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Chitosan/poly(lactic-co-glycolic)acid Nanoparticle Formulations with Finely-Tuned Size Distributions for Enhanced Mucoadhesion

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Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders

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Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

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Protective effects of dietary quercetin on cerebral ischemic injury: pharmacology, pharmacokinetics and bioavailability-enhancing nanoformulations

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In Vivo Assessment of Clobetasol Propionate-Loaded Lecithin-Chitosan Nanoparticles for Skin Delivery

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Gel-like TPGS-Based Microemulsions for Imiquimod Dermal Delivery: Role of Mesostructure on the Uptake and Distribution into the Skin

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Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS

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Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

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Formulation strategies for nose-to-brain delivery of therapeutic molecules

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In Vitro Evaluation of Curcumin- and Quercetin-Loaded Nanoemulsions for Intranasal Administration: Effect of Surface Charge and Viscosity

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Development and validation of a RP-HPLC method for the simultaneous detection and quantification of simvastatin’s isoforms and coenzyme Q10 in lecithin/chitosan nanoparticles

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Intranasal tetrandrine temperature-sensitive in situ hydrogels for the treatment of microwave-induced brain injury

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Anti-Inflammatory Properties of Statin-Loaded Biodegradable Lecithin/Chitosan Nanoparticles: A Step Toward Nose-to-Brain Treatment of Neurodegenerative Diseases

Clementino, A., Marchi, C., Pozzoli, M., Bernini, F., Zimetti, F., & Sonvico, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716380 · Cited by 29 · see citing works

Nose-to-brain co-delivery of repurposed simvastatin and BDNF synergistically attenuates LPS-induced neuroinflammation

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Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration

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Efficacy and Safety Profiles of Oral Atorvastatin-Loaded Nanoparticles: Effect of Size Modulation on Biodistribution

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Comparative Study of Donepezil-Loaded Formulations for the Treatment of Alzheimer’s Disease by Nasal Administration

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Crosslinked Chitosan Nanoparticles with Muco-Adhesive Potential for Intranasal Delivery Applications

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Efficient TNBC immunotherapy by dual reprogramming tumor-infiltrating dendritic cells and tumor-associated macrophages with stimulus-responsive miR155 nanocomplexes

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Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM)

Perrelli, A., Fatehbasharzad, P., Benedetti, V., Ferraris, C., Fontanella, M., Luca, E. D., Moglianetti, M., Battaglia, L., & Retta, S. F. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1873273 · Cited by 24 · see citing works

Polymeric nanoparticles for efficient nose-to-brain delivery

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Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy

Silva, A. M. D. S., de Caland, L. B., do Nascimento, E. G., Oliveira, A. L. C. D. S. L., de Araujo-Junior, R. F., Cornélio, A. M., Fernandes‐Pedrosa, M. D. F., & da Silva-Júnior, A. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092350 · Cited by 23 · see citing works

Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality

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Intranasal delivery of phenytoin-loaded nanoparticles to the brain suppresses pentylenetetrazol-induced generalized tonic clonic seizures in an epilepsy mouse model

Yousfan, A., Rubio, N., Al‐Ali, M., Nattouf, A. H., & Kafa, H. (2021) · Biomaterials Science · doi:10.1039/d1bm01251g · Cited by 22 · see citing works

How nano-engineered delivery systems can help marketed and repurposed drugs in Alzheimer’s disease treatment?

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Liquid Crystalline Nanoparticles for Nasal Delivery of Rosuvastatin: Implications on Therapeutic Efficacy in Management of Epilepsy

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Preparation and Properties of 5-Fluorouracil-Loaded Chitosan Microspheres for the Intranasal Administration

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Restoration of olfactory dysfunctions by nanomaterials and stem cells-based therapies: Current status and future perspectives

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Preparation and characterization of lamotrigine containing nanocapsules for nasal administration

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Preliminary Investigation on Simvastatin-Loaded Polymeric Micelles in View of the Treatment of the Back of the Eye

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Coenzyme Q10 protects against β‐cell toxicity induced by pravastatin treatment of hypercholesterolemia

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Drug Delivery to the brain: How Can Nanoencapsulated Statins Be Used in the Clinic?

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Hydrophilic and hydrophobic polymeric benznidazole-loaded nanoparticles: Physicochemical properties and in vitro antitumor efficacy

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Optimizing nasal drug delivery for peptides, proteins, and small molecules: strategic use of materials and techniques to target the CNS

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Mefenamic Acid Loaded and TPGS Stabilized Mucoadhesive Nanoemulsion for the Treatment of Alzheimer’s Disease: Development, Optimization, and Brain-Targeted Delivery via Olfactory Pathway

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Hybrid Nanoparticles as a Novel Tool for Regulating Psychosine-Induced Neuroinflammation and Demyelination In Vitro and Ex vivo

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Mucoadhesion as a strategy to enhance the direct nose-to-brain drug delivery

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Functionalized Nanoparticles in Drug Delivery: Strategies to Enhance Direct Nose-to-Brain Drug Delivery via Integrated Nerve Pathways

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pH/ROS dual-responsive nanoparticles with curcumin entrapment to promote antitumor efficiency in triple negative breast cancer

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Surface modification of nanocarriers as a strategy to enhance the direct nose-to-brain drug delivery

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Lipid nanocapsules: A Novel Strategy for Brain Targeting via Nasal Administration

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An AQbD-based Optimized and Green Isocratic HPLC Method for the Quantification of Simvastatin in Liposomes: Forced Degradation, Assessment of Drug Content, and Drug Entrapment

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Statins in Acute Ischemic Stroke: Mechanisms, Resistance, and Precision Strategies for Neurovascular and Cognitive Protection

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Lecithin and Chitosan as Building Blocks in Anti-Candida Clotrimazole Nanoparticles

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Polymeric Nanocarrier-Based Drug Formulations for Enhancing Nose-to-Brain Delivery

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Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions

Gama, F., Meirinho, S., Pires, P. C., Tinoco, J., Gaspar, M. C. M., Baltazar, G., Alves, G., & Santos, A. O. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01769-6 · Cited by 6 · see citing works

An overview of nanotechnological applications in biomedical engineering

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Intranasal route: The green corridor for Alzheimer's disease therapeutics

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Advances in polysaccharide-based formulations for intranasal drug delivery: A review

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Transferrin-Functionalized Chitosan Nanoparticles Enable Intranasal Brain Delivery of Cariprazine with Enhanced Neuropharmacological Efficacy

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Intranasal Poly(Lactic-co-Glycolic Acid) Nanoparticles of Mefenamic Acid Improve Motor Expressions and Neurochemical Injury in Aluminium Chloride Originated Alzheimer’s Disease

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EVALUATION OF CHITOSAN NANOPARTICLES BIODISTRIBUTION USING GROCOTT METHENAMINE SILVER STAINING

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Targeted Treatment Strategies for Mitochondria Dysfunction: Correlation with Neurological Disorders

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Bioadhesive Nanoformulations—Concepts and Preclinical Studies

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The effect of simvastatin-loaded methoxy poly(ethylene glycol)-polylactic acid nanoparticles on osteoblasts

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Formulation Strategies for Nose-to-Brain Drug Delivery

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Intranasal Novel Drug Delivery Systems

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Nasal Delivery of Micro and Nano Encapsulated Drugs

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Utilizing chitosan nanoparticles for the delivery of biologics to the brain via intranasal route

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A critical comparative insight on nanocarrier-based intranasal delivery of statins for neuroprotective applications

Paruparla, R., Lalan, M. S., Shah, P., & Vasdev, N. (2026) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2026.2614071

Intranasal delivery of a nanoencapsulated ursodeoxycholic acid-ferulic acid prodrug enables CNS exposure to antioxidant agents

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Development of polysaccharide nanoparticles for the nasal administration of drugs for the treatment of neurodegenerative diseases

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Anti-Inflammatory Properties of Statin-Loaded Biodegradable Lecithin/Chitosan Nanoparticles: A Step Toward Nose-to-Brain Treatment of Neurodegenerative Diseases

Clementino, A., Marchi, C., Pozzoli, M., Bernini, F., Zimetti, F., & Sonvico, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716380 · Cited by 29 · see citing works

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

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Simvastatin is delivered to the brain by high-strength intranasal cationic SMEDDS and nanoemulsions

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Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs

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