/science.1222942

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19 of 19 references verified0 citation errors · 0 not checkable

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  • Individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure.

    “Moreover, individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear [97] and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure [98].”
  • The prospective association between anxiety and depression is particularly strong and well established.

    “The prospective association between anxiety and depression is particularly strong and well established. 257”

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Authors
Southwick, S. M., & Charney, D. S.
Affiliations
  • United States Department of Veterans Affairs (US)
  • Mount Sinai Hospital (US)
Corresponding author
Charney, Dennis S.
Venue
Science
Published
2012-10-05
Volume
338
Issue
6103
Pages
79-82
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1996620918
Cited by
875
References
19
Citations by year
2026: 40 · 2025: 86 · 2024: 90 · 2023: 62 · 2022: 95 · 2021: 78 · 2020: 73 · 2019: 79 · 2018: 57 · 2017: 51 · 2016: 45 · 2015: 45 · 2014: 38 · 2013: 28 · 2012: 2
FWCI
41.03
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
resilience, depression, depression prevention, depression treatment, stress response, trauma, post-traumatic stress disorder, interindividual variability, risk and protective factors, genetic factors, neurobiology of stress
MeSH terms
Animals, Depressive Disorder, Humans, Stress Disorders, Post-Traumatic, Resilience, Psychological

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