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Cited by 419Muscle metabolism and nutritionCardiovascular and exercise physiologySports Performance and Training

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Energy supply and muscle fatigue in humans

SAHLIN, K., TONKONOGI, M., SÖDERLUND, K.·1998·Acta Physiologica Scandinavica
DOI 10.1046/j.1365-201x.1998.0298f.x
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Abstract

Limitations in energy supply is a classical hypothesis of muscle fatigue. The present paper reviews the evidence available from human studies that energy deficiency is an important factor in fatigue. The maximal rate of energy expenditure determined in skinned fibres is close to the rate of adenosine triphosphate (ATP) utilisation observed in vivo and data suggest that performance during short bursts of exercise (<5 s duration) primarily is limited by other factors than energy supply (e.g. V max of myosine adenosine triphosphatase (ATPase), motor unit recruitment, engaged muscle mass). Within 10 s of exercise maximal power output decreases considerably and coincides with depletion of phosphocreatine. During recovery, maximal force and power output is restored with a similar time course as the resynthesis of phosphocreatine. Increases in muscle store of phosphocreatine through dietary supplementation with creatine increases performance during high‐intensity exercise. These findings support the hypothesis that energy supply limits performance during high‐intensity exercise. It is well documented that pre‐exercise muscle glycogen content is related to performance during moderate intensity exercise. Recent data indicates that the interfibre variation in phosphocreatine is large after prolonged exercise to fatigue and that some fibres are depleted to the same extent as after high‐intensity exercise. Despite relatively small decreases in ATP, the products of ATP hydrolysis (Pi and free ADP) may increase considerably. FreeADP calculated from the creatine kinase reaction increases 10‐fold both after high‐intensity exercise and after prolonged exercise to fatigue. It is suggested that local increases in ADP may reach inhibitory levels for the contraction process.

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Crossref · 10.1046/j.1365-201x.1998.0298f.x

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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  • Anaerobic glycogen breakdown to lactate and aerobic carbohydrate metabolism allow muscles to generate ATP at rates 3-4 times faster than aerobic carbohydrate combustion and roughly seven times faster than fatty acid metabolism.

    “In addition, anaerobic glycogen breakdown to lactate and aerobic carbohydrate metabolism allows muscles to generate ATP at rates 3–4 times faster than aerobic carbohydrate combustion and roughly seven times faster than fatty acid metabolism [6, 7].”

    From Carbohydrate Storage and Supplementation Strategies for Peak Performance in Cross-Country Skiing (2026) · cites this paper as [7]

  • Limitation in energy supply is a classical hypothesis of muscle fatigue; limitations in the energy-generating processes likely limit the rates of energy expenditure and hence performance.

    “Limitation in energy supply is a classical hypothesis of muscle fatigue; it seems likely that limitations in the energy-generating processes indeed limit the rates of energy expenditure and hence performance [26].”

    From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [26]

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Research works printed but not linked: 1

  1. Hultman E., 1983, Biochemistry of Exercise, 13, 63

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Metadata

Authors
SAHLIN, K., TONKONOGI, M., & SÖDERLUND, K.
Affiliations
  • Karolinska Institutet (SE)
  • Stockholm University (SE)
Corresponding author
SAHLIN, K.
ORCID
SÖDERLUND, K.
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1998-02
Volume
162
Issue
3
Pages
261-266
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1046/j.1365-201x.1998.0298f.x
OpenAlex
W2008500674
Semantic Scholar
99ee02505eb29266765d3f485f37b510aa392c9e
Cited by
419
References
43
Citations by year
2026: 6 · 2025: 9 · 2024: 13 · 2023: 17 · 2022: 27 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 29 · 2017: 9 · 2016: 23 · 2015: 18 · 2014: 24 · 2013: 16 · 2012: 17
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1433 d)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
muscle fatigue, energy supply, ATP consumption, phosphocreatine depletion, creatine supplementation, high-intensity exercise, muscle glycogen, creatine kinase, myosin ATPase, skinned muscle fibers, post-exercise recovery
MeSH terms
Energy Metabolism, Humans, Muscle, Skeletal, Muscle Fatigue

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