Cited by 266Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsAdrenal Hormones and Disorders

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The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

Traish, Abdulamaged M., Saad, Farid, Guay, Andre·2009·Journal of Andrology

DOI 10.2164/jandrol.108.005751

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Abstract

ABSTRACT: A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR). Hypogonadal men are at higher risk for T2D. Here we evaluate the relationships between testosterone, metabolic syndrome (MetS), T2D, and IR and discuss the relationships among androgen deficiency and these factors, especially as it ultimately relates to the development of cardiovascular disease and erectile dysfunction (ED). Thus, a comprehensive literature search was carried out using PubMed, and relevant articles pertinent to androgen deficiency, T2D, IR, MetS, and ED were reviewed and discussed. Low testosterone precedes elevated fasting insulin, glucose, and hemoglobin A1c (HbA1C) values and may even predict the onset of diabetes. Treatment of prostate cancer patients with surgical or medical castration exacerbates IR and glycemic control, strengthening the link between testosterone deficiency and onset of T2D and IR. Androgen therapy of hypogonadal men improves insulin sensitivity, fasting glucose, and HbA1c levels. We suggest that androgen deficiency is associated with IR, T2D, MetS, and with increased deposition of visceral fat, which serves as an endocrine organ, producing inflammatory cytokines and thus promoting endothelial dysfunction and vascular disease.

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Research works printed but not linked: 6

10.1210/en.140.11.4939 · DOI
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10.1210/jc.81.3.1018 · DOI · Paper page
10.1210/jc.86.10.4913 · DOI
10.1210/jc.80.2.654 · DOI · Paper page

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Authors: Traish, A. M., Saad, F., & Guay, A.
Affiliations: Gulf Medical University (AE)
ORCID: Saad, Farid
Venue: Journal of Andrology
Publisher: Wiley
Published: 2009-01-02
Volume: 30
Issue: 1
Pages: 23-32
ISSN: 0196-3635 (ISSN-L)
1939-4640
DOI: 10.2164/jandrol.108.005751
OpenAlex: W2070295872
Cited by: 266
References: 104
Citations by year: 2026: 8 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 24 · 2015: 17 · 2014: 31 · 2013: 17 · 2012: 21
FWCI: 2.92
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1461 d)
Locations: Journal of Andrology (publishedVersion)
PubMed (publishedVersion)
Funders: School of Medicine, Boston University
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: androgen deficiency, hypogonadism, type 2 diabetes, insulin resistance, metabolic syndrome, erectile dysfunction, cardiovascular disease, castration, androgen therapy, visceral fat, endothelial dysfunction, inflammatory cytokines, glycemic control
MeSH terms: Diabetes Mellitus, Type 2, Humans, Hypogonadism, Erectile Dysfunction, Insulin Resistance, Male, Testosterone, Vascular Diseases

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The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

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