The RE-AIM framework: a systematic review of use over time
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We provided a synthesis of use, summarized key issues in applying, and highlighted exemplary applications in the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. We articulated key RE-AIM criteria by reviewing the published literature from 1999 to 2010 in several databases to describe the application and reporting on various RE-AIM dimensions. After excluding nonempirical articles, case studies, and commentaries, 71 articles were identified. The most frequent publications were on physical activity, obesity, and disease management. Four articles reported solely on 1 dimension compared with 44 articles that reported on all 5 dimensions of the framework. RE-AIM was broadly applied, but several criteria were not reported consistently.
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Literature reviews on applications of popular implementation frameworks such as RE-AIM and CFIR have enabled their advancement in implementation science.
“Literature reviews on the applications of popular implementation frameworks, such as the RE-AIM and the CFIR, have enabled their advancement in implementation science.”
From The NASSS (Non-Adoption, Abandonment, Scale-Up, Spread and Sustainability) framework use over time: A scoping review (2025) · cites this paper as [14]
The Methods and Discussion describe a literature review of RE-AIM applications that identifies problems and offers guidance for future use (page not provided). The paper does not address CFIR, and its stated aim to guide future applications does not establish that the review has already advanced either framework. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThese reviews have described and assessed the application of RE-AIM, enabling its advancement (e.g., enhanced RE-AIM/PRISM 2019) and novel applications, such as combining RE-AIM with PRECIS.
“These reviews have described and assessed the application of the RE-AIM, enabling its advancement (e.g., the enhanced RE-AIM/Pragmatic Robust Implementation and Sustainability Model (PRISM) 2019) and novel applications, such as combining the RE-AIM with the Pragmatic Explanatory Continuum Indicator Summary (PRECIS) model [14,15].”
From The NASSS (Non-Adoption, Abandonment, Scale-Up, Spread and Sustainability) framework use over time: A scoping review (2025) · cites this paper as [14]
The Abstract states that this review describes and assesses how RE-AIM was applied over time, and the Discussion says it aims to show the framework’s evolution and guide future use (page numbers unavailable). The paper does not address the 2019 RE-AIM/PRISM enhancement or combining RE-AIM with PRECIS, so it cannot establish those specific developments or that this review enabled them. (LLM, conf=0.85)
Experimental — accuracy not yet measuredApplications of popular implementation theories, models, and frameworks such as RE-AIM and CFIR have been well documented in the literature.
“The applications of popular implementation theories, models, and frameworks (TMFs), such as the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) and the Consolidated Framework for Implementation Research (CFIR), have been well documented in the literature.”
From The NASSS (Non-Adoption, Abandonment, Scale-Up, Spread and Sustainability) framework use over time: A scoping review (2025) · cites this paper as [14]
The Abstract reports a systematic review of 71 articles applying RE-AIM, supporting the claim that its applications are documented. The paper does not document applications of CFIR; its References list a paper introducing that framework, but not a review of its use. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSeveral literature reviews have been written on RE-AIM since its inception in 1999.
“For example, several literature reviews have been written on the RE-AIM since its inception in 1999 [14,15].”
From The NASSS (Non-Adoption, Abandonment, Scale-Up, Spread and Sustainability) framework use over time: A scoping review (2025) · cites this paper as [14]
According to the RE-AIM evaluation, during this pilot process evaluation, the pathway presented a moderate reach, with moderate to high acceptance rates.
“According to the RE-AIM evaluation,21 during this pilot process evaluation, our pathway presented a moderate reach, with moderate to high acceptance rates.”
From Implementing a PROACTive Care Pathway to Empower and Support Survivors of Breast Cancer (2023) · cites this paper as [21]
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- Authors
- Gaglio, B., Shoup, J. A., & Glasgow, R. E.
- Affiliations
- Kaiser Permanente (US)
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 2013-06
- Volume
- 103
- Issue
- 6
- Pages
- e38-e46
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC3698732
- OpenAlex
- W2028764578
- Cited by
- 1,029
- References
- 31
- Citations by year
- 2026: 73 · 2025: 104 · 2024: 107 · 2023: 84 · 2022: 131 · 2021: 139 · 2020: 109 · 2019: 87 · 2018: 61 · 2017: 34 · 2016: 32 · 2015: 33 · 2014: 28 · 2013: 7
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- National Cancer Institute
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Social Sciences › Decision Sciences › Management Science and Operations Research › Evaluation and Performance Assessment
- Health Sciences › Health Professions › General Health Professions › Public Health Policies and Education
- Keywords
- RE-AIM framework, implementation research, REACH regulation, effectiveness, adoption, implementation, maintenance, physical activity interventions, obesity intervention, reporting consistency
- MeSH terms
- Health Promotion, Humans, Program Evaluation
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