CoChat
Sign Up
Cited by 26

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The naked mole-rat as an animal model in biomedical research: current perspectives

Smith, Ewan St John, Schuhmacher, Laura-Nadine, Husson, Zoé·2015·Open Access Animal Physiology
DOI 10.2147/oaap.s50376
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2147/oaap.s50376

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 124

  1. [1]1. Jarvis JU. Eusociality in a mammal: cooperative breeding in naked mole-rat colonies. Science . 1981;212(4494):571–573.
  2. [2]2. Bennett NC, Faulkes CG. African Mole-Rats: Ecology and Eusociality . Cambridge University Press; 2000.
  3. [3]3. Faulkes CG, Bennett NC. Plasticity and constraints on social evolution in African mole-rats: ultimate and proximate factors. Philos Trans R Soc B Lond B Biol Sci . 2013;368(1618):20120347.
  4. [4]4. Jarvis JUM, Bennett NC. Ecology and behavior of the family Bathyergidae. In: Sherman P, Jarvis J, Alexander R, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:66–96.
  5. [5]5. Brett RA. The population structure of naked mole rat colonies. In: Sherman P, Jarvis J, Alexander R, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:97–136.
  6. [6]6. Lacey EA, Sherman PW. Social organization of naked mole-rat colonies: Evidence for divisions of Labor. In: Sherman P, Jarvis J, Alexander R, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:275–336.
  7. [7]7. Jarvis JUM. Reproduction of naked mole-rats. In: Sherman P, Jarvis J, Alexander M, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:384–425.
  8. [8]8. O’Riain MJ, Jarvis JU, Alexander R, Buffenstein R, Peeters C. Morphological castes in a vertebrate. Proc Natl Acad Sci U S A . 2000; 97(24):13194–13197.
  9. [9]9. Faulkes CG, Abbott DH, Liddell CE, George LM, Jarvis JUM. Hormonal and behavioral aspects of reproductive suppression in female naked mole-rats. In: Sherman P, Jarvis J, Alexander M, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:426–445.
  10. [10]10. Faulkes CG, Abbott DH, Jarvis JU. Social suppression of ovarian cyclicity in captive and wild colonies of naked mole-rats, Heterocephalus glaber. J Reprod Fertil . 1990;88(2):559–568.
  11. [11]11. Brett RA. The ecology of naked mole-rat colonies: burrowing, food and limiting factors. In: Sherman P, Jarvis J, Alexander R, editors. The Biology of the Naked Mole-Rat . Princeton University Press; 1991:137–184.
  12. [12]12. McNab BK. The metabolism of fossorial rodents: a study of convergence. Ecology . 1966;47(5):712–733.
  13. [13]13. McNab BK. The influence of body size on the energetics and distibution of fossorial and burrowing mammals. Ecology . 1979;60:1010–1021.
  14. [14]14. Buffenstein R, Yahav S. Is the naked mole-rat Heterocephalus glaber an endothermic yet poikilothermic? J therm Biol . 1991;16(4):227–232.
  15. [17]17. Yahav S, Buffenstein R. Huddling behavior facilitates homeothermy in the naked mole rat Heterocephalus-Glaber . Physiol Zool . 1991;64(3):871–884.
  16. [18]18. Buffenstein R, Woodley R, Thomadakis C, Daly TJ, Gray D a. Cold-induced changes in thyroid function in a poikilothermic mammal, the naked mole-rat. Am J Physiol Regul Integr Comp Physiol . 2001;280(1):R149–R155.
  17. [19]19. Healy K, Guillerme T, Finlay S, et al. Ecology and mode-of-life explain lifespan variation in birds and mammals. Proc Biol Sci . 2014;281(1784):20140298.
  18. [20]20. Buffenstein R. The naked mole-rat: a new long-living model for human aging research. J Gerontol A Biol Sci Med Sci . 2005;60(11):1369–1377.
  19. [21]21. Williams SA, Shattuck MR. Ecology, longevity and naked mole-rats: confounding effects of sociality? Proc Biol Sci . 2015;282:20141664.
  20. [22]22. Buffenstein R. Negligible senescence in the longest living rodent, the naked mole-rat: Insights from a successfully aging species. J Comp Physiol B . 2008;178(4):439–445.
  21. [23]23. O’Connor TP, Lee A, Jarvis JU, Buffenstein R. Prolonged longevity in naked mole-rats: Age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A Mol Integr Physiol . 2002;133(3):835–842.
  22. [24]24. Grimes KM, Reddy AK, Lindsey ML, Buffenstein R. And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat. Am J Physiol Heart Circ Physiol . 2014; 307(3):H284–H291.
  23. [26]26. MacRae SL, Zhang Q, Lemetre C, et al. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell . 2015;14(2):288–291.
  24. [27]27. Fang X, Seim I, Huang Z, et al. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep . 2014;8(5):1354–1364.
  25. [28]28. Schmidt CM, Blount JD, Bennett NC. Reproduction is associated with a tissue-dependent reduction of oxidative stress in eusocial female Damaraland mole-rats (Fukomys damarensis). PLoS One . 2014; 9(7):e103286.
  26. [29]29. Schmidt CM, Jarvis JUM, Bennett NC. The long-lived queen: reproduction and longevity in female eusocial Damaraland mole-rats (Fukomys damarensis). African Zool . 2013;48(1):193–196.
  27. [30]30. Squier TC. Oxidative stress and protein aggregation during biological aging. Exp Gerontol . 2001;36(9):1539–1550.
  28. [33]33. Rodriguez KA, Edrey YH, Osmulski P, Gaczynska M, Buffenstein R. Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One . 2012;7(5):e35890.
  29. [34]34. Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M, Buffenstein R. A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition. Biochim Biophys Acta . 2014;1842(11):2060–2072.
  30. [35]35. Zhao S, Lin L, Kan G, et al. High autophagy in the naked mole rat may play a significant role in maintaining good health. Cell Physiol Biochem . 2014;33(2):321–332.
  31. [36]36. Azpurua J, Ke Z, Chen IX, et al. Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proc Natl Acad Sci U S A . 2013;110(43):17350–17355.
  32. [37]37. Edrey YH, Medina DX, Gaczynska M, et al. Amyloid beta and the longest-lived rodent: The naked mole-rat as a model for natural protection from alzheimer’s disease. Neurobiol Aging . 2013;34(10):2352–2360.
  33. [38]38. Orr ME, Garbarino VR, Salinas A, Buffenstein R. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiol Aging . 2015;36(3):1496–1504.
  34. [39]39. Edrey YH, Casper D, Huchon D, et al. Sustained high levels of neuregulin-1 in the longest-lived rodents; A key determinant of rodent longevity. Aging Cell . 2012;11(2):213–222.
  35. [40]40. Hedhli N, Huang Q, Kalinowski A, et al. Endothelium-derived neuregulin protects the heart against ischemic injury. Circulation . 2011;123(20):2254–2262.
  36. [41]41. Li J, Ichikawa T, Janicki JS, Cui T. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets . 2009;13(7):785–794.
  37. [42]42. Mann GE, Niehueser-Saran J, Watson A, et al. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao . 2007;59(2):117–127.
  38. [43]43. Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem . 2009;284(20):13291–13295.
  39. [46]46. Lewis KN, Wason E, Edrey YH, Kristan DM, Nevo E, Buffenstein R. Regulation of Nrf2 signaling and longevity in naturally long-lived rodents. Proc Natl Acad Sci U S A . 2015;112(12):3722–3727.
  40. [47]47. Shimokawa I, Higami Y, Tsuchiya T, et al. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J . 2003;17(9):1108–1109.
  41. [48]48. Masoro EJ. Potential role of the modulation of fuel use in the antiaging action of dietary restriction. Ann N Y Acad Sci . 1992;663:403–411.
  42. [49]49. Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev . 2005;126(9):913–922.
  43. [50]50. Azpurua J, Yang JN, Van Meter M, et al. IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) . 2013;5(4):304–314.
  44. [51]51. Fang X, Nevo E, Han L, et al. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun . 2014;5:3966.
  45. [53]53. Manov I, Hirsh M, Iancu TC, et al. Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence. BMC Biol . 2013;11:91.
  46. [54]54. Seluanov A, Hine C, Azpurua J, et al. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A . 2009;106(46):19352–19357.
  47. [55]55. Delaney MA, Nagy L, Kinsel MJ, Treuting PM. Spontaneous histologic lesions of the adult naked mole rat (Heterocephalus glaber): a retrospective survey of lesions in a zoo population. Vet Pathol . 2013;50(4):607–621.
  48. [56]56. Greenberg RA. Telomeres, crisis and cancer. Curr Mol Med . 2005;5(2):213–218.
  49. [57]57. Liang S, Mele J, Wu Y, Buffenstein R, Hornsby PJ. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell . 2010;9(4):626–635.
  50. [58]58. Finch CE. Update on slow aging and negligible senescence – A mini-review. Gerontology . 2009;55(3):307–313.
  51. [59]59. Seluanov A, Chen Z, Hine C, et al. Telomerase activity coevolves with body mass not lifespan. Aging Cell . 2007;6(1):45–52.
  52. [60]60. Gorbunova V, Seluanov A. Coevolution of telomerase activity and body mass in mammals: From mice to beavers. Mech Ageing Dev . 2009;130(1–2):3–9.
  53. [61]61. Seluanov A, Hine C, Bozzella M, et al. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell . 2008;7(6):813–823.
  54. [63]63. Polyak K, Kato JY, Solomon MJ, et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev . 1994;8(1):9–22.
  55. [64]64. Zhang HS, Postigo AA, Dean DC. Active transcriptional repression by the Rb–E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition. Cell . 1999;97(1):53–61.
  56. [65]65. Dulić V, Kaufmann WK, Wilson SJ, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell . 1994;76(6):1013–1023.
  57. [66]66. Kohda D, Morton CJ, Parkar AA, et al. Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. Cell . 1996;86(5):767–775.
  58. [67]67. Tian X, Azpurua J, Hine C, et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature . 2013; 499(7458):346–349.
  59. [68]68. Keane M, Craig T, Alföldi J, et al. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics . 2014;30(24):3558–3560.
  60. [69]69. Gorbunova V, Hine C, Tian X, et al. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A . 2012;109(47):19392–19396.
  61. [70]70. Faulkes CG, Davies KT, Rossiter SJ, Bennett NC. Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance. Biol Lett . 2015;11(5):20150185.
  62. [71]71. Avivi A, Ashur-Fabian O, Joel A, et al. P53 in blind subterranean mole rats – loss-of-function versus gain-of-function activities on newly cloned Spalax target genes. Oncogene . 2007;26(17):2507–2512.
  63. [72]72. Tian X, Azpurua J, Ke Z, et al. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A . 2015;112(4):1053–1058.
  64. [73]73. Michiels C. Physiological and pathological responses to hypoxia. Am J Pathol . 2004;164(6):1875–1882.
  65. [74]74. Gao L, Tian S, Gao H, Xu Y. Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice. J Mol Neurosci . 2013;51(1):138–147.
  66. [75]75. Peers C, Dallas ML, Boycott HE, Scragg JL, Pearson HA, Boyle JP. Hypoxia and neurodegeneration. Ann N Y Acad Sci . 2009; 1177:169–177.
  67. [76]76. Harris JJ, Jolivet R, Attwell D. Synaptic energy use and supply. Neuron . 2012;75(5):762–777.
  68. [77]77. Howarth C, Gleeson P, Attwell D. Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab . 2012;32(7):1222–1232.
  69. [78]78. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev . 1997;77(3):731–758.
  70. [79]79. Haddad GG, Jiang C. O2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol . 1993;40(3):277–318.
  71. [80]80. Martin RL, Lloyd HG, Cowan AI. The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci . 1994;17(6):251–257.
  72. [81]81. Kristián T, Siesjö BK. Calcium in ischemic cell death. Stroke . 1998; 29(3):705–718.
  73. [82]82. Xiong ZG, Zhu XM, Chu XP, et al. Neuroprotection in Ischemia: blocking calcium-permeable acid-sensing ion channels. Cell . 2004; 118(6):687–698.
  74. [85]85. Nathaniel TI, Otukonyong E, Abdellatif A, Soyinka JO. Effect of hypoxia on metabolic rate, core body temperature, and c-fos expression in the naked mole rat. Int J Dev Neurosci . 2012;30(6):539–544.
  75. [86]86. Shams I, Avivi A, Nevo E. Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A . 2004;101(26):9698–9703.
  76. [87]87. Shams I, Avivi A, Nevo E. Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses. Comp Biochem Physiol A Mol Integr Physiol . 2005;142(3):376–382.
  77. [88]88. Johansen K, Lykkeboe G, Weber RE, Maloiy GM. Blood respiratory properties in the naked mole rat Heterocephalus glaber, a mammal of low body temperature. Respir Physiol . 1976;28(3):303–314.
  78. [89]89. Goldman BD, Goldman SL, Lanz T, Magaurin A, Maurice A. Factors Influencing Metabolic Rate in Naked Mole-Rats (Heterocephalus glaber). Physiol Behav . 1999;66(3):447–459.
  79. [90]90. Mink JW, Blumenschine RJ, Adams DB. Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. Am J Physiol . 1981;241(3):R203–R212.
  80. [92]92. Buck LT, Pamenter ME. Adaptive responses of vertebrate neurons to anoxia-Matching supply to demand. Respir Physiol Neurobiol . 2006;154(1–2):226–240.
  81. [93]93. Hochachka PW, Buck LT, Doll CJ, Land SC. Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci U S A . 1996;93(18):9493–9498.
  82. [94]94. Wood SC. Interactions between hypoxia and hypothermia. Annu Rev Physiol . 1991;53:71–85.
  83. [95]95. Sakoh M, Gjedde A. Neuroprotection in hypothermia linked to redistribution of oxygen in brain. Am J Physiol Hear Circ Physiol . 2003;285(1):H17–H25.
  84. [96]96. Gordon CJ. The therapeutic potential of regulated hypothermia. Emerg Med J . 2001;18(2):81–89.
  85. [97]97. Nathaniel TI, Otukonyong EE, Okon M, Chaves J, Cochran T, Nathaniel AI. Metabolic regulatory clues from the naked mole rat: toward brain regulatory functions during stroke. Brain Res Bull . 2013;98:44–52.
  86. [98]98. Larson J, Park TJ. Extreme hypoxia tolerance of naked mole-rat brain. Neuroreport . 2009;20(18):1634–1637.
  87. [99]99. Nathaniel TI, Saras A, Umesiri FE, Olajuyigbe F. Tolerance to oxygen nutrient deprivation in hippocampal of naked mole-rats. J Integr Neurosci . 2009;8(2):123–136.
  88. [100]100. Peterson BL, Larson J, Buffenstein R, Park TJ, Fall CP. Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. PLoS One . 2012;7(2):e31568.
  89. [101]101. Bickler PE, Donohoe PH, Buck LT. Hypoxia-induced silencing of NMDA receptors in turtle neurons. J Neurosci . 2000;20(10):3522–3528.
  90. [102]102. Zhao HW, Ross AP, Christian SL, Buchholz JN, Dre. Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels. J Neurosci Res . 2006;84(2):291–298.
  91. [103]103. Band M, Malik A, Joel A, Avivi A. Hypoxia associated NMDA receptor 2 subunit composition: Developmental comparison between the hypoxia-tolerant subterranean mole-rat, Spalax, and the hypoxia-sensitive rat. J Comp Physiol B . 2012;182(7):961–969.
  92. [104]104. Wilkie MP, Pamenter ME, Alkabie S, Carapic D, Shin DS, Buck LT. Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus). Comp Biochem Physiol C Toxicol Pharmacol . 2008;148(4):355–362.
  93. [105]105. Ellefsen S, Sandvik GK, Larsen HK, et al. Expression of genes involved in excitatory neurotransmission in anoxic crucian carp (Carassius carassius) brain. Physiol Genomics . 2008;35(1):5–17.
  94. [106]106. Bickler PE, Fahlman CS, Taylor DM. Oxygen sensitivity of NMDA receptors: Relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons. Neuroscience . 2003;118(1):25–35.
  95. [107]107. Peterson BL, Park TJ, Larson J. Adult naked mole-rat brain retains the NMDA receptor subunit GluN2D associated with hypoxia tolerance in neonatal mammals. Neurosci Lett . 2012;506(2):342–345.
  96. [108]108. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell . 2009;139(2):267–284.
  97. [109]109. Smith ES, Lewin GR. Nociceptors: a phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol . 2009;195(12):1089–1106.
  98. [110]110. Dubin AE, Patapoutian A. Nociceptors: The sensors of the pain pathway. J Clin Invest . 2010;120(11):3760–3772.
  99. [112]112. Woolf CJ, Walters ET. Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia. Trends Neurosci . 1991;14(2):74–78.
  100. [113]113. Kavaliers M. Evolutionary and comparative aspects of nociception. Brain Res Bull . 1988;21(6):923–931.
  101. [114]114. Sneddon LU. Evolution of nociception in vertebrates: comparative analysis of lower vertebrates. Brain Res Brain Res Rev . 2004;46(2):123–130.
  102. [115]115. Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain . 2006;10(4):287–333.
  103. [116]116. Lewin GR, Moshourab R. Mechanosensation and pain. J Neurobiol . 2004;61(1):30–44.
  104. [117]117. Molliver DC, Radeke MJ, Feinstein SC, Snider WD. Presence or absence of TrkA protein distinguishes subsets of small sensory neurons with unique cytochemical characteristics and dorsal horn projections. J Comp Neurol . 1995;361(3):404–416.
  105. [118]118. St John Smith E, Purfürst B, Grigoryan T, Park TJ, Bennett NC, Lewin GR. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: Comparative analysis using six species of bathyergidae. J Comp Neurol . 2012;520(12):2785–2803.
  106. [119]119. Park TJ, Comer C, Carol A, Lu Y, Hong HS, Rice FL. Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain. J Comp Neurol . 2003;465(1):104–120.
  107. [120]120. Kanui TI, Hole K. Morphine induces aggression but not analgesia in the naked mole-rat (Heterocephalus glaber). Comp Biochem Physiol C . 1990;96(1):131–133.
  108. [121]121. Park TJ, Lu Y, Jüttner R, et al. Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). PLoS Biol . 2008;6(1):e13.
  109. [122]122. LaVinka PC, Brand A, Landau VJ, Wirtshafter D, Park TJ. Extreme tolerance to ammonia fumes in African naked mole-rats: Animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers. J Comp Physiol A Neuroethol Sens Neural Behav Physiol . 2009;195(5):419–427.
  110. [123]123. Smith ES, Blass GR, Lewin GR, Park TJ. Absence of histamine-induced itch in the African naked mole-rat and “rescue” by Substance P. Mol Pain . 2010;6:29.
  111. [124]124. Brand A, Smith ES, Lewin GR, Park TJ. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. PLoS One . 2010;5(12):e15162.
  112. [125]125. LaVinka PC, Park TJ. Blunted behavioral and c Fos responses to acidic fumes in the african naked mole-rat. PLoS One . 2012; 7(9):e45060.
  113. [126]126. Smith ES, Omerbašić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR. The molecular basis of acid insensitivity in the African naked mole-rat. Science . 2011;334(6062):1557–1560.
  114. [127]127. Liu Z, Wang W, Zhang T, et al. Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals. Proc Biol Sci . 2013;281(1776):20132950.
  115. [128]128. Christiansen J, Douglas CG, Haldane JS. The absorption and dissociation of carbon dioxide by human blood. J Physiol . 1914;48(4):244–271.
  116. [129]129. Wilson SG, Mogil JS. Measuring pain in the (knockout) mouse: big challenges in a small mammal. Behav Brain Res . 2001;125(1–2):65–73.
  117. [130]130. Towett PK, Kanui TI, Juma FD. Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber). Brain Res Bull . 2006;71(1–3):60–68.
  118. [131]131. Kanui TI, Karim F, Towett PK. The formalin test in the naked mole-rat (Heterocephalus glaber): Analgesic effects of morphine, nefopam and paracetamol. Brain Res . 1993;600(1):123–126.
  119. [132]132. Towett PK, Kanui TI, Maloiy GMO, Juma F, Olongida Ole Miaron J. Activation of mu, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). Pharmacol Biochem Behav . 2009;91(4):566–572.
  120. [133]133. Tang CM, Yu J. Hypoxia-inducible factor-1 as a therapeutic target in cancer. J Gastroenterol Hepatol . 2013;28(3):401–405.
  121. [134]134. Liu H, Le W. Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease. Transl Neurodegener . 2014;3(1):7.
  122. [135]135. Rodriguez KA, Wywial E, Perez VI, et al. Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des . 2011;17(22):2290–2307.
  123. [136]136. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation and cancer: How are they linked? Free Radic Biol Med . 2011;49(11):1603–1616.
  124. [138]138. Roellig K, Drews B, Goeritz F, Hildebrandt TB. The long gestation of the small naked mole-rat (Heterocephalus glaber) studied with ultrasound biomicroscopy and 3d-ultrasonography. PLoS One . 2011;6(3):e17744. Creative Commons License © 2015 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms and incorporate the Creative Commons Attribution - Non Commercial (unported, 3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Download Article [PDF] © Copyright 2026 • Dove Medical Press Ltd The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees. Dove Medical Press is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC Copyright 2026 Informa PLC. All rights reserved. This site is owned and operated by Informa PLC ( “Informa”) whose registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 3099067. UK VAT Group: GB 365 4626 36

Cited by

Sorted by citations

See all 26

Metadata

Authors
Smith, E. S. J., Schuhmacher, L.-N., & Husson, Z.
Venue
Open Access Animal Physiology
Publisher
Informa UK Limited
Published
2015-08
Pages
137
ISSN
1179-2779
DOI
10.2147/oaap.s50376
Cited by
26
References
7
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review