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The role of microglia in multiple sclerosis
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“Activated microglia produce ROS/RNS and release pro-inflammatory factors into damaged areas, leading to oligodendrocyte loss and consequent neurodegeneration (Luo et al. 2017).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Luo et al. 2017
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,457
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329
Inflammatory cortical demyelination in early multiple sclerosis.
Lucchinetti, C. F., Popescu, B. F. G., Bunyan, R. F., Moll, N. M., Roemer, S. F., Lassmann, H., Brück, W., Parisi, J. E., Scheithauer, B. W., Giannini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100648 · Cited by 1,103
Differential roles of microglia and monocytes in the inflamed central nervous system
Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 856
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., et al. (2005) · Nature Medicine · doi:10.1038/nm1177 · Cited by 732 · cited 1×
“Ablation of microglia protected the gray and white matter in EAE mice.(47) Microglial Hv1 proton”
BackgroundInefficient clearance of myelin debris by microglia impairs remyelinating processes
Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141656 · Cited by 595
Flagged first, then by citations
Research works printed but not linked: 63
- [1]De Groot CJ Bergers E Kamphorst W Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions Brain 2001 124 Pt 8 1635 1645 11459754
- [2]Lassmann H Brück W Lucchinetti CF The immunopathology of multiple sclerosis: an overview Brain Pathol 2007 17 2 210 218 17388952 PMC8095582
- [4]Prineas JW Kwon EE Cho ES Immunopathology of secondary-progressive multiple sclerosis Ann Neurol 2001 50 5 646 657 11706971
- [5]Benveniste EN Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis J Mole Med (Berl) 1997 75 3 165 173 9106073
- [6]Ponomarev ED Shriver LP Maresz K Dittel BN Microglial cell activation and proliferation precedes the onset of CNS autoimmunity J Neurosci Res 2005 81 3 374 389 15959904
- [7]Frohman EM Racke MK Raine CS Multiple sclerosis – the plaque and its pathogenesis N Engl J Med 2006 354 9 942 955 16510748
- [9]Voss EV Škuljec J Gudi V Characterization of microglia during de-and remyelination: can they create a repair promoting environment? Neurobiol Dis 2012 45 1 519 528 21971527
- [10]Streit WJ Graeber MB Kreutzberg GW Functional plasticity of microglia: a review Glia 1988 1 5 301 307 2976393
- [15]Walker DG Lue L Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains Alzheimer’s ResTher 2015 7 1 56 PMC4543480 26286145
- [18]Boche D Perry VH Nicoll JA Review: activation patterns of microglia and their identification in the human brain Neuropathol Appl Neurobiol 2013 39 1 3 18 23252647
- [19]Durafourt BA Moore CS Zammit DA Comparison of polarization properties of human adult microglia and blood-derived macrophages Glia 2012 60 5 717 727 22290798
- [20]Giunti D Parodi B Cordano C Uccelli A Kerlero De Rosbo N Can we switch microglia’s phenotype to foster neuroprotection? Focus on multiple sclerosis Immunology 2014 141 3 328 339 24116890 PMC3930371
- [21]Melief J Koning N Schuurman KG Phenotyping primary human microglia: tight regulation of LPS responsiveness Glia 2012 60 10 1506 1517 22740309
- [22]Melief J Schuurman KG Garde MD Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed Glia 2013 61 11 1848 1861 24014207
- [23]Erny D de Angelis ALH Jaitin D Host microbiota constantly control maturation and function of microglia in the CNS Nat Neurosci 2015 18 7 965 977 26030851 PMC5528863
- [24]Xue J Schmidt SV Sander J Transcriptome-based network analysis reveals a spectrum model of human macrophage activation Immunity 2014 40 2 274 288 24530056 PMC3991396
- [27]Barnett MH Prineas JW Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion Ann Neurol 2004 55 4 458 468 15048884
- [29]Sun SW Liang HF Trinkaus K Cross AH Armstrong RC Song SK Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum Magn Reson Med 2006 55 2 302 308 16408263
- [31]Wolswijk G Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis Brain 2000 123 1 105 115 10611125
- [32]Smith KJ Kapoor R Felts PA Demyelination: the role of reactive oxygen and nitrogen species Brain Pathol 1999 9 1 69 92 9989453 PMC7161906
- [33]Bizzozero OA DeJesus G Callahan K Pastuszyn A Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis J Neurosci Res 2005 81 5 687 695 16007681
- [34]Butts BD Houde C Mehmet H Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease Cell Death Differ 2008 15 7 1178 1186 18483490
- [35]Blomgren K Hagberg H Free radicals, mitochondria, and hypoxia–ischemia in the developing brain Free Radic Biol Med 2006 40 3 388 397 16443153
- [36]Miller E Wachowicz B Majsterek I Advances in antioxidative therapy of multiple sclerosis Curr Med Chem 2013 20 37 4720 4730 23834174
- [37]Haider L Fischer MT Frischer JM Oxidative damage in multiple sclerosis lesions Brain 2011 134 Pt 7 1914 1924 21653539 PMC3122372
- [38]van Horssen J Drexhage JA Flor T Gerritsen W van der Valk P de Vries HE Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions Free Radic Biol Med 2010 49 8 1283 1289 20673799
- [39]van Horssen J Schreibelt G Bö L NAD(P)H: quinone oxidoreductase 1 expression in multiple sclerosis lesions Free Radic Biol Med 2006 41 2 311 317 16814112
- [40]Van Horssen J Schreibelt G Drexhage J Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression Free Radic Biol Med 2008 45 12 1729 1737 18930811
- [41]Gray E Thomas TL Betmouni S Scolding N Love S Elevated myeloperoxidase activity in white matter in multiple sclerosis Neurosci Lett 2008 444 2 195 198 18723077
- [42]Liu JS Zhao M Brosnan CF Lee SC Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions Am J Pathol 2001 158 6 2057 2066 11395383 PMC1891989
- [43]Fischer MT Sharma R Lim JL NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury Brain 2012 135 3 886 899 22366799 PMC3286337
- [45]Zeis T Probst A Steck AJ Stadelmann C Brück W Schaeren Wiemers N Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis Brain Pathol 2009 19 3 459 466 19016740 PMC8094783
- [46]Haider L Fischer MT Frischer JM Oxidative damage in multiple sclerosis lesions Brain 2011 134 Pt 7 1914 1924 21653539 PMC3122372
- [48]Liu J Tian D Murugan M Microglial Hv1 proton channel promotes cuprizone – induced demyelination through oxidative damage J Neurochem 2015 135 2 347 356 26173779 PMC4721248
- [49]Domingues HS Portugal CC Socodato R Relvas JB Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair Front Cell Dev Biol 2016 4 71 27551677 PMC4923166
- [50]Albert M Antel J Brück W Stadelmann C Extensive cortical remyelination in patients with chronic multiple sclerosis Brain Pathol 2007 17 2 129 138 17388943 PMC8095564
- [52]Neumann H Kotter MR Franklin R Debris clearance by microglia: an essential link between degeneration and regeneration Brain 2009 132 Pt 2 288 295 18567623 PMC2640215
- [53]Kotter MR Zhao C van Rooijen N Franklin RJ Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression Neurobiol Dis 2005 18 1 166 175 15649707
- [54]Kuhlmann T Miron V Cuo Q Wegner C Antel J Brück W Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis Brain 2008 131 Pt 7 1749 1758 18515322
- [55]Voß EV Škuljec J Gudi V Characterization of microglia during de- and remyelination: can they create a repair promoting environment? Neurobiol Dis 2012 45 1 519 528 21971527
- [57]Miron VE Boyd A Zhao J M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination Nature Neurosci 2013 16 9 1211 1218 23872599 PMC3977045
- [58]Di Penta Chiba A Alloza I A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation Plos One 2013 8 12 e83119 24349442 PMC3859644
- [59]Jadidi Niaragh F Mirshafiey A Th17 cell, the new player of neuroinflammatory process in multiple sclerosis Scand J Immunol 2011 74 1 1 13 21338381
- [60]Benveniste EN Cytokines: influence on glial cell gene expression and function Neuroimmunoendocrinology 1997 69 31 75 9353961
- [62]Almolda B González B Castellano B Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE J Neuroimmunol 2010 223 1–2 39 54 20451260
- [63]Bull ME Vahlenkamp TW Dow JL Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies Vet Immunol Immunopathol 2004 99 1–2 25 37 15113651
- [64]Roy A Liu X Pahan K Myelin basic protein-primed T cells induce neurotrophins in glial cells via α5β3 integrin J Biol Chem 2007 282 44 32222 32232 17823123 PMC2637617
- [65]Ebner F Brandt C Thiele P Microglial activation milieu controls regulatory T cell responses J Immunol 2013 191 11 5594 5602 24146044
- [66]Bsibsi M Peferoen LA Holtman IR Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin Acta Neuropathol 2014 128 2 215 229 24997049
- [67]Adams C Poston RN Buk SJ Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis J Neurol Sci 1989 92 2 291 306 2809622
- [68]Hickey WF The pathology of multiple sclerosis: a historical perspective J Neuroimmunol 1999 98 1 37 44 10426360
- [69]Prineas JW Graham JS Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown Ann Neurol 1981 10 2 149 158 7025748
- [70]Sriram S Rodriguez M Indictment of the microglia as the villain in multiple sclerosis Neurology 1997 48 2 464 470 9040740
- [71]Barnett MH Prineas JW Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion Ann Neurol 2004 55 4 458 468 15048884
- [72]Barnett MH Henderson AP Prineas JW The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion Mult Scler J 2006 12 2 121 132 16629415
- [73]Gay FW Early cellular events in multiple sclerosis: intimations of an extrinsic myelinolytic antigen Clin Neurol Neurosurg 2006 108 3 234 240 16364541
- [74]Henderson AP Barnett MH Parratt JD Prineas JW Multiple sclerosis: distribution of inflammatory cells in newly forming lesions Ann Neurol 2009 66 6 739 753 20035511
- [75]Weiner HL A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis J Neurol 2008 255 Suppl 1 3 11 18317671
- [76]Gandhi R Laroni A Weiner HL Role of the innate immune system in the pathogenesis of multiple sclerosis J Neuroimmunol 2010 221 1 7 14 19931190 PMC2854189
- [77]Bauer MK Lieb K Schulze Osthoff K Expression and regulation of cyclooxygenase-2 in rat microglia Eur J Biochem 1997 243 3 726 731 9057838
- [78]Streit WJ Microglia as neuroprotective, immunocompetent cells of the CNS Glia 2002 40 2 133 139 12379901
- [79]Aravalli RN Peterson PK Lokensgard JR Toll-like receptors in defense and damage of the central nervous system J Neuroimmune Pharmacol 2007 2 4 297 312 18040848
- [80]Murray PJ Allen JE Biswas SK Macrophage activation and polarization: nomenclature and experimental guidelines Immunity 2014 41 1 14 20 25035950 PMC4123412
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Metadata
- Authors
- Luo, C., Jian, C., Liao, Y., Huang, Q., Wu, Y., Liu, X., Zou, D., & Wu, Y.
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2017-06
- Volume
- Volume 13
- Pages
- 1661-1667
- ISSN
- 1178-2021
- PMC
- PMC5499932
- Cited by
- 187
- References
- 16
- Language
- en
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