Prolonged Depletion of Antioxidant Capacity after Ultraendurance Exercise
Open accessAbstract
PURPOSE: The purpose of this study was to examine the short- and long-term (up to 1 month) effects of an ultraendurance running event on redox homeostasis. METHODS: Markers of oxidative stress and antioxidant capacity in peripheral blood were assessed after a single-stage 233-km (143 miles) running event. Samples were collected from nine men (mean±SD: age=46.1±5.3 yr, body mass index=24.9±2.3 kg·m⁻², maximal oxygen uptake=56.3±3.3 mL·kg⁻¹·min⁻¹). Peripheral blood mononuclear cells were assayed for nonspecific DNA damage (frank strand breaks) and damage to DNA caused specifically by oxidative stress (formamidopyrimidine DNA glycosylase-dependent damage). Protein carbonylation and lipid peroxidation were assessed in plasma. Reduced glutathione (GSH) was measured in whole blood. RESULTS: Peripheral blood mononuclear cell frank strand breaks were elevated above baseline at 24 h after the race (P<0.001). Formamidopyrimidine DNA glycosylase-dependent oxidative DNA damage was increased immediately after the race (P<0.05). Protein carbonylation remained elevated for 7 d after the race (P<0.04), whereas lipid peroxidation was increased for 24 h (P<0.05) and fell below baseline 28 d later (P<0.05). GSH, a measure of antioxidant capacity, also showed a biphasic response, increasing by one-third after the race (P<0.01) and falling to two-thirds of baseline levels 24 h later (P<0.001). GSH remained depleted to approximately one-third of prerace values 28 d after the race (P<0.01). CONCLUSIONS: Ultraendurance exercise causes oxidative stress, which persists for one calendar month depending on the specific biomarker examined. These results suggest that ultraendurance events are associated with a prolonged period of reduced protection against oxidative stress.
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- Authors
- TURNER, J. E., HODGES, N. J., BOSCH, J. A., & ALDRED, S.
- Affiliations
- University of Birmingham (GB)
- Heidelberg University (DE)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2011-09
- Volume
- 43
- Issue
- 9
- Pages
- 1770-1776
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2055548700
- Cited by
- 49
- References
- 37
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Pure (University of Bath) (publishedVersion, other-oa)
- The University of Bath Online Publications Store (The University of Bath) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- oxidative stress, antioxidant capacity, redox homeostasis, DNA damage, protein carbonylation, lipid peroxidation, reduced glutathione, peripheral blood mononuclear cells, long-term training effects
- MeSH terms
- Antioxidants, DNA Damage, Glutathione, Humans, Leukocytes, Mononuclear, Male, Oxidation-Reduction, Physical Endurance, Running, Lipid Peroxidation, Exercise, Oxidative Stress, DNA-Formamidopyrimidine Glycosylase, Protein Carbonylation
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