Alzheimer’s disease and language impairments: social intervention and medical treatment
Open accessAbstract
Communication is very important for people to be successfully integrated into social environment and make and maintain relationship. Particularly, language difficulties lead to social exclusion of the people affected with Alzheimer's disease (AD) and contribute to a significant decrease in the quality of their life and also have a big impact on their family members who in most cases become their caregivers who need to communicate with their loved ones in order to meet their needs. Therefore, the goal of this study is to describe language impairments in the individual phases of AD and discuss their improvement with respect to AD on the basis of literature review. The authors of this article use traditional research methods in order to achieve the goal set mentioned earlier. First, a method of literature review of available sources describing language impairments in the individual phases of AD is exploited. Second, to show how informal caregivers and relevant drugs can successfully intervene in the improvement of these language impairments, a method of comparison of different research studies exploring such social intervention and medical treatment is used.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Language problems and impairment in executive functions typically emerge in the early to middle stages of AD.
“Language problems and impairment in executive functions typically emerge in the early to middle stages of AD (68, 69).”
From Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains (2025) · cites this paper as [68]
The Language impairments in AD section says language difficulties occur in the first phase and worsen in the moderate phase. The Early (mild) and Middle (moderate) phase sections also describe difficulties with complex activities and attention, but the paper does not establish that impairment in executive functions generally emerges in those stages. Page numbers are unavailable in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Leisure Activities and the Risk of Dementia in the Elderly
Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., Ambrose, A. F., Sliwinski, M., & Buschke, H. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022252 · Cited by 1,961 · see citing works
Bilingualism: consequences for mind and brain
Bialystok, E., Craik, F. I. M., & Luk, G. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.03.001 · Cited by 1,386 · see citing works
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
Rovio, S., Kåreholt, I., Helkala, E.-L., Viitanen, M., Winblad, B., Tuomilehto, J., Soininen, H., Nissinen, A., & Kivipelto, M. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70198-8 · Cited by 1,054 · see citing works
Bilingualism as a protection against the onset of symptoms of dementia
Bialystok, E., Craik, F. I. M., & Freedman, M. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.10.009 · Cited by 967 · see citing works
Delaying the onset of Alzheimer disease
Craik, F. I. M., Bialystok, E., & Freedman, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fc2a1c · Cited by 577 · see citing works
Rate of memory decline in AD is related to education and occupation: Cognitive reserve?
Stern, Y., Albert, S., Tang, M.-X., & Tsai, W.-Y. (1999) · Neurology · doi:10.1212/wnl.53.9.1942 · Cited by 557 · see citing works
Amieva, H., Jacqmin‐Gadda, H., Orgogozo, J., Carret, N. L., Helmer, C., Letenneur, L., Barberger‐Gateau, P., Fabrigoule, C., & Dartigues, J. (2005) · Brain · doi:10.1093/brain/awh451 · Cited by 437 · see citing works
Winblad, B. G., Kilander, L., Eriksson, S., Minthon, L., Båtsman, S., Wetterholm, A.-L., Jansson-Blixt, C., & Haglund, A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68350-5 · Cited by 388 · see citing works
Leisure activities and the risk of dementia in the elderly
Akbaraly, T. N., Portet, F., Fustinoni, S., Dartigues, J.-F., Artéro, S., Rouaud, O., Touchon, J., Ritchie, K. A., & Berr, C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b7849b · Cited by 321 · see citing works
Hilari, K., Needle, J. J., & Harrison, K. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.05.028 · Cited by 320 · see citing works
Exercise Plays a Preventive Role Against Alzheimer's Disease
Radak, Z. O., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H., & Boldogh, I. R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091531 · Cited by 316 · see citing works
Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
Zemek, F., Drtinová, L., Nepovimová, E., Šepsová, V., Korábečný, J., Klimeš, J., & Kuča, K. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.914168 · Cited by 307 · see citing works
Donepezil preserves cognition and global function in patients with severe Alzheimer disease
Black, S. E., Doody, R., Li, H., McRae, T. D., Jambor, K. M., Xu, Y., Sun, Y., Perdomo, C. A., & Richardson, S. (2007) · Neurology · doi:10.1212/01.wnl.0000266627.96040.5a · Cited by 255 · see citing works
Investigating the Effects of Communication Problems on Caregiver Burden
Savundranayagam, M. Y., Hummert, M. L., & Montgomery, R. J. V. (2005) · The Journals of Gerontology Series B · doi:10.1093/geronb/60.1.s48 · Cited by 243 · see citing works
International Classification of Diseases (ICD)
Zhang, Y. (2008) · Encyclopedia of Global Health · doi:10.4135/9781412963855.n640 · Cited by 216 · see citing works
Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors
Ferris, S. H., & Farlow, M. R. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s39959 · Cited by 181 · see citing works
Nepovimová, E., Uliassi, E., Korábečný, J., Peña‐Altamira, E., Samez, S., Pesaresi, A., Garcia, G. E., Bartolini, M., Andrisano, V., Bergamini, C., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5010804 · Cited by 154 · see citing works
Burns, A. S., Bernabei, R., Bullock, R. A., Cruz-Jentoft, A. J., Frölich, L., Höck, C., Raivio, M., Triau, E., Vandewoude, M. F. J., Wimo, A. B., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70261-8 · Cited by 154 · see citing works
Will a Healthy Lifestyle Help Prevent Alzheimer's Disease?
Pope, S. K., Shue, V. M., & Beck, C. K. (2003) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.24.100901.141015 · Cited by 127 · see citing works
Lethality of Alzheimer Disease and Its Impact on Nursing Home Placement
Arrighi, H. M., Neumann, P. J., Lieberburg, I. M., & Townsend, R. J. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819fe7d1 · Cited by 126 · see citing works
A Resurrection of 7-MEOTA: A Comparison with Tacrine
Soukup, O., Jun, D., Karasová, J. Ž., Patočka, J., Musílek, K., Korábečný, J., Krůšek, J., Kaniaková, M., Šepsová, V., Mandíková, J., et al. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310080011 · Cited by 103 · see citing works
‘Normal’ semantic–phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study
Laws, K. R., Duncan, A. L., & Gale, T. M. (2009) · Cortex · doi:10.1016/j.cortex.2009.04.009 · Cited by 101 · see citing works
Fritsch, T., McClendon, M. J., Smyth, K. A., & Ogrocki, P. K. (2002) · International Psychogeriatrics · doi:10.1017/s1041610202008554 · Cited by 85 · see citing works
Vestal, L., Smith-Olinde, L., Hicks, G., Hutton, T., & Hart, J. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.4.467 · Cited by 76 · see citing works
Functional communication with AD patients: a caregiver training program.
Ripich, D. N. (1994) · PubMed · Cited by 75 · see citing works
Phonetically Cued Word-Fluency, Gender Differences and Aging: A Reappraisal
Capitani, E., Laiacona, M., & Basso, A. (1998) · Cortex · doi:10.1016/s0010-9452(08)70781-0 · Cited by 73 · see citing works
Diniz, C. W. P., Soares, F. C., de Oliveira, T. C. G., de Macedo, L. D. E. D., Diniz, D. L. W. P., Bento-Torres, N. V. O., Bento‐Torres, J., & Tomás, A. M. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s68186 · Cited by 72 · see citing works
Alzheimer's disease — The ways of prevention
Kivipelto, M., & Solomon, A. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02982595 · Cited by 68 · see citing works
Donepezil treatment in severe Alzheimer's disease: a pooled analysis of three clinical trials
Winblad, B. G., Black, S. E., Homma, A., Schwam, E. M., Moline, M. L., Xu, Y., Perdomo, C. A., Swartz, J., & Albert, K. S. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903236731 · Cited by 60 · see citing works
Cognitive rehabilitation in dementia
Corner, L. (2002) · Clinical Effectiveness in Nursing · doi:10.1016/s1361-9004(02)00072-9 · Cited by 57 · see citing works
Enhancing Communication in Dementia of the Alzheimer's Type
Orange, J. B., & Colton‐Hudson, A. (1998) · Topics in Geriatric Rehabilitation · doi:10.1097/00013614-199812000-00007 · Cited by 53 · see citing works
Sköldunger, A., Johnell, K., Winblad, B. G., & Wimo, A. B. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310020011 · Cited by 52 · see citing works
Treatment effects of Memantine on language in moderate to severe Alzheimer's disease patients
Ferris, S. H., Ihl, R., Robert, P. H., Winblad, B. G., Gatz, G., Tennigkeit, F., & Gauthier, S. G. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.604 · Cited by 50 · see citing works
Savundranayagam, M. Y., Ryan, E. B., Anas, A. P., & Orange, J. B. (2007) · Clinical Gerontologist · doi:10.1300/j018v31n02_04 · Cited by 49 · see citing works
Cognitive Rehabilitation in Dementia
Clare, L., & Woods, B. T. (2001) · UCL Discovery (University College London) · Cited by 41 · see citing works
Effect of Donepezil on Cognition in Severe Alzheimer's Disease: A Pooled Data Analysis
Cummings, J. L., Jones, R. W., Wilkinson, D. G., López, O. L., Gauthier, S. G., Waldemar, G., Zhang, R. H., Xu, Y., Sun, Y., Richardson, S., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100078 · Cited by 36 · see citing works
Alzheimer's disease: cost cuts call for novel drugs development and national strategy
Marešová, P., Klímová, B., & Kuča, K. (2015) · Česká a slovenská farmacie · doi:10.36290/csf.2015.005 · Cited by 30 · see citing works
Effects of Oral Rivastigmine on Cognitive Domains in Mild-to-Moderate Alzheimer’s Disease
Farlow, M. R., Cummings, J. L., Olin, J. T., & Meng, X. (2010) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317510365344 · Cited by 23 · see citing works
(2021) · Palgrave Macmillan UK eBooks · doi:10.1057/978-1-349-96042-2_16532 · Cited by 23 · see citing works
Ferris, S. H., Schmitt, F. A., Saxton, J. A., Richardson, S., Mackell, J. A., Sun, Y., & Xu, Y. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt84 · Cited by 22 · see citing works
Grossberg, G. T., Schmitt, F. A., Meng, X., Tekin, S., & Olin, J. T. (2010) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317510385808 · Cited by 21 · see citing works
Assistive technologies for managing language disorders in dementia
Kuča, K., Klímová, B., & Marešová, P. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s95903 · Cited by 20 · see citing works
Schwam, E. M., & Xu, Y. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000269837 · Cited by 19 · see citing works
The effects of ageing and Alzheimer's disease on semantic and gender priming
Manenti, R. (2004) · Brain · doi:10.1093/brain/awh264 · Cited by 18 · see citing works
Semantic Fluency in Mild and Moderate Alzheimer's Disease
Pekkala, S. (2004) · Työväentutkimus Vuosikirja · Cited by 14 · see citing works
Alzheimer's disease: Unraveling the mystery
(2008) · PsycEXTRA Dataset · doi:10.1037/e530902008-001 · Cited by 12 · see citing works
Macoir, J., Laforce, R. J., Monetta, L., & Wilson, M. A. (2014) · Gériatrie et Psychologie Neuropsychiatrie du Viellissement · doi:10.1684/pnv.2014.0466 · Cited by 10 · see citing works
Drug Treatment of Alzheimer’s Disease
Filley, C. M. (2002) · Primary Care Case Reviews · doi:10.1097/00129300-200206000-00004 · Cited by 1 · see citing works
Advances in the Diagnosis and Treatment of Alzheimer’s Disease
Thal, L. J. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4217-9_5 · Cited by 1 · see citing works
Flagged first, then by citations
4 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [11]Shivanand P Review on Alzheimer’s disease: its cause, symptoms, and treatment at worldwide Int J Appl Biol Pharm Technol 2009 1 1 112 120
- [12]Eliopoulos C Carson VB Varcarolis E Cognitive disorders Evolve Resources for Varcarolis’ Foundations of Psychiatric Mental Health Nursing St Louis, MO Saunders Elsevier 2006
Cited by
Sorted by citations
Predicting probable Alzheimer's disease using linguistic deficits and biomarkers
Orimaye, S. O., Wong, J. S.-M., Golden, K. J., Wong, C. P., & Soyiri, I. N. (2017) · BMC Bioinformatics · doi:10.1186/s12859-016-1456-0 · Cited by 158 · see citing works
Alzheimer's disease and automatic speech analysis: A review
Pulido, M. L. B., Hernández, J. B. A., Ballester, M. Á. F., González, C. M. T., Mekyska, J., & Smékal, Z. (2020) · Expert Systems with Applications · doi:10.1016/j.eswa.2020.113213 · Cited by 120 · see citing works
Burden of caregivers of patients with Alzheimer's disease
Budzyńska, A., Talarska, D., & Bączyk, G. (2018) · Scandinavian Journal of Caring Sciences · doi:10.1111/scs.12626 · Cited by 118 · see citing works
Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications
Giri, P. M., Banerjee, A., Ghosal, A., & Layek, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073995 · Cited by 123 · see citing works
Speech and language impairments in dementia
Klímová, B., & Kamil, K. (2016) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2016.02.002 · Cited by 103 · see citing works
Marešová, P., Hruška, J., Klímová, B., Baraković, S., & Krejcar, O. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s264688 · Cited by 91 · see citing works
PPI Long Term Use: Risk of Neurological Adverse Events?
Novotný, M., Klímová, B., & Vališ, M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2018.01142 · Cited by 81 · see citing works
Computer-Based Cognitive Training in Aging
Klímová, B. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00313 · Cited by 78 · see citing works
Lindsay, H., Tröger, J., & König, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.642033 · Cited by 64 · see citing works
Chaudhary, S., Zhornitsky, S., Chao, H. H., van Dyck, C. H., & Li, C.-S. R. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221082834 · Cited by 61 · see citing works
Computer-Based Training Programs for Older People with Mild Cognitive Impairment and/or Dementia
Klímová, B., & Marešová, P. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00262 · Cited by 60 · see citing works
Klimova, B., & Kuca, K. (2015) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2015.07.004 · Cited by 47 · see citing works
Klímová, B., Vališ, M., & Kuča, K. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s181849 · Cited by 44 · see citing works
Li, Q. S., & Cai, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.620899 · Cited by 45 · see citing works
Use of the Internet as a prevention tool against cognitive decline in normal aging
Klímová, B. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s113758 · Cited by 46 · see citing works
E-learning as valuable caregivers’ support for people with dementia – A systematic review
Klímová, B., Vališ, M., Kuča, K., & Masopust, J. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-4641-9 · Cited by 44 · see citing works
The Effect of Mediterranean Diet on Cognitive Functions in the Elderly Population
Klímová, B., Novotný, M., Schlegel, P., & Vališ, M. (2021) · Nutrients · doi:10.3390/nu13062067 · Cited by 43 · see citing works
Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging
Toman, J., Klímová, B., & Vališ, M. (2018) · Nutrients · doi:10.3390/nu10101560 · Cited by 43 · see citing works
Robinson, F., & Nejat, G. (2022) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/20556683221101389 · Cited by 45 · see citing works
Kuča, K., Kühnová, J., Cimler, R., Dolezal, O., & Tomášková, H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s107969 · Cited by 40 · see citing works
Klímová, B. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00461 · Cited by 39 · see citing works
On the analysis of speech and disfluencies for automatic detection of Mild Cognitive Impairment
de Ipiña, K. L., de Lizarduy, U. M., Calvo, P. M., Beitia, B., García-Melero, J., Fernández, E., Ecay‐Torres, M., Faúndez-Zanuy, M., & Sanz, P. (2018) · Neural Computing and Applications · doi:10.1007/s00521-018-3494-1 · Cited by 38 · see citing works
Guo, Y., Yang, F., Hu, F., Li, W., Ruggiano, N., & Lee, H. Y. (2019) · JMIR Aging · doi:10.2196/15290 · Cited by 36 · see citing works
Klímová, B., & Vališ, M. (2018) · Nutrients · doi:10.3390/nu10070905 · Cited by 35 · see citing works
Vališ, M., Slaninová, G., Pražák, P., Poulová, P., Kacetl, J., & Klímová, B. (2019) · Journal of Psycholinguistic Research · doi:10.1007/s10936-019-09659-6 · Cited by 34 · see citing works
Klímová, B., Novotný, M., Kuča, K., & Vališ, M. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s218238 · Cited by 34 · see citing works
García‐Herranz, S., Mardomingo, C. D., Venero, C., & Peraita, H. (2019) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2019.1698710 · Cited by 32 · see citing works
Gallucci, M., Battista, M. E. D., Battistella, G., Falcone, C., Bisiacchi, P. S., & Giorgi, E. D. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1349869 · Cited by 32 · see citing works
Bilingualism as a strategy to delay the onset of Alzheimer’s disease
Klímová, B., Vališ, M., & Kuča, K. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s145397 · Cited by 28 · see citing works
Tripathi, M. K., Sharma, P. A., Tripathi, A., Tripathi, P. N., Srivastava, P., Seth, A., & Shrivastava, S. K. (2020) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-020-00318-w · Cited by 28 · see citing works
Nitrendipine and Dementia: Forgotten Positive Facts?
Novotný, M., Klímová, B., & Vališ, M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00418 · Cited by 27 · see citing works
Cao, M., Hu, P., Zhang, Y., Yan, Y., Shields, C. B., Zhang, Y., Hu, G., & Xiao, M. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12790 · Cited by 26 · see citing works
Performance Assessment of ChatGPT versus Bard in Detecting Alzheimer’s Dementia
Balamurali, B. T., & Chen, J. (2024) · Diagnostics · doi:10.3390/diagnostics14080817 · Cited by 24 · see citing works
Mahmoud, W. R., Nissan, Y. M., Elsawah, M. M., Refaey, R. H., Ragab, M. F., & Amin, K. M. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111651 · Cited by 24 · see citing works
McGilton, K. S., Höbler, F., Campos, J. L., Dupuis, K., Labreche, T., Guthrie, D. M., Jarry, J., Singh, G., & Wittich, W. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011945 · Cited by 24 · see citing works
Guo, Y., Yang, F., Hu, F., Li, W., Ruggiano, N., & Lee, H. Y. (2020) · JMIR Aging · doi:10.2196/18754 · Cited by 23 · see citing works
Parsapoor, M., Alam, M. R., & Mihailidis, A. (2023) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-023-02122-6 · Cited by 24 · see citing works
Fertan, E., Wong, A. A., Vienneau, N. A., & Brown, R. E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111937 · Cited by 22 · see citing works
de Ipiña, K. L., de Lizarduy, U. M., Calvo, P. M., Beitia, B., García-Melero, J., Ecay‐Torres, M., Estanga, A., & Faúndez-Zanuy, M. (2017) · IEEE International Work Conference on Bioinspired Intelligence (IWOBI) · doi:10.1109/iwobi.2017.7985526 · Cited by 21 · see citing works
Adhikari, S., Thapa, S., Singh, P., Huo, H., Bharathy, G. K., & Prasad, M. (2021) · International Joint Conference on Neural Networks (IJCNN) · doi:10.1109/ijcnn52387.2021.9534449 · Cited by 20 · see citing works
Šimonová, I., Klímová, B., Poulová, P., & Pražák, P. (2017) · Educational Gerontology · doi:10.1080/03601277.2017.1386351 · Cited by 19 · see citing works
Assistive technologies for managing language disorders in dementia
Kuča, K., Klímová, B., & Marešová, P. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s95903 · Cited by 20 · see citing works
Li, Z., Mu, C., Wang, B., & Jin, J. (2016) · Molecules · doi:10.3390/molecules21020132 · Cited by 17 · see citing works
The Role of Aptamer Loaded Exosome Complexes in the Neurodegenerative Diseases
Sekhon, S. S., Ahn, G., Park, G., Park, D. Y., Lee, S., Ahn, J., & Kim, Y. (2019) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-019-0392-6 · Cited by 17 · see citing works
Multi-Modal Detection of Alzheimer's Disease from Speech and TextPreprint
Mittal, A., Sahoo, S., Datar, A., Kadiwala, J., Shalu, H., & Mathew, J. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2012.00096 · Cited by 21 · see citing works
ALZUMERIC: A decision support system for diagnosis and monitoring of cognitive impairment
de Lizarduy, U. M., Salomón, P. C., Gómez‐Vilda, P., Ecay‐Torres, M., & de Ipiña, K. L. (2017) · Loquens · doi:10.3989/loquens.2017.037 · Cited by 14 · see citing works
Klímová, B., Kuča, K., Vališ, M., & Hort, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181281 · Cited by 13 · see citing works
Self-citationNeuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration
Olekšák, P., Novotný, M., Patočka, J., Nepovimová, E., Hort, J., Pavlik, J., Klímová, B., Vališ, M., & Kuča, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168908 · Cited by 13 · see citing works
Self-citationMcLaughlin, D. E., Klee, D., Memmott, T., Peters, B., Wiedrick, J. T., Fried-Oken, M. B., Oken, B., Deniz Erdogmus, B., Smith, D., Bedrick, S. D., et al. (2022) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2022.100950 · Cited by 13 · see citing works
Alhodieb, F. S., Rahman, M. A., Barkat, M. A., Alanezi, A. A., Barkat, H. A., Hadi, H. A., Harwansh, R. K., & Mittal, V. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0108 · Cited by 13 · see citing works
Senior Tourism and Information and Communication Technologies
Klímová, B. (2017) · Lecture notes in electrical engineering · doi:10.1007/978-981-10-5041-1_71 · Cited by 13 · see citing works
Why do music-based interventions benefit persons with neurodegenerative disease?
Hobeika, L., & Samson, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817422-7.00013-4 · Cited by 12 · see citing works
Klímová, B., Slaninová, G., Pražák, P., Kacetl, J., & Vališ, M. (2020) · Brain Sciences · doi:10.3390/brainsci10090573 · Cited by 12 · see citing works
İlik, F., Büyükgöl, H., Kayhan, F., Ertem, D. H., & Ekiz, T. (2019) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719874123 · Cited by 12 · see citing works
Shi, E. R. (2024) · Biolinguistics · doi:10.5964/bioling.14649 · Cited by 12 · see citing works
Turning the Spotlight to Cholinergic Pharmacotherapy of the Human Language System
Dávila, G., Torres‐Prioris, M. J., López-Barroso, D., & Berthier, M. L. (2023) · CNS Drugs · doi:10.1007/s40263-023-01017-4 · Cited by 10 · see citing works
Mobile Health Devices for Aging Population Groups: A Review Study
Klímová, B. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-44215-0_24 · Cited by 10 · see citing works
Klímová, B., Vališ, M., & Kuča, K. (2017) · Social Work in Health Care · doi:10.1080/00981389.2017.1316339 · Cited by 10 · see citing works
Kang, K., Zhang, P., Dumitrescu, L. C., Mukherjee, S., Lee, M. L., Choi, S., Trittschuh, E. H., Mez, J. B., Saykin, A. J., Gifford, K. A., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70335 · Cited by 7 · see citing works
Impaired Speaking-Induced Suppression in Alzheimer’s Disease
Kim, K. X., Dale, C. L., Ranasinghe, K. G., Kothare, H., Beagle, A. J., Lerner, H., Mizuiri, D., Gorno‐Tempini, M. L., Vossel, K. A., Nagarajan, S. S., et al. (2023) · eNeuro · doi:10.1523/eneuro.0056-23.2023 · Cited by 8 · see citing works
Mobile Phone Apps as Support Tools for People with Dementia
Klímová, B., Bouckova, Z., & Toman, J. (2018) · Lecture notes in electrical engineering · doi:10.1007/978-981-13-1328-8_2 · Cited by 8 · see citing works
Kaliappan, S., Liu, C., Jain, Y., Karkar, R., & Saha, K. (2025) · JMIR Aging · doi:10.2196/68890 · Cited by 7 · see citing works
Elderly People and Their Use of Smart Technologies: Benefits and Limitations
Klímová, B. (2016) · Smart innovation, systems and technologies · doi:10.1007/978-3-319-39690-3_36 · Cited by 7 · see citing works
Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains
Chen, C., Zhang, Z., Liu, Y., Hong, W., Karahan, H., Wang, J., Li, W., Diao, L., Yu, M., Saykin, A. J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adn1927 · Cited by 6 · see citing works
“Language problems and impairment in executive functions typically emerge in the early to middle stages of AD ( 68 , 69 ).”
Language dysfunction as a primary feature of cognitive decline in neurological populations
Leavitt, V. M., Simani, L., Borhani‐Haghighi, A., Koch, M. W., König, A., & Rusz, J. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-03015-w · Cited by 6 · see citing works
Les troubles du langage dans la maladie d’Alzheimer sont-ils une simple aphasie ?
Hazif‐Thomas, C., & Thomas, P. (2017) · Soins Gérontologie · doi:10.1016/j.sger.2017.03.009 · Cited by 6 · see citing works
Nanoparticles for the potential treatment of Alzheimer’s disease: A physiopathological approach
Martínez, N. M. N., Toledo, J. A., & Morales, J. O. (2023) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0548 · Cited by 6 · see citing works
Language Disorders in Alzheimer’s Disease and Phatic Function
Thomas, P., & Hazif‐Thomas, C. (2016) · Open Journal of Psychiatry · doi:10.4236/ojpsych.2016.63026 · Cited by 6 · see citing works
Problems Faced by Caregivers of Alzheimer’s Patients
Talib, A., Malik, S., & Yasin, S. A. (2021) · Pakistan Journal of Psychological Research · doi:10.33824/pjpr.2021.36.3.22 · Cited by 5 · see citing works
Language and Communication Interventions in People with Alzheimer’s Disease: A Systematic Review
Dimitriou, N., Νούσια, Α., Georgopoulou, E.-N., Μαρτζούκου, Μ., Liampas, I., Dardiotis, E., & Nasios, G. (2024) · Healthcare · doi:10.3390/healthcare12070741 · Cited by 5 · see citing works
Cooper, R. A., & Segrin, C. G. (2024) · Communication Monographs · doi:10.1080/03637751.2024.2354872 · Cited by 5 · see citing works
Nasrolahzadeh, M., Mohammadpoory, Z., & Haddadnia, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-88947-9 · Cited by 5 · see citing works
Alzheimer’s Disease: Physical Activities as an Effective Intervention Tool - A Mini-Review
Klímová, B., Marešová, P., & Kuča, K. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666181002132021 · Cited by 5 · see citing works
The “authentic subjective experience” of memory in Alzheimer’s disease
Haj, M. E., Moustafa, A. A., Roche, J., Pasquier, F., Kapogiannis, D., Gallouj, K., & Antoine, P. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0123 · Cited by 5 · see citing works
Ageing and Alzheimer disease - system dynamics model prediction
Tomášková, H., Kühnová, J., & Kuča, K. (2016) · Česká a slovenská farmacie · doi:10.36290/csf.2016.020 · Cited by 4 · see citing works
Spectral Clustering, Bayesian Spanning Forest, and Forest Process
Duan, L. L., Roy, A., & Initiative, A. D. N. (2023) · Journal of the American Statistical Association · doi:10.1080/01621459.2023.2250098 · Cited by 4 · see citing works
Lexical Diversity and Language Impairment
Zozuk, N. Č. (2023) · Journal of Linguistics/Jazykovedný casopis · doi:10.2478/jazcas-2023-0047 · Cited by 4 · see citing works
Delfino, L. L., Komatsu, R. S., Komatsu, C., Neri, A. L., & Cachioni, M. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-030005 · Cited by 4 · see citing works
Kwon, H. S., Koh, S., Choi, S. H., Jeong, J. H., Na, H. R., Lee, C., Yang, Y., Lee, A. Y., Lee, J., Park, K. W., et al. (2023) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2023.22.3.100 · Cited by 4 · see citing works
Cognitive Decline in Dementia with Special Focus on Language Impairments
Klímová, B., & Semrádová, I. (2016) · The European Proceedings of Social & Behavioural Sciences · doi:10.15405/epsbs.2016.05.02.9 · Cited by 4 · see citing works
Age-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary, S., Zhang, S., Chen, Y., Dominguez, J. C., Chao, H. H., & Li, C.-S. R. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1375435 · Cited by 3 · see citing works
Liu, Y., Hsu, J., Wang, S.-J., Yip, P.-K., Meguro, K., & Fuh, J. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0435-2 · Cited by 3 · see citing works
Marešová, P., & Klímová, B. (2018) · Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering · doi:10.1007/978-3-319-74935-8_10 · Cited by 3 · see citing works
Treatment costs of Parkinson’s disease in Central Europe
Marešová, P., Klímová, B., Vališ, M., Kuča, K., & Mohelská, H. (2016) · E+M Ekonomie a Management · doi:10.15240/tul/001/2016-3-003 · Cited by 3 · see citing works
Narrativity and Memory Analysis in Alzheimer’s Disease
Hazif‐Thomas, C., Billon, R., & Thomas, P. (2017) · Open Journal of Psychiatry · doi:10.4236/ojpsych.2017.74026 · Cited by 3 · see citing works
Selected rare paediatric communication neurological disorders
Klímová, B., Vališ, M., Hort, J., & Kuča, K. (2019) · Journal of Applied Biomedicine · doi:10.32725/jab.2018.002 · Cited by 3 · see citing works
Self-citationMobile applications as good intervention tools for individuals with depression
Marešová, P., Klímová, B., & Kuča, K. (2017) · Česká a slovenská farmacie · doi:10.36290/csf.2017.007 · Cited by 3 · see citing works
Organic Foods in Diets of Patients with Alzheimer’s Disease
Dziuba, S. T., Cierniak–Emerych, A., Klímová, B., Poulová, P., Napora, P., & Szromba, S. (2020) · Sustainability · doi:10.3390/su12041388 · Cited by 2 · see citing works
Dynamic Modeling of the Czech Republic Population with a Focus on Alzheimer’s Disease Patients
Tomášková, H., Marešová, P., Jun, D., Augustýnek, M., Honegr, J., & Klímová, B. (2018) · Lecture notes in computer science · doi:10.1007/978-3-319-75420-8_33 · Cited by 2 · see citing works
Cimler, R., Doležal, O., & Pscheidl, P. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-45246-3_24 · Cited by 2 · see citing works
Model of Empathic Pain Assessment and Treatment in Persons With Dementia
Starr, L. T., & Magan, K. C. (2020) · Research in Gerontological Nursing · doi:10.3928/19404921-20200402-01 · Cited by 2 · see citing works
Wearable and Portable Monitoring Devices for Older People
Klímová, B., & Marešová, P. (2017) · Lecture notes in electrical engineering · doi:10.1007/978-981-10-5041-1_72 · Cited by 2 · see citing works
e-Learning Tools for Informal Caregivers of Patients with Dementia—A Review Study
Klímová, B., & Pikhart, M. (2020) · Smart innovation, systems and technologies · doi:10.1007/978-981-15-5584-8_8 · Cited by 1 · see citing works
Mediterranean Diet and Neuro-Cognition: Focus on Alzheimer Disease
Talhaoui, A., Bikri, S., & Aboussaleh, Y. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-7327-7_4 · Cited by 1 · see citing works
Evaluation of Reminiscence Therapy on Language Outcomes Among People With Dementia
Busch, C. M., Gilbertson, L. R., & Feggestad, K. (2025) · Perspectives of the ASHA Special Interest Groups · doi:10.1044/2025_persp-25-00022 · Cited by 1 · see citing works
Articulation Characterization in AD Speech Production
Gómez‐Vilda, P., de Ipiña, K. L., Rodellar, V., Alonso, D. P., & Ecay‐Torres, M. (2016) · Biosystems & biorobotics · doi:10.1007/978-3-319-46669-9_140 · Cited by 1 · see citing works
Aranda, L., Gordillo-Villatoro, M., Enamorado, J. M., & López‐Zamora, M. (2017) · Revista de Logopedia Foniatría y Audiología · doi:10.1016/j.rlfa.2017.02.002 · Cited by 1 · see citing works
Intensive naming training for low-educated demented and non-demented elderly
Ferreira, A. C. D. S., Silva, A. A., Paiva, L. R., Satler, C. E., & Cera, M. L. (2020) · Dementia & Neuropsychologia · doi:10.1590/1980-57642020dn14-040011 · Cited by 1 · see citing works
Haeger, A., Muising, J., Romanzetti, S., Fimm, B., Matz, O., Schulz, J. B., Heim, S., & Reetz, K. (2024) · Brain and Behavior · doi:10.1002/brb3.3420
López‐Zamora, M., Cánovas-Cano, M., & Aranda, L. (2019) · Revista de Psicopatología y Psicología Clínica · doi:10.5944/rppc.22937 · Cited by 1 · see citing works
- Authors
- Kuca, K., Maresova, P., Klimova, B., Valis, M., & Hort, J.
- Affiliations
- Charles University (CZ)
- ORCID
- Hort, Jakub
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2015-08
- Volume
- 10
- Pages
- 1401
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC4555976
- OpenAlex
- W1617817728
- Cited by
- 122
- References
- 54
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 13 · 2019: 16 · 2018: 11 · 2017: 19 · 2016: 16 · 2015: 2
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Univerzita Hradec Králové
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, language impairment, social exclusion, social intervention, medical treatment, informal caregivers, caregiver burden, quality of life, communication, disease progression
- MeSH terms
- Alzheimer Disease, Cholinesterase Inhibitors, Communication, Humans, Interpersonal Relations, Language Disorders, Social Support, Caregivers, Excitatory Amino Acid Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
