Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Open accessAbstract
Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.
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This latter class, of which artemisinin is a member, are typically bioactive and therefore potential targets for development as pharmaceuticals.
“This latter class, of which artemisinin is a member, are typically bioactive and therefore potential targets for development as pharmaceuticals (22).”
From <i>Artemisia annua</i> mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [22]
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Cites
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“The most common SLs in Artemisia species are guaianolides, eudesmanolides, and germacranolides.”
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MethodStructure-Activity Relationships of Sesquiterpene Lactones
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BackgroundInfluentialTetraploid Artemisia annua hairy roots produce more artemisinin than diploids
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New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives
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A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate
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“For some compounds, individual clinical cases were reported: artemether oral treatmentwas used in a patientwith pituitary macroadenoma [28], and artesunate was used in laryngeal squamous cell carcinoma [29] and metastatic uveal melanoma [30] with good results and lack of side effects.”
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“Moreover, in a mouse model of contact hypersensitivity, topical administration of artemisinin produced anti-inflammatory and immunomodulatory effects [47].”
BackgroundA comparative study of mist and bubble column reactors in the in vitro production of artemisinin
Kim, Y., Wyslouzil, B. E., & Weathers, P. J. (2001) · Plant Cell Reports · doi:10.1007/s002990100342 · Cited by 75 · cited 1× · see citing works
“An example is that of artemisinin extracted with toluene from the vegetal product in [134] and subjected to a process of alkaline hydrolysis at 50C for 45 minutes.”
MethodPeng, C. A., Ferreira, J., & Wood, A. J. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.043 · Cited by 74 · cited 4× · see citing works
“HPLC is the most commonly used technique for the quantification of artemisinin and its derivatives in plants, using detection methods like UV detection (HPLC-UV) or diode array detection (HPLC-DAD), mass spectrometry (HPLC-MS), HPLC/tandemmass spectrometry (LC/MS/MS), evaporative light scattering detector (HPLC-ELSD),…”
BackgroundMethodInfluentialNO inhibitory guaianolide-derived terpenoids from Artemisia argyi
Wang, S., Li, J., Sun, J. L., Zeng, K., Cui, J., Jiang, Y., & Tu, P. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.12.005 · Cited by 72 · cited 1× · see citing works
“The chloroform extract was repeatedly fractioned and the resulting subfractions were purified by semipreparative HPLC to afford artemisinin A and isoartemisolide [120].”
MethodLiu, C., Zhou, H.-Y., & Zhao, Y. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.08.038 · Cited by 69 · cited 3× · see citing works
“On the other hand, its sensitivity is lower than other detection methods, such as ECD and MS [113, 138, 139].”
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Noori, S., Naderi, G., Hassan, Z. M., Habibi, Z., Bathaie, S. Z., & Hashemi, S. M. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.05.003 · Cited by 65 · cited 1× · see citing works
“Both artemisinin and dihydroartemisinin suppress delayed hypersensitivity to sheep blood cells in mice, manifesting immunosuppressive action [49, 50].”
BackgroundReview : Role of mast cells in gastrointestinal mucosal defense
Penissi, A. B., Rudolph, M. I., & Piezzi, R. (2003) · Biocell · doi:10.32604/biocell.2003.27.163 · Cited by 62 · cited 1× · see citing works
“Thus, it is believed that stabilization of mast cells may be a key mechanism in the protection of gastrointestinal tract from injury [73, 74].”
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“25% ethanol as cosolvent to the supercritical fluid extraction with CO 2 , the artemisinin extraction yields were substantially improved [115, 116].”
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“This compound was diazo-coupled with the same diazonium Fast Red TR salt, producing a yellow colour in 5 minutes [132].”
BackgroundMethodAnti-Helicobacter pylori Potential of Artemisinin and Its Derivatives
Goswami, S., Bhakuni, R. S., Chinniah, A., Pal, A., Kar, S. K., & Das, P. K. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00407-12 · Cited by 61 · see citing works
Anti-tumor effects of dihydroartemisinin on human osteosarcoma
Ji, Y., Zhang, Y.-C., Pei, L., Shi, L., Yan, J., & Ma, X.-H. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0716-6 · Cited by 61 · cited 1× · see citing works
“The 𝛾-lactone ring, usually with an 𝛼-methylene group, is a significant characteristic of SLs.”
BackgroundLee, I., Ryu, D.-K., Lim, J., Cho, S., Kang, B. Y., & Choi, H. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.034 · Cited by 60 · cited 1× · see citing works
“Artesunate is therapeutically relevant to inflammatory responses of microglial cells [52] and inhibits production of interleukin IL-1β, IL-6, and IL-8 in human rheumatoid arthritis through NF-κB inhibition [53].”
BackgroundAnalysis of Artemisinin in Artemisia annua L. by LC-MS with Selected Ion Monitoring
Wang, M., Park, C., Wu, Q., & Simon, J. E. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051061p · Cited by 59 · see citing works
Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum
Ortet, R., Prado, S., Mouray, E., & Thomas, O. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.09.022 · Cited by 59 · cited 1× · see citing works
“The antimalarial activity may be attributed to the exomethylene group of the lactone function [81].”
BackgroundThomas, C. G., Ward, S. A., & Edwards, G. (1992) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(92)80355-t · Cited by 58 · cited 1× · see citing works
“Thus, it is necessary to have an intermediate step in which by treatment with acids or bases they are transformed into more reactive compounds, such as enolate/carboxylates or α,β-unsaturated decalones, and then reaction with certain reagents to form colored compounds or to bleach, depending on concentration [122, 127…”
BackgroundDimeric Guaianolides and Sesquiterpenoids from Artemisia anomala
Wen, J., Shi, H., Xu, Z., Chang, H., Jia, C., Zan, K., Jiang, Y., & Tu, P. (2009) · Journal of Natural Products · doi:10.1021/np900462u · Cited by 58 · cited 1× · see citing works
“Other anti-inflammatory sesquiterpene lactones mentioned in the literature are dimeric guaianolides from Artemisia anomala [67], and those isolated from Artemisia khorassanica Podl.”
BackgroundNaesens, L. M. J., Bonnafous, P., Agut, H., & Clercq, E. D. (2006) · Journal of Clinical Virology · doi:10.1016/s1386-6532(06)70015-4 · Cited by 57 · cited 1× · see citing works
“Another NF-𝜅B inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-𝜅B mediated reporter gene assay [56, 57].”
MethodShishan, Z., & Mei-Yi, Z. (1986) · Analytical Chemistry · doi:10.1021/ac00293a006 · Cited by 56 · cited 1× · see citing works
“Thus, it is necessary to have an intermediate step in which by treatment with acids or bases they are transformed into more reactive compounds, such as enolate/carboxylates or α,β-unsaturated decalones, and then reaction with certain reagents to form colored compounds or to bleach, depending on concentration [122, 127…”
BackgroundLee, S. H., Lee, M.-Y., Kang, H., Han, D. C., Son, K., Yang, D. C., Sung, N., Lee, C. W., Kim, H. M., & Kwon, B. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2003.08.008 · Cited by 56 · cited 1× · see citing works
“They inhibit tumor growth in mouse xenograft models and in human tumour xenograft [37].”
BackgroundZhu, X., Yang, L., Li, Y. J., Zhang, D., Chen, Y., Kostecká, P., Kmonı́èková, E., & Zídek, Z. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71016-8 · Cited by 55 · cited 3× · see citing works
“Arteannuin B also inhibited lipopolysaccharide- (LPS-) induced in vitro production of nitric oxide (NO) and secretion of cytokines (VEGF, IL-1b, IL-6, and TNF-α) [54].”
BackgroundMethodInfluentialHypoglycemic properties of some preparations and compounds from Artemisia ludoviciana Nutt
Anaya‐Eugenio, G. D., Rivero‐Cruz, I., Rivera‐Chávez, J., & Mata, R. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.05.051 · Cited by 53 · cited 1× · see citing works
“One of the compounds was the known guaianolide ludartin which manifested significant hypoglycemic effect on its own [103].”
BackgroundNoori, S., & Hassan, Z. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.026 · Cited by 53 · cited 1× · see citing works
“Tehranolide selectively inhibits proliferation of breast cancer cells through cell cycle arrest and apoptosis [43] and also modifies the immune responses and increases antitumor immunity [44].”
BackgroundLangroudi, L., Hassan, Z. M., Ebtekar, M., Mahdavi, M., Pakravan, N., & Noori, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.005 · Cited by 53 · cited 1× · see citing works
“Artemisinin diminishes the number of regulatory T cells in murine breast cancer model [51].”
BackgroundGravett, A. M., Liu, W. M., Krishna, S., Chan, W., Haynes, R. K., Wilson, N., & Dalgleish, A. G. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1355-4 · Cited by 52 · cited 1× · see citing works
“The antimalarial drug artemisinin and its derivatives are very potent anticancer compounds, highly selective on cancer cells with almost no side effects on normal cells and a broad spectrum of action: leukaemia, colon, melanoma, osteosarcoma, pancreas, breast, ovarian, prostate, hepatic, renal, central nervous system,…”
BackgroundMartínez, M. J. A., Bedoya, L. M., Ticona, L. A., & Bermejo, P. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-59514-0.00002-x · Cited by 51 · see citing works
Jia, Q.-Q., Wang, J., Long, J., Zhao, Y. D., Chen, S., Zhai, J., Wei, L.-B., Zhang, Q., Chen, Y., & Long, H. (2013) · Molecules · doi:10.3390/molecules181013061 · Cited by 50 · cited 1× · see citing works
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
MethodAntiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua
Foglio, M. A., Dias, P. C., Antônio, M. A., Possenti, A., Rodrigues, R. A. F., da Silva, É. F., Rehder, V. L. G., & de Carvalho, J. E. (2002) · Planta Medica · doi:10.1055/s-2002-32570 · Cited by 49 · cited 1× · see citing works
“Previous treatment with indomethacin, a cyclooxygenase inhibitor, blocked the antiulcerogenic activity of compounds on ethanol-induced ulcer, suggesting that the activity is the consequence of an increase in prostaglandin synthesis [76].”
BackgroundEffect of ultrasound on the extraction of artemisinin from Artemisia annua
Briars, R., & Paniwnyk, L. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.06.043 · Cited by 48 · cited 1× · see citing works
“After HPLC analysis it was observed that ultrasonic extraction at lower temperature is better than at a higher temperature, also improving the purity [110].”
BackgroundDetermination of Artemisinin in Artemisia annua L. by Reversed Phase HPLC
Qian, G., Yang, Y., & Ren, Q. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200048890 · Cited by 46 · see citing works
Vulgarone B, the Antifungal Constituent in the Steam-Distilled Fraction of Artemisia douglasiana
Meepagala, K. M., Kuhajek, J. M., Sturtz, G., & Wedge, D. E. (2003) · Journal of Chemical Ecology · doi:10.1023/a:1024842009802 · Cited by 45 · see citing works
Bhandari, P., Gupta, A. P., Singh, B., & Kaul, V. K. (2005) · Journal of Separation Science · doi:10.1002/jssc.200500198 · Cited by 45 · cited 1× · see citing works
“2% trifluoroacetic acid in water/acetonitrile (35 : 65, v/v), derivatization with anisaldehyde reagent in acidic medium, and densitometric determination at 426 nm in absorptionreflectance mode [144].”
MethodBrengio, S. D., Belmonte, S. A., Guerreiro, E., Giordano, Ó. S., Pietrobon, E. O., & Sosa, M. A. (2000) · Journal of Parasitology · doi:10.1645/0022-3395(2000)086[0407:tsldda]2.0.co;2 · Cited by 45 · cited 1× · see citing works
“After removing impurities by treatment with lead tetraacetate solution, the filtrate was extracted three times with chloroform and the resulting extract was chromatographed with ethyl acetate-hexane (1 : 9) to yield dehydroleucodine [71, 100].”
MethodHairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica
Mannan, A., Shaheen, N., Arshad, W., Qureshi, R. A., Zia, M., & Mirza, B. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i18.59272 · Cited by 41 · see citing works
Jiménez, V., Kemmerling, U., Paredes, R., Maya, J. D., Sosa, M. A., & Galanti, N. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.06.005 · Cited by 40 · cited 1× · see citing works
“Chagas disease or American Trypanosomiasis is caused by the flagellated protozoan parasite Trypanosoma cruzi and is one of the world’s neglected tropical diseases [83].”
BackgroundSusceptibility of Pneumocystis carinii to artemisinin in vitro
Merali, S., & Meshnick, S. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.6.1225 · Cited by 40 · cited 1× · see citing works
“Artemisinin and its derivatives showed antifungal properties against Pneumocystis carinii in vitro [89, 90].”
BackgroundLone, S. H., Bhat, K. A., Naseer, S., Rather, R. A., Khuroo, M. A., & Tasduq, S. A. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.09.027 · Cited by 40 · cited 1× · see citing works
“Yet, other factors can influence the potency of SLs: number of alkylating groups, lipophilicity, molecular geometry and size, chemical environment, other functional groups neighboring the 𝛼M𝛾L, and the target sulfhydryl [2, 5].”
BackgroundInhibitors of the LPS-induced NF-?B activation from
Jin, H. Z., Lee, J.-H., LEE, D., HONG, Y., KIM, Y., & LEE, J. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.06.034 · Cited by 39 · cited 2× · see citing works
“(iv )i nj ec tio n vo lu m e: 1μ L [1 58 ]”
BackgroundEmami, S. A., Rabe, S. Z. T., Iranshahi, M., Ahi, A., & Mahmoudi, M. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923971003677808 · Cited by 39 · cited 1× · see citing works
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
MethodYomogin, an inhibitor of nitric oxide production in LPS-activated macrophages
Ryu, J., Lee, H. J., Jeong, Y. S., Ryu, S. Y., & Han, Y. N. (1998) · Archives of Pharmacal Research · doi:10.1007/bf02974648 · Cited by 39 · see citing works
Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori
Vega, A. E., Wendel, G. H., María, A., & Pelzer, L. E. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.04.051 · Cited by 37 · cited 2× · see citing works
“As mentioned earlier, artemisinin and dehydroleucodine show strong antimicrobial activity againstHelicobacter pylori, the major cause of chronic gastritis and peptic ulcer [77, 78].”
BackgroundGuardia, T., Juárez, A., Guerreiro, E., Guzmán, J. A., & Pelzer, L. E. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00211-3 · Cited by 36 · cited 2× · see citing works
“The sesquiterpene lactone also inhibited inflammation in the granuloma test, probably by interfering with transcription factors, such as NF-κB and cytokines [59].”
BackgroundWang, Y., Huang, Z., Wang, C., Wang, L., Meng, S., Zhang, Y., Chen, T., & Fan, Y. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05454.x · Cited by 35 · cited 1× · see citing works
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
MethodReddy, A. M., Lee, J., Seo, J. H., Kim, B. H., Chung, E. Y., Ryu, S. Y., Kim, Y. S., Lee, C.-K., Min, K. R., & Kim, Y. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02969271 · Cited by 34 · cited 1× · see citing works
“Another NF-κB inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-κB mediated reporter gene assay [56, 57].”
MethodFerreira, J., Charles, D. J., Wood, K. V., Janick, J., & Simon, J. E. (1994) · Phytochemical Analysis · doi:10.1002/pca.2800050306 · Cited by 34 · see citing works
Noori, S., Taghikhani, M., Hassan, Z. M., Allameh, A., & Mostafaei, A. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.01.007 · Cited by 33 · cited 1× · see citing works
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
MethodDias, P. C., Foglio, M. A., Possenti, A., Nogueira, D. C. F., & de Carvalho, J. E. (2001) · Phytotherapy Research · doi:10.1002/ptr.758 · Cited by 33 · cited 1× · see citing works
“For the medium polarity fraction, it was demonstrated that the active compounds of Artemisia annua act by increasing the prostaglandin levels in the gastric mucosa [75].”
BackgroundChung, E. Y., Byun, Y. H., Shin, E. J., Chung, H. S., Lee, Y. H., & Shin, S. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-2208-8 · Cited by 32 · see citing works
Repetto, M. G., & Boveris, A. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791383992 · Cited by 31 · cited 1× · see citing works
“Sesquiterpene lactones of the guaianolide and eudesmanolide types are considered to be of interest in treatment of gastric and peptic ulcers because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage [70].”
BackgroundAlejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31 · cited 2× · see citing works
“In the case of MS analysis, generally using ESI positive ionisation mode, the pseudo-molecular ions are in the form [M + Na], [M + H], [2M + Na], [2M + K], and [M + NH4] [148, 152].”
MethodPreparation and Characterization of Solid Dispersions of Artemether by Freeze-Dried Method
Ansari, M. T., Hussain, A., Nadeem, S., Majeed, H., Saeed-ul-Hassan, S., Tariq, I., Mahmood, Q., Khan, A. K., & Murtaza, G. (2015) · BioMed Research International · doi:10.1155/2015/109563 · Cited by 30 · see citing works
Li, Q., Weina, P. J., & Milhous, W. K. (2007) · Current Drug Therapy · doi:10.2174/157488507781695649 · Cited by 30 · cited 1× · see citing works
“Some disadvantages of artemisinin, such as low solubility, short plasma half-life, and poor bioavailability [19], were surpassed by the semisynthetic or fully synthetic derivatives, such as artesunate, artemether, dihydroartemisinin, and artemisone.”
BackgroundArantes, F. F. P., Barbosa, L. C. A., Maltha, C. R. A., Demuner, A. J., Fidêncio, P. H., & Carneiro, J. W. D. M. (2011) · Journal of Chemometrics · doi:10.1002/cem.1385 · Cited by 30 · see citing works
In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb
Martins, A., Mignon, R., Bastos, M., Batista, D., Neng, N. R., Nogueira, J. M. F., Vizetto‐Duarte, C., Custódio, L. M. B., Varela, J. C. S., & Rauter, A. P. (2014) · Phytotherapy Research · doi:10.1002/ptr.5133 · Cited by 29 · see citing works
Natividad, G. M., Broadley, K. J., Kariuki, B. M., Kidd, E. J., Ford, W. R., & Simons, C. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.042 · Cited by 29 · cited 2× · see citing works
“Yomogin was separated through repeated recrystallization with methanol and its structure was confirmed by X-ray crystallography [62].”
BackgroundMethodLiu, S., Tian, N., Liu, Z., Huang, J., Li, J., & Ferreira, J. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.089 · Cited by 29 · see citing works
Artemisia annua L.: evidence of sesquiterpene lactones’ fraction antinociceptive activity
Favero, F. D. F., Grando, R., Nonato, F. R., Sousa, I. M. D. O., Queiroz, N. D. C. A., Longato, G. B., Zafred, R. R. T., de Carvalho, J. E., Spindola, H. M., & Foglio, M. A. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-266 · Cited by 28 · see citing works
A spectrophotometric assay for quantification of artemisinin
Bharati, A., & Sabat, S. C. (2010) · Talanta · doi:10.1016/j.talanta.2010.06.015 · Cited by 27 · cited 1× · see citing works
“The reaction is completed in 15 minutes and the reaction product is stable for 5 hours [123].”
BackgroundHighly Oxygenated Guaianolides fromArtemisia dubia
Huang, Z., Pei, Y., Liu, C.-M., Lin, S. H., Tang, J., Huang, D., Song, T.-F., Lu, L.-H., Gao, Y., & Zhang, W. (2010) · Planta Medica · doi:10.1055/s-0030-1249957 · Cited by 27 · cited 1× · see citing works
“Eight highly oxygenated guaianolides, named artemdubolides A–H, were isolated from Artemisia dubia and two of them manifested reduced cytotoxicity on human colon carcinoma Colo205 and human melanoma MDA-MB-435 cells in vitro [42].”
BackgroundCho, S.-H., Na, Y.-E., & Ahn, Y. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.01998.x · Cited by 27 · cited 1× · see citing works
“casei) and Escherichia coli [86].”
Quality of Artesunate Tablets Sold in Pharmacies in Kumasi, Ghana
Ofori-Kwakye, K., Asantewaa, Y., & Gaye, O. (2008) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v7i4.14704 · Cited by 27 · see citing works
Ryu, S., Oak, M.-H., & Kim, K.-M. (2000) · Planta Medica · doi:10.1055/s-0029-1243124 · Cited by 27 · cited 1× · see citing works
“7 cells by suppressing i-NOS enzyme expression [60] and blocks the degranulation ofmast cells by inhibiting the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner [61].”
BackgroundKim, B. H., Lee, J., Seo, J. H., Lee, H. Y., Ryu, S. Y., Ahn, B. W., Lee, C., Hwang, B. Y., Han, S., & Kim, Y. S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.069 · Cited by 25 · see citing works
ZENG, Y.-T., Jiang, J., Lao, H., Guo, J., LUN, Y.-N., & Yang, M. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3012 · Cited by 23 · cited 1× · see citing works
“The aerial parts of Artemisia amygdalina Decne produce significant amounts of ludartin, a highly cytotoxic guaianolide, also found in Artemisia indica [34].”
BackgroundKim, H. G., Yang, J. H., Han, E. H., Choi, J. H., Khanal, T., Jeong, M. H., Jeong, T. C., & Jeong, H. G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.02.017 · Cited by 23 · cited 1× · see citing works
“decreased PMA-induced COX-2 expression and PGE 2 production, as well as COX-2 promoter-driven luciferase activity in a dose-dependent manner [48].”
BackgroundDetermination of Artemisinin in Selected Artemisia L. Species of Turkey by Reversed Phase HPLC
Erdemolu, N., & Kartal, M. (2007) · Cited by 23 · see citing works
ANALYSIS OF ARTEMISININ ISOLATED FROM Artemisia Annua L. BY TLC AND HPLC
Ghafouri, H., Sariri, R., Naghavi, M. R., Aryakia, E., Dolatyari, A., Fazeli, S. A. S., Ramazani, H., & Farahmand, Z. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2012.685916 · Cited by 22 · cited 1× · see citing works
“It was observed that after derivatization the extinction coefficient increased 30–40 times [136].”
BackgroundReys, J. R. M., Lima, P., Cioletti, A. G., Ribeiro, A. S., DEABREU, F., Goulart, M. O. F., & Kubota, L. T. (2008) · Talanta · doi:10.1016/j.talanta.2008.07.043 · Cited by 21 · cited 1× · see citing works
“developed a feasible alternative method that uses an amperometric detector based on hemin adsorbed on silica gel modified for quantification of artemisinin [146].”
MethodHemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin
Lone, S. H., & Bhat, K. A. (2015) · Tetrahedron Letters · doi:10.1016/j.tetlet.2015.02.100 · Cited by 20 · cited 1× · see citing works
“Ludartin is a position isomer of arglabin and can be easily converted into clinically important antitumor arglabin [36].”
BackgroundQuantitative HPTLC Analysis of Artemisinin in Dried<i>Artemisia annua</i>L.: A Practical Approach
Widmer, V., Handloser, D., & Reich, E. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701451555 · Cited by 20 · cited 1× · see citing works
“developed an extract fromArtemisia annua leaves (obtained by sonication in toluene) on silica gel 60 plates with mobile phase cyclohexane : ethyl acetate : acetic acid (20 : 10 : 1), derivatization with anisaldehyde reagent in ethanol : water (10 : 8), heated at 100C, for 12 minutes, and densitometric evaluation of fl…”
MethodArtemisia scoparia – A new source of artemisinin
Singh, A., & Sarin, R. (2010) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v5i1.4901 · Cited by 20 · see citing works
Koobkokkruad, T., Chochai, A., Kerdmanee, C., & De‐Eknamkul, W. (2007) · Phytochemical Analysis · doi:10.1002/pca.976 · Cited by 19 · cited 1× · see citing works
“This is based on the transformation of artemisinin after treatment with ammonia vapors in a compound containing chromophore group, 10-azadesoxyartemisinin, detected by UV based TLC densitometry [143].”
MethodNoori, S., Hassan, Z. M., Taghikhani, M., Rezaei, B., & Habibi, Z. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.11.002 · Cited by 17 · cited 2× · see citing works
“Dihydroartemisinin also impaired growth of ductal carcinoma in mice and decreased the levels of interleukin IL-4 [50].”
Background[Extraction of artemisinin and synthesis of its derivates artesunate and artemether].
Chekem, L., & Wierucki, S. (2006) · PubMed · Cited by 16 · see citing works
Three new eudesmane sesquiterpenes from Artemisia vestita
Tian, S., Chai, X., Zan, K., Zeng, K., & Tu, P. (2013) · Chinese Chemical Letters · doi:10.1016/j.cclet.2013.05.020 · Cited by 16 · see citing works
Kim, S. H., & Kim, T. S. (2002) · Planta Medica · doi:10.1055/s-2002-34937 · Cited by 15 · cited 1× · see citing works
“So, these combinations can be used in therapy of myeloid leukemias [40].”
BackgroundInduction of Apoptosis by Yomogin in Human Promyelocytic Leukemic HL-60 Cells
Jeong, S.-H., Koo, S.-J., Ha, J., Ryu, S., Park, H.-J., & Lee, K. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.1106 · Cited by 15 · cited 1× · see citing works
“Moreover, yomogin induces apoptosis in human promyelocytic leukemia HL-60 cells through caspase-8 activation, Bid cleavage, and Bax translocation to mitochondria, followed by release of cytochrome c into the cytoplasm [41].”
BackgroundCytotoxic Components ofArtemisia princeps
Ryu, S. Y., Kim, J. S., & Choi, S. (1997) · Planta Medica · doi:10.1055/s-2006-957714 · Cited by 15 · cited 1× · see citing works
“Yomogin (Figure 1), a eudesmane sesquiterpene lactone isolated from Artemisia princeps, has been shown to inhibit tumor cell proliferation [39].”
BackgroundDehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
Priestap, H. A., Galvis, A., Rivero, N., Costantino, V., López, L. A., & Barbieri, M. A. (2012) · Phytochemistry Letters · doi:10.1016/j.phytol.2012.05.018 · Cited by 14 · cited 1× · see citing works
“The organic phase was evaporated to dryness and subjected to column chromatography, while monitoring the resulting fractions by TLC to give pure dehydroparishinB [101].”
MethodNoori, S., Taghikhani, M., Hassan, Z. M., Allameh, A., & Mostafaei, A. (2009) · PubMed · doi:10.22034/iji.2009.17095 · Cited by 14 · see citing works
Synthesis of Dihydroartemisinin using Ni/TiO 2 catalyst Prepared by Sol Gel Method
Kardon, L. B. S., Wikara, T., & Tursiloadi, S. (2014) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2014.40101 · Cited by 14 · see citing works
Miraldi, E., Ferri, S., & Franchi, G. G. (1998) · Phytochemical Analysis · doi:10.1002/(sici)1099-1565(199811/12)9:6 · Cited by 13 · see citing works
Ghafouri, H., Sariri, R., & Naghavi, M. R. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2013.803200 · Cited by 12 · see citing works
Arvestolides A–C, new rare sesquiterpenes from the aerial parts of Artemisia vestita
Tian, S., Chai, X., Zan, K., Zeng, K., Guo, X., Jiang, Y., & Tu, P. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.07.023 · Cited by 12 · cited 3× · see citing works
“1465 [151] and artemisinin m/z 305 [153], [M + H] in case of artecaninm/z 279.”
BackgroundShin, S. (2010) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.3839/jksabc.2010.108 · Cited by 12 · cited 1× · see citing works
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BackgroundQUANTIFICATION OF SANTONIN FROM ARTEMISIA PALLENS WALL BY HPTLC
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BackgroundGC-MS study and isolation of a sesquiterpene lactone from Artemisia pallens.
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“This latter class, of which artemisinin is a member, are typically bioactive and therefore potential targets for development as pharmaceuticals (22).”
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“The rte isia species are well known by its content of sesquiterpene lactones [40,41,43,50].”
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“Artemisia diffusa _ Maceration _ nhexane/ethyl acetate/methanol [1:1:1] Tehranolide _ [36]”
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“Some research revealed that Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent [11].”
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“α,β-unsaturated-structure bearing sesquiterpene lactones obtained from feverfew plant have lipophilic character which generally affects their potency [212,213].”
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“Terpenes, particularly sesquiterpene lactones, which are typical for Artemisia , are extremely diverse and plentiful and exhibit a wide range of therapeutic effects: anticancer, antimalarial, anti-inammatory, immunomodulatory, antiulcerogenic, antibacterial, antifungal and antiviral effects [21].”
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“Of these plants, the members of Asteraceae family, approximately 23,600 species, include different classes of sesquiterpenes that proved many applicable biological activities including the anti-inflammatory, antimicrobial, and anticancer effects, as they are important chemo-preventive agents rich in antioxidants [2,3].”
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“Usually, the reported mechanism of action of sesquiterpene lactones involves the presence of an α-methylene γ-lactone ring and an α, β unsaturated cyclopentanone ring [29].”
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“Remarkably, no severe side effects have been reported for this drug or its more water-soluble derivatives, such as artemeter, artesunate or artemisone [45,79].”
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“The rhizomes are rich in different phytoconstituents, mainly guaianolides sesquiterpene lactones [18,19].”
BackgroundAnti-Inflammatory Sesquiterpenoid Dimers from Artemisia Atrovirens
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“They are characterized by the presence of an α-methylene-γ-lactone functional group, which readily reacts with nucleophiles within cells [9].”
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“Sesquiterpene lactones constitute a group of plant secondary metabolites which could be further subdivided into structurally distinct groups including guaianolides [12].”
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Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
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“Previous phytochemical investigations of the plants from this genus reported that germacranolides possessing an α-methylene-γ-lactone group in the structure showed potent cytotoxic activity [12].”
BackgroundApproach of utilizing Artemisia herbs to treat covid-19
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“Additionally, the possibility of yomogin penetrating the BBB was supported by using the Boiled-Egg algorithm of Swiss ADME calculations.”
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“While multiple SL extraction, isolation, identification and quantification methods were developed (Ivanescu et al., 2015), a total of 16 guaianolide SL metabolites could be detected in leaf extracts of C.”
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Sesquiterpene Lactones with COX ‐2 Inhibition Activity from Artemisia lavandulaefolia
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“argyi, exhibit various biological and pharmaceutical activities, including anti-oxidant, anti-inflammatory and anti-apoptosis activities [15,22,23,28].”
BackgroundBăieș, M.-H., Gherman, C. M., Boros, Z., Olah, D. I., Vlase, A.-M., Cozma-Petruț, A. P., Györke, A., Miere, D., Vlase, L., Crișan, G., et al. (2022) · Pathogens · doi:10.3390/pathogens11091065 · Cited by 17 · see citing works
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“The wide range of biological activities exhibited by STLs is mainly attributed to the α-methylene-γ-lactone group present in their structure [4].”
BackgroundPhytochemical diversity and pharmacological effects of sesquiterpenes from Artemisia spp.
Rezaei, A., Emami, S. A., & Akaberi, M. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-09962-8 · Cited by 16 · see citing works
Selim, D. A., Shawky, E. M., Ghareeb, D. A., Abdulmalek, S. A., & El-Khair, R. M. A. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102306 · Cited by 14 · see citing works
“…dide-hydro, 4-ketone respectively, where the most prominent peaks corresponded to the protonated ions [M + H] + , loss of carboxylic acid from ester 58, followed by loss of water molecule from each corresponding lactone (Ivanescu, Miron, & Corciova, 2015) (Barbero & Prandi, 2018).”
BackgroundNatural sources and pharmacological properties of santalenes and santalols
Hachlafi, N. E., Benkhaira, N., Mssillou, I., Touhtouh, J., Aanniz, T., Chamkhi, I., Omari, N. E., Khalid, A., Abdalla, A. N., Aboulagras, S., et al. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118567 · Cited by 14 · see citing works
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“Artemisinin and its derivatives are sesquiterpene trioxanes [23] that have demonstrated efficacy against human parasitic infections such as malaria [24].”
BackgroundLatin American Natural Product Database (LANaPDB): An Update
Gómez‐García, A., Jiménez, D. A. A., Zamora, W. J., Barazorda-Ccahuana, H. L., Chávez‐Fumagalli, M. Á., Valli, M., Andricopulo, A. D., Bolzani, V. D. S., Olmedo, D. A., Solís, P. N., et al. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01560 · Cited by 20 · see citing works
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Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19
Manayi, A., Nabavi, S. M., Khayatkashani, M., Habtemariam, S., & Kashani, H. R. K. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06827-7 · Cited by 14 · see citing works
Tuasha, N., Escobar, Z., Seifu, D., Gadisa, E., Petros, B., Sterner, O., & Oredsson, S. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.02.011 · Cited by 16 · see citing works
“Studies involving structure-activity relationships indicate that rapid Michael type of addition takes place when cytotoxic SLs react with thiols, such as free sulfhydryl groups in mainly the amino acid cystine in proteins [17,21].”
BackgroundWang, Y., Ma, Y., Huang, X., Li, T.-Z., He, X.-F., Zhang, X., & Chen, J. (2022) · Fitoterapia · doi:10.1016/j.fitote.2022.105399 · Cited by 13 · see citing works
Băieș, M.-H., Cotuţiu, V.-D., Spînu, M., Mathe, A., Cozma-Petruț, A. P., Bolboaca, S. D., Engberg, R. M., Collin, A., & Cozma, V. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-03983-3 · Cited by 13 · see citing works
“Sesquiterpene lactones, such as artemisinin, dihydroartemisinin, ridentin, hanphyllin, dehydroleucodine, and santonin, constitute the most important molecules responsible for the antiparasitic activity of plants from the Artemisia genus [26–28].”
BackgroundGanash, A. A., & Alghamdi, R. A. (2021) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.202100348 · Cited by 13 · see citing works
Halophyte Artemisia caerulescens L.: Metabolites from In Vitro Shoots and Wild Plants
Pieracci, Y., Vento, M., Pistelli, L., Lombardi, T., & Pistelli, L. (2022) · Plants · doi:10.3390/plants11081081 · Cited by 12 · see citing works
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Li, Q., Liu, X., Zhang, X., Du, Y., Chen, G., Xiang, P., Ling, W., & Wang, D. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100905 · Cited by 11 · see citing works
Two new eudesmane sesquiterpene glucosides from the aerial parts of Artemisia vulgaris
Hạnh, T. T. H., Vinh, L. B., Cường, N. X., & Quang, T. H. (2022) · Natural Product Research · doi:10.1080/14786419.2022.2025591 · Cited by 11 · see citing works
“The (1)H and (13)C NMR data of 1 exhibited the characteristic resonance for an eudesmane-type sesquiterpene glycoside, one of main components reported from Artemisia species (Ivanescu et al. 2015).”
BackgroundHe, X., Ma, Y., Li, T.-Z., & Chen, J. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113930 · Cited by 11 · see citing works
Hajj, J. E., Karam, L., Jaber, A., Cheble, E., Akoury, E., Kobeissy, P. H., Ibrahim, J.-N., & Yassin, A. (2024) · Molecules · doi:10.3390/molecules29225431 · Cited by 11 · see citing works
Li, Y., Du, X., & Mao, J. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5766 · Cited by 11 · see citing works
“…annua , Artemisia atrovirens , Capillary artemisia , Artemisia mongolica and Artemisia nilagirica ) have been used as traditional medicines to treat a variety of diseases (145), such as malaria, dysmenorrhea, amenorrhea, hepatitis, inflam‑ mation, bruising, jaundice, bleeding and cancer (27,146).”
InfluentialGuaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages
Wang, Q., Zhang, T., Ke, C., Tang, C., Yao, S., Lin, L., & Ye, Y. (2021) · Phytochemistry · doi:10.1016/j.phytochem.2021.112955 · Cited by 11 · see citing works
Trifan, A., Czerwińska, M. E., Mardari, C., Zengin, G., Sinan, K. I., Korona‐Głowniak, I., Skalicka‐Woźniak, K., & Luca, S. V. (2022) · Plants · doi:10.3390/plants11212874 · Cited by 11 · see citing works
“Moreover, sesquiterpene lactones are acknowledged to act as anti-inflammatory and immunomodulatory effectors and their underlying mechanism relates to the inhibition of the NF-κB pathway [66].”
BackgroundSecondary metabolites from Ajania salicifolia and their chemotaxonomic significance
Shi, Z.-N., Wu, H., Pang, X., Chen, J., & Zhu, Y. (2016) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2016.11.012 · Cited by 11 · see citing works
“In the tribe Anthemideae, sesquiterpenoids were isolated from species in the genera Achillea (Saeidnia et al., 2011), Anthemis (Staneva et al., 2008), Artemisia (Ivanescu et al., 2015), Chrysanthemum (Kumar et al., 2005), and Tanacetum (Ivanescu et al., 2015).”
BackgroundRP-HPLC Method for the Determination and Quantification of Artesunate
Saeed, M. A., Ansari, M. T., Ahmad, B., & Zaman, M. (2020) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmaa037 · Cited by 11 · see citing works
Bioactive principles, antibacterial and anticancer properties of Artemisia arborescens L.
Sultana, S., Makeen, H. A., Alhazmi, H. A., Mohan, S., Bratty, M. A., Najmi, A., Homeida, H. E., Khuwaja, G., Ullah, S. N. M. N., Zafar, A., et al. (2023) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha51113008 · Cited by 10 · see citing works
Vu, Q. V., Sayama, S., Ando, M., & Kataoka, T. (2024) · Molecules · doi:10.3390/molecules29081866 · Cited by 10 · see citing works
“…including eudesmanolides (e.g., alantolactone) and germacranolides (e.g., parthenolide and costunolide) [19,20]. into several The biological activities of sesquiterpene lactones are mainly attributed to an α -methylene- γ -lactone moiety, which mainly reacts with the thiol groups of proteins [21].”
BackgroundCombating multidrug-resistant (MDR) Staphylococcus aureus infection using terpene and its derivative
Salikin, N. H., Keong, L. C., Azemin, W.-A., Philip, N., Yusuf, N., Daud, S. A., & Rashid, S. A. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-04190-w · Cited by 10 · see citing works
“Sesquiterpenes have demonstrated antimicrobial, anti-inflammatory, antitumor, analgesic, antifungal, antiparasitic, antiviral, and insect deterrent properties, rendering them an appealing reservoir of natural therapeutic metabolites (Ivanescu et al. 2015).”
Intakhan, N., Siriyasatien, P., & Chanmol, W. (2021) · Acta Tropica · doi:10.1016/j.actatropica.2021.106260 · Cited by 10 · see citing works
Abdalla, M. A., Famuyide, I. M., Wooding, M., McGaw, L. J., & Mühling, K. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112267 · Cited by 10 · see citing works
“Sesquiterpene lactones are well known for their anti-inflammatory, antimicrobial, anticancer, antiviral, immunomodulatory and anti-ulcer properties [15].”
BackgroundSainz, P., Cruz-Estrada, Á., Diaz, C. E., & González‐Coloma, A. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-017-9516-2 · Cited by 10 · see citing works
“In Artemisia species, the most common ones are guaianolides, eudesmanolides and germacranolides (Ivanescu et al. 2015) (Fig.”
BackgroundAntifungal Activity of the Sesquiterpene Lactones from Psephellus bellus
Nawrot, J., Adamski, Z., Kamińska-Kolat, B., Kubisiak-Rzepczyk, H., Kroma, A., Nowak, G., & Gornowicz‐Porowska, J. (2021) · Plants · doi:10.3390/plants10061180 · Cited by 10 · see citing works
“Moreover, reported data indicated [18] that the MIC is of little value without the corresponding ability to interpret its clinical meaning.”
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Indira, M., Suluvoy, J. K., Thathapudi, J. J., & Srirama, K. (2024) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-024-00556-z · Cited by 9 · see citing works
“Its potent anticancer affects are primarily due to the endoperoxide bond, which is activated by ferrous (Fe 2 + ) ions leading to cytotoxic activity [119].”
Mechanistic elucidations of sesquiterpenes ameliorating viral infections: A review
Katiyar, D., Bansal, P., Kumar, A., Prakash, S., & Rao, N. G. R. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14452 · Cited by 9 · see citing works
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“longipedunculata [9], sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent [10].”
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Sesquiterpenes from Artemisia princeps regulate inflammatory responses in RAW 264.7 macrophages
Kim, N. Y., Kim, S., Lee, H. J., & Ryu, J. (2022) · Natural Product Research · doi:10.1080/14786419.2022.2089881 · Cited by 8 · see citing works
“…were reported from Artemisia genus including A. kulbadica, A. glabella, A. macrocephala and A. tridentata, and they were reported to have anti-oxidant, anti-cancer, anti-nociceptive, immunomodulatory activities (Ezzatzadeh et al. 2012; Turi et al. 2014; Ivanescu et al. 2015; Shoaib et al. 2017).”
Backgroundla Pava, L. D. A.-D., González‐Cortazar, M., Zamilpa, A., Cuéllar-Ordaz, J. A., de la Crúz-Crúz, H. A., Higuera-Piedrahita, R. I., & López‐Arellano, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305155 · Cited by 8 · see citing works
- Authors
- Ivanescu, B., Miron, A., & Corciova, A.
- Affiliations
- Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
- ORCID
- Miron, Anca
- Venue
- Journal of Analytical Methods in Chemistry
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-21
- ISSN
- 2090-8865 (ISSN-L)
- 2090-8873
- PMC
- PMC4606394
- OpenAlex
- W1950362769
- Cited by
- 201
- References
- 156
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 34 · 2023: 19 · 2022: 34 · 2021: 21 · 2020: 19 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 4
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Analytical Methods in Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Social Fund (POSDRU/159/1.5/S/136893)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Keywords
- sesquiterpene lactones, Artemisia, eudesmanolides, guaianolides, germacranolides, α-methylene-γ-lactones, biological activity, natural product identification, quantification, extraction and separation, thermolabile compounds, Michael addition
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