The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Roles of Antimicrobial Peptides in Innate Host Defense
Open accessAbstract
Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological role in vivo has been proposed to be the elimination of pathogenic microorganisms, including Gram-positive and -negative bacteria, fungi, and viruses. Genes encoding these peptides are expressed in a variety of cells in the host, including circulating phagocytic cells and mucosal epithelial cells, demonstrating a wide range of utility in the innate immune system. Expression of these genes is tightly regulated; they are induced by pathogens and cytokines as part of the host defense response, and they can be suppressed by bacterial virulence factors and environmental factors which can lead to increased susceptibility to infection. New research has also cast light on alternative functionalities, including immunomodulatory activities, which are related to their unique structural characteristics. These peptides represent not only an important component of innate host defense against microbial colonization and a link between innate and adaptive immunity, but also form a foundation for the development of new therapeutic agents.
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Cites
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Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
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Cited by
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides
Browne, K., Chakraborty, S., Chen, R., Willcox, M. D., Black, D. S., Walsh, W. R., & Kumar, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197047 · Cited by 482
Antimicrobial Peptides: Primeval Molecules or Future Drugs?
Peters, B. M., Shirtliff, M. E., & Jabra-Rizk, M. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001067 · Cited by 425
Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens
Cheng, H.-Y., Ning, M.-X., Chen, D.-K., & Ma, W.-T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00607 · Cited by 244
3D Immunocompetent Organ‐on‐a‐Chip Models
Maharjan, S., Cecen, B., & Zhang, Y. S. (2020) · Small Methods · doi:10.1002/smtd.202000235 · Cited by 62
Biofilm‐induced profiles of immune response gene expression by oral epithelial cells
Ebersole, J. L., Peyyala, R., & Gonzalez, O. A. (2019) · Molecular Oral Microbiology · doi:10.1111/omi.12251 · Cited by 39
Metadata
- Authors
- Diamond, G., Beckloff, N., Weinberg, A., & Kisich, K.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-07-01
- Volume
- 15
- Issue
- 21
- Pages
- 2377-2392
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2147574532
- Cited by
- 642
- References
- 18
- FWCI
- 22.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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