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Cited by 373

The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.

Role of inflammatory cells in airway remodeling in COPD

Open access
Wang, Yujie, Xu, Jiayan, Meng, Yaqi, Adcock, Ian M, Yao, Xin·2018·International Journal of Chronic Obstructive Pulmonary Disease
DOI 10.2147/copd.s176122
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Abstract

COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD. Chronic inflammation in COPD mainly involves the infiltration of neutrophils, macrophages, lymphocytes, and other inflammatory cells into the small airways. The contribution of resident airway structural cells to the inflammatory process is also important in COPD. Airway remodeling consists of detrimental changes in structural tissues and cells including airway wall thickening, epithelial metaplasia, goblet cell hypertrophy, and smooth muscle hyperplasia. Persistent airway inflammation might contribute to airway remodeling and small airway obstruction. However, the underlying mechanisms remain unclear. In this review, we will provide an overview of recent insights into the role of major immunoinflammatory cells in COPD airway remodeling.

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Metadata

Authors
Wang, Y., Xu, J., Meng, Y., Adcock, I. M., & Yao, X.
Venue
International Journal of Chronic Obstructive Pulmonary Disease
Publisher
Informa UK Limited
Published
2018-10
Volume
Volume 13
Pages
3341-3348
ISSN
  • 1176-9106 (ISSN-L)
  • 1178-2005
DOI
10.2147/copd.s176122
OpenAlex
W2895954347
Cited by
373
References
83
FWCI
15.73
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.