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Cited by 201Cardiovascular and exercise physiologyMuscle metabolism and nutritionSports Performance and Training

Metabolic Factors in Fatigue1

Sahlin, Kent·1992·Sports Medicine
DOI 10.2165/00007256-199213020-00005
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Abstract

The supply of energy is of fundamental importance for the ability to sustain exercise. The maximal duration of exercise is negatively related to the relative intensity both during dynamic and static exercise. Since exercise intensity is linearly related to the rate of energy utilisation this suggests that energetic deficiency plays a major role in the aetiology of muscle fatigue. Characteristic metabolic changes in the muscle are generally observed at fatigue--the pattern being different after short term exercise (lactate accumulation and phosphocreatine depletion) from after prolonged exercise at moderate intensity (glycogen depletion). A common metabolic denominator at fatigue during these and many other conditions is a reduced capacity to generate ATP and is expressed by an increased catabolism of the adenine nucleotide pool in the muscle fibre. Transient increases in ADP are suggested to occur during energetic deficiency and may be the cause of fatigue. Experimental evidence from human studies demonstrate that near maximal power output can be attained during acidotic conditions. Decreases in muscle pH is therefore unlikely to affect the contractile machinery by a direct effect. However, acidosis may interfere with the energy supply possibly by reducing the glycolytic rate, and could by this mechanism be related to muscle fatigue.

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  • Exercise above lactate threshold incurs a nonlinear increase in metabolic, respiratory, and perceptual stress and more rapid fatigue due to metabolic acidosis or accelerated muscle glycogen depletion.

    “Exercise above LT incurs a nonlinear increase in metabolic, respiratory, and perceptual stress and a more rapid fatigue development due to the effects of metabolic acidosis on contractile function or an accelerated depletion of muscle glycogen (Sahlin, 1992).”

    From Contemporary Nutrition Strategies to Optimize Performance in Distance Runners and Race Walkers (2019) · cites this paper as Sahlin, 1992

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Authors
Sahlin, K.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Sahlin, Kent
Venue
Sports Medicine
Publisher
Springer Science and Business Media LLC
Published
1992-02
Volume
13
Issue
2
Pages
99-107
ISSN
0112-1642 (ISSN-L)
DOI
10.2165/00007256-199213020-00005
OpenAlex
W2061685389
Cited by
201
References
40
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 13 · 2013: 12 · 2012: 5
FWCI
6.10
Type
journal article
Language
en
Open access
closed
Locations
  • Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
muscle fatigue, ATP production, adenine nucleotide metabolism, phosphocreatine depletion, glycogen depletion, lactate accumulation, muscle acidosis, exercise intensity, exercise duration, glycolysis
MeSH terms
Adenosine Diphosphate, Adenosine Triphosphate, AMP Deaminase, Fatigue, Humans, Inosine Monophosphate, Maximal Voluntary Ventilation, Muscle Contraction, Exercise

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