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Cited by 101Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersEsophageal Cancer Research and Treatment

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Food and Gastroesophageal Reflux Disease

Surdea-Blaga, Teodora, Negrutiu, Dana E., Palage, Mariana, Dumitrascu, Dan L.·2019·Current Medicinal Chemistry
DOI 10.2174/0929867324666170515123807
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Abstract

Gastroesophageal reflux disease is a chronic condition with a high prevalence in western countries. Transient lower esophageal sphincter relaxation episodes and a decreased lower esophageal sphincter pressure are the main mechanisms involved. Currently used drugs are efficient on reflux symptoms, but only as long as they are administered, because they do not modify the reflux barrier. Certain nutrients or foods are generally considered to increase the frequency of gastroesophageal reflux symptoms, therefore physicians recommend changes in diet and some patients avoid bothering foods. This review summarizes current knowledge regarding food and gastroesophageal reflux. For example, fat intake increases the perception of reflux symptoms. Regular coffee and chocolate induce gastroesophageal reflux and increase the lower esophageal exposure to acid. Spicy foods might induce heartburn, but the exact mechanism is not known. Beer and wine induce gastroesophageal reflux, mainly in the first hour after intake. For other foods, like fried food or carbonated beverages data on gastroesophageal reflux is scarce. Similarly, there are few data about the type of diet and gastroesophageal reflux. Mediterranean diet and a very low carbohydrate diet protect against reflux. Regarding diet-related practices, consistent data showed that a “short-meal-to-sleep interval” favors reflux episodes, therefore some authors recommend that dinner should be at least four hours before bedtime. All these recommendations should consider patient’s weight, because several meta-analyses showed a positive association between increased body mass index and gastroesophageal reflux disease.

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Crossref · 10.2174/0929867324666170515123807

Cites

94 of 94 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 94 references

Research works printed but not linked: 2

  1. Khan M.; Santana J.; Donnellan C.; Preston C.; Moayyedi P.; Medical treatments in the short term management of reflux oesophagitis. Cochrane Database Syst Rev 2007(2)
  2. Yancy W.S.; Provenzale D.; Westman E.C.; Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports. Altern Ther Health Med 2001,7(6),120-116-119

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Metadata

Authors
Surdea-Blaga, T., Negrutiu, D. E., Palage, M., & Dumitrascu, D. L.
Affiliations
  • 2nd Dept. of Internal Medicine, ‘Iuliu Hatieganu' University of Medicine and Farmacy, Cluj-Napoca, Romania
  • Iuliu Hațieganu University of Medicine and Pharmacy (RO)
Corresponding author
Dumitrascu, Dan L.
ORCID
Venue
Current Medicinal Chemistry
Publisher
Bentham Science Publishers Ltd.
Published
2019-09-12
Volume
26
Issue
19
Pages
3497-3511
ISSN
0929-8673 (ISSN-L)
DOI
10.2174/0929867324666170515123807
OpenAlex
W2615285755
Cited by
101
References
94
Citations by year
2026: 4 · 2025: 17 · 2024: 14 · 2023: 11 · 2022: 14 · 2021: 14 · 2020: 16 · 2019: 5
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
gastroesophageal reflux disease, dietary factors, lower esophageal sphincter relaxation, lower esophageal sphincter pressure, dietary fat intake, coffee, chocolate, spicy food, alcohol, fried foods, soft drinks, Mediterranean diet, low-carbohydrate diet, body mass index, reflux symptoms
MeSH terms
Beverages, Eating, Food, Gastroesophageal Reflux, Humans, Obesity, Body Mass Index

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.