Cited by 131Treatment of Major DepressionSchizophrenia research and treatmentTryptophan and brain disorders

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

Minocycline: Therapeutic Potential in Psychiatry

Dean, Olivia M., Data-Franco, João, Giorlando, Francesco, Berk, Michael·2012·CNS Drugs

DOI 10.2165/11632000-000000000-00000

Open this paper in CoChat — free account

Abstract

Pharmacological interventions to treat psychiatric illness have previously focused on modifying dysfunctional neurotransmitter systems to improve symptoms. However, imperfect understanding of the aetiology of these heterogeneous syndromes has been associated with poor treatment outcomes for many individuals. Growing evidence suggests that oxidative stress, inflammation, changes in glutamatergic pathways and neurotrophins play important roles in many psychiatric illnesses including mood disorders, schizophrenia and addiction. These novel insights into pathophysiology allow new treatment targets to be explored. Minocycline is an antibiotic that can modulate glutamate-induced excitotoxicity, and has antioxidant, anti-inflammatory and neuroprotective effects. Given that these mechanisms overlap with the newly understood pathophysiological pathways, minocycline has potential as an adjunctive treatment in psychiatry. To date there have been promising clinical indications that minocycline may be a useful treatment in psychiatry, albeit from small trials most of which were not placebo controlled. Case reports of individuals with schizophrenia, psychotic symptoms and bipolar depression have shown serendipitous benefits of minocycline treatment on psychiatric symptoms. Minocycline has been trialled in open-label or small randomized controlled trials in psychiatry. Results vary, with findings supporting use in schizophrenia, but showing less benefit for nicotine dependence and obsessive-compulsive disorder. Given the limited data from rigorous clinical trials, further research is required. However, taken together, the current evidence suggests minocycline may be a promising novel therapy in psychiatry.

Integrity signals

Registry

Crossref · 10.2165/11632000-000000000-00000

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2
Kernt, M. (2010) · Clinical ophthalmology · doi:10.2147/opth.s11216 · Cited by 34
Retracted
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178
Self-citation
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069
Self-citation
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,060
Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894
The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity
Castrén, E., & Rantamäki, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20758 · Cited by 864
Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review
Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.024 · Cited by 858
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718
Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice
Chen, D., Endres, R. L., Erickson, C. A., Weis, K. F., McGregor, M. W., Kawaoka, Y., & Payne, L. G. (2000) · Nature Medicine · doi:10.1038/80538 · Cited by 547
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
Dean, O., Giorlando, F., & Berk, M. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100057 · Cited by 494
Self-citation
Oxidative stress in schizophrenia: An integrated approach
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.008 · Cited by 482
Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
Perera, T. D., Coplan, J. D., Lisanby, S. H., Lipira, C. M., Arif, M., Carpio, C., Spitzer, G., Santarelli, L., Scharf, B., Hen, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-07.2007 · Cited by 476
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458
Minocycline and Neurodegenerative Diseases
Kim, H.-S., & Suh, Y.-H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.040 · Cited by 447
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
Bocchio-Chiavetto, L., Bagnardi, V., Zanardini, R., Molteni, R., Gabriela Nielsen, M., Placentino, A., Giovannini, C., Rillosi, L., Ventriglia, M., Riva, M. A., et al. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003611319 · Cited by 435
Glutamate transmission in addiction
Kalivas, P. W., LaLumiere, R. T., Knackstedt, L. A., & Shen, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.011 · Cited by 410
A Double-Blind, Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Early-Phase Schizophrenia
Levkovitz, Y., Mendlovich, S., Riwkes, S., Braw, Y., Levkovitch-Verbin, H., Gal, G., Fennig, S., Treves, I., & Kron, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04666yel · Cited by 387
Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity
Kraus, R. L., Pasieczny, R., Lariosa-Willingham, K. D., Turner, M. S., Jiang, A., & Trauger, J. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03219.x · Cited by 322
Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia
Liu, Z., Yang, F., Won, S. J., Neumann, M., Hu, D., Zhou, L., Weinstein, P. R., & Liu, J. (2006) · Stroke · doi:10.1161/01.str.0000251791.64910.cd · Cited by 291
Minocycline as a Neuroprotective Agent
Stirling, D. P., Koochesfahani, K. M., Steeves, J. D., & Tetzlaff, W. (2005) · The Neuroscientist · doi:10.1177/1073858405275175 · Cited by 280
Lower serum vitamin E concentrations in major depression
Maes, M. H. J., Vos, N. D., Pioli, R., Demedts, P., Wauters, A., Neels, H. M., & Christophe, A. B. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00121-4 · Cited by 274
Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of 1H-MRS findings.
Luykx, J. J., Laban, K. G., van den Heuvel, M. P., Boks, M. P. M., Mandl, R. C. W., Kahn, R. S., & Bakker, S. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.05.014 · Cited by 235
Placebo-controlled trial of cytisine for smoking cessation
West, R., Zatonski, W., Cedzynska, M., Lewandowska, D., Pazik, J., Aveyard, P., & Stapleton, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102035 · Cited by 234
Minocycline for acne vulgaris: efficacy and safety
Garner, S. E., Eady, E. A., Bennett, C., Newton, J. N., Thomas, K., & Popescu, C. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002086.pub2 · Cited by 227
Safety of long-term high-dose minocycline in the treatment of acne
Goulden, V., GLASS, D., & Cunliffe, W. J. (1996) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1996.tb06972.x · Cited by 218
The Neurochemical Circuitry of Schizophrenia
Carlsson, A. (2006) · Pharmacopsychiatry · doi:10.1055/s-2006-931483 · Cited by 199
A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease
Ninds Net-Pd Investigators (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181342f32 · Cited by 174
Altered expression of neurotrophic factors in patients with major depression
Otsuki, K., Uchida, S., Watanuki, T., Wakabayashi, Y., Fujimoto, M., Matsubara, T., Funato, H., & Watanabe, Y. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.010 · Cited by 163
Cortical Bcl-2 protein expression and apoptotic regulation in schizophrenia
Jarskog, L. F., Gilmore, J. H., Selinger, E. S., & Lieberman, J. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00988-4 · Cited by 161
Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
Zhang, L., Kitaichi, K., Fujimoto, Y., Nakayama, H., Shimizu, E., Iyo, M., & Hashimoto, K. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.015 · Cited by 159
Blockade of Acute Microglial Activation by Minocycline Promotes Neuroprotection and Reduces Locomotor Hyperactivity after Closed Head Injury in Mice: A Twelve-Week Follow-Up Study
Homsi, S., Piaggio, T., Croci, N., Noble, F., Plotkine, M., Marchand-Leroux, C., & Jafarian-Tehrani, M. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1223 · Cited by 158
The role of glutamate on the action of antidepressants
Hashimoto, K. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.013 · Cited by 157
The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
Bian, Q., Kato, T. A., Monji, A., Hashioka, S., Mizoguchi, Y., Horikawa, H., & Kanba, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.031 · Cited by 155
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin
Gonçalves, J., Baptista, S., Martins, T., Milhazes, N., Borges, F., Ribeiro, C. F., Malva, J. O., & Silva, A. P. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07059.x · Cited by 152
Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study
Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.021 · Cited by 149 · cited 1×
“Treatment with antidepressants for example have been shown to reduce oxidative stress levels and inflammation, and increase neurotrophins and neurogenesis.([5,86,87]) There is evidence that some antidepressants normalize cytokine levels.”
Background
Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice
Homsi, S., Federico, F., Croci, N., Palmier, B., Plotkine, M., Marchand‐Leroux, C., & Jafarian-Tehrani, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.031 · Cited by 147
Minocycline attenuates the development of diabetic neuropathic pain: Possible anti-inflammatory and anti-oxidant mechanisms
Pabreja, K., Dua, K., Sharma, S., Padi, S. S. V., & Kulkarni, S. K. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.014 · Cited by 146
Minocycline as Adjunctive Therapy for Schizophrenia: An Open-Label Study
Miyaoka, T., Yasukawa, R., Yasuda, H., Hayashida, M., Inagaki, T., & Horiguchi, J. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181593d45 · Cited by 146
Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia
Ikeda, Y., Yahata, N., Ito, I., Nagano, M., Toyota, T., Yoshikawa, T., Okubo, Y., & Suzuki, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.017 · Cited by 143
Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression
Selley, M. L. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00135-6 · Cited by 139
Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage
Morimoto, N., Shimazawa, M., Yamashima, T., Nagai, H., & Hara, H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.062 · Cited by 137
Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor
Dhir, A., & Kulkarni, S. K. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.028 · Cited by 133
Altered expression of neurotrophic factors in patients with major depression
大朏, 孝. (2008) · Medical Entomology and Zoology · Cited by 128
Methamphetamine‐Induced Early Increase of IL‐6 and TNF‐α mRNA Expression in the Mouse Brain
Gonçalves, J., Martins, T., Ferreira, R., Milhazes, N., Borges, F., Ribeiro, C., Malva, J. O., Macedo, T. R. A., & Silva, A. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1432.043 · Cited by 120
A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE(S,R)-SULFOXIMINE.
Watanabe, T., Sagisaka, H., Arakawa, S., Shibaya, Y., Watanabe, M., Igarashi, I., Tanaka, K., Totsuka, S., Takasaki, W., & Manabe, S. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.455 · Cited by 113
Anti-inflammatory properties of Doxycycline and Minocycline in experimental models: an in vivo and in vitro comparative study
Leite, L. M., Carvalho, A. G. G., Ferreira, P. L. F. T., Pessoa, I. X., Gonçalves, D. O., Lopes, A. D. A., Góes, J. G. D. S., Castro‐Alves, V., Leal, L. K. A. M., Brito, G. A. D. C., et al. (2011) · Inflammopharmacology · doi:10.1007/s10787-011-0077-5 · Cited by 113
BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity
Rakofsky, J. J., Ressler, K. J., & Dunlop, B. W. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.121 · Cited by 112
Inhibitory Effects of Ketamine on Lipopolysaccharide-Induced Microglial Activation
Chang, Y. F., Lee, J.-J., Hsieh, C., Hsiao, G., Chou, D., & Sheu, J. (2009) · Mediators of Inflammation · doi:10.1155/2009/705379 · Cited by 108
Does minocycline have antidepressant effect?
Pae, C., Marks, D. M., Han, C., & Patkar, A. A. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.12.005 · Cited by 108
Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite
Schildknecht, S., Pape, R., Müller, N., Robotta, M., Marquardt, A., Bürkle, A., Drescher, M., & Leist, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169565 · Cited by 107
Possible antipsychotic effects of minocycline in patients with schizophrenia
Miyaoka, T., Yasukawa, R., YASUDA, H., Hayashida, M., Inagaki, T., & Horiguchi, J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.013 · Cited by 105
Minocycline Attenuates Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Administration of the NMDA Receptor Antagonist Dizocilpine
Zhang, L., Shirayama, Y., Iyo, M., & Hashimoto, K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301313 · Cited by 105
Serological observations in patients suffering from acute manic episodes
Wadee, A. A., Kuschke, R. H., Wood, L. A., Berk, M., Ichim, L., & Maes, M. H. J. (2002) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.390 · Cited by 104
Self-citation
Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells
Martínez, E. M. G., Sanz‐Blasco, S., Karachitos, A., Bández, M. J., Fernández-Gómez, F.-J., Perez‐Alvarez, S., de Mera, R. M. M.-F., Jordán, M. J., Aguirre, N., Galindo, M. F., et al. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.07.028 · Cited by 103
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline
Fujita, Y., Ishima, T., Kunitachi, S., Hagiwara, H., Zhang, L., Iyo, M., & Hashimoto, K. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.031 · Cited by 99
Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction
Tata, D. Α., & Yamamoto, B. K. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01770.x · Cited by 95
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide
Terrence Deak, B., Bellamy, C., D’Agostino, L. G., Rosanoff, M., McElderry, N. K., & Bordner, K. A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.024 · Cited by 82
Inhibitory action of minocycline on lipopolysaccharide-lnduced release of nitric oxide and prostaglandin E2 in BV2 microglial cells
Kim, S., Kong, P., Kim, B.-S., Sheen, D., Nam, S.-Y., & Chun, W. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980066 · Cited by 81
Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity
Ahuja, M., Bishnoi, M., & Chopra, K. (2007) · Toxicology · doi:10.1016/j.tox.2007.11.003 · Cited by 74
Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat
Kim, B. J., Kim, M., Park, J., Lee, S., Kim, Y. J., Ryu, S., Kim, Y. H., & Yoon, B. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.12.025 · Cited by 73
The platelet as a peripheral marker in psychiatric illness
Plein, H., & Berk, M. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.251 · Cited by 71
Self-citation
Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia‐induced changes in the expression of the potassium chloride co‐transporter 2 (KCC2) at the spinal cord
Morgado, C., Pereira‐Terra, P., Cruz, C. D., & Tavares, I. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01333.x · Cited by 70
Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans
Sofuoglu, M., Mooney, M. E., Kosten, T. R., Waters, A. J., & Hashimoto, K. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2014-5 · Cited by 70
Neuropeptide S produces hyperlocomotion and prevents oxidative stress damage in the mouse brain: A comparative study with amphetamine and diazepam
de Castro, A. A., Moretti, M., Casagrande, T. S., Martinello, C., Petronilho, F. C., Steckert, A. V., Guerrini, R., Calo’, G., Dal‐Pizzol, F., Quevedo, J., et al. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.10.015 · Cited by 68
The Specificity of Platelet Glutamate Receptor Supersensitivity in Psychotic Disorders
Berk, M., Plein, H., & Belsham, B. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)80002-8 · Cited by 66
Self-citation
BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments
Maeng, S., Hunsberger, J. G., Pearson, B. L., Yuan, P., Wang, Y., Wei, Y., McCammon, J., Schloesser, R. J., Zhou, R., Du, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803736105 · Cited by 65
The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats
Zhang, X., Xu, Y., Wang, J., Zhou, Q., Pu, S., Jiang, W., & Du, D. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0713-7 · Cited by 64
Platelet Glutamate Receptor Supersensitivity in Major Depressive Disorder
Berk, M., Plein, H., & Ferreira, D. (2001) · Clinical Neuropharmacology · doi:10.1097/00002826-200105000-00002 · Cited by 63
Self-citation
Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence
Camfield, D., Sarris, J. J., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.011 · Cited by 62
Self-citation
Complementary medicine, self-help, and lifestyle interventions for Obsessive Compulsive Disorder (OCD) and the OCD spectrum: A systematic review
Sarris, J., Camfield, D., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.051 · Cited by 59 · cited 1×
“Similarly, there have been amultitude of studies investigating other neutraceuticals, especially vitamins E andC in psychiatry.([93,94]) Recent evidence has suggested N-acetyl cysteine([95]) as a potential therapeutic in psychiatry and there is a rapidly growing field investigating anti-inflammatory medications for th…”
BackgroundSelf-citation
Possible antidepressant effect of minocycline
Levine, J., Cholestoy, A., & Zimmerman, J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.4.582b · Cited by 59
Minocycline Augmentation of Pharmacotherapy in Obsessive-Compulsive Disorder
Rodríguez, C. I., Bender, J., Marcus, S. M., Snape, M. F., Rynn, M. A., & Simpson, H. B. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09l05805blu · Cited by 56
Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats
Nie, H., Zhang, H., & Weng, H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.049 · Cited by 53
Serotonin-induced platelet intracellular calcium mobilization in various psychiatric disorders: is it specific to bipolar disorder?
Suzuki, K., Kusumi, I., Sasaki, Y., & Koyama, T. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00221-4 · Cited by 50
Antipsychotic Medication and Oxidative Cell Stress
Lepping, P., Delieu, J., Mellor, R., Williams, J. H. H., Hudson, P. R., & Hunter-Lavin, C. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09r05268yel · Cited by 49
Minocycline affects cocaine sensitization in mice
Chen, H., Uz, T., & Manev, H. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.078 · Cited by 49
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats
Molina-Hernández, M., Téllez-Alcántara, N. P., Pérez-García, J., Olivera-Lopez, J. I., & Jaramillo, M. T. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.06.010 · Cited by 46
Increased apoptosis and different regulation of pro-apoptosis protein bax and anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression
Yang, D., Liu, X., Zhang, R., Cheng, K., Mu, J., Fang, L., & Xie, P. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.046 · Cited by 45
Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms
Kelly, D. L., Vyas, G. R., Richardson, C. M., Koola, M. M., McMahon, R. P., Buchanan, R. W., & Wehring, H. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.08.005 · Cited by 44
A Study on the Mechanisms by Which Minocycline Protects Against MDMA (‘Ecstasy’)-Induced Neurotoxicity of 5-HT Cortical Neurons
Orío, L., Llopis, N., Torres, E., Izco, M., O’Shea, E., & Colado, M. I. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9120-3 · Cited by 42
Minocycline reduced craving for cigarettes but did not affect smoking or intravenous nicotine responses in humans
Sofuoglu, M., Waters, A. J., Mooney, M. E., & O’Malley, S. S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.11.004 · Cited by 37
Oxidative pathways as a drug target for the treatment of autism
Villagonzalo, K.-A., Dodd, S., Dean, O. M., Gray, K. M., Tonge, B. J., & Berk, M. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.528394 · Cited by 36
Self-citation
A case of methamphetamine use disorder treated with the antibiotic drug minocycline
Tanibuchi, Y., Shimagami, M., Fukami, G., Sekine, Y., Iyo, M., & Hashimoto, K. (2010) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.12.005 · Cited by 33
Anti-Inflammatory Drugs in Psychiatry
Berthold‐Losleben, M., Heitmann, S., & Himmerich, H. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809789352221 · Cited by 32
Antidepressant drugs and cytokines in mood disorders
Nishida, A., Hisaoka, K., Zensho, H., Uchitomi, Y., Morinobu, S., & Yamawaki, S. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00190-x · Cited by 31
Differential Regulation of Immediate-Early Gene Expression in the Prefrontal Cortex of Rats with a High vs Low Behavioral Response to Methamphetamine
Shilling, P. D., Kuczenski, R. T., Segal, D. S., Barrett, T. B., & Kelsoe, J. R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301162 · Cited by 29
Functional neuroimaging of minocycline's effect in a patient with schizophrenia
Chaves, C., de Marque, C. R., Wichert‐Ana, L., Maia‐de‐Oliveira, J. P., Itikawa, E. N., Crippa, J. A. S., Zuardi, A. W., Todd, K. G., Baker, G. B., Dursun, S. M., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.01.020 · Cited by 23
Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocycline
Zhong, J., & Lee, W. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.005 · Cited by 22
Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia
Bastos, L. F. S., de Oliveira, A. C. P., Schlachetzki, J. C. M., & Fiebich, B. L. (2011) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2010.544659 · Cited by 19
Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin
Tang, C.-M., Hwang, C., Chen, S., & Yang, D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.024 · Cited by 16
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice
Kumar, A., Garg, R., Gaur, V., & Kumar, P. (2011) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.81506 · Cited by 12
Dimensions of improvement in a clinical trial ofN-acetyl cysteine for bipolar disorder
Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00530.x · Cited by 7
Self-citation

Research works printed but not linked: 2

Garner, 2003, Cochrane Database Syst Rev, &NA;, CD002086
Levine, 1996, Am J Psychiatry, 153, 582

Sorted by citations

Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
Millan, M. J., Fone, K. C. F., Steckler, T., & Horan, W. P. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.008 · Cited by 376
Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies
Skvarc, D., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 318
Self-citation
Biomarkers and clinical staging in psychiatry
McGorry, P. D., Keshavan, M. S., Goldstone, S. D., Amminger, G. P., Allott, K., Berk, M., Lavoie, S., Pantelis, C., Yung, A. R., Wood, S. J., et al. (2014) · World Psychiatry · doi:10.1002/wps.20144 · Cited by 324
Self-citation
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252
Self-citation
Microglial activation and progressive brain changes in schizophrenia
Laskaris, L., Biase, M. A. D., Everall, I., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V., & Pantelis, C. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13364 · Cited by 237

See all 131

Authors: Dean, O. M., Data-Franco, J., Giorlando, F., & Berk, M.
Affiliations: Barwon Health (AU)
Mental Health Research Institute (AU)
The University of Melbourne (AU)
Corresponding author: Dean, Olivia M.
ORCID: Dean, Olivia M.
Giorlando, Francesco
Venue: CNS Drugs
Publisher: Springer Science and Business Media LLC
Published: 2012-05
Volume: 26
Issue: 5
Pages: 391-401
ISSN: 1172-7047 (ISSN-L)
DOI: 10.2165/11632000-000000000-00000
OpenAlex: W2159126784
Cited by: 131
References: 98
Citations by year: 2026: 5 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 13 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 18 · 2013: 19 · 2012: 4
FWCI: 12.12
Type: journal article
Language: en
Open access: closed
Locations: CNS Drugs (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: minocycline, adjunctive therapy, schizophrenia, bipolar depression, psychosis, nicotine dependence, obsessive-compulsive disorder, oxidative stress, neuroinflammation, glutamate excitotoxicity, neuroprotection, antioxidant activity, mood disorders, addiction
MeSH terms: Animals, Anti-Bacterial Agents, Mental Disorders, Humans, Inflammation, Minocycline, Nerve Growth Factors, Drug Delivery Systems, Oxidative Stress, Glutamic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Minocycline: Therapeutic Potential in Psychiatry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks