CoChat
Sign Up
Cited by 266Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 100 of the 104 references it cites were found in a registry or an index.

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

Traish, Abdulamaged M., Saad, Farid, Guay, Andre·2009·Journal of Andrology
DOI 10.2164/jandrol.108.005751
Open this paper in CoChat — free account

Abstract

ABSTRACT: A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR). Hypogonadal men are at higher risk for T2D. Here we evaluate the relationships between testosterone, metabolic syndrome (MetS), T2D, and IR and discuss the relationships among androgen deficiency and these factors, especially as it ultimately relates to the development of cardiovascular disease and erectile dysfunction (ED). Thus, a comprehensive literature search was carried out using PubMed, and relevant articles pertinent to androgen deficiency, T2D, IR, MetS, and ED were reviewed and discussed. Low testosterone precedes elevated fasting insulin, glucose, and hemoglobin A1c (HbA1C) values and may even predict the onset of diabetes. Treatment of prostate cancer patients with surgical or medical castration exacerbates IR and glycemic control, strengthening the link between testosterone deficiency and onset of T2D and IR. Androgen therapy of hypogonadal men improves insulin sensitivity, fasting glucose, and HbA1c levels. We suggest that androgen deficiency is associated with IR, T2D, MetS, and with increased deposition of visceral fat, which serves as an endocrine organ, producing inflammatory cytokines and thus promoting endothelial dysfunction and vascular disease.

Overview

Integrity signals

Registry

Crossref · 10.2164/jandrol.108.005751

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 104 references

Research works printed but not linked: 6

  1. 10.1210/en.140.11.4939 · DOI
  2. 10.1210/jc.82.6.1807 · DOI
  3. 10.1210/jc.84.10.3673 · DOI
  4. 10.1210/jc.81.3.1018 · DOI · Paper page
  5. 10.1210/jc.86.10.4913 · DOI
  6. 10.1210/jc.80.2.654 · DOI · Paper page

Cited by

Sorted by citations

See all 266

Related

Metadata

Authors
Traish, A. M., Saad, F., & Guay, A.
Affiliations
Gulf Medical University (AE)
ORCID
Saad, Farid
Venue
Journal of Andrology
Publisher
Wiley
Published
2009-01-02
Volume
30
Issue
1
Pages
23-32
ISSN
  • 0196-3635 (ISSN-L)
  • 1939-4640
DOI
10.2164/jandrol.108.005751
OpenAlex
W2070295872
Cited by
266
References
104
Citations by year
2026: 8 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 24 · 2015: 17 · 2014: 31 · 2013: 17 · 2012: 21
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1461 d)
Locations
  • Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
School of Medicine, Boston University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
androgen deficiency, hypogonadism, type 2 diabetes, insulin resistance, metabolic syndrome, erectile dysfunction, cardiovascular disease, castration, androgen therapy, visceral fat, endothelial dysfunction, inflammatory cytokines, glycemic control
MeSH terms
Diabetes Mellitus, Type 2, Humans, Hypogonadism, Erectile Dysfunction, Insulin Resistance, Male, Testosterone, Vascular Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review