Sex Differences in Pharmacokinetics and Pharmacodynamics

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Goodman and Gilman's the Pharmacological Basis of Therapeutics

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High Blood Alcohol Levels in Women: The Role of Decreased Gastric Alcohol Dehydrogenase Activity and First-Pass Metabolism

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Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure

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Exploring the Biological Contributions to Human Health

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Gender Differences in Pharmacokinetics of Alcohol

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Sex Differences in Pharmacokinetics and Pharmacodynamics

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Olanzapine

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Effect of age and gender on the activity of human hepatic CYP3A

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Sex and body weight are major determinants of venlafaxine pharmacokinetics

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Editorial: Differences in Pain Biology, Perception, and Coping Strategies: Towards Sex and Gender Specific Treatments

Gazerani, P., Aloisi, A. M., & Ueda, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.697285 · Cited by 18

Sex-Related Differences in Pancreatic Ductal Adenocarcinoma Progression and Response to Therapy

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Sex-related differences in the efficacy and toxicity of cancer treatments

Santaballa, A., Rodríguez, J. A. M., Cardeña-Gutiérrez, A., Callejo, V. M., Higuera, O., Bernárdez, B., Moreno, E., & Majem, M. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03893-2 · Cited by 17

Clinical relevance and methodological approach for the assessment of drug–drug interactions in cancer patients: a position statement from the Italian Association of Medical Oncology (AIOM) and the Italian Society of Pharmacology (SIF)

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Impact of Gender Difference on Characteristics and Outcome of Chronic Hepatitis C

Saif-Al-Islam, M., Mohamed, H. S., Younis, M. A., Abdel-Hamid, M., Ali, M. M., & Khalaf, S. (2020) · Open Journal of Gastroenterology · doi:10.4236/ojgas.2020.1011027 · Cited by 17

Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men

Zamora, A., Ramos, R., Comas‐Cufí, M., García-Gil, M., Martí‐Lluch, R., Plana, N., Alves‐Cabratosa, L., Ponjoan, A., Rodríguez-Borjabad, C., Ibarretxe, D., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27963-z · Cited by 18

Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial

van Eijnatten, E. J. M., Roelofs, J. J. M., Camps, G., Huppertz, T., Lambers, T. T., & Smeets, P. A. M. (2024) · Food & Function · doi:10.1039/d3fo04063a · Cited by 17

Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation

Bertocchi, I., Cifarelli, L., Oberto, A., Eva, C. E., Sprengel, R., Mirza, N. R., & Muglia, P. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16361 · Cited by 17

CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches

Sun, M., Manson, M. L., Guo, T., & de Lange, E. C. M. (2024) · CNS Drugs · doi:10.1007/s40263-024-01082-3 · Cited by 18

Warm-up music and low-dose caffeine enhance the activity profile and psychophysiological responses during simulated combat in female taekwondo athletes

Delleli, S., Ouergui, I., Messaoudi, H., Bridge, C. A., Ardigò, L. P., & Chtourou, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-64880-1 · Cited by 17

Sex differences in biomarkers and biologic mechanisms in psoriatic diseases and spondyloarthritis

Dang, S., Wither, J., Jurišica, I., Chandran, V., & Eder, L. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103394 · Cited by 17

Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

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Gendered Agricultural Space and Safety: Towards Embodied, Situated Knowledge

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Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis

Alfares, I., Javaid, M. S., Chen, Z. Z., Anderson, A., Antonic‐Baker, A., & Kwan, P. (2021) · CNS Drugs · doi:10.1007/s40263-021-00794-0 · Cited by 17

Pharmacokinetics of rifampicin in Mexican patients with tuberculosis and healthy volunteers

Medellín‐Garibay, S. E., Milán‐Segovia, R. D. C., Magaña-Aquino, M., Portales‐Pérez, D. P., & Romano‐Moreno, S. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12275 · Cited by 17

The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions

Mulrenin, I. R., Garcia, J. E., Fashe, M. M., Loop, M. S., Daubert, M. A., Urrutia, R. P., & Lee, C. R. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.2002845 · Cited by 16

Se(XY) matters: the importance of incorporating sex in microphysiological models

Kouthouridis, S., Robson, E., Hartung, A., Raha, S., & Zhang, B. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.04.005 · Cited by 16

Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone

Toya, M., Kushioka, J., Shen, H., Utsunomiya, T., Hirata, H., Tsubosaka, M., Gao, Q., Chow, S. K., Zhang, N., & Goodman, S. B. (2024) · Bone and Joint Research · doi:10.1302/2046-3758.131.bjr-2023-0040.r3 · Cited by 16

Insights into Women’s Occupational Health and Safety: A Decade in Review of Primary Data Studies

Bolghanabadi, S., Haghighi, A., & Jahangiri, M. (2024) · Safety · doi:10.3390/safety10020047 · Cited by 16

Sex differences in text-mined possible adverse drug events associated with drugs for psychosis

Sørup, F. K. H., Eriksson, R., Westergaard, D., Hallas, J., Brunak, S., & Andersen, S. E. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120903466 · Cited by 16

Population pharmacokinetics of a posaconazole tablet formulation in transplant adult allogeneic stem cell recipients

Lorenzo, D. P., Rebollo, N., Sánchez‐Hernandez, J. G., Castañeda, A. Z., Vázquez-López, L., Otero, M. J., & Pérez‐Blanco, J. S. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106049 · Cited by 16

Effect of GLP-1R rs2254336 and rs3765467 polymorphisms on gastrointestinal adverse reactions in type 2 diabetes patients treated with liraglutide

Long, J., Liu, Y., Duan, Y., Li, Y., Yang, G., Ren, Z., Wei, T., & Liu, D. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-021-03225-7 · Cited by 20

Modulation of Secondary Cancer Risks from Radiation Exposure by Sex, Age and Gonadal Hormone Status: Progress, Opportunities and Challenges

Biegon, A. R., Cohen, S., & Franceschi, D. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050725 · Cited by 16

Sex differences in side effects of antiseizure medications in pediatric patients with epilepsy: A systematic review

Giuliano, L., Vecchio, C., Mastrangelo, V., Durante, V., Zambrelli, E., Cantalupo, G., Neve, A. L., Ermio, C., & Mostacci, B. (2022) · Seizure · doi:10.1016/j.seizure.2022.09.013 · Cited by 16

Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Allen, J. B., Ludtka, C., & James, B. D. (2023) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092222-030857 · Cited by 18

Geschlechterunterschiede in der Pharmakotherapie

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Why do we keep ignoring sex in kidney disease?

Jankowska, M., Soler, M. J., Stevens, K., & Torrá, R. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad183 · Cited by 17

Probiotic supplementation mitigates sex-dependent nociceptive changes and gut dysbiosis induced by prenatal opioid exposure

Singh, S., Abu, Y. F., Antoine, D., Gomez, D., Tao, J., Truitt, B., & Roy, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2464942 · Cited by 15

Sex and Gender in Randomized Controlled Trials of Adults Receiving Maintenance Dialysis: A Meta-epidemiologic Study

Collister, D., Pyne, L., Bhasin, A. A., Ahmed, S. B., Smyth, B. J., Herrington, W. G., Jardine, M., & Walsh, M. W. (2022) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2022.10.015 · Cited by 15

International Trends in Adverse Drug Event-Related Mortality from 2001 to 2019: An Analysis of the World Health Organization Mortality Database from 54 Countries

Koyama, T., Iinuma, S., Yamamoto, M., Niimura, T., Osaki, Y., Nishimura, S., Harada, K., Zamami, Y., & Hagiya, H. (2023) · Drug Safety · doi:10.1007/s40264-023-01387-0 · Cited by 15

Sex Differences in the Prognostic Role of Achieving Target Doses of Heart Failure Medications: Data from the Swedish Heart Failure Registry

Ferrari, A., Stolfo, D., Uijl, A., Orsini, N., Benson, L., Sinagra, G., Mol, P. G. M., de Vries, S. T., Dahlström, U., Rosano, G. M. C., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3272 · Cited by 15

The relationship between gender and pharmacology

Younes, S. (2024) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2024.100192 · Cited by 18

Leveraging In Silico and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan

Yang, K., González, D., Woodhead, J. L., Bhargava, P., & Ramanathan, M. K. (2025) · Clinical and Translational Science · doi:10.1111/cts.70272 · Cited by 16

Focusing a Gender Lens on Emergency Medicine Research: 2012 Update

McGregor, A. J., Greenberg, M. R., Safdar, B., Seigel, T. A., Hendrickson, R. G., Poznanski, S., Davenport, M., Miner, J. R., & Choo, E. K. (2013) · Academic Emergency Medicine · doi:10.1111/acem.12085 · Cited by 16

Interindividual and Intraindividual Variation of Methylphenidate Concentrations in Serum and Saliva of Patients With Attention-Deficit/Hyperactivity Disorder

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Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects

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The Impact of Age and Gender on Outcomes of Patients With Advanced Renal Cell Carcinoma Treated With Targeted Therapy

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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Mockeliūnas, L., Keutzer, L., Sturkenboom, M. G. G., Bolhuis, M. S., Hulskotte, L. M. G., Akkerman, O. W., & Simonsson, U. S. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040753 · Cited by 15

Differences in medication adherence by sex and organ type among adolescent and young adult solid organ transplant recipients

Vaisbourd, Y., Dahhou, M., Zhang, X., Sapir‐Pichhadze, R., Cardinal, H., Johnston, O., Blydt‐Hansen, T. D., Tibbles, L. A., Hamiwka, L. A., Urschel, S., et al. (2022) · Pediatric Transplantation · doi:10.1111/petr.14446 · Cited by 15

Review of the pharmacokinetics of nanodrugs

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Sex and gender-based analysis in pharmacy practice research: A scoping review

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Establishing an in vitro permeation model to predict the in vivo sex-related influence of PEG 400 on oral drug absorption

Mai, Y., Murdan, S., Awadi, M., & Basit, A. W. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.002 · Cited by 15

Psychopharmacology and Women

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Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder

Bui, T. A., O’Croinin, B. R., Dennett, L., Winship, I. R., & Greenshaw, A. J. (2025) · Microbiology · doi:10.1099/mic.0.001568 · Cited by 14

Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review

Juginović, A., Kekić, A., Aranza, I., Biloš, V., & Armanda, M. (2025) · Life · doi:10.3390/life15071023 · Cited by 14

Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Llopis‐Lorente, J., Baroudi, S., Koloskoff, K., Mora, M. T., Basset, M., Romero, L., Bénito, S., Dayan, F., Sáiz, J., & Trénor, B. (2023) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2023.107860 · Cited by 14

Comparison of maternal venous blood metabolomics collected as dried blood spots, dried blood microsamplers, and plasma for integrative environmental health research

Petrick, L. M., Guan, H., Page, G. P., Dolios, G., Niedzwiecki, M. M., Wright, R. O., & Wright, R. J. (2024) · Environment International · doi:10.1016/j.envint.2024.108663 · Cited by 14

Withdrawal of prenylamine: perspectives on pharmacological, clinical and regulatory outcomes following the first QT-related casualty

Shah, R. R., & Stonier, P. (2018) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098618780854 · Cited by 14

Descriptive Analysis of Dosing and Outcomes for Patients with Ibrutinib-Treated Relapsed or Refractory Chronic Lymphocytic Leukemia in a Canadian Centre

Uminski, K., Brown, K. R., Bucher, O., Hibbert, I., Dhaliwal, D. H. S., Johnston, J. B., Geirnaert, M., Dawe, D. E., & Banerji, V. (2019) · Current Oncology · doi:10.3747/co.26.4957 · Cited by 14

Gender Differences in Characteristics and Outcomes in Heart Failure Patients Referred for End-Stage Treatment

Fluschnik, N., Memenga, F., Kondziella, C., Goßling, A., Becher, P. M., Schrage, B., Schnabel, R. B., Bernadyn, J., Bremer, W., Grahn, H., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13567 · Cited by 14

Sex and Circadian Timing Modulate Oxaliplatin Hematological and Hematopoietic Toxicities

Dulong, S., de Souza, L. E. B., Machowiak, J., Peuteman, B., Duvallet, G., Boyenval, D., Roth, E., Asgarova, A., Chang, Y., Li, X., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112465 · Cited by 14

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment

Fu, J., Cuppen, B. V. J., Welsing, P. M. J., van Wietmarschen, H., Harms, A. C., Berger, R., Koval, S., Fritsch-Stork, R. D. E., Bijlsma, J. W. J., Hankemeier, T., et al. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0284-1 · Cited by 14

Association Between Nonvitamin K Antagonist Oral Anticoagulants or Warfarin and Liver Injury: A Cohort Study

Zhao, J., Blais, J. E., Chui, C. S. L., Suh, I.-H., Chen, E. Y. H., Seto, W., Mok, M. T. C., Yan, V. K. C., Lau, W. C. Y., Wong, I. C. K., et al. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000678 · Cited by 14

The Influence of Different Disease States on Rituximab Pharmacokinetics

Wang, X., Du, W., Zhang, X., & Li, P. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200719004035 · Cited by 14

The Effects of Sex on Pharmacogenetically Guided Drug Treatment

Mezzalira, S., & Toffoli, G. (2021) · Pharmacogenomics · doi:10.2217/pgs-2021-0088 · Cited by 14

Assessing City-Wide Pharmaceutical Emissions to Wastewater via Modelling and Passive Sampling

Zillien, C., Groenveld, T., Schut, O., Beeltje, H., Blanco-Ania, D., Posthuma, L., Roex, E., & Ragas, A. (2024) · Environment International · doi:10.1016/j.envint.2024.108524 · Cited by 13

Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview

Jia, Q., He, Q., Li, Y., Li, M., Lin, J., Tang, Z., Zhu, X., & Xiang, X. (2022) · Molecules · doi:10.3390/molecules27248670 · Cited by 13

The Safety Profiles of Two First-Generation NTRK Inhibitors: Analysis of Individual Case Safety Reports from the FDA Adverse Event Reporting System (FAERS) Database

Liguori, V., Gaio, M., Zinzi, A., Cagnotta, C., Riccardi, C., Docimo, G., & Capuano, A. (2023) · Biomedicines · doi:10.3390/biomedicines11092538 · Cited by 13

Is there a gender gap in clinical neurosciences? A cross-sectional analysis of female participation in academic neurology, neurosurgery, and psychiatry

Hakvoort, K., Conzen, C., Gutzmann, A., Losse, E. M., Tauber, S. C., Chechko, N., & Höllig, A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105458 · Cited by 13

Gender-specific linkages: frailty, polypharmacy, anti-cholinergic burden, and 5-year mortality risk—a real-world analysis

Chou, Y., Chen, Y.-M., Lin, C. S., Chen, J. P., Kuo, F.-H., Lin, C.-F., Chen, Y., & Lin, S. (2023) · PeerJ · doi:10.7717/peerj.16262 · Cited by 13

Sub-anesthetic dose of esketamine decreases postoperative opioid self-administration after spine surgery: a retrospective cohort analysis

Zheng, H., Zhang, P., Shi, S., Zhang, X., Cai, Q., & Gong, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-54617-5 · Cited by 13

Brief Report: Efficacy and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Females Living With HIV: An Integrated Analysis of 5 Trials

Orkin, C. M., Ajana, F., Kityo, C. M., Koenig, E., Natukunda, E., Gandhi‐Patel, B., Wang, H., Liu, Y., Wei, X., White, K., et al. (2021) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002789 · Cited by 13

Gender differences in Damp-Heat Syndrome: A review

Yuan, S., Wang, N., Wang, J.-L., Pan, J., Xue, X., Zhang, Y., & Ma, T. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112128 · Cited by 13

Real-World Safety of Sacubitril/Valsartan in Women and Men With Heart Failure and Reduced Ejection Fraction: A Meta-analysis

Nuechterlein, K., AlTurki, A., Ni, J., Martínez‐Sellés, M., Martens, P., Russo, V., Backelin, C. N., & Huynh, T. T. (2021) · CJC Open · doi:10.1016/j.cjco.2021.09.009 · Cited by 14

Analgesic use and the risk of renal cell carcinoma – Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study

Bruinsma, F., Jordan, S. J., Bassett, J. K., Severi, G., MacInnis, R. J., Walsh, J., Aitken, T., Jenkins, M. A., Carroll, R. P., Jefford, M., et al. (2021) · Cancer Epidemiology · doi:10.1016/j.canep.2021.102036 · Cited by 13

Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D

Chary, S., Amrein, K., Mahmoud, S. H., Lasky-Su, J. A., & Christopher, K. B. (2022) · Metabolites · doi:10.3390/metabo12030207 · Cited by 13

Dexamethasone exposure in normal‐weight and obese hospitalized COVID ‐19 patients: An observational exploratory trial

Abouir, K., Gosselin, P., Guerrier, S., Daali, Y., Desmeules, J. A., Grosgurin, O., Reny, J., Samer, C. F., Calmy, A., & Lorenzini, K. I. (2022) · Clinical and Translational Science · doi:10.1111/cts.13297 · Cited by 13

Sex Associated Differences in the Clinical Outcomes of Left Ventricular Assist Device Recipients: Insights from INTERMACS

Shetty, N., Parcha, V., Abdelmessih, P., Patel, N., Hasnie, A., Kalra, R., Pandey, A., Breathett, K. K., Morris, A., Arora, G., et al. (2023) · Circulation: Heart Failure · doi:10.1161/circheartfailure.122.010189 · Cited by 9

Body weight, gender and pregnancy affect enantiomer‐specific ketorolac pharmacokinetics

Välitalo, P. A. J., Kemppainen, H., Kulo, A., Smits, A., Calsteren, K. V., Olkkola, K. T., Hoon, J. N. J. M. D., Knibbe, C. A. J., & Allegaert, K. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13311 · Cited by 13

HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model

Tóth, K., Spencer, J. F., Ying, B., Tollefson, A. E., & Wold, W. S. M. (2017) · Viruses · doi:10.3390/v9060147 · Cited by 13

Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats

Chen, X. F., Song, D., Nakada, S., Qiu, J., Iwamoto, K., Chen, R. H., Lim, Y., Jusko, W. J., & Stonestreet, B. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200421123242 · Cited by 13

Gender medicine: Towards a gender-specific treatment of neuropsychiatric disorders

Biskup, E. M., Martínková, J., & Ferretti, M. T. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00029-1 · Cited by 13

Sex, Gender, and Cardiovascular Disease in Chronic Kidney Disease

Yi, T. W., & Levin, A. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.04.009 · Cited by 13

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage

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Gender differences in new hypoglycemic drug effects on renal outcomes: a systematic review

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