Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats
Open accessAbstract
Reactive oxygen species (ROS) play an important role in ageing and age-related neurodegenerative changes including Parkinson's disease (PD). PD is characterized by signs of major oxidative stress and mitochondrial damage in the pars compacta of the substantia nigra. Present study was designed to investigate whether the Centella asiatica extract (CAE) would prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in aged Sprague-Dawley rats. Adult, male Sprague-dawley rats of 300-350 g were divided into control, C. asiatica alone, MPTP alone (20 mg/kg, for 21 days) and MPTP with C. asiatica (300 mg/kg for 21 days) groups. Effect of aqueous extract of C. asiatica on oxidative biomarker levels in corpus striatum and hippocampus homogenate was examined. MPTP-challenged rats elicited a significant increase in lipid hydroperoxides (LPO) (p < 0.01), protein-carbonyl-content (PCC) (p < 0.01) and xanthine oxidase (XO) (p < 0.01) when compared with control rats. There was a significant decrease in total antioxidants (TA) (p < 0.001), superoxide dismutase (SOD) (p < 0.001), glutathione peroxidase (GPx) (p < 0.01) and catalase (CAT) (p < 0.001) levels with MPTP treatment. Supplementation of CAE reduced LPO and PCC and significantly increased (p < 0.01) TA and antioxidant enzyme levels (p < 0.01) in corpus striatum and hippocampus. These results show that administration of C. asiatica was effective in protecting the brain against neurodegenerative disorders such as Parkinsonism.
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C. asiatica extracts enhance brain antioxidants, decrease lipid peroxidation and provide neuroprotection against MPTP toxicity in rodent models.
“An experiment checking for their activity against Parkinson's used rodent models treated with MPTP (a neurotoxin that destroys dopaminergic neurons and induces ROS formation) to demonstrate the action of C. asiatica extracts in enhancing brain antioxidants, decreasing lipid peroxidation and providing neuroprotection against MPTP toxicity. 60”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [60]
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- Authors
- Haleagrahara, N., & Ponnusamy, K.
- Affiliations
- IMU University (MY)
- St. Matthew's University (KY)
- Venue
- The Journal of Toxicological Sciences
- Publisher
- Japanese Society of Toxicology
- Published
- 2010
- Volume
- 35
- Issue
- 1
- Pages
- 41-47
- ISSN
- 0388-1350 (ISSN-L)
- 1880-3989
- OpenAlex
- W1964694445
- Cited by
- 123
- References
- 1
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 6
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Funders
- International Medical University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- Centella asiatica, Parkinson's disease, MPTP-induced neurotoxicity, neuroprotection, oxidative stress, reactive oxygen species, lipid peroxidation, protein carbonylation, xanthine oxidase, antioxidant enzymes, substantia nigra pars compacta, striatum, hippocampus, aged rats, neurodegeneration
- MeSH terms
- Animals, Antioxidants, Corpus Striatum, Disease Models, Animal, Hippocampus, Male, Phytotherapy, Oxidoreductases, Plant Extracts, Triterpenes, Lipid Peroxidation, Treatment Outcome, Rats, Sprague-Dawley, Oxidative Stress, Neuroprotective Agents, Parkinsonian Disorders, Centella, Rats
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