The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Thermosensitive liposomal drug delivery systems: state of the art review
Open accessAbstract
Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.
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Cites
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Cited by
Yusuf, V. F., Malek, N. I., & Kailasa, S. K. (2022) · ACS Omega · doi:10.1021/acsomega.2c05310 · Cited by 894
Moradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514
Liposomal Delivery Systems: Design Optimization and Current Applications
Abu Lila, A. S., & Ishida, T. (2017) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00624 · Cited by 382
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Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy
Dunne, M., Regenold, M., & Allen, C. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.007 · Cited by 150
Metadata
- Authors
- Hossann, M., Kneidl, B., Peller, M., Lindner, L., & Winter, G.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2014-09
- Volume
- 9
- Pages
- 4387
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2004426884
- Cited by
- 342
- References
- 80
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hossann, M., Kneidl, B., Peller, M., Lindner, L., & Winter, G. (2014). Thermosensitive liposomal drug delivery systems: state of the art review. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s49297
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
