Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Role of the microbiota in immunity and inflammation.

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The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Inflammasomes: mechanism of action, role in disease, and therapeutics

Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works

Role of the normal gut microbiota

Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001 · see citing works

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works

Mechanism and Regulation of NLRP3 Inflammasome Activation

He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759 · see citing works

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614 · see citing works

IL-10: The Master Regulator of Immunity to Infection

Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,236 · see citing works

Microbial tryptophan catabolites in health and disease

Roager, H. M., & Licht, T. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05470-4 · Cited by 2,236 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,910 · see citing works

The healthy human microbiome

Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0307-y · Cited by 1,891 · see citing works

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1703 · Cited by 1,834 · see citing works

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.

Iyer, S. S., & Cheng, G. (2012) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v32.i1.30 · Cited by 1,611 · see citing works

Understanding the mechanism of IL-1β secretion

Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309 · see citing works

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288 · see citing works

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113 · see citing works

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., et al. (2012) · Science · doi:10.1126/science.1221789 · Cited by 1,073 · see citing works

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060 · see citing works

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019 · see citing works

Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.048 · Cited by 960 · see citing works

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 959 · see citing works

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926 · see citing works

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2187 · Cited by 777 · see citing works

Roles of intestinal epithelial cells in the maintenance of gut homeostasis

Okumura, R., & Takeda, K. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.20 · Cited by 712 · see citing works

Gut microbiota‐derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages

Krishnan, S., Ding, Y., Saedi, N., Choi, M., Sridharan, G. V., Sherr, D. H., Yarmush, M. L., Alaniz, R. C., Jayaraman, A., & Lee, K. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.109 · Cited by 679 · see citing works

The Roles of Antimicrobial Peptides in Innate Host Defense

Diamond, G., Beckloff, N., Weinberg, A., & Kisich, K. O. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682325 · Cited by 643 · see citing works

Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome

Natividad, J. M., Agus, A., Planchais, J., Lamas, B., Jarry, A. C., Martin, R., Michel, M.-L., Chong-Nguyen, C., Roussel, R., Straube, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.001 · Cited by 642 · see citing works

The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works

Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.

O′Neil, D. A., Porter, E. M., Elewaut, D. S., Anderson, G. M., Eckmann, L., Ganz, T., & Kagnoff, M. F. (1999) · PubMed · Cited by 596 · see citing works

Nod2 is required for the regulation of commensal microbiota in the intestine

Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564 · see citing works

Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101387 · Cited by 548 · see citing works

Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis

Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works

Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium

O′Neil, D. A., Porter, E. M., Elewaut, D. S., Anderson, G. M., Eckmann, L., Ganz, T., & Kagnoff, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6718 · Cited by 522 · see citing works

NOD1 and NOD2 signalling links ER stress with inflammation

Keestra, A. M., Byndloss, M. X., Seyffert, N., Young, B. M., Chávez‐Arroyo, A., Tsai, A. Y., Cevallos, S. A., Winter, M. G., Pham, O., Tiffany, C. R., et al. (2016) · Nature · doi:10.1038/nature17631 · Cited by 519 · see citing works

The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome

Gevers, D., Knight, R., Petrosino, J. F., Huang, K., McGuire, A. L., Birren, B. W., Nelson, K. E., White, O., Methé, B. A., & Huttenhower, C. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001377 · Cited by 493 · see citing works

γδ T cells in homeostasis and host defence of epithelial barrier tissues

Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479 · see citing works

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium

Wehkamp, J., Harder, J., Wehkamp, K., Meissner, B. W.-V., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5750-5758.2004 · Cited by 471 · see citing works

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446 · see citing works

A functional role for NLRP6 in intestinal inflammation and tumorigenesis

Chen, G. Y., Liu, M., Wang, F., Bertin, J., & Núñez, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100412 · Cited by 436 · see citing works

Quantitative imaging of gut microbiota spatial organization

Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., & Sonnenburg, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.002 · Cited by 433 · see citing works

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

Knodler, L. A., Crowley, S. M., Sham, H. P., Yang, H., Wrande, M., Ma, C., Ernst, R. K., Steele‐Mortimer, O., Celli, J., & Vallance, B. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.07.002 · Cited by 430 · see citing works

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

Rauch, I., Deets, K. A., Ji, D. X., von Moltke, J., Tenthorey, J. L., Lee, A. Y., Philip, N. H., Ayres, J. S., Brodsky, I. E., Gronert, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.016 · Cited by 403 · see citing works

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

Chen, K. W., Groß, C. J., Sotomayor, F. V., Stacey, K. J., Tschopp, J., Sweet, M. J., & Schroder, K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.028 · Cited by 400 · see citing works

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., & Hooper, L. V. (2017) · Science · doi:10.1126/science.aal4677 · Cited by 396 · see citing works

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

Franchi, L., Kamada, N., Nakamura, Y., Burberry, A., Kuffa, P., Suzuki, S., Shaw, M. H., Kim, Y., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2263 · Cited by 394 · see citing works

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

Larsson, E., Tremaroli, V., Lee, Y. S., Koren, O., Nookaew, I., Fricker, A. D., Nielsen, J., Ley, R. E., & Bäckhed, F. (2011) · Gut · doi:10.1136/gutjnl-2011-301104 · Cited by 386 · see citing works

Maintenance of intestinal homeostasis by mucosal barriers

Okumura, R., & Takeda, K. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0063-z · Cited by 368 · see citing works

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

Franchi, L., Kanneganti, T.-D., Dubyak, G. R., & Núñez, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610762200 · Cited by 356 · see citing works

The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

Lim, M. Y., You, H. J., Yoon, H. S., Kwon, B., Lee, J. Y., Lee, S., Song, Y., Lee, K., Sung, J., & Ko, G. (2016) · Gut · doi:10.1136/gutjnl-2015-311326 · Cited by 340 · see citing works

A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi∥, T., Roers, A., Yagita∥, H., Ohteki, T., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.013 · Cited by 331 · see citing works

No Vacancy: How Beneficial Microbes Cooperate with Immunity To Provide Colonization Resistance to Pathogens

Sassone‐Corsi, M., & Raffatellu, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403169 · Cited by 330 · see citing works

Antimicrobial Defense of the Intestine

Mukherjee, S., & Hooper, L. V. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.028 · Cited by 320 · see citing works

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

Seo, S.-U., Kamada, N., Muñoz-Planillo, R., Kim, Y.-G., Kim, D., Koizumi, Y., Hasegawa, M., Himpsl, S. D., Browne, H. P., Lawley, T. D., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.004 · Cited by 318 · see citing works

Induction of Human β-Defensin 2 by the ProbioticEscherichia coliNissle 1917 Is Mediated through Flagellin

Schlee, M., Wehkamp, J., Altenhoefer, A., Oelschlaeger, T. A., Stange, E. F., & Fellermann, K. (2007) · Infection and Immunity · doi:10.1128/iai.01563-06 · Cited by 315 · see citing works

ATP release and purinergic signaling in NLRP3 inflammasome activation

Gombault, A., Baron, L., & Couillin, I. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00414 · Cited by 308 · see citing works

The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system

Heiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304 · see citing works

γδ intraepithelial lymphocytes are essential mediators of host–microbial homeostasis at the intestinal mucosal surface

Ismail, A. S., Severson, K. M., Vaishnava, S., Behrendt, C. L., Yu, X., Benjamin, J. L., Ruhn, K. A., Hou, B., DeFranco, A. L., Yarovinsky, F., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019574108 · Cited by 302 · see citing works

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

Devlin, A. S., Marcobal, A. M., Dodd, D., Nayfach, S., Plummer, N. S., Meyer, T., Pollard, K. S., Sonnenburg, J. L., & Fischbach, M. A. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.10.021 · Cited by 300 · see citing works

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma

Chi, W., Li, F., Chen, H., Wang, Y., Zhu, Y., Yang, X., Zhu, J., Wu, F., Ouyang, H. W., Ge, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402819111 · Cited by 298 · see citing works

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Kaushal, V, Dye, R., Pakavathkumar, P., Foveau, B., Flores, J., Hyman, B., Ghetti, B., Koller, B. H., & LeBlanc, A. C. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.16 · Cited by 297 · see citing works

Cutting Edge: <i>Candida albicans</i> Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L., & Sutterwala, F. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901323 · Cited by 296 · see citing works

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Behnsen, J., Jellbauer, S., Wong, C. P., Edwards, R. A., George, M. D., Ouyang, W., & Raffatellu, M. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.003 · Cited by 279 · see citing works

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

Ramanan, D., Tang, M. S., Bowcutt, R., Loke, P., & Cadwell, K. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.015 · Cited by 269 · see citing works

Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

Brough, D., & Rothwell, N. J. (2007) · Journal of Cell Science · doi:10.1242/jcs.03377 · Cited by 265 · see citing works

Regulation of Homeostasis and Inflammation in the Intestine

MacDonald, T. T., Monteleone, I., Fantini, M. C., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.047 · Cited by 262 · see citing works

Role of the Inflammasome, IL-1 β , and IL-18 in Bacterial Infections

Sahoo, M., Ceballos‐Olvera, I., del Barrio, L., & Re, F. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/212680 · Cited by 258 · see citing works

Potential role of the intestinal microbiota in programming health and disease: Figure 1

Goulet, O. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv039 · Cited by 254 · see citing works

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

Harrison, O. J., Srinivasan, N., Pott, J., Schiering, C., Krausgruber, T., Ilott, N. E., & Maloy, K. J. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.13 · Cited by 244 · see citing works

Bacterial Flagellin Stimulates Toll‐Like Receptor 5–Dependent Defense against Vancomycin‐Resistant <i>Enterococcus</i> Infection

Kinnebrew, M. A., Ubeda, C., Zenewicz, L. A., Smith, N., Flavell, R. A., & Pamer, E. G. (2010) · The Journal of Infectious Diseases · doi:10.1086/650203 · Cited by 236 · see citing works

Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

Cyktor, J. C., & Turner, J. (2011) · Infection and Immunity · doi:10.1128/iai.00047-11 · Cited by 227 · see citing works

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

Franceschini, A., Capece, M., Chiozzi, P., Falzoni, S., Sanz, J. M., Sarti, A. C., Bonora, M., Pinton, P., & Di Virgilio, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-268714 · Cited by 225 · see citing works

Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells

Duan, J., Chung, H., Troy, E. B., & Kasper, D. L. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.01.005 · Cited by 224 · see citing works

The intestinal microbiota: its role in health and disease

Biedermann, L., & Rogler, G. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-014-2476-2 · Cited by 214 · see citing works

The intestinal microbiota and its role in human health and disease

Kataoka, K. (2016) · The Journal of Medical Investigation · doi:10.2152/jmi.63.27 · Cited by 214 · see citing works

Regulation of Intestinal Epithelial Cells Properties and Functions by Amino Acids

Kong, S., Zhang, Y. H., & Zhang, W. (2018) · BioMed Research International · doi:10.1155/2018/2819154 · Cited by 211 · see citing works

Cytokines IL-17 and IL-22 in the host response to infection

Valeri, M., & Raffatellu, M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw111 · Cited by 202 · see citing works

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

Su, D., Nie, Y., Zhu, A., Chen, Z., Wu, P., Zhang, L., Luo, M., Sun, Q., Cai, L., Lai, Y.-C., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00498 · Cited by 197 · see citing works

Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals

Lüthold, R. V., Fernandes, G. D. R., de Moraes, A. C. F., Folchetti, L. G. D., & Ferreira, S. R. G. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.007 · Cited by 195 · see citing works

P2X7 receptor regulation of non-classical secretion from immune effector cells

Dubyak, G. (2012) · Cellular Microbiology · doi:10.1111/cmi.12001 · Cited by 189 · see citing works

The interplay between host immune cells and gut microbiota in chronic inflammatory diseases

Kim, D.-H., Zeng, M. Y., & Núñez, G. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.24 · Cited by 184 · see citing works

Paneth cells: their role in innate immunity and inflammatory disease

Elphick, D. A., & Mahida, Y. R. (2005) · Gut · doi:10.1136/gut.2005.068601 · Cited by 183 · see citing works

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

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Roles of the intestinal microbiota in pathogen protection

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Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

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Intestinal mucus and their glycans: A habitat for thriving microbiota

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Childhood Development and the Microbiome—The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development

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The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine

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Effects of Bacillus subtilis and Bacillus licheniformis on growth performance, immunity, short chain fatty acid production, antioxidant capacity, and cecal microflora in broilers

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Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

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Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals

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Impact of Microbial Metabolites on Microbiota–Gut–Brain Axis in Inflammatory Bowel Disease

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Structural diversity, functional aspects and future therapeutic applications of human gut microbiome

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A review of heat stress in chickens. Part I: Insights into physiology and gut health

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Role of Microbiota-Derived Extracellular Vesicles in Gut-Brain Communication

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Gut Microbiota Changes and Their Correlation with Cognitive and Neuropsychiatric Symptoms in Alzheimer’s Disease

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Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis─A Potential Therapeutic Intervention to Improve Lung Health

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The Intestinal Microbiota: Impacts of Antibiotics Therapy, Colonization Resistance, and Diseases

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Lactobacillus reuteri J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice

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Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update

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Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis

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