Sex Differences in Pharmacokinetics and Pharmacodynamics

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Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure

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Gender Differences in Pharmacokinetics of Alcohol

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Sex Differences in Pharmacokinetics and Pharmacodynamics

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Olanzapine

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Effect of age and gender on the activity of human hepatic CYP3A

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Sex differences in the prescription of antihypertensive medications in primary care patients: an observational study

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Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex

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Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT‐P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects

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Sex and Heart Failure Treatment Prescription and Adherence

Farrero, M., Bellumkonda, L., Otero, I. G., & Molina, B. D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.630141 · Cited by 12

Sex Differences in Characteristics and Outcomes in Elderly Heart Failure Patients With Preserved Ejection Fraction: A Post-hoc Analysis From TOPCAT

Sun, J., Tai, S., Guo, Y., Tang, L., Yang, H., Li, X., Xing, Z., Fu, L., & Zhou, S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.721850 · Cited by 11

Pharmacokinetic variation

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What have we learned so far from the sex/gender issue in heart failure? An overview of current evidence

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Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine

Calleja, S., Zubiaur, P., Ochoa, D., Villapalos‐García, G., Mejía-Abril, G. P., Soria‐Chacartegui, P., Navares‐Gómez, M., de Miguel, A., Román, M. C., Martín‐Vílchez, S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1110460 · Cited by 11

Medetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice

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Efficacy and Safety of High-Dose Chemotherapy with Treosulfan and Melphalan in Multiple Myeloma

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Implications of Sex Differences on the Treatment Effectiveness in Heart Failure with Reduced Ejection Fraction Related to Clinical Endpoints and Quality of Life

Aydin, D., Allach, Y., & Brugts, J. J. (2023) · Current Heart Failure Reports · doi:10.1007/s11897-023-00638-6 · Cited by 11

Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period

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Grand Challenge in Psychopharmacology: Setting Priorities to Shape a Bright Future

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Tissue Distribution and Gender-Specific Protein Expression of Cytochrome P450 in five Mouse Genotypes with a Background of FVB

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Intact Female Mice Acquire Trace Eyeblink Conditioning Faster than Male and Ovariectomized Female Mice

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Chronic Kidney Disease in the Transgender, Nonbinary, or Gender Diverse Person

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Sex bias and omission exists in Batten disease research: Systematic review of the use of animal disease models

McShane, A., & Mole, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166489 · Cited by 11

Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline

Zubiaur, P., Matas, M., Martín‐Vílchez, S., Soria‐Chacartegui, P., Villapalos‐García, G., Figueiredo-Tor, L., Calleja, S., Navares‐Gómez, M., de Miguel, A., Novalbos, J., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102001 · Cited by 11

From sexless to sexy: Why it is time for human genetics to consider and report analyses of sex

Powers, M. S., Smith, P. H., McKee, S. A., & Ehringer, M. A. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0136-8 · Cited by 11

Exploring the views of successful applicants for medical school about gender medicine using a gender-sensitive video assignment

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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Álvarez-Jiménez, R., Weerink, M. A. S., Hannivoort, L. N., Su, H., Struys, M. M. R. F., Loer, S. A., & Colin, P. J. (2021) · Anesthesiology · doi:10.1097/aln.0000000000004049 · Cited by 11

Small Extracellular Vesicles from Breast Cancer Cells Induce Cardiotoxicity

Osorio-Méndez, J. J., Gómez, L. A., Montoya-Ortiz, G., Novoa-Herrán, S. S., & Domínguez-Romero, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030945 · Cited by 10

Pulmonary nontuberculous mycobacterial infections among women with cystic fibrosis and non-cystic fibrosis bronchiectasis

Gross, J. E., Jones, M. C., Buige, A., Prevots, D. R., & Kasperbauer, S. H. (2025) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666251323181 · Cited by 11

Seasonal and temperature effect on serum lithium concentrations

Cheng, S., Buckley, N. A., Siu, W., Chiew, A. L., Vecellio, E., & Chan, B. S. H. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419889160 · Cited by 10

Treatment of depression: Are psychotropic drugs appropriately dosed in women and in the elderly? Dosages of psychotropic drugs by sex and age in routine clinical practice

Greil, W., de Bardeci, M., Seifert, J., Bernegger, X., Cattapan, K., Stassen, H. H., Wagner, A. L., Sieberer, M. G., Grohmann, R., & Toto, S. (2021) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2809 · Cited by 10

Nosocomial infections in female compared with male patients with decompensated liver cirrhosis

Griemsmann, M., Tergast, T. L., Simon, N., Kabbani, A., Manns, M. P., Wedemeyer, H. H., Cornberg, M., & Maasoumy, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-07084-9 · Cited by 10

Fetal glucocorticoid exposure leads to sex‐specific changes in drug‐transporter function at the blood‐brain barrier in juvenile guinea pigs

Eng, M. E., Bloise, E., & Matthews, S. G. (2022) · The FASEB Journal · doi:10.1096/fj.202101552rr · Cited by 10

Physiologically-Based Pharmacokinetic Modeling to Predict Methylphenidate Exposure Affected by Interplay Among Carboxylesterase 1 Pharmacogenetics, Drug-Drug Interactions, and Sex

Xiao, J., Shi, J., Thompson, B., Smith, D. E., Zhang, T., & Zhu, H. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.04.019 · Cited by 10

Why We Need Sex-Gender Medicine: The Striking Example of Type 2 Diabetes

Seghieri, G., Franconi, F., & Campesi, I. (2022) · Diabetology · doi:10.3390/diabetology3030034 · Cited by 10

Association between alcoholic beverage intake and hyperuricemia in Chinese adults: Findings from the China Health and Nutrition Survey

Wu, Y., & Shin, D. (2023) · Medicine · doi:10.1097/md.0000000000033861 · Cited by 10

Gender Effect on Clinical Profiles, Pharmacological Treatments and Prognosis in Patients Hospitalized for Heart Failure

Fazzini, L., Casati, M., Martis, A., Perra, F., Rubiolo, P., Deidda, M., Mercuro, G., & Dessalvi, C. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13030881 · Cited by 11

Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats

Chiang, Y., Berthold, E. C., Kuntz, M. A., Kanumuri, S. R. R., Senetra, A. S., Mukhopadhyay, S., Hampson, A. J., McCurdy, C. R., & Sharma, A. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00277 · Cited by 10

Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study

Choi, S. J., Oh, J. S., Hong, S., Lee, C., Yoo, B., & Kim, Y. (2019) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2018.407 · Cited by 10

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

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Phase 1 study of Z-Endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors

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Sex Differences in Cocaine Sensitization Vary by Mouse Strain

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Effects of co-treatment of Rauwolfia vomitoria and Gongronema latifolium on neurobehaviour and the neurohistology of the cerebral cortex in mice

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The efficacy and tolerability of paliperidone in mania of bipolar disorder: A preliminary meta-analysis.

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Distinct Alteration of Gene Expression Programs in the Small Intestine of Male and Female Mice in Response to Ablation of Intestinal Fabp Genes

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How does biological sex affect the physiological response to nanomaterials?

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Sex and gender differences in trauma victims presenting for treatment

Christiansen, D. M. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00043-7 · Cited by 9

Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner

Staley, H. A., Jernigan, J. E., Bolen, M. L., Titus, A. M., Neighbarger, N., Cole, C., Menees, K. B., Wallings, R. L., & Tansey, M. G. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03271-9 · Cited by 9

Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study

Baré, M., Lleal, M., Sevilla‐Sánchez, D., Roig, S. O., Herranz, S., Ferrández, O., Corral-Vázquez, C., Molist‐Brunet, N., Nazco, G. J., Martín‐González, C., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043639 · Cited by 9

Differences in pharmacologic and demographic factors in male and female patients with vascular dementia, Alzheimer's disease, and mixed vascular dementia

Stanley, M. C., Poupore, N. S., Knisely, K., Miller, A., Imeh‐Nathaniel, A., Roley, L. T., Nathaniel, S. I., Goodwin, R. L., & Nathaniel, T. I. (2023) · Frontiers in Dementia · doi:10.3389/frdem.2023.1137856 · Cited by 9

An original donor-dependent spheroid system for the prediction of idiosyncratic drug-induced liver injury risk

Cherradi, S., Taulet, N., & Duong, H. T. (2023) · In vitro models · doi:10.1007/s44164-023-00057-w · Cited by 9

Sex and gender differences in pain perception and management in clinical settings

Morgan, J., Magwood, K., Smith, J., Jenkins, M., McGregor, A. J., & Quesnelle, K. M. (2024) · All Life · doi:10.1080/26895293.2024.2367421 · Cited by 15

J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

Jin, R., Wang, M., Shukla, M., Lei, Y., An, D., Du, J., & Li, G. (2024) · Translational research · doi:10.1016/j.trsl.2024.08.007 · Cited by 9

Neurological manifestations of encephalitic alphaviruses, traumatic brain injuries, and organophosphorus nerve agent exposure

VanderGiessen, M., de Jager, C., Leighton, J., Xie, H., Theus, M. H., Johnson, E. A., & Kehn‐Hall, K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1514940 · Cited by 9

Sex differences in diagnosis and treatment of heart failure: toward precision medicine

Lee, S. Y., & Park, S. (2025) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2024.338 · Cited by 10

Are we ignoring sex differences in haematological malignancies? A call for improved reporting

Paltiel, O., Ratnasingam, S., & Lee, H. (2025) · British Journal of Haematology · doi:10.1111/bjh.20044 · Cited by 9

Acute and Subacute Oral Toxicity Assessment of Kinkeliba (Combretum micranthum G. Don) Ethanolic Extract in BALB/c Mice

Sall, I. M., Hașaș, A.-D., Amiali, M., Vodnar, D. C., Aziez, M., Semzenisi, E., Hodor, D., Pop, R., & Tăbăran, F. (2025) · Plants · doi:10.3390/plants14121776 · Cited by 11

Integrating gender medicine into modern healthcare: Progress and barriers

Artiles, R. F., Gebhard, C. E., & Gebhard, C. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70089 · Cited by 9

Sex differences in hepatic enzymes and transporters involved in pharmacokinetics

Behal, M., McCalla, Z., & Wang, X. (2025) · Liver Research · doi:10.1016/j.livres.2025.10.003 · Cited by 9

Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open‐Label Crossover Study in Healthy Volunteers

Febbraro, S., Shea, T., & Cravo, A. S. (2020) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.777 · Cited by 9

Development of a Physiologically Based Pharmacokinetic Model for Prediction of Ethanol Concentration-Time Profile in Different Organs

Sadighi, A., Leggio, L., & Akhlaghi, F. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa129 · Cited by 9

Hypokalaemia in patients treated with intravenous flucloxacillin: Incidence and risk factors

Leegwater, E., Westgeest, A. C., Schippers, E. F., Wilms, E. B., van Nieuwkoop, C., & Visser, L. E. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15236 · Cited by 9

Association between lower-level of environmental lead exposure and reactive and proactive aggression in youth: Sex differences

Glenn, A. L., Li, Y., & Liu, J. (2022) · Journal of Environmental Science and Health Part C · doi:10.1080/26896583.2022.2157183 · Cited by 9

Gender representation in drug development studies for diabetes mellitus. A systematic review

Herskind, A. E. J., & Nørgaard, B. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102815 · Cited by 9

Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial

Frey, M., Smigielski, L., Tini, E., Fekete, S., Fleischhaker, C., Wewetzer, C., Karwautz, A. F. K., Correll, C. U., Gerlach, M., Taurines, R., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092202 · Cited by 9

Strategies for Improving Enrollment of Diverse Populations with a Focus on Lipid-Lowering Clinical Trials

Ogungbe, O., Grant, J. K., Ayoola, A., Bansah, E. C., Miller, H., Plante, T. B., Sheikhattari, P., Commodore-Mensah, Y. Y., Turkson‐Ocran, R., Juraschek, S. P., et al. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01942-2 · Cited by 9

Sex and Age Differences in Geriatric Pharmacotherapy

Hilmer, S. N., & Rochon, P. A. (2023) · Public Policy & Aging Report · doi:10.1093/ppar/prad021 · Cited by 9

The use of artificial neural networks and decision trees: Implications for health-care research

Smith, S., & McConnell, S. (2024) · Open Computer Science · doi:10.1515/comp-2022-0279 · Cited by 10

Italian Association of Hospital Cardiologists Position Paper ‘Gender discrepancy: time to implement gender-based clinical management’

Lucà, F., Pavan, D., Gulizia, M. M., Manes, M. T., Abrignani, M. G., Benedetto, F. A., Bisceglia, I., Brigido, S., Caldarola, P., Calvanese, R., et al. (2024) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suae034 · Cited by 10

Population Pharmacokinetics of Trametinib and Impact of Nonadherence on Drug Exposure in Oncology Patients as Part of the Optimizing Oral Targeted Anticancer Therapies Study

Ravix, A., Bandiera, C., Cardoso, E., Lata-Pedreira, A., Chtioui, H., Decosterd, L. A., Wagner, D., Schneider, M. P., Csajka, C., & Guidi, M. (2024) · Cancers · doi:10.3390/cancers16122193 · Cited by 9

HIV infection in women: Do sex and gender matter?

Belden, K. A., & Squires, K. (2008) · Current Infectious Disease Reports · doi:10.1007/s11908-008-0067-y · Cited by 9

Therapeutic Drug Monitoring in Pregnant Patients

Johnson‐Davis, K. L., & Doyle, K. J. (2019) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000709 · Cited by 9

Mycophenolic Acid Trough Concentration and Dose Are Associated with Hematologic Abnormalities but Not Rejection in Kidney Transplant Recipients

Jung, H., Lee, S., Jeon, Y., Choi, J., Cho, J., Park, S.-H., Kim, Y.-L., Kim, H.-K., Huh, S., Won, D. I., et al. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e185 · Cited by 9

Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism

Mejía-Abril, G. P., Zubiaur, P., Navares‐Gómez, M., Villapalos‐García, G., Román, M. C., Ochoa, D., & Abad‐Santos, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.660639 · Cited by 9

Polypharmacy and Cardiovascular Diseases: Consideration for Older Adults and Women

Patel, S., Kumar, M., Beavers, C. J., Karamat, S., & Alenezi, F. A. M. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01055-1 · Cited by 9

Qu’est-ce que la psychologie évolutive ?

Elimari, N., & Lafargue, G. (2022) · L’Année psychologique · doi:10.3917/anpsy1.231.0173 · Cited by 10

Gender differences in randomised, controlled trials in intensive care units

Kristensen, M., Vestergaard, T. R., & Bülow, H. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12337 · Cited by 9

Chronic Organic Solvent Exposure Changes Visual Tracking in Men and Women

de Oliveira, A. R., Neto, A. D. A. C., de Medeiros, P. C. B., de Andrade, M. J. O., & dos Santos, N. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00666 · Cited by 9

Association between early life antibiotic use and childhood overweight and obesity: a narrative review

Partap, U., Allcock, S. H., Parker, E., Gurdasani, D., Young, E. H., & Sandhu, M. S. (2018) · Global Health · doi:10.1017/gheg.2018.16 · Cited by 9

Pharmacokinetics and Pharmacodynamics: The Role of Sex and Gender

Franconi, F., Sanna, M., Straface, E., Chessa, R., & Rosano, G. M. C. (2011) · Springer eBooks · doi:10.1007/978-0-85729-832-4_12 · Cited by 9

Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review

Lombrea, A., Romanescu, M., Jianu, N., Andor, M., Suciu, M., Man, D. E., Danciu, C., Dehelean, C. A., & Buda, V. (2023) · Pharmaceuticals · doi:10.3390/ph16060853 · Cited by 8

Sex Differences in Serious Adverse Events Reported Following Booster Doses of COVID-19 Vaccination in Thailand: A Countrywide Nested Unmatched Case-Control Study

Janekrongtham, C., Salazar, M., & Doungngern, P. (2023) · Vaccines · doi:10.3390/vaccines11121772 · Cited by 8

Contribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study

Guillot, J., Justice, A. C., Gordon, K. S., Skanderson, M., Pariente, A., Bezin, J., & Rentsch, C. T. (2024) · Journal of General Internal Medicine · doi:10.1007/s11606-024-08817-4 · Cited by 8

Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings

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